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Search results 601 to 700 out of 819 for Lrp6

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Type Details Score
Publication
34431536 | J:312371
First Author: Da Silva F
Year: 2021
Journal: EMBO J
Title: Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex.
Volume: 40
Issue: 19
Pages: e108041
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Publication
32369449 | J:294228
First Author: Kalailingam P
Year: 2020
Journal: J Clin Invest
Title: Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome.
Volume: 130
Issue: 8
Pages: 4081-4093
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Publication
37228654 | J:335806
 
First Author: Yan L
Year: 2023
Journal: Front Cell Dev Biol
Title: Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.
Volume: 11
Pages: 1084245
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Publication
17064353 | J:118503
First Author: Verani R
Year: 2007
Journal: J Neurochem
Title: Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.
Volume: 100
Issue: 1
Pages: 242-50
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Publication
12412008 | J:80135
First Author: Heller RS
Year: 2002
Journal: Dev Dyn
Title: Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.
Volume: 225
Issue: 3
Pages: 260-70
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Publication
24191021 | J:202984
First Author: Rockich BE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Volume: 110
Issue: 47
Pages: E4456-64
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Publication
30254141 | J:272616
 
First Author: Iwai-Takekoshi L
Year: 2018
Journal: Development
Title: Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.
Volume: 145
Issue: 21
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Publication
18635608 | J:139251
First Author: Lin C
Year: 2008
Journal: Development
Title: Tissue-specific requirements of beta-catenin in external genitalia development.
Volume: 135
Issue: 16
Pages: 2815-25
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Publication
23293290 | J:194074
First Author: Ahn Y
Year: 2013
Journal: Development
Title: Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.
Volume: 140
Issue: 3
Pages: 583-93
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Publication
26288816 | J:244839
First Author: Kimura-Yoshida C
Year: 2015
Journal: EBioMedicine
Title: Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure.
Volume: 2
Issue: 6
Pages: 513-27
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Publication
15800025 | J:174493
First Author: Muzio L
Year: 2005
Journal: Cereb Cortex
Title: A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.
Volume: 15
Issue: 12
Pages: 2021-8
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Publication
34193412 | J:314221
 
First Author: Wang Q
Year: 2021
Journal: Sci Adv
Title: Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.
Volume: 7
Issue: 27
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Publication
15342465 | J:98338
First Author: Chu EY
Year: 2004
Journal: Development
Title: Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.
Volume: 131
Issue: 19
Pages: 4819-29
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Publication
18800919 | J:148823
First Author: Corrigan PM
Year: 2009
Journal: Stem Cells Dev
Title: Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.
Volume: 18
Issue: 5
Pages: 759-72
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Publication
26273529 | J:227247
 
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
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Publication
19562671 | J:152099
First Author: Bi Y
Year: 2009
Journal: J Cell Biochem
Title: Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.
Volume: 108
Issue: 1
Pages: 295-303
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Publication
18351675 | J:122362
First Author: Harwood BN
Year: 2008
Journal: Dev Dyn
Title: Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.
Volume: 237
Issue: 4
Pages: 1099-111
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Publication
21905163 | J:176660
First Author: Abler LL
Year: 2011
Journal: Dev Dyn
Title: A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Volume: 240
Issue: 10
Pages: 2364-77
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Publication
19515997 | J:154534
First Author: Martinez G
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Volume: 50
Issue: 10
Pages: 4794-806
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Publication
24859004 | J:219394
First Author: Boroviak T
Year: 2014
Journal: Nat Cell Biol
Title: The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
Volume: 16
Issue: 6
Pages: 516-28
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Publication
27480124 | J:237787
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
18772438 | J:138776
First Author: Pan W
Year: 2008
Journal: Science
Title: Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.
Volume: 321
Issue: 5894
Pages: 1350-3
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Publication
21536646 | -
First Author: Liang J
Year: 2011
Journal: Mol Cell Biol
Title: Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.
Volume: 31
Issue: 13
Pages: 2577-90
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Publication
23791946 | J:245356
First Author: Chu ML
Year: 2013
Journal: Structure
Title: structural Studies of Wnts and identification of an LRP6 binding site.
Volume: 21
Issue: 7
Pages: 1235-42
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Publication
16890161 | J:201264
First Author: Yamamoto H
Year: 2006
Journal: Dev Cell
Title: Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.
Volume: 11
Issue: 2
Pages: 213-23
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Publication
12897152 | J:166025
First Author: Liu G
Year: 2003
Journal: Mol Cell Biol
Title: A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.
Volume: 23
Issue: 16
Pages: 5825-35
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Publication
19107203 | J:166010
First Author: Piao S
Year: 2008
Journal: PLoS One
Title: Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.
Volume: 3
Issue: 12
Pages: e4046
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Publication
27089893 | J:245076
First Author: Li Y
Year: 2016
Journal: Biochem J
Title: Post-transcriptional regulation of Wnt co-receptor LRP6 and RNA-binding protein HuR by miR-29b in intestinal epithelial cells.
Volume: 473
Issue: 11
Pages: 1641-9
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GO Term
GO:1990909 | Wnt signalosome
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Publication
35055125 | J:318852
 
First Author: St-Arnaud R
Year: 2022
Journal: Int J Mol Sci
Title: NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH.
Volume: 23
Issue: 2
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Publication
30689807 | J:288536
     
First Author: Thompson JJ
Year: 2019
Journal: Carcinogenesis
Title: Blood vessel epicardial substance (BVES) reduces LRP6 receptor and cytoplasmic -catenin levels to modulate Wnt signaling and intestinal homeostasis.
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Interaction Experiment
Kubota T (2008)
Description: Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.
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Publication
23987510 | -
First Author: Özhan G
Year: 2013
Journal: Dev Cell
Title: Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.
Volume: 26
Issue: 4
Pages: 331-45
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Publication
17332414 | -
First Author: Mani A
Year: 2007
Journal: Science
Title: LRP6 mutation in a family with early coronary disease and metabolic risk factors.
Volume: 315
Issue: 5816
Pages: 1278-82
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Publication
21304492 | -
First Author: Tanneberger K
Year: 2011
Journal: EMBO J
Title: Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.
Volume: 30
Issue: 8
Pages: 1433-43
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Publication
18509060 | -
First Author: Cselenyi CS
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
Volume: 105
Issue: 23
Pages: 8032-7
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Publication
22491013 | -
First Author: Jiang Y
Year: 2012
Journal: EMBO J
Title: Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.
Volume: 31
Issue: 10
Pages: 2336-49
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Protein Domain
IPR040236 | TMEM198
Type: Family
Description: TMEM198 is a membrane scaffold protein that promotes LRP6 phosphorylation and Wnt signaling activation [].
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GO Term
GO:1904887 | Wnt signalosome assembly
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HT Experiment
GSE87742 | Identification of Eda targets during Meibomian gland development
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q8BG75
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
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Protein
A0A087WRW1
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Protein
D6RJ24
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
D3Z7R8
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
Q8CFU0
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Publication
11029007 | J:166033
First Author: Tamai K
Year: 2000
Journal: Nature
Title: LDL-receptor-related proteins in Wnt signal transduction.
Volume: 407
Issue: 6803
Pages: 530-5
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Protein
A0A494BAN5
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
A0A0U1RNX9
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein Domain
IPR022247 | Casein_kinase-1_gamma_C
Type: Domain
Description: This domain family is found in eukaryotes, and is typically between 54 and 99 amino acids in length. The family is found in association with . CK1gamma is a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells.
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HT Experiment
E-GEOD-56461 | The transcriptional response to Norrin/Fz4 signaling
Series Id: GSE56461
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR031574 | LYPD6
Type: Family
Description: Ly6/PLAUR domain-containing protein 6 (LYPD6) is a higher eukaryotic protein expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel []. LYPD6 carries an LU protein domain - about 80 amino acids long characterised by a conserved pattern of 10 cysteine residues []. It is a positive feedback regulator of Wnt/beta-catenin signalling, e.g. for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6 [].
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Protein Domain
IPR045695 | TMEM131-like_conserved
Type: Domain
Description: Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localisation. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region []. This entry represents a conserved domain found in TMEM131 and TMEM131L. This domain is C-terminal to the CHD1 domain.
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Publication
19403274 | J:157283
First Author: Darvas M
Year: 2009
Journal: Eur Neuropsychopharmacol
Title: Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6.
Volume: 19
Issue: 9
Pages: 670-81
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Protein
A2AQT3
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Publication
19653121 | -
First Author: Zhang Y
Year: 2010
Journal: Mol Biol Rep
Title: Identification and characterization of human LYPD6, a new member of the Ly-6 superfamily.
Volume: 37
Issue: 4
Pages: 2055-62
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Publication
17035101 | J:116140
First Author: Nam JS
Year: 2007
Journal: Gene Expr Patterns
Title: Dynamic expression of R-spondin family genes in mouse development.
Volume: 7
Issue: 3
Pages: 306-12
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Publication
21907199 | J:176651
First Author: Lin C
Year: 2011
Journal: FEBS Lett
Title: Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.
Volume: 585
Issue: 19
Pages: 3120-5
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Protein
A0A087WQG5
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein
A0A087WRG7
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Publication
26048454 | -
First Author: Lara-Castillo N
Year: 2015
Journal: Rev Endocr Metab Disord
Title: LRP receptor family member associated bone disease.
Volume: 16
Issue: 2
Pages: 141-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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