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Search results 601 to 700 out of 1199 for Ik

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Type Details Score
Publication
30599154 | J:285200
 
First Author: Minakaki G
Year: 2019
Journal: Behav Brain Res
Title: Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.
Volume: 363
Pages: 199-215
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27102485 | J:232473
First Author: Pillai PS
Year: 2016
Journal: Science
Title: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.
Volume: 352
Issue: 6284
Pages: 463-6
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Publication
20865787 | J:174159
First Author: Peckl-Schmid D
Year: 2010
Journal: Eur J Immunol
Title: HAX1 deficiency: impact on lymphopoiesis and B-cell development.
Volume: 40
Issue: 11
Pages: 3161-72
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Publication
30269989 | J:269360
First Author: Park MH
Year: 2018
Journal: Neuron
Title: Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Volume: 100
Issue: 1
Pages: 167-182.e9
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Publication
22343901 | J:182598
First Author: Lu C
Year: 2012
Journal: Nature
Title: IDH mutation impairs histone demethylation and results in a block to cell differentiation.
Volume: 483
Issue: 7390
Pages: 474-8
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Publication
25572173 | J:222467
First Author: Ran L
Year: 2015
Journal: Cancer Discov
Title: Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth.
Volume: 5
Issue: 3
Pages: 304-15
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Publication
30733438 | J:270214
First Author: Park MK
Year: 2019
Journal: Nat Commun
Title: PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression.
Volume: 10
Issue: 1
Pages: 636
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Publication
23982142 | J:203937
First Author: Ock S
Year: 2013
Journal: FASEB J
Title: IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter.
Volume: 27
Issue: 12
Pages: 4899-908
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Publication
28781602 | J:330156
 
First Author: Choi WG
Year: 2017
Journal: Nutr Metab (Lond)
Title: eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.
Volume: 14
Pages: 48
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Publication
21596854 | J:174877
First Author: Hanash AM
Year: 2011
Journal: Blood
Title: Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.
Volume: 118
Issue: 2
Pages: 446-55
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Publication
17571165 | J:124172
First Author: Choi CS
Year: 2007
Journal: J Clin Invest
Title: Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.
Volume: 117
Issue: 7
Pages: 1995-2003
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Publication
36434042 | J:332205
First Author: Lee B
Year: 2022
Journal: Exp Mol Med
Title: SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.
Volume: 54
Issue: 11
Pages: 2036-2046
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Publication
24526703 | J:248323
First Author: Eom GH
Year: 2014
Journal: Circ Res
Title: Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.
Volume: 114
Issue: 7
Pages: 1133-43
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Publication
30523025 | J:272940
First Author: Thoudam T
Year: 2019
Journal: Diabetes
Title: PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity.
Volume: 68
Issue: 3
Pages: 571-586
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Publication
27385159 | J:247017
First Author: Go Y
Year: 2016
Journal: Diabetes
Title: Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
Volume: 65
Issue: 10
Pages: 2876-87
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19737867 | J:153357
First Author: Penack O
Year: 2009
Journal: J Exp Med
Title: NOD2 regulates hematopoietic cell function during graft-versus-host disease.
Volume: 206
Issue: 10
Pages: 2101-10
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31835034 | J:358686
First Author: Villette V
Year: 2019
Journal: Cell
Title: Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice.
Volume: 179
Issue: 7
Pages: 1590-1608.e23
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36693373 | J:337518
First Author: Elias LJ
Year: 2023
Journal: Cell
Title: Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity.
Volume: 186
Issue: 3
Pages: 577-590.e16
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27169360 | J:235771
 
First Author: Kriegbaum MC
Year: 2016
Journal: Sci Rep
Title: C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes.
Volume: 6
Pages: 25833
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33853949 | J:332456
 
First Author: Radhakrishnan K
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.
Volume: 118
Issue: 16
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27335120 | J:259639
First Author: Hennings JC
Year: 2017
Journal: J Am Soc Nephrol
Title: The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.
Volume: 28
Issue: 1
Pages: 209-217
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Publication
31551444 | J:284630
First Author: Sivertsen Ã…srud K
Year: 2019
Journal: Sci Rep
Title: Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.
Volume: 9
Issue: 1
Pages: 13789
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Publication
38088236 | J:346719
First Author: Kruglov AA
Year: 2024
Journal: Eur J Immunol
Title: Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses.
Volume: 54
Issue: 3
Pages: e2350664
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34552205 | J:331530
First Author: Kang HJ
Year: 2021
Journal: Exp Mol Med
Title: Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.
Volume: 53
Issue: 9
Pages: 1390-1401
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25009180 | J:212255
First Author: Takeo K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.
Volume: 111
Issue: 29
Pages: 10544-9
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Publication
26302406 | J:227348
First Author: Kourtidis A
Year: 2015
Journal: Nat Cell Biol
Title: Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Volume: 17
Issue: 9
Pages: 1145-57
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Publication
28893978 | J:252894
First Author: Cekanaviciute E
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.
Volume: 114
Issue: 40
Pages: 10713-10718
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Publication
29078297 | J:254309
First Author: Kang JK
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Increased intracellular Ca2+ concentrations prevent membrane localization of PH domains through the formation of Ca2+-phosphoinositides.
Volume: 114
Issue: 45
Pages: 11926-11931
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Publication
29149594 | J:251937
First Author: Brouwer JM
Year: 2017
Journal: Mol Cell
Title: Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Volume: 68
Issue: 4
Pages: 659-672.e9
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Publication
29230053 | J:258026
First Author: Gladwyn-Ng I
Year: 2018
Journal: Nat Neurosci
Title: Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly.
Volume: 21
Issue: 1
Pages: 63-71
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Publication
26350455 | J:282035
First Author: Heier C
Year: 2015
Journal: J Biol Chem
Title: G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.
Volume: 290
Issue: 43
Pages: 26141-50
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Publication
- | J:296700
     
First Author: Petras M
Year: 2020
Journal: bioRxiv
Title: Early immune response in mice immunized with a semi-split inactivated vaccine against SARS-CoV-2 containing S protein-free particles and subunit S protein.
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Publication
22556255 | J:317223
First Author: Sonkusare SK
Year: 2012
Journal: Science
Title: Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.
Volume: 336
Issue: 6081
Pages: 597-601
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Publication
12842084 | J:85026
First Author: Beverly LJ
Year: 2003
Journal: Cancer Cell
Title: Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis.
Volume: 3
Issue: 6
Pages: 551-64
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Publication
33914869 | J:305428
 
First Author: Mogollón I
Year: 2021
Journal: Development
Title: The initiation knot is a signaling center required for molar tooth development.
Volume: 148
Issue: 9
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Publication
36302750 | J:330725
First Author: Gross D
Year: 2022
Journal: Cell Death Dis
Title: IK(Ca) channels control breast cancer metabolism including AMPK-driven autophagy.
Volume: 13
Issue: 10
Pages: 902
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Publication
17237796 | -
First Author: Qiu X
Year: 2007
Journal: Nat Struct Mol Biol
Title: Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Volume: 14
Issue: 2
Pages: 106-13
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18669894 | J:140214
First Author: Caminschi I
Year: 2008
Journal: Blood
Title: The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.
Volume: 112
Issue: 8
Pages: 3264-73
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Publication
29276005 | -
First Author: Faundes V
Year: 2018
Journal: Am J Hum Genet
Title: Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.
Volume: 102
Issue: 1
Pages: 175-187
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Publication
30811418 | J:271856
First Author: Muise ES
Year: 2019
Journal: PLoS One
Title: Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.
Volume: 14
Issue: 2
Pages: e0211568
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Publication
26832969 | J:236289
 
First Author: Kwon DH
Year: 2016
Journal: Nat Commun
Title: MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification.
Volume: 7
Pages: 10492
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Publication
20622117 | J:162237
First Author: Lu SX
Year: 2010
Journal: J Immunol
Title: Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.
Volume: 185
Issue: 3
Pages: 1912-9
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Publication
23092893 | J:259536
First Author: Liu Y
Year: 2012
Journal: Sci Signal
Title: Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.
Volume: 5
Issue: 247
Pages: ra77
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Publication
32400277 | J:313050
First Author: Ko MS
Year: 2021
Journal: Autophagy
Title: Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.
Volume: 17
Issue: 5
Pages: 1205-1221
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Publication
20308550 | J:159321
First Author: Vivanco I
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Volume: 107
Issue: 14
Pages: 6459-64
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Publication
30381375 | J:268986
First Author: Tsai JJ
Year: 2018
Journal: Blood
Title: Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Volume: 132
Issue: 26
Pages: 2763-2774
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Publication
37828026 | J:341629
First Author: Blair LM
Year: 2023
Journal: Nat Commun
Title: Oncogenic context shapes the fitness landscape of tumor suppression.
Volume: 14
Issue: 1
Pages: 6422
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Publication
32193290 | J:289110
First Author: Starrett JH
Year: 2020
Journal: Cancer Res
Title: Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations.
Volume: 80
Issue: 10
Pages: 2017-2030
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Publication
21035759 | J:167909
First Author: Misu H
Year: 2010
Journal: Cell Metab
Title: A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Volume: 12
Issue: 5
Pages: 483-95
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Publication
25015078 | J:246235
First Author: Nam YS
Year: 2014
Journal: Circ Res
Title: Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling.
Volume: 115
Issue: 5
Pages: 493-503
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Publication
21760897 | J:175532
First Author: Lu SX
Year: 2011
Journal: PLoS One
Title: Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation.
Volume: 6
Issue: 7
Pages: e21611
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Publication
31134063 | J:296474
 
First Author: Min BK
Year: 2019
Journal: Front Immunol
Title: Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Volume: 10
Pages: 944
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Publication
37155882 | J:342409
First Author: Chanda D
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Volume: 120
Issue: 20
Pages: e2219644120
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Publication
36049655 | J:350001
First Author: He Y
Year: 2022
Journal: J Thorac Oncol
Title: A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.
Volume: 17
Issue: 12
Pages: 1375-1386
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28052262 | J:251257
First Author: Olsen MB
Year: 2017
Journal: Cell Rep
Title: NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Volume: 18
Issue: 1
Pages: 82-92
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Publication
34914943 | J:344683
First Author: Andersen MK
Year: 2022
Journal: Gastroenterology
Title: Loss of Sucrase-Isomaltase Function Increases Acetate Levels and Improves Metabolic Health in Greenlandic Cohorts.
Volume: 162
Issue: 4
Pages: 1171-1182.e3
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24440720 | J:208791
First Author: Chudnovsky Y
Year: 2014
Journal: Cell Rep
Title: ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.
Volume: 6
Issue: 2
Pages: 313-24
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Publication
23558169 | J:198193
First Author: Rohle D
Year: 2013
Journal: Science
Title: An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Volume: 340
Issue: 6132
Pages: 626-30
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23733752 | J:199472
First Author: Ghosh A
Year: 2013
Journal: Cancer Res
Title: PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD.
Volume: 73
Issue: 15
Pages: 4687-96
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33589425 | J:307163
     
First Author: Pitarresi JR
Year: 2021
Journal: Cancer Discov
Title: PTHrP drives pancreatic cancer growth and metastasis and reveals a new therapeutic vulnerability.
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36973273 | J:340981
First Author: Thoudam T
Year: 2023
Journal: Nat Commun
Title: Enhanced Ca(2+)-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease.
Volume: 14
Issue: 1
Pages: 1703
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Publication
28855339 | -
First Author: Zhang Z
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.
Volume: 114
Issue: 38
Pages: E7949-E7958
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Publication
27893462 | J:239741
First Author: Mace EM
Year: 2017
Journal: J Clin Invest
Title: Biallelic mutations in IRF8 impair human NK cell maturation and function.
Volume: 127
Issue: 1
Pages: 306-320
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Publication
38718791 | J:348844
First Author: Gallage S
Year: 2024
Journal: Cell Metab
Title: A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Volume: 36
Issue: 6
Pages: 1371-1393.e7
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27108798 | J:231957
First Author: McEntagart M
Year: 2016
Journal: Am J Hum Genet
Title: A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect.
Volume: 98
Issue: 5
Pages: 981-992
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23382691 | J:322676
First Author: Lauc G
Year: 2013
Journal: PLoS Genet
Title: Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Volume: 9
Issue: 1
Pages: e1003225
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Publication
35461826 | J:325294
First Author: Choi J
Year: 2022
Journal: Gastroenterology
Title: Estrogen-Related Receptor γ Maintains Pancreatic Acinar Cell Function and Identity by Regulating Cellular Metabolism.
Volume: 163
Issue: 1
Pages: 239-256
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Publication
35378329 | J:325407
 
First Author: Wolff G
Year: 2022
Journal: Mol Metab
Title: Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
Volume: 60
Pages: 101487
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Publication
22581285 | J:187460
First Author: Bierhaus A
Year: 2012
Journal: Nat Med
Title: Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Volume: 18
Issue: 6
Pages: 926-33
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32198206 | J:290058
First Author: Polina I
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes.
Volume: 117
Issue: 14
Pages: 7990-8000
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17504264 | J:125053
First Author: Agoston DV
Year: 2007
Journal: J Neurochem
Title: Ikaros is expressed in developing striatal neurons and involved in enkephalinergic differentiation.
Volume: 102
Issue: 6
Pages: 1805-16
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18313668 | J:136568
First Author: Kiehl TR
Year: 2008
Journal: Exp Neurol
Title: Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotype.
Volume: 211
Issue: 1
Pages: 107-14
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18456412 | J:139407
First Author: Chen L
Year: 2008
Journal: Neuroscience
Title: The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons.
Volume: 154
Issue: 2
Pages: 482-95
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23889563 | J:321454
First Author: Zhang L
Year: 2013
Journal: Br J Pharmacol
Title: Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease.
Volume: 170
Issue: 3
Pages: 661-70
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35229718 | J:327479
   
First Author: MacKay CE
Year: 2022
Journal: Elife
Title: A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.
Volume: 11
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15790496 | J:97087
First Author: Kakinuma S
Year: 2005
Journal: Mutat Res
Title: Frequent retention of heterozygosity for point mutations in p53 and Ikaros in N-ethyl-N-nitrosourea-induced mouse thymic lymphomas.
Volume: 572
Issue: 1-2
Pages: 132-41
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23732910 | J:204570
First Author: Bottardi S
Year: 2013
Journal: Mol Cell Biol
Title: Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cells.
Volume: 33
Issue: 16
Pages: 3064-76
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25730764 | J:265639
First Author: Crowley JJ
Year: 2015
Journal: Nat Genet
Title: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.
Volume: 47
Issue: 4
Pages: 353-60
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Publication
35355021 | J:330907
First Author: Bapat SP
Year: 2022
Journal: Nature
Title: Obesity alters pathology and treatment response in inflammatory disease.
Volume: 604
Issue: 7905
Pages: 337-342
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Publication
28613412 | J:346516
 
First Author: Brasen JC
Year: 2018
Journal: Acta Physiol (Oxf)
Title: Myoendothelial coupling through Cx40 contributes to EDH-induced vasodilation in murine renal arteries: evidence from experiments and modelling.
Volume: 222
Issue: 1
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15347667 | J:94478
First Author: Begenisich T
Year: 2004
Journal: J Biol Chem
Title: Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.
Volume: 279
Issue: 46
Pages: 47681-7
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Publication
28472061 | J:245516
First Author: Caudle RM
Year: 2017
Journal: PLoS One
Title: Sex differences in mouse Transient Receptor Potential Cation Channel, Subfamily M, Member 8 expressing trigeminal ganglion neurons.
Volume: 12
Issue: 5
Pages: e0176753
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Publication
30369314 | J:316390
First Author: Wang Q
Year: 2018
Journal: J Am Heart Assoc
Title: Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy.
Volume: 7
Issue: 16
Pages: e008842
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26840527 | J:256657
First Author: Sonkusare SK
Year: 2016
Journal: J Physiol
Title: Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.
Volume: 594
Issue: 12
Pages: 3271-85
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Publication
30773277 | J:277682
First Author: Burrage LC
Year: 2019
Journal: Am J Hum Genet
Title: Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.
Volume: 104
Issue: 3
Pages: 422-438
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Publication
37562402 | J:339343
First Author: Kolabas ZI
Year: 2023
Journal: Cell
Title: Distinct molecular profiles of skull bone marrow in health and neurological disorders.
Volume: 186
Issue: 17
Pages: 3706-3725.e29
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Protein
A0A1W2P8A0
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
V9GX03
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
Q8BPU9
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
A0A140LHN2
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
A0A1W2P808
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Protein Domain
IPR028325 | VG_K_chnl
Type: Family
Description: Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.This entry represents the the voltage-gated Kv channel and the KCNQ channel. KCNQ channels differ from other voltage-gated 6 TM helix channels, chiefly in that they possess no tetramerisation domain.
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Protein
Q4L139
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: true
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Protein
Q9JK97
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
P97414
Organism: Mus musculus/domesticus
Length: 668  
Fragment?: false
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Protein
Q9Z351
Organism: Mus musculus/domesticus
Length: 759  
Fragment?: false
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Protein
B7ZBV7
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
Q3UWF6
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: true
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Protein
B7ZBV5
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q99NF6
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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