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Search results 601 to 700 out of 1482 for Itgam

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Type Details Score
Publication
21248714 | J:186875
First Author: Ferenbach DA
Year: 2011
Journal: Kidney Int
Title: The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice.
Volume: 79
Issue: 9
Pages: 966-76
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Publication
21273560 | J:184165
First Author: Withers SB
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat.
Volume: 31
Issue: 4
Pages: 908-13
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Publication
29375297 | J:310533
 
First Author: Brown LN
Year: 2017
Journal: Front Mol Neurosci
Title: Macrophage-Mediated Glial Cell Elimination in the Postnatal Mouse Cochlea.
Volume: 10
Pages: 407
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Publication
15699170 | J:132846
First Author: Cailhier JF
Year: 2005
Journal: J Immunol
Title: Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation.
Volume: 174
Issue: 4
Pages: 2336-42
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Publication
22689949 | J:185594
First Author: Zhang W
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.
Volume: 109
Issue: 26
Pages: 10388-93
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Publication
30011025 | J:265901
First Author: Nagatake T
Year: 2018
Journal: Int Immunol
Title: Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice.
Volume: 30
Issue: 10
Pages: 471-481
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Publication
24173355 | J:205044
First Author: You H
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Macrophages directly mediate diabetic renal injury.
Volume: 305
Issue: 12
Pages: F1719-27
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Publication
16357332 | J:128684
First Author: Cailhier JF
Year: 2006
Journal: Am J Respir Crit Care Med
Title: Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation.
Volume: 173
Issue: 5
Pages: 540-7
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Publication
21814168 | J:194716
First Author: Guo S
Year: 2011
Journal: Kidney Int
Title: Macrophages are essential contributors to kidney injury in murine cryoglobulinemic membranoproliferative glomerulonephritis.
Volume: 80
Issue: 9
Pages: 946-58
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Publication
16251406 | J:102404
First Author: Duffield JS
Year: 2005
Journal: Am J Pathol
Title: Conditional ablation of macrophages halts progression of crescentic glomerulonephritis.
Volume: 167
Issue: 5
Pages: 1207-19
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Allele
Tg(ITGAM-TK)620Zbz | MGI:4839616
Name: transgene insertion 620, Universitatsspital Zurich, Biologisches Zentrallaboratorium
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5811402 | B6.Cg-Tg(ITGAM-TK)620Zbz/Cnrm
Attribute String: congenic, mutant strain, transgenic
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Publication
15665833 | J:96037
First Author: Heppner FL
Year: 2005
Journal: Nat Med
Title: Experimental autoimmune encephalomyelitis repressed by microglial paralysis.
Volume: 11
Issue: 2
Pages: 146-52
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Publication
29634489 | J:265437
First Author: Kälin S
Year: 2018
Journal: J Clin Invest
Title: CNS myeloid cells critically regulate heat hyperalgesia.
Volume: 128
Issue: 7
Pages: 2774-2786
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Allele
Tg(ITGAM-PLA2G2A)1Winth | MGI:5648230
Name: transgene insertion 1, Menno de Winther
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5756058 | STOCK Tg(ITGAM-PLA2G2A)1Winth/Cnrm
Attribute String: transgenic, mutant stock
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Publication
10839814 | J:120534
First Author: Launay P
Year: 2000
Journal: J Exp Med
Title: Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice.
Volume: 191
Issue: 11
Pages: 1999-2009
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Genotype
Genotype
Symbol: Tg(ITGAM-HBEGF/EGFP)34Lan/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ITGAM-HBEGF/EGFP)34Lan/?
Background: NOD.FVB-Tg(ITGAM-HBEGF/EGFP)34Lan/Jdk
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ctsk/Ctsk Tg(Itgam-cre)AJva/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Itgam-FCAR)83Rcmo/?
Background: involves: C57BL/6 * NOD
Zygosity: ot
Has Mutant Allele: true
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Publication
23959857 | J:202607
First Author: Arendt LM
Year: 2013
Journal: Cancer Res
Title: Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.
Volume: 73
Issue: 19
Pages: 6080-93
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Publication
24606124 | J:213062
First Author: Soung do Y
Year: 2014
Journal: Mol Endocrinol
Title: Runx1-mediated regulation of osteoclast differentiation and function.
Volume: 28
Issue: 4
Pages: 546-53
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Publication
33416832 | J:307806
 
First Author: Deuse T
Year: 2021
Journal: J Exp Med
Title: The SIRPα-CD47 immune checkpoint in NK cells.
Volume: 218
Issue: 3
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Publication
25066922 | J:320010
First Author: Ji H
Year: 2014
Journal: Hepatology
Title: T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury.
Volume: 60
Issue: 6
Pages: 2052-2064
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Publication
27480204 | J:254085
 
First Author: Fukasawa K
Year: 2016
Journal: Sci Rep
Title: ATF3 controls proliferation of osteoclast precursor and bone remodeling.
Volume: 6
Pages: 30918
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Allele
Tg(Itgax-cre)1-1Reiz | MGI:3763248
Name: transgene insertion 1-1, Boris Reizis
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
26378024 | J:291741
First Author: Chang J
Year: 2015
Journal: Oncotarget
Title: Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.
Volume: 6
Issue: 32
Pages: 33500-11
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Publication
30202063 | J:267587
First Author: Malecova B
Year: 2018
Journal: Nat Commun
Title: Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy.
Volume: 9
Issue: 1
Pages: 3670
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Publication
30385721 | J:287895
 
First Author: Chung S
Year: 2018
Journal: JCI Insight
Title: TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration.
Volume: 3
Issue: 21
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Publication
27520357 | J:235601
First Author: Truong LD
Year: 2016
Journal: Am J Pathol
Title: Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury.
Volume: 186
Issue: 10
Pages: 2601-13
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Publication
25909889 | J:258691
First Author: Yuan X
Year: 2015
Journal: Cell Death Differ
Title: Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss.
Volume: 22
Issue: 12
Pages: 2046-57
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Publication
18202187 | J:131371
First Author: Henderson NC
Year: 2008
Journal: Am J Pathol
Title: Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.
Volume: 172
Issue: 2
Pages: 288-98
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Publication
30674531 | J:274209
First Author: Vuong L
Year: 2019
Journal: Cancer Res
Title: An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.
Volume: 79
Issue: 7
Pages: 1480-1492
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Publication
34318714 | J:310432
First Author: Rochford I
Year: 2021
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
Volume: 321
Issue: 4
Pages: L686-L702
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Publication
20837697 | J:165808
First Author: Kranich J
Year: 2010
Journal: J Exp Med
Title: Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner.
Volume: 207
Issue: 10
Pages: 2271-81
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Publication
25497089 | J:222659
First Author: Valdearcos M
Year: 2014
Journal: Cell Rep
Title: Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.
Volume: 9
Issue: 6
Pages: 2124-38
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Publication
30944158 | J:274910
First Author: Eldredge LC
Year: 2019
Journal: J Immunol
Title: Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ.
Volume: 202
Issue: 9
Pages: 2772-2781
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Publication
19059913 | J:147602
First Author: Sugatani T
Year: 2009
Journal: J Biol Chem
Title: Impaired micro-RNA pathways diminish osteoclast differentiation and function.
Volume: 284
Issue: 7
Pages: 4667-78
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Publication
31018807 | J:289714
First Author: Li P
Year: 2019
Journal: Innate Immun
Title: Regulation of dendritic cell function improves survival in experimental sepsis through immune chaperone.
Volume: 25
Issue: 4
Pages: 235-243
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Strain
MGI:3763375 | B6.Cg-Tg(Itgax-cre)1-1Reiz/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5502319 | NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5501034 | B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
Attribute String: congenic, mutant strain, transgenic
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Publication
26561586 | J:228057
First Author: Katakam AK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.
Volume: 112
Issue: 47
Pages: 14664-9
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Publication
22102809 | J:311503
First Author: Gaspar M
Year: 2011
Journal: PLoS Pathog
Title: Murid herpesvirus-4 exploits dendritic cells to infect B cells.
Volume: 7
Issue: 11
Pages: e1002346
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Publication
33853474 | J:323628
First Author: Wang LT
Year: 2021
Journal: Autophagy
Title: WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Volume: 17
Issue: 12
Pages: 4202-4217
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Publication
31604965 | J:285291
First Author: Aarts S
Year: 2019
Journal: Sci Rep
Title: Depletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH.
Volume: 9
Issue: 1
Pages: 14702
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Publication
29668708 | J:262049
First Author: Kaisar MMM
Year: 2018
Journal: PLoS Biol
Title: Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.
Volume: 16
Issue: 4
Pages: e2005504
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Publication
25816748 | J:222427
First Author: Zhu C
Year: 2015
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.
Volume: 36
Issue: 5
Pages: 1994-2003
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Publication
38536935 | J:347021
First Author: Gleeson PJ
Year: 2024
Journal: Sci Transl Med
Title: The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis.
Volume: 16
Issue: 740
Pages: eadl6149
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Publication
23071306 | J:190695
First Author: Varvel NH
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
Volume: 109
Issue: 44
Pages: 18150-5
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Publication
18250479 | J:131970
First Author: Kanamaru Y
Year: 2008
Journal: J Immunol
Title: Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation.
Volume: 180
Issue: 4
Pages: 2669-78
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Publication
34712223 | J:347022
 
First Author: Lauriero G
Year: 2021
Journal: Front Immunol
Title: Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy.
Volume: 12
Pages: 694787
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Publication
30995475 | J:284423
First Author: de Tymowski C
Year: 2019
Journal: Cell Rep
Title: CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis.
Volume: 27
Issue: 3
Pages: 762-775.e5
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Publication
17393381 | J:120833
First Author: Kanamaru Y
Year: 2007
Journal: Eur J Immunol
Title: Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor.
Volume: 37
Issue: 4
Pages: 1116-28
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Genotype
Genotype
Symbol: Runx3/Runx3 Tg(Itgax-cre)1-1Reiz/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Itgax-cre)1-1Reiz/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Publication
10766246 | -
First Author: Bianchi E
Year: 2000
Journal: Nature
Title: Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.
Volume: 404
Issue: 6778
Pages: 617-21
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Publication
11812992 | -
First Author: Ostermann G
Year: 2002
Journal: Nat Immunol
Title: JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.
Volume: 3
Issue: 2
Pages: 151-8
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Publication
12130787 | -
First Author: Lu TT
Year: 2002
Journal: Science
Title: Integrin-mediated long-term B cell retention in the splenic marginal zone.
Volume: 297
Issue: 5580
Pages: 409-12
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Protein Domain
IPR015439 | Integrin_bsu-2
Type: Family
Description: Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. An integrin receptor is a heterodimer composed of alpha and beta subunits. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.Integrin Beta-2 is also referred to as ITGB2 and is known to interact with three different alpha integrin chains: ITGAL, ITGAM and ITGAX. These three integrin heterodimers are associated with leukocyte adhesion deficiency (LAD), which is characterised by recurrent bacterial infections. LFA-1 (ITGB2/ITGAL) is one of the most well studied of these integrins. Engagement of LFA-1 results in increased AP-1 dependent gene expression, which is mediated by the nuclear translocation of JAB1 []. The ligand for LFA-1 is JAM-1, a member of the endothelial immunoglobulin superfamily. JAM-1 contributes to LFA-1 dependent transendothelial migration of leukocytes and LFA-1 mediated arrest of T cells []. Studies of marginal zone (MZ) B cells also showed that LFA-1, together with alpha4beta1, is required for localisation of those cells in the splenic MZ and that these integrins are necessary for lymphoid tissue compartmentalization [].
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Publication
31626629 | J:280963
First Author: Madaro L
Year: 2019
Journal: PLoS Genet
Title: Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
Volume: 15
Issue: 10
Pages: e1008408
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Publication
19668347 | J:152473
First Author: Qian B
Year: 2009
Journal: PLoS One
Title: A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth.
Volume: 4
Issue: 8
Pages: e6562
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Publication
15576846 | J:136941
First Author: Ghesquiere SA
Year: 2005
Journal: J Lipid Res
Title: Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.
Volume: 46
Issue: 2
Pages: 201-10
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Publication
36038291 | J:337134
First Author: Chrisikos TT
Year: 2022
Journal: J Immunol
Title: STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells.
Volume: 209
Issue: 7
Pages: 1286-1299
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Publication
24845831 | J:274128
 
First Author: Rahman M
Year: 2014
Journal: Nat Commun
Title: The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.
Volume: 5
Pages: 3944
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Publication
26485285 | J:227478
First Author: Zhang MZ
Year: 2015
Journal: J Clin Invest
Title: Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension.
Volume: 125
Issue: 11
Pages: 4281-94
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Publication
27815317 | J:246554
First Author: Wang X
Year: 2017
Journal: Diabetes
Title: Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy.
Volume: 66
Issue: 2
Pages: 494-504
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Publication
36367776 | J:335587
 
First Author: Zhou Y
Year: 2023
Journal: J Exp Med
Title: Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration.
Volume: 220
Issue: 2
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Publication
31947933 | J:337195
 
First Author: Chrisikos TT
Year: 2020
Journal: Cancers (Basel)
Title: STAT3 Inhibits CD103(+) cDC1 Vaccine Efficacy in Murine Breast Cancer.
Volume: 12
Issue: 1
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Publication
20124100 | J:159650
First Author: Melillo JA
Year: 2010
Journal: J Immunol
Title: Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function.
Volume: 184
Issue: 5
Pages: 2638-45
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Publication
34215755 | J:308438
First Author: Liu B
Year: 2021
Journal: Nat Commun
Title: The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Volume: 12
Issue: 1
Pages: 4105
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Publication
36422999 | J:339850
 
First Author: Zhang H
Year: 2023
Journal: JCI Insight
Title: Gsk3β regulates the resolution of liver ischemia/reperfusion injury via MerTK.
Volume: 8
Issue: 1
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Publication
32245889 | J:291826
First Author: Schonfeld M
Year: 2020
Journal: J Biol Chem
Title: The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma.
Volume: 295
Issue: 20
Pages: 7126-7137
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Publication
26512111 | J:227472
First Author: Celhar T
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: RNA sensing by conventional dendritic cells is central to the development of lupus nephritis.
Volume: 112
Issue: 45
Pages: E6195-204
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Publication
27466430 | J:236008
First Author: Lawler C
Year: 2016
Journal: J Virol
Title: Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection.
Volume: 90
Issue: 20
Pages: 9046-57
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Publication
32910932 | J:311040
First Author: Woo YD
Year: 2021
Journal: J Allergy Clin Immunol
Title: Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling.
Volume: 147
Issue: 4
Pages: 1242-1260
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Publication
35997026 | J:338122
First Author: Yaku A
Year: 2022
Journal: Circulation
Title: Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.
Volume: 146
Issue: 13
Pages: 1006-1022
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Publication
37078793 | J:336555
First Author: Scortegagna M
Year: 2023
Journal: Cancer Res
Title: Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.
Volume: 83
Issue: 12
Pages: 2016-2033
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Publication
31586035 | J:280940
First Author: Ma W
Year: 2019
Journal: J Immunol
Title: The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis.
Volume: 203
Issue: 10
Pages: 2689-2700
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Publication
22685599 | J:187843
First Author: Otero JE
Year: 2012
Journal: PLoS One
Title: Constitutively active canonical NF-κB pathway induces severe bone loss in mice.
Volume: 7
Issue: 6
Pages: e38694
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Publication
28446459 | J:272786
First Author: Morris SM Jr
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Distinct roles of arginases 1 and 2 in diabetic nephropathy.
Volume: 313
Issue: 4
Pages: F899-F905
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Publication
29854847 | J:313224
 
First Author: Ohl K
Year: 2018
Journal: J Immunol Res
Title: CD11c-Specific Deletion Reveals CREB as a Critical Regulator of DC Function during the Germinal Center Response.
Volume: 2018
Pages: 8947230
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Publication
31987897 | J:287733
 
First Author: Porsche CE
Year: 2020
Journal: Mol Cell Endocrinol
Title: Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.
Volume: 505
Pages: 110740
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Publication
22610069 | J:191359
First Author: Lehmann SM
Year: 2012
Journal: Nat Neurosci
Title: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Volume: 15
Issue: 6
Pages: 827-35
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