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Search results 601 to 677 out of 677 for Ikbkb

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Hits by Strain

Type Details Score
Protein Domain
IPR046375 | IKBKB_SDD_sf
Type: Homologous_superfamily
Description: This superfamily represents the C-terminal scaffold dimerization domain (SDD) found in inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) []. IKBKB is one of the core component of IKB kinases (IKK), which is an enzyme that quickly becomes active in response to diverse stresses. The SDD consists primarily of two long α-helices []. This domain can also be found in inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKA).
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Allele
Ikbkb<tm1Ver> | MGI:2386269
Name: inhibitor of kappaB kinase beta; targeted mutation 1, Inder M Verma
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3773070 | B6.Cg-Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/J
Attribute String: congenic, targeted mutation, mutant strain
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Allele
Tg(KRT5-IKBKB)1Armz | MGI:4456367
Name: transgene insertion 1, Angel Ramirez
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(KRT5-IKBKB)2Armz | MGI:4456368
Name: transgene insertion 2, Angel Ramirez
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Ikbkb/Ikbkb
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Protein
A0AUV3
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Publication
29748387 | -
First Author: Tang Q
Year: 2018
Journal: J Biol Chem
Title: Mechanism of vaccinia viral protein B14-mediated inhibition of IκB kinase β activation.
Volume: 293
Issue: 26
Pages: 10344-10352
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Publication
30425986 | J:290021
 
First Author: Nakagawa MM
Year: 2018
Journal: Front Cell Dev Biol
Title: Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks.
Volume: 6
Pages: 143
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Publication
38848366 | J:352742
First Author: Burt KG
Year: 2024
Journal: Sci Adv
Title: Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration.
Volume: 10
Issue: 23
Pages: eadj3194
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Publication
26896735 | J:335357
First Author: Tétreault MP
Year: 2016
Journal: Gastroenterology
Title: Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis.
Volume: 150
Issue: 7
Pages: 1609-1619.e11
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Strain
MGI:5708159 | B6D2-Tg(KRT5-IKBKB)1Armz/Cnbc
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Cd19/Cd19<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(KRT5-IKBKB)1Armz/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(KRT5-IKBKB)2Armz/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ighg1/Ighg1<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Twist2/Twist2<+>
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
34585163 | J:352702
First Author: Tichy ED
Year: 2021
Journal: STAR Protoc
Title: Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections.
Volume: 2
Issue: 4
Pages: 100830
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Publication
27043411 | J:259593
First Author: Xing Y
Year: 2016
Journal: Nat Immunol
Title: Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.
Volume: 17
Issue: 5
Pages: 565-73
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Publication
26502405 | J:234056
First Author: Finkin S
Year: 2015
Journal: Nat Immunol
Title: Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Volume: 16
Issue: 12
Pages: 1235-44
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Publication
21708930 | J:176805
First Author: Kometani K
Year: 2011
Journal: J Exp Med
Title: CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway.
Volume: 208
Issue: 7
Pages: 1447-57
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Publication
32661025 | J:294220
First Author: Lei Z
Year: 2020
Journal: J Neurosci
Title: NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE.
Volume: 40
Issue: 33
Pages: 6444-6456
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Publication
38727309 | J:348358
 
First Author: Mussbacher M
Year: 2024
Journal: Cells
Title: Effects of Chronic Inflammatory Activation of Murine and Human Arterial Endothelial Cells at Normal Lipoprotein and Cholesterol Levels In Vivo and In Vitro.
Volume: 13
Issue: 9
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Genotype
Genotype
Symbol: Ikbkb/Ikbkb Tnfrsf1a/Tnfrsf1a
Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chuk/Chuk Ikbkb/Ikbkb
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chuk/Chuk Ikbkb/Ikbkb Tnfrsf1a/Tnfrsf1a
Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd19/Cd19<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tnfrsf13c/Tnfrsf13c
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sh3kbp1/Sh3kbp1 Cd79a/Cd79a<+> Gt(ROSA)26Sor/?
Background: involves: BALB/c * C57BL/6 * NZB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ighg1/Ighg1<+> Prdm1/Prdm1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Tagln-cre)1Her/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
33979621 | J:317321
First Author: Tichy ED
Year: 2021
Journal: Cell Rep
Title: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.
Volume: 35
Issue: 6
Pages: 109098
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Publication
36653597 | J:334555
First Author: Koerner L
Year: 2023
Journal: Cell Death Differ
Title: NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer.
Volume: 30
Issue: 4
Pages: 938-951
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Publication
31900382 | J:339468
First Author: Page A
Year: 2020
Journal: Int J Oral Sci
Title: IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.
Volume: 12
Issue: 1
Pages: 1
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Publication
25600109 | J:359422
First Author: Lin LC
Year: 2015
Journal: Mol Psychiatry
Title: Somatostatin, neuronal vulnerability and behavioral emotionality.
Volume: 20
Issue: 3
Pages: 377-87
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Publication
30975638 | J:276377
First Author: Pascual M
Year: 2019
Journal: Blood
Title: PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas.
Volume: 133
Issue: 22
Pages: 2401-2412
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Publication
37730678 | J:340766
First Author: Botta C
Year: 2023
Journal: Nat Commun
Title: Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance.
Volume: 14
Issue: 1
Pages: 5825
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Publication
16782029 | J:113365
First Author: Sasaki Y
Year: 2006
Journal: Immunity
Title: Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.
Volume: 24
Issue: 6
Pages: 729-39
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Publication
27451974 | J:236862
First Author: Jin HY
Year: 2016
Journal: Leukemia
Title: Concurrent PI3K and NF-κB activation drives B-cell lymphomagenesis.
Volume: 30
Issue: 11
Pages: 2267-2270
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Publication
25923440 | J:220371
First Author: Xu Y
Year: 2015
Journal: PLoS One
Title: Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Volume: 10
Issue: 4
Pages: e0125211
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Publication
22984075 | J:190654
First Author: Fuller DM
Year: 2012
Journal: J Immunol
Title: The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
Volume: 189
Issue: 8
Pages: 4005-13
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Publication
21821676 | J:205219
First Author: Page A
Year: 2011
Journal: Mol Cancer Res
Title: IKKβ overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia.
Volume: 9
Issue: 10
Pages: 1329-38
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Publication
37069623 | J:335722
First Author: Schlett JS
Year: 2023
Journal: Mol Neurodegener
Title: NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss.
Volume: 18
Issue: 1
Pages: 24
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Publication
32151223 | J:331521
First Author: Jiang Y
Year: 2021
Journal: J Cereb Blood Flow Metab
Title: Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease.
Volume: 41
Issue: 2
Pages: 219-235
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Publication
33139957 | J:350396
First Author: Shan B
Year: 2020
Journal: Nat Metab
Title: Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity.
Volume: 2
Issue: 11
Pages: 1332-1349
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Publication
36853944 | J:340316
First Author: Winkler W
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Mouse models of human multiple myeloma subgroups.
Volume: 120
Issue: 10
Pages: e2219439120
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Publication
32647171 | J:292290
First Author: Arra M
Year: 2020
Journal: Nat Commun
Title: LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.
Volume: 11
Issue: 1
Pages: 3427
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Publication
28923684 | J:252121
First Author: McCoy AM
Year: 2017
Journal: Am J Pathol
Title: IKKβ Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
Volume: 187
Issue: 12
Pages: 2635-2644
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Publication
34807912 | J:350938
First Author: Shen Y
Year: 2021
Journal: PLoS Genet
Title: NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.
Volume: 17
Issue: 11
Pages: e1009933
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Igh-J/? Igh/? Tg(Cr2-cre)3Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
21775687 | J:179149
First Author: Shen S
Year: 2011
Journal: J Immunol
Title: Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.
Volume: 187
Issue: 5
Pages: 2122-9
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Publication
30463008 | J:270706
First Author: Nakagawa MM
Year: 2018
Journal: Cell Rep
Title: Constitutive Activation of the Canonical NF-κB Pathway Leads to Bone Marrow Failure and Induction of Erythroid Signature in Hematopoietic Stem Cells.
Volume: 25
Issue: 8
Pages: 2094-2109.e4
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Publication
28687790 | J:253714
First Author: Wang C
Year: 2017
Journal: Sci Rep
Title: Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.
Volume: 7
Issue: 1
Pages: 4880
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Publication
21411734 | J:172516
First Author: Molinero LL
Year: 2011
Journal: J Immunol
Title: High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Volume: 186
Issue: 8
Pages: 4609-17
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Protein
Q5D0E0
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
A0A0R4J0T4
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
Q05DR8
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: true
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Protein
Q60680
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
Q3TPN9
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q3UDK0
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: true
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Protein
Q8CBT3
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
Q3U2E5
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
E9QNL4
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
E9Q605
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q3U2A3
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Publication
26555174 | J:226752
First Author: Kondylis V
Year: 2015
Journal: Cancer Cell
Title: NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
Volume: 28
Issue: 5
Pages: 582-598
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Publication
38906984 | J:350176
First Author: Jong Huat T
Year: 2024
Journal: Sci Rep
Title: The impact of astrocytic NF-κB on healthy and Alzheimer's disease brains.
Volume: 14
Issue: 1
Pages: 14305
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Publication
24799710 | J:211053
First Author: Miller ML
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.
Volume: 111
Issue: 20
Pages: 7397-402
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Publication
38051594 | J:349513
 
First Author: Xiao D
Year: 2023
Journal: J Clin Invest
Title: DNA methylation-mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation.
Volume: 134
Issue: 3
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Publication
26231118 | J:254637
First Author: Wang S
Year: 2015
Journal: Immunity
Title: MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism.
Volume: 43
Issue: 2
Pages: 289-303
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Publication
25132550 | J:217312
First Author: Dannappel M
Year: 2014
Journal: Nature
Title: RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
Volume: 513
Issue: 7516
Pages: 90-4
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Publication
23665120 | J:198485
First Author: Myant KB
Year: 2013
Journal: Cell Stem Cell
Title: ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
Volume: 12
Issue: 6
Pages: 761-73
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Publication
19879843 | J:157297
First Author: Srinivasan L
Year: 2009
Journal: Cell
Title: PI3 kinase signals BCR-dependent mature B cell survival.
Volume: 139
Issue: 3
Pages: 573-86
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Publication
31138793 | J:278509
First Author: Rosenbaum M
Year: 2019
Journal: Nat Commun
Title: Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Volume: 10
Issue: 1
Pages: 2352
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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