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Search results 601 to 700 out of 1004 for Ngf

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Type Details Score
Publication
11437236 | -
First Author: Wiesmann C
Year: 2001
Journal: Cell Mol Life Sci
Title: Nerve growth factor: structure and function.
Volume: 58
Issue: 5-6
Pages: 748-59
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Publication
27056327 | -
First Author: Nadezhdin KD
Year: 2016
Journal: J Biol Chem
Title: Structural Basis of p75 Transmembrane Domain Dimerization.
Volume: 291
Issue: 23
Pages: 12346-57
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Protein Domain
IPR041448 | TNFR16_TM
Type: Domain
Description: This is the helical trans-membrane domain found in tumor necrosis factor receptor superfamily member 16 (also known as p75 neurotrophin receptor , and nerve growth factor receptor-NGFR). p75 plays prominent biological functions such the induction of cell death, and it demonstrates several other activities, like survival, axonal growth, and cell migration. The trans-membrane (TM) domain of p75 stabilizes the receptor dimers through a disulfide bond, essential for the NGF signalling Structural and mutational analysis indicate that Cys257 plays the key role in this stabilisation process. Furthermore, although the p75-C257A mutant is still capable to form dimers and bind to NGF, it is unable to transduce the signals triggered by NGF binding in some cell signalling paradigms [].
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Genotype
Genotype
Symbol: Bax/Bax Ngf/Ngf
Background: involves: 129S7/SvEvBrd * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Ngf/Ngf<+>
Background: involves: 129S7/SvEvBrd * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Ngf/Ngf
Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR020425 | Nerve_growth_factor_bsu
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. Although NGF was originally identified in snake venom, its most abundant and best studied source is the submaxillary gland of adult male mice []. Mouse NGF is a high molecular weight hexamer, composed of 2 subunits each of alpha, beta and gamma polypeptides. The beta subunit (NGF-beta) is responsible for the physiological activity of the complex []. NGF-beta induces its cell survival effects through activation of neurotrophic tyrosine kinase receptor type 1 (NTRK1; also called TrkA), and can induce cell death by binding to the low affinity nerve growth factor receptor, p75NTR []. The neurotrophin has been shown to be involved in sympathetic axon growth and innervation of target fields [].
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Protein Domain
IPR020437 | Nerve_growth_factor_bsu_mml
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. Although NGF was originally identified in snake venom, its most abundant and best studied source is the submaxillary gland of adult male mice []. Mouse NGF is a high molecular weight hexamer, composed of 2 subunits each of alpha, beta and gamma polypeptides. The beta subunit (NGF-beta) is responsible for the physiological activity of the complex []. NGF-beta induces its cell survival effects through activation of neurotrophic tyrosine kinase receptor type 1 (NTRK1; also called TrkA), and can induce cell death by binding to the low affinity nerve growth factor receptor, p75NTR []. The neurotophin has been shown to be involved in sympathetic axon growth and innervation of target fields []. Mammalian NGF-beta tend to be higher potency NTRK1 agonsits than their snake venom counterparts []. In humans, NGF-beta gene mutations can cause a loss of pain perception [].
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Publication
7969471 | -
First Author: Götz R
Year: 1994
Journal: Nature
Title: Neurotrophin-6 is a new member of the nerve growth factor family.
Volume: 372
Issue: 6503
Pages: 266-9
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Protein Domain
IPR020431 | Neurotrophin-6
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. This entry represents Neurotrophin-6 (NT-6), which has been identified in two species of platty fish []. It has been shown to have trophic effects on embryonic sympathetic neurons, similar to those of NGF [].
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Protein Coding Gene
MGI:97513 | Furin
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P23188
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
A0A0G2JEK0
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Publication
1477101 | -
First Author: Koyama J
Year: 1992
Journal: Biochim Biophys Acta
Title: Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.
Volume: 1160
Issue: 3
Pages: 287-92
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Publication
1995338 | -
First Author: Inoue S
Year: 1991
Journal: FEBS Lett
Title: Amino acid sequences of nerve growth factors derived from cobra venoms.
Volume: 279
Issue: 1
Pages: 38-40
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Publication
14529729 | -
First Author: Katzir I
Year: 2003
Journal: Toxicon
Title: Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors.
Volume: 42
Issue: 5
Pages: 481-90
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Publication
28073000 | J:238406
First Author: Monje M
Year: 2017
Journal: Cancer Cell
Title: Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer.
Volume: 31
Issue: 1
Pages: 1-2
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Publication
9698438 | J:107703
First Author: Guidry G
Year: 1998
Journal: Dev Biol
Title: Target-dependent development of the vesicular acetylcholine transporter in rodent sweat gland innervation.
Volume: 199
Issue: 2
Pages: 175-84
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Protein
Q99PE5
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Protein
Q3U1M0
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Protein
A0A1B0GT57
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
S5MI68
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
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Protein
Q3TAJ2
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Publication
17502098 | -
First Author: Li J
Year: 2007
Journal: Structure
Title: Crystal structures of the BAR-PH and PTB domains of human APPL1.
Volume: 15
Issue: 5
Pages: 525-33
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Publication
17581628 | -
First Author: Zhu G
Year: 2007
Journal: EMBO J
Title: Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
Volume: 26
Issue: 14
Pages: 3484-93
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Publication
18854421 | -
First Author: Deepa SS
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: APPL1: role in adiponectin signaling and beyond.
Volume: 296
Issue: 1
Pages: E22-36
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Protein Domain
IPR035275 | Smim3
Type: Family
Description: Smim3 (Small integral membrane protein 3) also known as NID67 (NGF-induced differentiation clone 67) may be involved in forming or regulating ion channels in neuronal differentiation. It is strongly induced by NGF (Nerve Growth Factor) and FGF (Fibroblast Growth Factor), both of which cause these cells to differentiate. The amino acid sequence of NID67 is strongly conserved among rat, mouse and human. This family of small membrane proteins is only 60 amino acids long and analysis of the predicted peptide sequence reveals a stretch of 29 hydrophobic and uncharged residues which very likely comprise a trans-membrane region [].
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Protein Domain
IPR037929 | APPL1_BAR
Type: Domain
Description: Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing (APPL) proteins are effectors of the small GTPase Rab5 that function in endosome-mediated signaling []. They contain BAR, pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. They form homo- and hetero-oligomers that are mediated by their BAR domains []. Vertebrates contain two APPL proteins, APPL1 and APPL2. APPL1 interacts with diverse receptors (e.g. NGF receptor TrkA, FSHR, adiponectin receptors) and signaling proteins (e.g. Akt, PI3K), and may function as an adaptor linked to many distinct signaling pathways []. This entry represents the BAR domain of APPL1.
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Protein
P21237
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
P20181
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein
Q80VU4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
S5MVY4
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
Q8VHH4
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
Q3V1A4
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
H9H9S8
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
Q541P3
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Publication
8488558 | -
First Author: Bradshaw RA
Year: 1993
Journal: Trends Biochem Sci
Title: Nerve growth factor revisited.
Volume: 18
Issue: 2
Pages: 48-52
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Publication
12914971 | -
First Author: Johnson RA
Year: 2003
Journal: Brain Res
Title: Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain.
Volume: 983
Issue: 1-2
Pages: 108-14
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Publication
14507970 | -
First Author: Arvanian VL
Year: 2003
Journal: J Neurosci
Title: Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat.
Volume: 23
Issue: 25
Pages: 8706-12
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Publication
14499950 | -
First Author: Ying Z
Year: 2003
Journal: Brain Res
Title: Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord.
Volume: 987
Issue: 1
Pages: 93-9
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Publication
10869436 | J:63270
First Author: Xie CW
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene.
Volume: 97
Issue: 14
Pages: 8116-21
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Publication
18063676 | -
First Author: Tsao D
Year: 2008
Journal: Endocrinology
Title: TrkB agonists ameliorate obesity and associated metabolic conditions in mice.
Volume: 149
Issue: 3
Pages: 1038-48
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Publication
8843580 | -
First Author: Kostiza T
Year: 1996
Journal: Toxicon
Title: Nerve growth factors from snake venoms: chemical properties, mode of action and biological significance.
Volume: 34
Issue: 7
Pages: 787-806
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Publication
11288731 | -
First Author: Kukhtina VV
Year: 2001
Journal: J Nat Toxins
Title: Two forms of nerve growth factor from cobra venom prevent the death of PC12 cells in serum-free medium.
Volume: 10
Issue: 1
Pages: 9-16
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Protein Domain
IPR002072 | Nerve_growth_factor-rel
Type: Domain
Description: During the development of the vertebrate nervous system, many neuronsbecome redundant (because they have died, failed to connect to targetcells, etc.) and are eliminated. At the same time, developing neurons sendout axon outgrowths that contact their target cells []. Such cells controltheir degree of innervation (the number of axon connections) by thesecretion of various specific neurotrophic factors that are essential forneuron survival. One of these is nerve growth factor (NGF or beta-NGF), a vertebrate protein that stimulatesdivision and differentiation of sympathetic and embryonic sensory neurons [,]. NGF is mostly found outside the centralnervous system (CNS), but slight traces have been detected in adult CNStissues, although a physiological role for this is unknown []; it has alsobeen found in several snake venoms [, ].NGF is a protein of about 120 residues that is cleaved from a largerprecursor molecule. It contains six cysteines all involved in intrachaindisulphide bonds. A schematic representation of the structure of NGF is shownbelow:+------------------------+| || |xxxxxxCxxxxxxxxxxxxxxxxxxxxxCxxxxCxxxxxCxxxxxxxxxxxxxCxCxxxx| | | |+--------------------------|-----+ |+---------------------+'C': conserved cysteine involved in a disulphide bond.This entry also contains NGF-related proteins such as neutrophin 3, which promotes the survival of visceral and proprioceptive sensory neurons, and brain-derived neurotrophin, which promotes the survival of neuronal populations that are located either in the central nervous system or directly connected to it [, ].
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Protein Domain
IPR020408 | Nerve_growth_factor-like
Type: Family
Description: During the development of the vertebrate nervous system, many neuronsbecome redundant (because they have died, failed to connect to targetcells, etc.) and are eliminated. At the same time, developing neurons sendout axon outgrowths that contact their target cells []. Such cells controltheir degree of innervation (the number of axon connections) by thesecretion of various specific neurotrophic factors that are essential forneuron survival. One of these is nerve growth factor (NGF or beta-NGF), a vertebrate protein that stimulatesdivision and differentiation of sympathetic and embryonic sensory neurons [,]. NGF is mostly found outside the centralnervous system (CNS), but slight traces have been detected in adult CNStissues, although a physiological role for this is unknown []; it has alsobeen found in several snake venoms [, ].NGF is a protein of about 120 residues that is cleaved from a largerprecursor molecule. It contains six cysteines all involved in intrachaindisulphide bonds. A schematic representation of the structure of NGF is shownbelow:+------------------------+| || |xxxxxxCxxxxxxxxxxxxxxxxxxxxxCxxxxCxxxxxCxxxxxxxxxxxxxCxCxxxx| | | |+--------------------------|-----+ |+---------------------+'C': conserved cysteine involved in a disulphide bond.This entry also contains NGF-related proteins such as neutrophin 3, which promotes the survival of visceral and proprioceptive sensory neurons, and brain-derived neurotrophin, which promotes the survival of neuronal populations that are located either in the central nervous system or directly connected to it [, ].
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Protein Domain
IPR020432 | Neurotrophin-4
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outsidethe central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. Neurotrophin-4 (NT-4) exerts its effects by binding to neurotrophic tyrosine kinase receptor type 2 (NTRK2; also called TrkB). NT-4 has been shown to play a crucial role in the development of long-term memory []. It has also been implicated in the regulation of appetite and in body weight control [].
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Protein Domain
IPR015578 | Neurotrophin-3
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF or beta-NGF), a vertebrate protein that stimulates division and differentiation of sympathetic and embryonic sensory neurons [, ]. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ].NGF is a protein of about 120 residues that is cleaved from a larger precursor molecule. It contains six cysteines all involved in intrachain disulphide bonds.Neurotrophin-3 is a neurotrophic factor related to NGF and BDNF []. NT-3 and its receptor TrkC are found in the spinal cord, and their expression is altered by voluntary exercise [, , ]. In the brain, NT-3 and NT-4/5 may function synergistically with oleic acid to increase GAP-43 expression [].
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Protein Domain
IPR020433 | Venom_nerve_growth_factor
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival andoutgrowth activities. In contrast to mammalian NGFs, which exist as multimeric complexes of alpha, beta and gamma subunits, snake venom NGFs exist almost exclusively as beta-chains []. They act as low-potency neurotrophic tyrosine kinase receptor type 1 (NTRK1; also called TrkA) agonists [], and have been shown to promote survival and differentiation of cultured cells [].
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Protein Domain
IPR019846 | Nerve_growth_factor_CS
Type: Conserved_site
Description: During the development of the vertebrate nervous system, many neuronsbecome redundant (because they have died, failed to connect to targetcells, etc.) and are eliminated. At the same time, developing neurons sendout axon outgrowths that contact their target cells []. Such cells controltheir degree of innervation (the number of axon connections) by thesecretion of various specific neurotrophic factors that are essential forneuron survival. One of these is nerve growth factor (NGF or beta-NGF), a vertebrate protein that stimulatesdivision and differentiation of sympathetic and embryonic sensory neurons [,]. NGF is mostly found outside the centralnervous system (CNS), but slight traces have been detected in adult CNStissues, although a physiological rolefor this is unknown []; it has alsobeen found in several snake venoms [, ].NGF is a protein of about 120 residues that is cleaved from a largerprecursor molecule. It contains six cysteines all involved in intrachaindisulphide bonds. A schematic representation of the structure of NGF is shownbelow:+------------------------+| || |xxxxxxCxxxxxxxxxxxxxxxxxxxxxCxxxxCxxxxxCxxxxxxxxxxxxxCxCxxxx| | | |+--------------------------|-----+ |+---------------------+'C': conserved cysteine involved in a disulphide bond.This entry also contains NGF-related proteins such as neutrophin 3, which promotes the survival of visceral and proprioceptive sensory neurons, and brain-derived neurotrophin, which promotes the survival of neuronal populations that are located either in the central nervous system or directly connected to it [, ].This entry covers the central region of the proteins and include two of the six cysteines involved in disulphide bonds.
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HT Experiment
E-GEOD-23530 | WT vs Hypomethylated DRG Gene Expression
Series Id: GSE23530
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
11553291 | J:127897
First Author: Ritter AM
Year: 2001
Journal: Eur J Neurosci
Title: Excess target-derived neurotrophin-3 alters the segmental innervation of the skin.
Volume: 14
Issue: 3
Pages: 411-8
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Protein
E2IUB1
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
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Publication
7188352 | J:14600
First Author: Barde YA
Year: 1982
Journal: EMBO J
Title: Purification of a new neurotrophic factor from mammalian brain.
Volume: 1
Issue: 5
Pages: 549-53
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Publication
9517463 | J:46745
First Author: Linnarsson S
Year: 1997
Journal: Eur J Neurosci
Title: Learning deficit in BDNF mutant mice.
Volume: 9
Issue: 12
Pages: 2581-7
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Publication
16632412 | -
 
First Author: Lebrun B
Year: 2006
Journal: Auton Neurosci
Title: Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview.
Volume: 126-127
Pages: 30-8
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Publication
17949819 | -
First Author: Kozisek ME
Year: 2008
Journal: Pharmacol Ther
Title: Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies.
Volume: 117
Issue: 1
Pages: 30-51
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Protein Domain
IPR020430 | Brain-der_neurotrophic_factor
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. Originally purified from pig brain [], the neurotrophin BDNF is expressed in a range of tissues and cell types in the CNS and periphery. It exerts its effects by binding to neurotrophic tyrosine kinase receptor type 2 (NTRK2; also called TrkB) and the low affinity nerve growth factor receptor, p75NTR. While the former receptor mediates the neurotrophin's prosurvival functions, activation of p75NTR by BDNF has been shown to promote apoptosis and to inhibit axonal growth []. BDNF is a key regulator of synaptic plasticity, and plays an important role in learning and memory []. Several lines of evidence suggest that it is also involved in the control of food intake and body weight []. A number of clinical studies have demonstrated an association between aberrant BDNF levels and disorders and disease states, such as depression, epilepsy, bipolar disorder, Parkinson's disease and Alzheimer's disease [].
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Protein
A0A1B4Z9M7
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
W8QD88
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Protein
Q99NV8
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Publication
2236018 | -
First Author: Jones KR
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of a human gene that is a member of the nerve growth factor family.
Volume: 87
Issue: 20
Pages: 8060-4
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Publication
8527932 | -
First Author: Rosenfeld RD
Year: 1995
Journal: Protein Expr Purif
Title: Purification and identification of brain-derived neurotrophic factor from human serum.
Volume: 6
Issue: 4
Pages: 465-71
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Publication
1645620 | J:41382
First Author: Soppet D
Year: 1991
Journal: Cell
Title: The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.
Volume: 65
Issue: 5
Pages: 895-903
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Publication
10894779 | J:63419
First Author: Pozniak CD
Year: 2000
Journal: Science
Title: An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.
Volume: 289
Issue: 5477
Pages: 304-6
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Publication
12205295 | J:135382
First Author: Capsoni S
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.
Volume: 99
Issue: 19
Pages: 12432-7
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Publication
12359148 | J:79383
First Author: Capsoni S
Year: 2002
Journal: Mol Cell Neurosci
Title: Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Volume: 21
Issue: 1
Pages: 15-28
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Publication
15207235 | J:91561
First Author: Zhou FQ
Year: 2004
Journal: Neuron
Title: NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC.
Volume: 42
Issue: 6
Pages: 897-912
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Publication
6648531 | J:7262
First Author: Francke U
Year: 1983
Journal: Science
Title: The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1.
Volume: 222
Issue: 4629
Pages: 1248-51
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Publication
7534333 | J:23780
First Author: Awatsuji H
Year: 1995
Journal: J Neurochem
Title: Interferons suppress nerve growth factor synthesis as a result of interference with cell growth in astrocytes cultured from neonatal mouse brain.
Volume: 64
Issue: 4
Pages: 1476-82
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Publication
3589669 | J:20118
First Author: Wistow G
Year: 1987
Journal: Science
Title: Recruitment of enzymes as lens structural proteins.
Volume: 236
Issue: 4808
Pages: 1554-6
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Publication
14659533 | J:127896
First Author: Zwick M
Year: 2003
Journal: Pain
Title: Transgenic mice possessing increased numbers of nociceptors do not exhibit increased behavioral sensitivity in models of inflammatory and neuropathic pain.
Volume: 106
Issue: 3
Pages: 491-500
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Publication
37808473 | J:347997
 
First Author: Calvo-Enrique L
Year: 2023
Journal: Front Mol Neurosci
Title: Enhanced TrkA signaling impairs basal forebrain-dependent behavior.
Volume: 16
Pages: 1266983
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Protein
F6TBT6
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
A0A0A6YY02
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Publication
9722946 | J:49566
First Author: Buanne P
Year: 1998
Journal: Genomics
Title: Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.
Volume: 51
Issue: 2
Pages: 233-42
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Publication
16919030 | -
First Author: Adly MA
Year: 2006
Journal: J Cutan Pathol
Title: Expression of nerve growth factor and its high-affinity receptor, tyrosine kinase A proteins, in the human scalp skin.
Volume: 33
Issue: 8
Pages: 559-68
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Publication
9547236 | -
First Author: Yoon SO
Year: 1998
Journal: J Neurosci
Title: Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.
Volume: 18
Issue: 9
Pages: 3273-81
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Protein Domain
IPR020461 | NTRK1
Type: Family
Description: Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. NTRK1 (also termed TrkA) is a high-affinity receptor for nerve growth factor (NGF). The receptor is expressed in the dorsal root ganglia, trigeminal ganglia and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons []. It is also expressed in peripheral sites, such as scalp skin []. Whereas p75NTR activation by NGF induces apoptosis, NTRK1 mediates the growth factor's cell survival-promoting effects [].
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Publication
17868035 | J:289093
First Author: Masuda S
Year: 2008
Journal: Biochem J
Title: Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Volume: 409
Issue: 2
Pages: 429-38
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Publication
3848399 | J:7928
First Author: Evans BA
Year: 1985
Journal: EMBO J
Title: Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous.
Volume: 4
Issue: 1
Pages: 133-8
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Publication
9070890 | J:38625
First Author: Mukasa T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF.
Volume: 231
Issue: 3
Pages: 770-4
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Publication
9182757 | J:40779
First Author: Kouhara H
Year: 1997
Journal: Cell
Title: A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Volume: 89
Issue: 5
Pages: 693-702
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Publication
7748562 | J:37535
First Author: Messersmith EK
Year: 1995
Journal: Neuron
Title: Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord.
Volume: 14
Issue: 5
Pages: 949-59
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Publication
11278671 | J:69410
First Author: Sun YF
Year: 2001
Journal: J Biol Chem
Title: Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.
Volume: 276
Issue: 19
Pages: 16240-7
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Publication
17218959 | J:139242
First Author: Vaughn AE
Year: 2007
Journal: Cell Death Differ
Title: Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons.
Volume: 14
Issue: 5
Pages: 973-81
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Publication
27989802 | J:238420
First Author: Hayakawa Y
Year: 2017
Journal: Cancer Cell
Title: Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
Volume: 31
Issue: 1
Pages: 21-34
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Publication
29249692 | J:253745
First Author: Renz BW
Year: 2018
Journal: Cancer Cell
Title: β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.
Volume: 33
Issue: 1
Pages: 75-90.e7
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Publication
7546744 | J:119622
First Author: Greenlund LJ
Year: 1995
Journal: Neuron
Title: Role of BCL-2 in the survival and function of developing and mature sympathetic neurons.
Volume: 15
Issue: 3
Pages: 649-61
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Publication
15147324 | J:90300
First Author: Hannila SS
Year: 2004
Journal: Eur J Neurosci
Title: TrkA and mitogen-activated protein kinase phosphorylation are enhanced in sympathetic neurons lacking functional p75 neurotrophin receptor expression.
Volume: 19
Issue: 10
Pages: 2903-8
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Publication
9835221 | J:54742
First Author: Bergmann I
Year: 1998
Journal: Neurosci Lett
Title: Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75.
Volume: 255
Issue: 2
Pages: 87-90
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Publication
9267038 | J:113179
First Author: McNulty JA
Year: 1997
Journal: J Submicrosc Cytol Pathol
Title: Pinealocyte ultrastructure in mutant mice that lack sympathetic innervation to the pineal gland.
Volume: 29
Issue: 3
Pages: 305-11
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Publication
9315882 | J:107543
First Author: Yeo TT
Year: 1997
Journal: J Neurosci
Title: Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
Volume: 17
Issue: 20
Pages: 7594-605
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Publication
11301022 | J:292901
First Author: Putcha GV
Year: 2001
Journal: Neuron
Title: Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis.
Volume: 29
Issue: 3
Pages: 615-28
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Publication
16932756 | J:132340
First Author: Wright KM
Year: 2007
Journal: Cell Death Differ
Title: Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons.
Volume: 14
Issue: 3
Pages: 625-33
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Publication
23831387 | J:214024
 
First Author: Pellegrino MJ
Year: 2013
Journal: Mol Cell Neurosci
Title: STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.
Volume: 56
Pages: 272-82
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Publication
16337913 | J:105512
First Author: Jacobs WB
Year: 2005
Journal: Neuron
Title: p63 is an essential proapoptotic protein during neural development.
Volume: 48
Issue: 5
Pages: 743-56
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Publication
14654461 | J:106248
First Author: Golan H
Year: 2004
Journal: Cereb Cortex
Title: Involvement of tumor necrosis factor alpha in hippocampal development and function.
Volume: 14
Issue: 1
Pages: 97-105
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Publication
11685224 | J:109370
First Author: Barker V
Year: 2001
Journal: Nat Neurosci
Title: TNFalpha contributes to the death of NGF-dependent neurons during development.
Volume: 4
Issue: 12
Pages: 1194-8
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Publication
11906694 | J:75437
First Author: Akassoglou K
Year: 2002
Journal: Neuron
Title: Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation.
Volume: 33
Issue: 6
Pages: 861-75
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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