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  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
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Search results 601 to 700 out of 2075 for Numb

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0.018s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
F8WJ74
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: false
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Protein
E9QLZ9
Organism: Mus musculus/domesticus
Length: 804  
Fragment?: false
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Protein
A0A1D5RLT6
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
E0CXT5
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
O08846
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
Q571F3
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
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Protein
A0A0G2JE79
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q3TRI2
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
A2AM80
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
A0A140LJ06
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Protein
A0A0A6YW06
Organism: Mus musculus/domesticus
Length: 785  
Fragment?: false
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Protein
F6RCM5
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
E0CYH9
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
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Protein
E9QKR1
Organism: Mus musculus/domesticus
Length: 562  
Fragment?: false
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Protein
J3QNM3
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
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Protein
A0A0A0MQI4
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
B8JJF3
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
D6RFA7
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
Q3U6M5
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
E9Q4F9
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
F6TQN9
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: true
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Protein
F2Z465
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein
Q3TYD2
Organism: Mus musculus/domesticus
Length: 940  
Fragment?: true
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Protein
E9QKQ9
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
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Protein
H7BX82
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: true
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Protein
E9PX84
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
A0A0R4J104
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q3TBZ6
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q0VB06
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
B2RRQ8
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Publication
2146028 | J:23352
First Author: Carthew RW
Year: 1990
Journal: Cell
Title: seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.
Volume: 63
Issue: 3
Pages: 561-77
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Publication
9334332 | J:44146
First Author: Hu G
Year: 1997
Journal: Genes Dev
Title: Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Volume: 11
Issue: 20
Pages: 2701-14
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Publication
11752454 | -
First Author: Susini L
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Siah-1 binds and regulates the function of Numb.
Volume: 98
Issue: 26
Pages: 15067-72
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Publication
9858595 | -
First Author: Hu G
Year: 1999
Journal: Mol Cell Biol
Title: Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.
Volume: 19
Issue: 1
Pages: 724-32
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Protein Domain
IPR013010 | Znf_SIAH
Type: Domain
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. SINA/Siah family proteins represent mammalian homologs of the Drosophila SINA (seven in absentia) protein. SINA is required for R7 photoreceptor cell differentiation within the sevenless pathway []. Members of this family are E3 ubiquitin ligases that regulate ubiquitination and protein degradation. Siahs are known to recognise several target proteins including Deleted in Colorectal Cancer (DCC), synaptophysin and Numb and promote their degradation [, ]. SINA/Siah sequences are highly conserved from plants to mammals. Whereas the N terminus and RING domain of Siah bind E2 proteins, the C terminus can be considered as a substrate- and cofactor-interaction domain (substrate-binding domain, SBD) that interacts with a number of proteins, some of which are degraded []. The SBD domain displays some sequence similarities with the C-terminal region of TRAF proteins. It contains a cysteine-rich region, the SIAH-type zinc finger, with eight totally conserved Cys and His residues that coordinate two zinc atoms []. The crystal structure of SIAH-type zinc finger has been solved []. It folds in two subdomains, each one binding one zinc atom and consisting of two β-strands and an alpha helice.
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Protein
Q61474
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
Q920Q6
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q3TE41
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q2M2Q8
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
Q9WVG6
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q8BZI0
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: false
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Protein
P70429
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q8K2Y9
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
Q9JIH2
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q6P2K6
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
Q8BUL6
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: false
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Protein
Q9Z2Y3
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Protein
Q3UBG2
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
Q99JP6
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
Q8C886
Organism: Mus musculus/domesticus
Length: 610  
Fragment?: false
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Protein
Q5FWH6
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Protein
Q5DU31
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q61189
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
Q8BSM5
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
Q8BUP8
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q922R5
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
B2RPU2
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
Q9Z1S8
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
Q9D240
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Protein
Q8BH49
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q924S7
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q9QWW1
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Publication
11742346 | -
First Author: Polekhina G
Year: 2002
Journal: Nat Struct Biol
Title: Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
Volume: 9
Issue: 1
Pages: 68-75
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Protein
Q8K1I7
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
O08969
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
Q9QYE9
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Protein
Q6P6N5
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q9ERS5
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
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Protein
Q8BW88
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q9WV95
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
P70460
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
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Protein
Q9QZC7
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Protein
Q9DBA9
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Protein
Q924S8
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
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Protein
Q8K124
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein
Q14B98
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Q505A4
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
Q8R2X2
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: true
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Protein
F8WIK5
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: true
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Protein
Q3V2K7
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
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Protein
A0A0R4J1V5
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
Q8CIU5
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q3ZB57
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
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Protein
Q3U5J8
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
Q8BTJ6
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q9D097
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
F7BZ65
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
A0A2I3BQ18
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
Q8R1D9
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
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Protein
A0A0J9YV29
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Protein
A0A087WRL5
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
E9PVP4
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
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Protein
D3YUP1
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
E9QKD9
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
X2CUM2
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Protein
D3Z6A9
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
D3YV71
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: false
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Protein
A0A5F8MPI5
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
B1AYB9
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom