Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
Mecom adjacent non-protein coding RNA; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1232
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1042
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
129
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
795
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1051
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
994
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
52
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
45
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
116
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
606
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
718
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
843
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
949
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
949
 |
Fragment?: |
false |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
Mecom adjacent non-protein coding RNA; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
lncRNA Gene |
Type: |
lncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
ncRNA_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2016-10-28 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5805663 |
Age: |
postnatal week 7.6-14.1 |
Image: |
Dataset 2 |
Note: |
There was little or no staining observed. |
Specimen Label: |
Dataset 2 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mannr/Mannr |
Background: |
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mannr/Mannr<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
MDS1 and EVI1 complex locus; endonuclease-mediated mutation 1, Toshio Suda |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
MDS1 and EVI1 complex locus; targeted mutation 4, Archibald Perkins |
Allele Type: |
Targeted |
Attribute String: |
Inducible, Modified isoform(s), Recombinase |
|
•
•
•
•
•
|
Publication |
First Author: |
Goff LA |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. |
Volume: |
112 |
Issue: |
22 |
Pages: |
6855-62 |
|
•
•
•
•
•
|
Allele |
Name: |
MDS1 and EVI1 complex locus; targeted mutation 4.1, Archibald Perkins |
Allele Type: |
Targeted |
Attribute String: |
Inducible, Modified isoform(s), Recombinase |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, congenic, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Sauvageau M |
Year: |
2013 |
Journal: |
Elife |
Title: |
Multiple knockout mouse models reveal lincRNAs are required for life and brain development. |
Volume: |
2 |
|
Pages: |
e01749 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion NG190, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
MDS1 and EVI1 complex locus; targeted mutation 1.1, Fernando D Camargo |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Lai KM |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e0125522 |
|
•
•
•
•
•
|
Allele |
Name: |
runt related transcription factor 1; targeted mutation 2.1, Hiroaki Honda |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Toshio Suda |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 2, Toshio Suda |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Runx1/Runx1<+> |
Background: |
B6.129P2-Runx1 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Mecom/Mecom<+> |
Background: |
involves: 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the PR/SET domain found in PR domain zinc finger protein 3 (PRDM3, also known as MECOM or EVI-1). PRDM3 and PRDM16 share protein sequences similarities and have functions in hematopoietic and neuronal stem cells and in adipose tissue differentiation. They also act as oncoproteins (Mel1 and Evi1) involved in translocation-induced leukemia. PRDM3 and PRDM16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes []. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Mecom/Mecom<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai SF |
Year: |
2020 |
Journal: |
Cancer Discov |
Title: |
Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1500-1513 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li BE |
Year: |
2013 |
Journal: |
Blood |
Title: |
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. |
Volume: |
122 |
Issue: |
12 |
Pages: |
2039-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fenouille N |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. |
Volume: |
23 |
Issue: |
3 |
Pages: |
301-313 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Mecom/Mecom<+> |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu H |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9. |
Volume: |
5 |
Issue: |
1 |
Pages: |
13-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Casamassimi A |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
Multifaceted Role of PRDM Proteins in Human Cancer. |
Volume: |
21 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|