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Search results 601 to 700 out of 746 for Mbd2

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Type Details Score
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29022913 | J:278709
First Author: Wang J
Year: 2017
Journal: Cell Death Dis
Title: MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI.
Volume: 8
Issue: 10
Pages: e3120
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Interaction Experiment
Phesse TJ (2008)
Description: Deficiency of Mbd2 attenuates Wnt signaling.
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Protein
Q9Z2E1
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q9Z2E1-2
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Publication
12504854 | J:80802
First Author: Jiang CL
Year: 2002
Journal: Genomics
Title: MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Volume: 80
Issue: 6
Pages: 621-9
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Interaction Experiment
Weaver IC (2014)
Description: The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor.
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Publication
12183469 | -
First Author: Brackertz M
Year: 2002
Journal: J Biol Chem
Title: Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.
Volume: 277
Issue: 43
Pages: 40958-66
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Protein
Q8C255
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q8C255-2
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: false
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Protein
Q8C255-3
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Allele
Mbd2<em2Smoc> | MGI:7290991
Name: methyl-CpG binding domain protein 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
25135974 | -
 
First Author: Weaver IC
Year: 2014
Journal: Philos Trans R Soc Lond B Biol Sci
Title: The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor.
Volume: 369
Issue: 1652
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Strain
MGI:6355009 | C57BL/6JSmoc-Mbd2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
14610093 | -
First Author: Ghoshal K
Year: 2004
Journal: J Biol Chem
Title: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.
Volume: 279
Issue: 8
Pages: 6783-93
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HT Experiment
GSE128828 | Methyl-CpG binding domain 2 (Mbd2) is an Epigenetic Regulator of Autism-Risk Genes and Cognition [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(Mbd2-EGFP)DK105Gsat | MGI:4847223
Name: transgene insertion DK105, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003697 | STOCK Tg(Mbd2-EGFP)DK105Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Mbd2<tm1.1Joez> | MGI:5924954
Name: methyl-CpG binding domain protein 2; targeted mutation 1.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag
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Allele
Mbd1<tm1.1Joez> | MGI:5925213
Name: methyl-CpG binding domain protein 1; targeted mutation 1.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag
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Allele
Mecp2<em7.1Bird> | MGI:6437877
Name: methyl CpG binding protein 2; endonuclease-mediated mutation 7.1, Adrian Bird
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Strain
MGI:5925237 | B6.129(FVB)-Mbd2<tm1.1Joez>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5925243 | B6.129(FVB)-Mbd1<tm1.1Joez>/J
Attribute String: targeted mutation, mutant strain, congenic
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Publication
12124384 | -
First Author: Saito M
Year: 2002
Journal: J Biol Chem
Title: The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
Volume: 277
Issue: 38
Pages: 35434-9
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Publication
11756549 | J:76630
First Author: Feng Q
Year: 2002
Journal: Mol Cell Biol
Title: Identification and functional characterization of the p66/p68 components of the MeCP1 complex.
Volume: 22
Issue: 2
Pages: 536-46
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Protein
A0A1D5RM07
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Publication
17694084 | -
First Author: Denslow SA
Year: 2007
Journal: Oncogene
Title: The human Mi-2/NuRD complex and gene regulation.
Volume: 26
Issue: 37
Pages: 5433-8
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Publication
10947852 | -
First Author: Tatematsu KI
Year: 2000
Journal: Genes Cells
Title: MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.
Volume: 5
Issue: 8
Pages: 677-88
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Publication
24307175 | -
First Author: Cramer JM
Year: 2014
Journal: J Biol Chem
Title: Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.
Volume: 289
Issue: 3
Pages: 1294-302
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Protein Domain
IPR040386 | P66
Type: Family
Description: P66alpha and P66beta interact with MBDs (methyl-binding domain-containing proteins) via a coiled-coil region on each []. P66 and MBD2 form a complex with the nucleosome remodeling and deacetylation (NuRD) complex. This MBD2-NuRD complex recognizes methylated DNA and silences expression of associated genes through histone deacetylase and nucleosome remodeling functions [, ].
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Protein Domain
IPR025884 | MeCpG-bd_2/3_C_dom
Type: Domain
Description: CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain is found at the C terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 []and MBD3 []. The latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex [], an abundant deacetylase complex.
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Protein Domain
IPR037965 | MBD3
Type: Family
Description: Methyl-CpG-binding domain protein 3 (MBD3) is a transcriptional repressor and plays a role in gene silencing. It binds to DNA with a preference for sites containing methylated CpG dinucleotides but only as part of a complex [, ]. It forms a heterodimer with MBD2 []and is a component of the NuRD []and the MeCP1 []complexes.
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Protein
F6WZH1
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
Q9D9H3
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
Q8CHY6
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q3UXB0
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
A0A1D5RM58
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Protein
Q0P5Y0
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
Q8K591
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
E9QMN5
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
Q6P237
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
F6UPR7
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
A0A1I7Q4G8
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Publication
23239876 | -
First Author: Walavalkar NM
Year: 2013
Journal: J Biol Chem
Title: Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).
Volume: 288
Issue: 5
Pages: 3419-27
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Publication
29894688 | J:262547
First Author: Zhu D
Year: 2018
Journal: Cancer Cell
Title: BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Volume: 33
Issue: 6
Pages: 1004-1016.e5
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Publication
18942147 | J:140708
First Author: Jin SG
Year: 2008
Journal: Dev Dyn
Title: Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.
Volume: 237
Issue: 11
Pages: 3435-43
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Protein
Q9Z2D8
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: false
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Protein
D3YTR5
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
D3YTR4
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
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Publication
21490301 | -
First Author: Gnanapragasam MN
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex.
Volume: 108
Issue: 18
Pages: 7487-92
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Publication
10444591 | J:56739
First Author: Zhang Y
Year: 1999
Journal: Genes Dev
Title: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Volume: 13
Issue: 15
Pages: 1924-35
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Publication
23525608 | J:290484
First Author: Narayanan N
Year: 2013
Journal: Int J Physiol Pathophysiol Pharmacol
Title: Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Volume: 5
Issue: 1
Pages: 32-42
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Publication
19494294 | J:149293
First Author: Aoki K
Year: 2009
Journal: J Immunol
Title: Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1.
Volume: 182
Issue: 12
Pages: 7698-707
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Publication
19155510 | J:144321
First Author: Wu M
Year: 2009
Journal: J Immunol
Title: Beta-defensin-2 promotes resistance against infection with P. aeruginosa.
Volume: 182
Issue: 3
Pages: 1609-16
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Publication
14752047 | J:215655
First Author: Sekimata M
Year: 2004
Journal: Nucleic Acids Res
Title: Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF.
Volume: 32
Issue: 2
Pages: 590-7
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Publication
19933858 | J:157484
First Author: Wu M
Year: 2009
Journal: J Immunol
Title: Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis.
Volume: 183
Issue: 12
Pages: 8054-60
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Publication
12529184 | -
First Author: Roloff TC
Year: 2003
Journal: BMC Genomics
Title: Comparative study of methyl-CpG-binding domain proteins.
Volume: 4
Issue: 1
Pages: 1
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Protein Domain
IPR001739 | Methyl_CpG_DNA-bd
Type: Domain
Description: Methylation at CpG dinucleotide, the most common DNA modification ineukaryotes, has been correlated with gene silencing associated with variousphenomena such as genomic imprinting, transposon and chromosome X inactivation, differentiation, and cancer. Effects of DNA methylation are mediated through proteins which bind to symmetrically methylated CpGs. Such proteins contain a specific domain of ~70 residues, the methyl-CpG-binding domain (MBD), which is linked to additional domains associated with chromatin, such as the bromodomain, the AT hook motif,the SET domain, or the PHD finger. MBD-containing proteins appear to act as structural proteins, which recruit a variety of histone deacetylase (HDAC) complexes and chromatin remodelling factors, leading to chromatin compaction and, consequently, to transcriptional repression. The MBD of MeCP2, MBD1, MBD2, MBD4 and BAZ2 mediates binding to DNA, in case of MeCP2, MBD1 and MBD2 preferentially to methylated CpG. In case of human MBD3 and SETDB1 the MBD has been shown to mediate protein-protein interactions [, ].The MBD folds into an alpha/beta sandwich structure comprising a layer oftwisted beta sheet, backed by another layer formed by the alpha1 helix and ahairpin loop at the C terminus. These layers are both amphipathic, with the alpha1 helix and the beta sheet lying parallel and the hydrophobic faces tightly packed against each other. The beta sheet is composed of two long inner strands (beta2 and beta3) sandwiched by two shorter outer strands (beta1 and beta4) [].
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Publication
33561390 | J:309631
First Author: Tillotson R
Year: 2021
Journal: Mol Cell
Title: Neuronal non-CG methylation is an essential target for MeCP2 function.
Volume: 81
Issue: 6
Pages: 1260-1275.e12
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Publication
20062804 | J:157242
First Author: Yu S
Year: 2010
Journal: PLoS One
Title: Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.
Volume: 5
Issue: 1
Pages: e8579
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Publication
12700672 | J:83077
First Author: Lee GH
Year: 2003
Journal: Oncogene
Title: Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.
Volume: 22
Issue: 15
Pages: 2374-82
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Publication
17030610 | J:117667
First Author: Gu P
Year: 2006
Journal: Mol Cell Biol
Title: Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression.
Volume: 26
Issue: 24
Pages: 9471-83
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Protein
B1AYB6
Organism: Mus musculus/domesticus
Length: 1498  
Fragment?: false
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Protein
Q3TU27
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
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Protein
Q69ZJ2
Organism: Mus musculus/domesticus
Length: 1753  
Fragment?: true
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Protein
A0A0N4SWA0
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
Q3UG18
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
B4XVP4
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Protein
B1AYB5
Organism: Mus musculus/domesticus
Length: 1728  
Fragment?: false
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Protein
Q8BUR7
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
Q9Z2D6
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
Q3TY92
Organism: Mus musculus/domesticus
Length: 1003  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom