|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 647 out of 647 for Mcm2

<< First    < Previous  |  Next >    Last >>
0.021s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
A0A0A0MQF4
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR031327 | MCM
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
•
•
•
•
•
Protein
P97311
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
•
•
•
•
•
Protein
Q61881
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
P49718
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
•
•
•
•
•
Protein
P49717
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
P25206
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein
Q542I2
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
•
•
•
•
•
Protein
Q3U4T8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
Q3V122
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
•
•
•
•
•
Protein
Q921D5
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3UA65
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3UC10
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
•
•
•
•
•
Protein
Q8BQ03
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
•
•
•
•
•
Protein
Q3UZH2
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein
Q9D077
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3ULD6
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein
Q5DTS8
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
•
•
•
•
•
Protein
Q542F4
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3UDI8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
Q3UI57
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein
Q3ULG5
Organism: Mus musculus/domesticus
Length: 794  
Fragment?: false
•
•
•
•
•
Protein
Q8C1Z0
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3UXG9
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
•
•
•
•
•
Protein
D3Z6N3
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
•
•
•
•
•
Protein
A0A2R8VKJ4
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
•
•
•
•
•
Protein
H9KV11
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
•
•
•
•
•
Publication
22771115 | -
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
•
•
•
•
•
Publication
30743181 | -
 
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
•
•
•
•
•
Protein
Q9CWV1
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
•
•
•
•
•
Protein
Q2KHI9
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
•
•
•
•
•
Protein
A0A1W2P804
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
•
•
•
•
•
Protein
A0A2R8VHP7
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
•
•
•
•
•
Protein
D3Z2K9
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
•
•
•
•
•
Protein
A0A1W2P801
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
•
•
•
•
•
Protein
D3Z0J6
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
•
•
•
•
•
Publication
15345747 | -
First Author: Ballif BA
Year: 2004
Journal: Mol Cell Proteomics
Title: Phosphoproteomic analysis of the developing mouse brain.
Volume: 3
Issue: 11
Pages: 1093-101
•
•
•
•
•
Publication
19131326 | -
First Author: Sweet SM
Year: 2009
Journal: Mol Cell Proteomics
Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume: 8
Issue: 5
Pages: 904-12
•
•
•
•
•
Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
•
•
•
•
•
Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
•
•
•
•
•
Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
•
•
•
•
•
Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•
Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
•
•
•
•
•
Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom