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Search results 601 to 700 out of 2317 for Nkx2-1

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Type Details Score
Publication  
First Author: Ah-Cann C
Year: 2021
Journal: Development
Title: A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
Volume: 148
Issue: 13
Publication
First Author: Li S
Year: 2023
Journal: Stem Cell Reports
Title: DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury.
Volume: 18
Issue: 9
Pages: 1841-1853
Publication    
First Author: Miura A
Year: 2023
Journal: Elife
Title: Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung.
Volume: 12
Publication
First Author: Mahoney JE
Year: 2014
Journal: Dev Cell
Title: The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
Volume: 30
Issue: 2
Pages: 137-50
Publication
First Author: Gerner-Mauro KN
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.
Volume: 117
Issue: 22
Pages: 12182-12191
Publication
First Author: Wei W
Year: 2022
Journal: J Biol Chem
Title: Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching.
Volume: 298
Issue: 10
Pages: 102490
Publication
First Author: Zhang K
Year: 2022
Journal: Nat Commun
Title: mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity.
Volume: 13
Issue: 1
Pages: 7252
Publication    
First Author: Khattar D
Year: 2022
Journal: Elife
Title: PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors.
Volume: 11
Publication
First Author: Li S
Year: 2016
Journal: Dev Biol
Title: Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.
Volume: 416
Issue: 2
Pages: 338-46
Publication    
First Author: Rankin SA
Year: 2021
Journal: Elife
Title: Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Volume: 10
Publication
First Author: Mitani A
Year: 2009
Journal: Am J Respir Crit Care Med
Title: Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice.
Volume: 180
Issue: 4
Pages: 326-38
Publication
First Author: Woo J
Year: 2011
Journal: PLoS One
Title: Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation.
Volume: 6
Issue: 7
Pages: e22493
Publication
First Author: Kim HT
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.
Volume: 116
Issue: 51
Pages: 25697-25706
Publication  
First Author: Chen SY
Year: 2023
Journal: Development
Title: The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung.
Volume: 150
Issue: 16
Publication
First Author: Volckaert T
Year: 2013
Journal: Development
Title: Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors.
Volume: 140
Issue: 18
Pages: 3731-42
Publication
First Author: Shu W
Year: 2007
Journal: Development
Title: Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.
Volume: 134
Issue: 10
Pages: 1991-2000
Publication
First Author: Ishizaki-Asami R
Year: 2020
Journal: Dev Biol
Title: Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development.
Volume: 458
Issue: 2
Pages: 237-245
Publication  
First Author: Merino RM
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons.
Volume: 118
Issue: 51
Publication    
First Author: Granger AJ
Year: 2020
Journal: Elife
Title: Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner.
Volume: 9
Publication
First Author: Liu H
Year: 2023
Journal: PLoS Biol
Title: DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models.
Volume: 21
Issue: 4
Pages: e3002078
Publication  
First Author: Stoupa A
Year: 2018
Journal: EMBO Mol Med
Title: TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology.
Volume: 10
Issue: 12
Publication
First Author: Chen B
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.
Volume: 102
Issue: 47
Pages: 17184-9
Publication
First Author: Ehrman JM
Year: 2022
Journal: J Neurosci
Title: Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants.
Volume: 42
Issue: 16
Pages: 3344-3364
Publication
First Author: Ha HY
Year: 2008
Journal: Proteomics
Title: Morphogenetic lung defects of JSAP1-deficient embryos proceeds via the disruptions of the normal expressions of cytoskeletal and chaperone proteins.
Volume: 8
Issue: 5
Pages: 1071-80
Publication
First Author: Flodby P
Year: 2016
Journal: Am J Respir Cell Mol Biol
Title: The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development.
Volume: 55
Issue: 1
Pages: 135-49
Publication
First Author: Furushima K
Year: 2005
Journal: Dev Dyn
Title: Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.
Volume: 232
Issue: 4
Pages: 1056-61
Publication  
First Author: Jones MR
Year: 2018
Journal: Front Genet
Title: A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis.
Volume: 9
Pages: 746
Publication
First Author: Biehl MJ
Year: 2018
Journal: Dev Biol
Title: Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling.
Volume: 442
Issue: 1
Pages: 87-100
Publication
First Author: Mori T
Year: 2004
Journal: Eur J Neurosci
Title: The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons.
Volume: 19
Issue: 12
Pages: 3129-41
Publication
First Author: Langer L
Year: 2012
Journal: Mech Dev
Title: SOX2 hypomorphism disrupts development of the prechordal floor and optic cup.
Volume: 129
Issue: 1-4
Pages: 1-12
Publication
First Author: Zhang K
Year: 2020
Journal: Cell Rep
Title: Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation.
Volume: 31
Issue: 3
Pages: 107521
Publication
First Author: McCarthy DM
Year: 2011
Journal: J Neurosci
Title: Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain.
Volume: 31
Issue: 38
Pages: 13400-11
Publication
First Author: Zhao R
Year: 2024
Journal: Sci Adv
Title: Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally.
Volume: 10
Issue: 31
Pages: eadk4331
Publication
First Author: Lu J
Year: 2017
Journal: Nat Neurosci
Title: Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells.
Volume: 20
Issue: 10
Pages: 1377-1383
Publication    
First Author: Lee BR
Year: 2021
Journal: Elife
Title: Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization.
Volume: 10
Publication
First Author: Paul A
Year: 2017
Journal: Cell
Title: Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.
Volume: 171
Issue: 3
Pages: 522-539.e20
Publication
First Author: Gouwens NW
Year: 2020
Journal: Cell
Title: Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells.
Volume: 183
Issue: 4
Pages: 935-953.e19
Publication
First Author: Yao Z
Year: 2021
Journal: Cell
Title: A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Volume: 184
Issue: 12
Pages: 3222-3241.e26
Publication
First Author: Ishino Y
Year: 2017
Journal: J Neurosci
Title: Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells.
Volume: 37
Issue: 41
Pages: 9901-9916
Publication
First Author: Graybuck LT
Year: 2021
Journal: Neuron
Title: Enhancer viruses for combinatorial cell-subclass-specific labeling.
Volume: 109
Issue: 9
Pages: 1449-1464.e13
Publication
First Author: Mayer C
Year: 2018
Journal: Nature
Title: Developmental diversification of cortical inhibitory interneurons.
Volume: 555
Issue: 7697
Pages: 457-462
Publication
First Author: Nery S
Year: 2002
Journal: Nat Neurosci
Title: The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations.
Volume: 5
Issue: 12
Pages: 1279-87
Publication
First Author: Miyoshi G
Year: 2015
Journal: J Neurosci
Title: Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons.
Volume: 35
Issue: 37
Pages: 12869-89
Publication
First Author: Marsh ED
Year: 2016
Journal: BMC Neurosci
Title: Developmental interneuron subtype deficits after targeted loss of Arx.
Volume: 17
Issue: 1
Pages: 35
Publication
First Author: Yang Y
Year: 2017
Journal: Cereb Cortex
Title: Impaired Interneuron Development after Foxg1 Disruption.
Volume: 27
Issue: 1
Pages: 793-808
Publication
First Author: Lodato S
Year: 2011
Journal: J Neurosci
Title: Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy.
Volume: 31
Issue: 12
Pages: 4650-62
Publication  
First Author: Mitsogiannis MD
Year: 2020
Journal: Front Cell Dev Biol
Title: Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.
Volume: 8
Pages: 624181
Publication
First Author: Cheong H
Year: 2014
Journal: Autophagy
Title: Analysis of a lung defect in autophagy-deficient mouse strains.
Volume: 10
Issue: 1
Pages: 45-56
Publication
First Author: Jin JZ
Year: 2006
Journal: Dev Dyn
Title: Expression and functional analysis of Tgif during mouse midline development.
Volume: 235
Issue: 2
Pages: 547-53
Publication
First Author: Pensold D
Year: 2017
Journal: Cereb Cortex
Title: The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.
Volume: 27
Issue: 12
Pages: 5696-5714
Publication
First Author: McCarthy DM
Year: 2012
Journal: Dev Neurosci
Title: Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo.
Volume: 34
Issue: 4
Pages: 366-78
Publication
First Author: Londhe VA
Year: 2008
Journal: Dev Dyn
Title: NF-kB induces lung maturation during mouse lung morphogenesis.
Volume: 237
Issue: 2
Pages: 328-38
Publication
First Author: Gerlini R
Year: 2019
Journal: Cell Death Dis
Title: Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
Volume: 10
Issue: 10
Pages: 747
Publication
First Author: Ramasamy SK
Year: 2007
Journal: Dev Biol
Title: Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development.
Volume: 307
Issue: 2
Pages: 237-47
Publication
First Author: Miller MF
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Wnt ligands signal in a cooperative manner to promote foregut organogenesis.
Volume: 109
Issue: 38
Pages: 15348-53
Publication
First Author: Zhang Z
Year: 2024
Journal: Nat Commun
Title: Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
Volume: 15
Issue: 1
Pages: 4108
Publication
First Author: Prall OW
Year: 2007
Journal: Cell
Title: An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
Volume: 128
Issue: 5
Pages: 947-59
Publication
First Author: Imbriglio T
Year: 2019
Journal: FASEB J
Title: Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.
Volume: 33
Issue: 12
Pages: 14204-14220
Publication
First Author: Tian J
Year: 2006
Journal: Cancer Res
Title: Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia.
Volume: 66
Issue: 21
Pages: 10399-407
Publication
First Author: Lovgren AK
Year: 2007
Journal: Mol Cell Biol
Title: cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis.
Volume: 27
Issue: 12
Pages: 4416-30
Publication
First Author: Trowe MO
Year: 2013
Journal: Development
Title: Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.
Volume: 140
Issue: 11
Pages: 2299-309
Publication
First Author: Wojahn I
Year: 2019
Journal: Respir Res
Title: TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung.
Volume: 20
Issue: 1
Pages: 292
Publication
First Author: Mehler MF
Year: 2019
Journal: J Neurosci
Title: Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks.
Volume: 39
Issue: 10
Pages: 1892-1909
Publication  
First Author: Steinecke A
Year: 2017
Journal: eNeuro
Title: Neocortical Chandelier Cells Developmentally Shape Axonal Arbors through Reorganization but Establish Subcellular Synapse Specificity without Refinement.
Volume: 4
Issue: 3
Publication  
First Author: Boggild S
Year: 2016
Journal: BMC Cell Biol
Title: Spatiotemporal patterns of sortilin and SorCS2 localization during organ development.
Volume: 17
Pages: 8
Publication
First Author: Ehrman LA
Year: 2014
Journal: J Neurosci
Title: The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.
Volume: 34
Issue: 10
Pages: 3767-78
Publication  
First Author: Didier-Mathon H
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures.
Volume: 14
Pages: 1286747
Publication
First Author: Ashique AM
Year: 2009
Journal: Sci Signal
Title: The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.
Volume: 2
Issue: 95
Pages: ra70
Publication
First Author: Tokizane K
Year: 2024
Journal: Cell Metab
Title: DMH(Ppp1r17) neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication.
Volume: 36
Issue: 2
Pages: 377-392.e11
Publication  
First Author: Tsuji S
Year: 2023
Journal: Life Sci Alliance
Title: Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.
Volume: 6
Issue: 6
Publication
First Author: Taniguchi H
Year: 2011
Journal: Neuron
Title: A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.
Volume: 71
Issue: 6
Pages: 995-1013
Publication
First Author: Wefelmeyer W
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Activity-dependent mismatch between axo-axonic synapses and the axon initial segment controls neuronal output.
Volume: 112
Issue: 31
Pages: 9757-62
Publication
First Author: Wang X
Year: 2019
Journal: Cell Rep
Title: Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells.
Volume: 26
Issue: 11
Pages: 3145-3159.e5
Publication
First Author: Raju CS
Year: 2018
Journal: Cereb Cortex
Title: Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Volume: 28
Issue: 6
Pages: 1946-1958
Publication
First Author: Pan-Vazquez A
Year: 2020
Journal: Neuron
Title: Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment.
Volume: 106
Issue: 2
Pages: 265-276.e6
Publication
First Author: Tai Y
Year: 2019
Journal: Neuron
Title: Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM.
Volume: 102
Issue: 2
Pages: 358-372.e9
Publication  
First Author: Gomez L
Year: 2023
Journal: Development
Title: Developmental emergence of cortical neurogliaform cell diversity.
Volume: 150
Issue: 15
Publication
First Author: Schappe MS
Year: 2024
Journal: Nature
Title: A vagal reflex evoked by airway closure.
Volume: 627
Issue: 8005
Pages: 830-838
Publication
First Author: Hou Y
Year: 2021
Journal: Cell Rep
Title: Topographical organization of mammillary neurogenesis and efferent projections in the mouse brain.
Volume: 34
Issue: 6
Pages: 108712
Publication
First Author: Lu Y
Year: 2007
Journal: Dev Biol
Title: Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
Volume: 310
Issue: 2
Pages: 442-53
Publication
First Author: Pei L
Year: 2011
Journal: Nat Med
Title: Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Volume: 17
Issue: 11
Pages: 1466-72
Publication  
First Author: Ko HA
Year: 2013
Journal: Neurosci Lett
Title: Cell type-selective expression of the zinc finger-containing gene Nolz-1/Zfp503 in the developing mouse striatum.
Volume: 548
Pages: 44-9
Publication
First Author: Jia Z
Year: 2014
Journal: Mol Cell Biol
Title: Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity.
Volume: 34
Issue: 20
Pages: 3895-910
Publication
First Author: Hashimoto K
Year: 2019
Journal: Genes Cells
Title: Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.
Volume: 24
Issue: 6
Pages: 436-448
Publication
First Author: Guo H
Year: 2017
Journal: Dev Biol
Title: Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.
Volume: 430
Issue: 1
Pages: 214-223
Publication
First Author: Salvatierra J
Year: 2014
Journal: J Neurosci
Title: The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.
Volume: 34
Issue: 50
Pages: 16809-20
Publication
First Author: Koike S
Year: 2011
Journal: Dev Dyn
Title: Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development.
Volume: 240
Issue: 2
Pages: 413-21
Publication
First Author: Moon S
Year: 2018
Journal: Cell Death Dis
Title: Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Volume: 9
Issue: 11
Pages: 1118
Publication
First Author: Ding W
Year: 2021
Journal: Sci China Life Sci
Title: Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice.
Volume: 64
Issue: 3
Pages: 419-433
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Kishimoto K
Year: 2011
Journal: Exp Cell Res
Title: Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.
Volume: 317
Issue: 15
Pages: 2110-23
Publication
First Author: Na E
Year: 2022
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia.
Volume: 322
Issue: 4
Pages: L550-L563
Publication
First Author: Shibata M
Year: 2011
Journal: J Neurosci
Title: MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.
Volume: 31
Issue: 9
Pages: 3407-22
Publication
First Author: Paronett EM
Year: 2015
Journal: Cereb Cortex
Title: Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.
Volume: 25
Issue: 10
Pages: 3977-93
Publication
First Author: Havrilak JA
Year: 2017
Journal: Dev Biol
Title: Endothelial cells are not required for specification of respiratory progenitors.
Volume: 427
Issue: 1
Pages: 93-105
Publication
First Author: Abdelhamed ZA
Year: 2013
Journal: Hum Mol Genet
Title: Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects.
Volume: 22
Issue: 7
Pages: 1358-72
Publication
First Author: Chakraborty S
Year: 2023
Journal: Nat Genet
Title: Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness.
Volume: 55
Issue: 2
Pages: 280-290
Publication
First Author: Kariyawasam D
Year: 2015
Journal: Endocrinology
Title: DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.
Volume: 156
Issue: 3
Pages: 1171-80
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication
First Author: Yu D
Year: 2022
Journal: Sci Adv
Title: Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Volume: 8
Issue: 18
Pages: eabm2545