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Search results 601 to 686 out of 686 for Muc1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:5432352 | B6.Cg-Il10<tm1Cgn> Tg(MUC1)79.24Gend
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
26996122 | J:234412
First Author: Wang P
Year: 2016
Journal: Int J Cancer
Title: Predictive imaging of chemotherapeutic response in a transgenic mouse model of pancreatic cancer.
Volume: 139
Issue: 3
Pages: 712-8
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Strain
MGI:3836619 | B6.Cg-Kras<tm4Tyj> Ptf1a<tm1.1(cre)Cvw> Tg(MUC1)79.24Gend
Attribute String: targeted mutation, transgenic, congenic
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Genotype
Genotype
Symbol: Tg(Ela1-TAg*)79Mjt/? Tg(MUC1)79.24Gend/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Ptf1a/Ptf1a<+> Tg(MUC1)79.24Gend/?
Background: B6.Cg-Kras Ptf1a Tg(MUC1)79.24Gend
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il10/Il10 Tg(MUC1)79.24Gend/?
Background: B6.Cg-Il10 Tg(MUC1)79.24Gend
Zygosity: cx
Has Mutant Allele: true
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Publication
8468055 | J:4213
First Author: Bornstein P
Year: 1993
Journal: Genomics
Title: Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene.
Volume: 15
Issue: 3
Pages: 607-13
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Publication
33235206 | J:309176
First Author: Nakajima K
Year: 2020
Journal: Transl Psychiatry
Title: Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice.
Volume: 10
Issue: 1
Pages: 407
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Publication
17785207 | J:124969
First Author: Siveke JT
Year: 2007
Journal: Cancer Cell
Title: Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Volume: 12
Issue: 3
Pages: 266-79
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Publication
31348885 | J:278341
First Author: Dvela-Levitt M
Year: 2019
Journal: Cell
Title: Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
Volume: 178
Issue: 3
Pages: 521-535.e23
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Protein Domain
IPR000082 | SEA_dom
Type: Domain
Description: The SEA domain has been named after the first three proteins in which it was identified (Sperm protein, Enterokinase and Agrin). The SEA domain has around 120 residues, it is an extracellular domain found in a number of cell surface and secreted proteins in which it could be present in one or two copies []. Many SEA domains possess autoproteolysis activity. The SEA domain is closely associated with regions receiving extensive O-glycosylation and is present adjacent to the transmembrane segment in quite a number of type I transmembrane proteins on the cell surface, such as mucin-1 (MUC1) and Notch receptors and in type II single-pass transmembrane proteins such as enterokinase and matriptases. It also present in interphotoreceptor matrix proteoglycans (IMPG1 and IMPG2) []. It has been proposed that carbohydrates are required to stabilise SEA domains and protect them against proteolytic degradation and that the extent of substitution may control proteolytic processing [, ].The SEA domain contains an about 80-residue conserved region and an about 40-residue segment that separates the conserved region from the subsequent C-terminal domains with an alternating conformation of β-sheets and α-helices. Structural analysis of MUC1 SEA domain revealed that it adopts a ferredoxin-like fold in which the cleavage site is located in the middle of the β-hairpin of the second and third β-strands. MUC1 SEA domain undergoes autoproteolysis at the glycine-serine peptide bond and the Ser responsible of this activity is located in the consensus motif GSXXX (X: a hydrophobic residue) [, , ].Some proteins known to contain a SEA domain include:Vertebrate agrin, an heparan sulfate proteoglycan of the basal lamina of the neuromuscular junction. It is responsible for the clustering of acetylcholine receptors (AChRs) and other proteins at the neuromuscular junction.Mammalian enterokinase. It catalyses the conversion of trypsinogen to trypsin which in turn activates other proenzymes, including chymotrypsinogen, procarboxypeptidases, and proelastases.63kDa sea urchin sperm protein (SP63). It might mediate sperm-egg or sperm-matrix interactions.Animal perlecan, a heparan sulfate containing proteoglycan found in all basement membranes. It interacts with other basement membrane components such as laminin and collagen type IV and serves as an attachment substrate for cells.Some vertebrate epithelial mucins. They form a family of secreted and cell surface glycoproteins expressed by epithelial tissues and implicated in epithelial cell protection, adhesion modulation and signaling.Mammalian cell surface antigen 114/A10, an integral transmembrane protein that is highly expressed in hematopoietic progenitor cells and IL-3-dependent cell lines.
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Protein Domain
IPR036364 | SEA_dom_sf
Type: Homologous_superfamily
Description: The SEA domain has been named after the first three proteins in which it was identified (Sperm protein, Enterokinase and Agrin). The SEA domain has around 120 residues, it is an extracellular domain found in a number of cell surface and secreted proteins in which it could be present in one or two copies []. Many SEA domains possess autoproteolysis activity. The SEA domain is closely associated with regions receiving extensive O-glycosylation and is present adjacent to the transmembrane segment in quite a number of type I transmembrane proteins on the cell surface, such as mucin-1 (MUC1) and Notch receptors and in type II single-pass transmembrane proteins such as enterokinase and matriptases. It also present in interphotoreceptor matrix proteoglycans (IMPG1 and IMPG2) []. It has been proposed that carbohydrates are required to stabilise SEA domains and protect them against proteolytic degradation and that the extent of substitution may control proteolytic processing [, ].The SEA domain contains an about 80-residue conserved region and an about 40-residue segment that separates the conserved region from the subsequent C-terminal domains with an alternating conformation of β-sheets and α-helices. Structural analysis of MUC1 SEA domain revealed that it adopts a ferredoxin-like fold in which the cleavage site is located in the middle of the β-hairpin of the second and third β-strands. MUC1 SEA domain undergoes autoproteolysis at the glycine-serine peptide bond and the Ser responsible of this activity is located in the consensus motif GSXXX (X: a hydrophobic residue) [, , ].Some proteins known to contain a SEA domain include:Vertebrate agrin, an heparan sulfate proteoglycan of the basal lamina of the neuromuscular junction. It is responsible for the clustering of acetylcholine receptors (AChRs) and other proteins at the neuromuscular junction.Mammalian enterokinase. It catalyses the conversion of trypsinogen to trypsin which in turn activates other proenzymes, including chymotrypsinogen, procarboxypeptidases, and proelastases.63kDa sea urchin sperm protein (SP63). It might mediate sperm-egg or sperm-matrix interactions.Animal perlecan, a heparan sulfate containing proteoglycan found in all basement membranes. It interacts with other basement membrane components such as laminin and collagen type IV and serves as an attachment substrate for cells.Some vertebrate epithelial mucins. They form a family of secreted and cell surface glycoproteins expressed by epithelial tissues and implicated in epithelial cell protection, adhesion modulation and signaling.Mammalian cell surface antigen 114/A10, an integral transmembrane protein that is highly expressed in hematopoietic progenitor cells and IL-3-dependent cell lines.
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Protein
Q02496
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
Q8R1W8
Organism: Mus musculus/domesticus
Length: 798  
Fragment?: false
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Protein
A0A140LJ72
Organism: Mus musculus/domesticus
Length: 8478  
Fragment?: false
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Protein
O35419
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: true
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Protein
A0A140LIA5
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: true
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Protein
Q99K60
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Protein
A0A140LI05
Organism: Mus musculus/domesticus
Length: 2566  
Fragment?: true
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Protein
Q80Y91
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: true
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Protein
Q91WF4
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: true
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Protein
A0A140T8V8
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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Protein
E9PWP7
Organism: Mus musculus/domesticus
Length: 4499  
Fragment?: false
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Protein
A0A0R4J0H1
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Protein
Q8R0K3
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: true
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Protein
Q9D1H1
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Publication
7670383 | -
First Author: Bork P
Year: 1995
Journal: Protein Sci
Title: The SEA module: a new extracellular domain associated with O-glycosylation.
Volume: 4
Issue: 7
Pages: 1421-5
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Publication
9762901 | -
First Author: Sasaki T
Year: 1998
Journal: FEBS Lett
Title: Inhibition of glycosaminoglycan modification of perlecan domain I by site-directed mutagenesis changes protease sensitivity and laminin-1 binding activity.
Volume: 435
Issue: 2-3
Pages: 169-72
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Publication
9030729 | -
First Author: Costell M
Year: 1997
Journal: Eur J Biochem
Title: Characterization of recombinant perlecan domain I and its substitution by glycosaminoglycans and oligosaccharides.
Volume: 243
Issue: 1-2
Pages: 115-21
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Publication
27977898 | -
First Author: Pei J
Year: 2017
Journal: Protein Sci
Title: Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54.
Volume: 26
Issue: 3
Pages: 617-630
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Publication
19436292 | J:149537
First Author: Julien S
Year: 2009
Journal: Br J Cancer
Title: Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model.
Volume: 100
Issue: 11
Pages: 1746-54
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Publication
20530670 | J:161602
First Author: Deguchi T
Year: 2010
Journal: Cancer Res
Title: Increased immunogenicity of tumor-associated antigen, mucin 1, engineered to express alpha-gal epitopes: a novel approach to immunotherapy in pancreatic cancer.
Volume: 70
Issue: 13
Pages: 5259-69
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Publication
10898511 | J:62734
First Author: Apostolopoulos V
Year: 2000
Journal: Eur J Immunol
Title: A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo.
Volume: 30
Issue: 6
Pages: 1733-9
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Publication
19196663 | J:148729
First Author: Ilkovitch D
Year: 2009
Journal: Blood
Title: Urokinase-mediated recruitment of myeloid-derived suppressor cells and their suppressive mechanisms are blocked by MUC1/sec.
Volume: 113
Issue: 19
Pages: 4729-39
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Publication
23189185 | J:195006
First Author: Madsen CB
Year: 2012
Journal: PLoS One
Title: Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response.
Volume: 7
Issue: 11
Pages: e50139
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Publication
25531332 | J:224797
First Author: Kumar S
Year: 2015
Journal: Oncogene
Title: NCOA3-mediated upregulation of mucin expression via transcriptional and post-translational changes during the development of pancreatic cancer.
Volume: 34
Issue: 37
Pages: 4879-89
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Publication
23420890 | J:194459
First Author: Farkas AM
Year: 2013
Journal: J Immunol
Title: Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes.
Volume: 190
Issue: 7
Pages: 3319-27
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Publication
36252012 | J:335482
First Author: Cantero-Recasens G
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.
Volume: 119
Issue: 43
Pages: e2205277119
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Publication
29463649 | J:261633
 
First Author: Shalom-Barak T
Year: 2018
Journal: Mol Cell Biol
Title: Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor α Coactivator.
Volume: 38
Issue: 9
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Publication
8938153 | J:37621
First Author: Rye PD
Year: 1996
Journal: Int J Cancer
Title: Brain metastasis model in athymic nude mice using a novel MUC1-secreting human breast-cancer cell line, MA11.
Volume: 68
Issue: 5
Pages: 682-7
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Publication
10022473 | J:52400
First Author: Morikane K
Year: 1999
Journal: Cancer Immunol Immunother
Title: Organ-specific pancreatic tumor growth properties and tumor immunity.
Volume: 47
Issue: 5
Pages: 287-96
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Publication
19556244 | J:153445
First Author: Argüeso P
Year: 2009
Journal: J Biol Chem
Title: Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier.
Volume: 284
Issue: 34
Pages: 23037-45
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Publication
32427590 | J:308942
 
First Author: Li W
Year: 2020
Journal: JCI Insight
Title: MUC1-C drives stemness in progression of colitis to colorectal cancer.
Volume: 5
Issue: 12
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Publication
37174625 | J:336761
 
First Author: Breugelmans T
Year: 2023
Journal: Cells
Title: IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
Volume: 12
Issue: 9
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Protein
A0A5F8MPQ6
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: true
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Protein
Q80XH2
Organism: Mus musculus/domesticus
Length: 1243  
Fragment?: false
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Publication
21314937 | J:207670
First Author: Kretschmer C
Year: 2011
Journal: Mol Cancer
Title: Identification of early molecular markers for breast cancer.
Volume: 10
Issue: 1
Pages: 15
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Publication
9298934 | J:42582
First Author: Pietersz GA
Year: 1997
Journal: Cancer Immunol Immunother
Title: Comparison of the biological properties of two anti-mucin-1 antibodies prepared for imaging and therapy.
Volume: 44
Issue: 6
Pages: 323-8
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Publication
9330472 | J:44771
First Author: Lofthouse SA
Year: 1997
Journal: Vaccine
Title: Induction of T1 (cytotoxic lymphocyte) and/or T2 (antibody) responses to a mucin-1 tumour antigen.
Volume: 15
Issue: 14
Pages: 1586-93
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Publication
30995255 | J:274632
First Author: Nguyen TM
Year: 2019
Journal: PLoS One
Title: The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.
Volume: 14
Issue: 4
Pages: e0214793
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Publication
23474825 | J:320503
First Author: Saxena A
Year: 2013
Journal: Int J Colorectal Dis
Title: Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer.
Volume: 28
Issue: 9
Pages: 1267-79
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Protein
Z4YJS5
Organism: Mus musculus/domesticus
Length: 1151  
Fragment?: false
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Protein
P19467
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
Q3V1S6
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
A2ASQ1
Organism: Mus musculus/domesticus
Length: 1950  
Fragment?: false
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Protein
Q8VHK8
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
Q8BHM9
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q14C59
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
Q8BZ10
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
Q1JRP2
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
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Protein
Q3UQ41
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q5S248
Organism: Mus musculus/domesticus
Length: 423  
Fragment?: false
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Protein
D3YZU3
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q6PCM6
Organism: Mus musculus/domesticus
Length: 1194  
Fragment?: true
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Protein
Z4YK85
Organism: Mus musculus/domesticus
Length: 1927  
Fragment?: false
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Protein
A0A0G2JET7
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
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Protein
Q147T9
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
Q8VEC3
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
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Protein
G5E8Q8
Organism: Mus musculus/domesticus
Length: 1348  
Fragment?: false
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Protein
Q9DBI0
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
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Protein
D3YTR8
Organism: Mus musculus/domesticus
Length: 1099  
Fragment?: false
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Protein
M0QWP1
Organism: Mus musculus/domesticus
Length: 2034  
Fragment?: false
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Protein
A0A2R8W6T9
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
Q0X0F1
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Protein
Q8CC97
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Protein
B2RY54
Organism: Mus musculus/domesticus
Length: 1099  
Fragment?: false
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Protein
Q5DID3
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
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Protein
P56677
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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Protein
Q8BIK6
Organism: Mus musculus/domesticus
Length: 829  
Fragment?: false
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Protein
Q543E3
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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Protein
P97435
Organism: Mus musculus/domesticus
Length: 1069  
Fragment?: false
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Protein
E9Q6Y6
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false
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Protein
Q05793
Organism: Mus musculus/domesticus
Length: 3707  
Fragment?: false
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Protein
Q3UHH3
Organism: Mus musculus/domesticus
Length: 2672  
Fragment?: false
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Protein
B1B0C7
Organism: Mus musculus/domesticus
Length: 4375  
Fragment?: false
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Protein
E9PZ16
Organism: Mus musculus/domesticus
Length: 4383  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom