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Search results 601 to 700 out of 2139 for Lck

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:6145093 | C57BL/6-Tg(Lck-Cdkn2a)2Mtkn/MtknRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Genotype
Genotype
Symbol: Igbp1/? Tg(Lck-cre)1Cwi/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igbp1/Igbp1<+> Tg(Lck-cre)1Cwi/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-CrmA)1Hed/?
Background: involves: BALB/c * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-CrmA)1Hed/?
Background: involves: BALB/c * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-CrmA)1Hed/Tg(Lck-CrmA)1Hed
Background: involves: BALB/c * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LckNotch1)9Erob/?
Background: involves: C57BL/6 * CBA/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-Bcl2l1)1Cant/?
Background: B6.Cg-Tg(Lck-Bcl2l1)1Cant
Zygosity: ot
Has Mutant Allele: true
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Publication
11359801 | J:69487
First Author: Ohteki T
Year: 2001
Journal: J Immunol
Title: Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice.
Volume: 166
Issue: 11
Pages: 6509-13
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Publication
31108170 | J:294439
 
First Author: Rudak PT
Year: 2019
Journal: Brain Behav Immun
Title: Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes.
Volume: 80
Pages: 793-804
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Publication
17433077 | J:125537
First Author: Stephensen CB
Year: 2007
Journal: Immunology
Title: Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance.
Volume: 121
Issue: 4
Pages: 484-98
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Publication
25677619 | J:220491
First Author: Kosaka A
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity.
Volume: 458
Issue: 3
Pages: 549-54
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Publication
18802005 | J:142743
First Author: Kometani K
Year: 2008
Journal: Blood
Title: Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development.
Volume: 112
Issue: 12
Pages: 4565-73
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Publication
29654322 | J:262624
First Author: Murera D
Year: 2018
Journal: Sci Rep
Title: CD4 T cell autophagy is integral to memory maintenance.
Volume: 8
Issue: 1
Pages: 5951
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Publication
8062594 | J:20495
First Author: Volpi EV
Year: 1994
Journal: Cytogenet Cell Genet
Title: Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-->p34.3 and its position relative to the 1p marker D1S57.
Volume: 67
Issue: 3
Pages: 187-9
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Publication
17878361 | J:152346
First Author: Filby A
Year: 2007
Journal: J Immunol
Title: Fyn regulates the duration of TCR engagement needed for commitment to effector function.
Volume: 179
Issue: 7
Pages: 4635-44
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Publication
20498059 | J:161294
First Author: Jang IK
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection.
Volume: 107
Issue: 23
Pages: 10620-5
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Publication
11514606 | J:71098
First Author: Gong Q
Year: 2001
Journal: J Exp Med
Title: Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development.
Volume: 194
Issue: 4
Pages: 507-18
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Publication
23209318 | J:190827
First Author: Kortum RL
Year: 2013
Journal: J Immunol
Title: A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
Volume: 190
Issue: 1
Pages: 147-58
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Publication
30307073 | J:296496
First Author: Yang JQ
Year: 2019
Journal: Clin Exp Allergy
Title: Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
Volume: 49
Issue: 1
Pages: 92-107
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Publication
23386701 | J:210129
First Author: Gupta A
Year: 2013
Journal: Mutagenesis
Title: T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.
Volume: 28
Issue: 3
Pages: 263-70
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Publication
34171408 | J:312530
 
First Author: Zhong G
Year: 2021
Journal: Neuroscience
Title: The Serum SIRT1 Protein is Associated with the Severity of Injury and Neurological Recovery in Mice with Traumatic Spinal Cord Injury.
Volume: 469
Pages: 103-109
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Publication
11781827 | J:73364
First Author: Beneke R
Year: 2001
Journal: Oncogene
Title: Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice.
Volume: 20
Issue: 56
Pages: 8136-41
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Publication
26423150 | J:226234
First Author: Rampoldi F
Year: 2015
Journal: J Immunol
Title: Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation.
Volume: 195
Issue: 9
Pages: 4228-43
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Publication
21098294 | J:167147
First Author: Zhang N
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Dicer controls CD8+ T-cell activation, migration, and survival.
Volume: 107
Issue: 50
Pages: 21629-34
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Publication
14614856 | J:174583
First Author: Ye M
Year: 2003
Journal: Immunity
Title: Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential.
Volume: 19
Issue: 5
Pages: 689-99
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Publication
17905674 | -
First Author: Ingley E
Year: 2008
Journal: Biochim Biophys Acta
Title: Src family kinases: regulation of their activities, levels and identification of new pathways.
Volume: 1784
Issue: 1
Pages: 56-65
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Publication
18563293 | -
First Author: Engen JR
Year: 2008
Journal: Cell Mol Life Sci
Title: Structure and dynamic regulation of Src-family kinases.
Volume: 65
Issue: 19
Pages: 3058-73
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Strain
MGI:5140602 | B6.Cg-Il7r<tm1Imx> Tg(Lck-Il7r)1676Trma/J
Attribute String: targeted mutation, mutant strain, transgenic
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Publication
11123301 | J:66400
First Author: Porter BO
Year: 2001
Journal: J Immunol
Title: Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail.
Volume: 166
Issue: 1
Pages: 262-9
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Publication
9794394 | J:50443
First Author: Takeda K
Year: 1998
Journal: J Immunol
Title: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.
Volume: 161
Issue: 9
Pages: 4652-60
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Publication
18292512 | J:131542
First Author: Owaki T
Year: 2008
Journal: J Immunol
Title: STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production.
Volume: 180
Issue: 5
Pages: 2903-11
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Publication
25393615 | J:222312
First Author: McIlwain DR
Year: 2015
Journal: Eur J Immunol
Title: T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.
Volume: 45
Issue: 2
Pages: 418-27
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Publication
8898201 | J:93005
First Author: Robey E
Year: 1996
Journal: Cell
Title: An activated form of Notch influences the choice between CD4 and CD8 T cell lineages.
Volume: 87
Issue: 3
Pages: 483-92
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Strain
MGI:3588067 | NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:2174515 | B6.Cg-Tg(Lck-cre)548Jxm/J
Attribute String: congenic, mutant strain, transgenic
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Publication
17460775 | J:123860
First Author: Cheng Y
Year: 2007
Journal: Neoplasia
Title: Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.
Volume: 9
Issue: 4
Pages: 315-21
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Strain
MGI:3690772 | B6.Cg-Fas<tm1Cgn> Tg(Lck-cre)I57Jxm
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
18487203 | J:138744
First Author: Shrimali RK
Year: 2008
Journal: J Biol Chem
Title: Selenoproteins mediate T cell immunity through an antioxidant mechanism.
Volume: 283
Issue: 29
Pages: 20181-5
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Publication
9692885 | J:67905
First Author: Takahama Y
Year: 1998
Journal: Eur J Immunol
Title: Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.
Volume: 28
Issue: 7
Pages: 2159-66
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Publication
15356128 | J:92765
First Author: Hazenbos WL
Year: 2004
Journal: J Immunol
Title: Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes.
Volume: 173
Issue: 6
Pages: 3810-5
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Allele
Tg(Lck-Nr4a1)2Brv | MGI:2386333
Name: transgene insertion 2, Rodrigo Bravo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-ZAP70-Y315F)1Achn | MGI:2388333
Name: transgene insertion 1, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-ZAP70-Y319F)1Achn | MGI:2388335
Name: transgene insertion 1, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-ZAP70-Y319F)2Achn | MGI:2388336
Name: transgene insertion 2, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:3714735 | B6.Cg-Tg(Lck-Tnfsf4)1Nish
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:5475168 | C.Cg-Tg(Lck-Tnfsf4)1Nish
Attribute String: mutant strain, transgenic, congenic
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Publication
22171643 | J:194882
 
First Author: Rabieyousefi M
Year: 2011
Journal: BMC Immunol
Title: Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension.
Volume: 12
Pages: 67
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Strain
MGI:4398898 | C3HeB/FeJ-Tg(Lck-Hhex)1Hro
Attribute String: coisogenic, mutant strain, transgenic
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Publication
21972292 | J:178854
First Author: Jiang S
Year: 2011
Journal: Blood
Title: Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.
Volume: 118
Issue: 20
Pages: 5487-97
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Publication
28783701 | J:261262
 
First Author: Chen T
Year: 2017
Journal: Sci Immunol
Title: PPAR-γ promotes type 2 immune responses in allergy and nematode infection.
Volume: 2
Issue: 9
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Publication
17088084 | J:116118
First Author: Laiosa CV
Year: 2006
Journal: Immunity
Title: Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors.
Volume: 25
Issue: 5
Pages: 731-44
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Allele
Tg(Lck-cre)3778Nik | MGI:2655490
Name: transgene insertion 3778, Nigel Killeen
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Lck-icre)3779Nik | MGI:2655492
Name: transgene insertion 3779, Nigel Killeen
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
22363451 | J:224051
First Author: Zhang L
Year: 2012
Journal: PLoS One
Title: TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.
Volume: 7
Issue: 2
Pages: e30592
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Publication
16606674 | J:123779
First Author: Kinjyo I
Year: 2006
Journal: J Exp Med
Title: Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.
Volume: 203
Issue: 4
Pages: 1021-31
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Allele
Tg(LckIl4)1315Dbl | MGI:3052795
Name: transgene insertion 1315, David Lewis
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CD8aCD8b)57Scr | MGI:3055355
Name: transgene insertion 57, The Scripps Research Institute
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Lck-Tal1)#Led | MGI:3528075
Name: transgene insertion, Philip Leder
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5439639 | B6(Cg)-Tg(Lck-Cd1d1)1Aben/J
Attribute String: transgenic, mutant strain
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Publication
16565721 | J:112556
First Author: Martins GA
Year: 2006
Journal: Nat Immunol
Title: Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.
Volume: 7
Issue: 5
Pages: 457-65
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Publication
17114420 | J:140605
First Author: Yamamoto M
Year: 2006
Journal: J Immunol
Title: Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Volume: 177
Issue: 11
Pages: 7520-4
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Strain
MGI:6148744 | C.Cg-Cxcr4<tm1Yiw> Tg(Lck-cre)1Jtak/YiwRbrc
Attribute String: mutant stock, transgenic, targeted mutation
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Strain
MGI:6148725 | D1.129P2(Cg)-Cxcr4<tm1Yiw> Tg(Lck-cre)1Jtak/YiwRbrc
Attribute String: mutant strain, congenic, transgenic, targeted mutation
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Publication
26132627 | J:238318
First Author: Sanjo H
Year: 2015
Journal: PLoS One
Title: Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis.
Volume: 10
Issue: 7
Pages: e0128761
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Publication
16940043 | J:112837
First Author: Sato S
Year: 2006
Journal: Int Immunol
Title: TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
Volume: 18
Issue: 10
Pages: 1405-11
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Allele
Tg(Lck-Blr1)29Cys | MGI:3703239
Name: transgene insertion 29, Jason G Cyster
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Stat5b*)1Mafa | MGI:3776805
Name: transgene insertion 1, Michael A Farrar
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(Lck-Socs3)1Kubo | MGI:3783708
Name: transgene insertion 1, Masato Kubo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Akt1*E40K)E-3Pnt | MGI:3803797
Name: transgene insertion E-3, Philip N Tsichlis
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(Lck-Tnfsf14)24Yxf | MGI:3849832
Name: transgene insertion 24, Yang-Xin Fu
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck/Emu-Rftn1)1Ayos | MGI:3850830
Name: transgene insertion 1, Akihiko Yoshimura
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Akt2)1Test | MGI:4397666
Name: transgene insertion 1, Joseph R Testa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6438691 | B6.Cg-Tg(Lck-tTA)1Doi/Tac
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:4819115 | FVB/N-Tg(Emu-FGFR3)A5Wmk
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:4819116 | FVB/N-Tg(Emu-FGFR3)D3Wmk
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tg(Lck-cre)#Nik | MGI:4819511
Name: transgene insertion, Nigel Killeen
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
34257516 | J:322350
 
First Author: Wenxiu J
Year: 2021
Journal: Mediators Inflamm
Title: Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
Volume: 2021
Pages: 5927064
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Allele
Tg(CD2-Fyn/Lck)1Rza | MGI:4946118
Name: transgene insertion 1, Rose Zamoyska
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CD2-Fyn/Lck)3Rza | MGI:4946119
Name: transgene insertion 3, Rose Zamoyska
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
19530243 | J:153923
First Author: Timakhov RA
Year: 2009
Journal: Genes Chromosomes Cancer
Title: Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.
Volume: 48
Issue: 9
Pages: 786-94
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Allele
Tg(Lck-Ppp3ca*)28Naka | MGI:5635497
Name: transgene insertion 28, Toshinori Nakayama
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(Lck-Tax)53Hall | MGI:5636649
Name: transgene insertion 53, William W Hall
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-cre/ERT2)51.17Ics | MGI:7346211
Name: transgene insertion 51.17, Mouse Clinical Institute
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Tg(Lck-Hhex)1Hro/?
Background: C3HeB/FeJ-Tg(Lck-Hhex)1Hro
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myb/Myb Tg(Lck-cre)1Cwi/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-FADD)1Hed/Tg(Lck-FADD)1Hed
Background: involves: BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-FADD)1Hed/?
Background: involves: BALB/c * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-FADD)1Hed/?
Background: involves: BALB/c * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Map3k7/Map3k7 Tg(Lck-cre)1Jtak/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fas/Fas Tg(Lck-cre)I57Jxm/?
Background: B6.Cg-Fas Tg(Lck-cre)I57Jxm
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ceacam1/Ceacam1 Tg(Lck-cre)1Cwi/?
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-Tnfsf4)1Nish/?
Background: B6.Cg-Tg(Lck-Tnfsf4)1Nish
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stat3/Stat3 Tg(Lck-cre)1Jtak/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Socs1/Socs1 Tg(Lck-cre)1Jtak/?
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Akt1/Akt1 Tg(Lck-cre)1Cwi/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adam10/Adam10 Tg(Lck-cre)#Zhu/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: B2m/B2m Tg(LckNotch1)9Erob/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Emu-FGFR3)A5Wmk/?
Background: FVB/N-Tg(Emu-FGFR3)A5Wmk
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Emu-FGFR3)D3Wmk/?
Background: FVB/N-Tg(Emu-FGFR3)D3Wmk
Zygosity: ot
Has Mutant Allele: true
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