| Type |
Details |
Score |
| Publication |
| First Author: |
Hopper RK |
| Year: |
2016 |
| Journal: |
Circulation |
| Title: |
In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug. |
| Volume: |
133 |
| Issue: |
18 |
| Pages: |
1783-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong KH |
| Year: |
2008 |
| Journal: |
Circulation |
| Title: |
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. |
| Volume: |
118 |
| Issue: |
7 |
| Pages: |
722-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bauer EM |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. |
| Volume: |
6 |
| Issue: |
12 |
| Pages: |
e28578 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
George PM |
| Year: |
2014 |
| Journal: |
Circ Res |
| Title: |
Evidence for the involvement of type I interferon in pulmonary arterial hypertension. |
| Volume: |
114 |
| Issue: |
4 |
| Pages: |
677-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
West JD |
| Year: |
2019 |
| Journal: |
Pulm Circ |
| Title: |
Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension. |
|
|
| Pages: |
2045894019856483 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jeong EM |
| Year: |
2022 |
| Journal: |
Cardiovasc Res |
| Title: |
Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension. |
| Volume: |
118 |
| Issue: |
16 |
| Pages: |
3211-3224 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
White K |
| Year: |
2012 |
| Journal: |
Circulation |
| Title: |
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. |
| Volume: |
126 |
| Issue: |
9 |
| Pages: |
1087-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu MH |
| Year: |
2011 |
| Journal: |
J Vasc Res |
| Title: |
Absence of the adenosine A2A receptor confers pulmonary arterial hypertension and increased pulmonary vascular remodeling in mice. |
| Volume: |
48 |
| Issue: |
2 |
| Pages: |
171-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma Z |
| Year: |
2019 |
| Journal: |
Circulation |
| Title: |
Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1. |
| Volume: |
139 |
| Issue: |
13 |
| Pages: |
1629-1642 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gore B |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
e100310 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshikawa N |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice. |
| Volume: |
7 |
| Issue: |
12 |
| Pages: |
e52522 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao D |
| Year: |
2011 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Attenuated renal vascular responses to acute angiotensin II infusion in smooth muscle-specific Na+/Ca2+ exchanger knockout mice. |
| Volume: |
301 |
| Issue: |
3 |
| Pages: |
F574-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shah M |
| Year: |
2018 |
| Journal: |
J Surg Res |
| Title: |
Echocardiography allows for analysis of pulmonary arterial flow in mice with congenital diaphragmatic hernia. |
| Volume: |
221 |
|
| Pages: |
35-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eraly SA |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. |
| Volume: |
281 |
| Issue: |
8 |
| Pages: |
5072-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bordenave J |
| Year: |
2020 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension. |
| Volume: |
40 |
| Issue: |
3 |
| Pages: |
766-782 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Furuya M |
| Year: |
2008 |
| Journal: |
Lab Invest |
| Title: |
Impaired placental neovascularization in mice with pregnancy-associated hypertension. |
| Volume: |
88 |
| Issue: |
4 |
| Pages: |
416-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu B |
| Year: |
2024 |
| Journal: |
Cardiovasc Res |
| Title: |
ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport. |
| Volume: |
120 |
| Issue: |
7 |
| Pages: |
756-768 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alexander DL |
| Year: |
1997 |
| Journal: |
Cancer Res |
| Title: |
Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells. |
| Volume: |
57 |
| Issue: |
20 |
| Pages: |
4498-506 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nesnow S |
| Year: |
1995 |
| Journal: |
Toxicology |
| Title: |
Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A/J mice. |
| Volume: |
105 |
| Issue: |
2-3 |
| Pages: |
403-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hecht SS |
| Year: |
1998 |
| Journal: |
Carcinogenesis |
| Title: |
Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
157-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nesnow S |
| Year: |
1998 |
| Journal: |
Environ Health Perspect |
| Title: |
Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons. |
| Volume: |
106 Suppl 6 |
|
| Pages: |
1337-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hecht SS |
| Year: |
2002 |
| Journal: |
Cancer Lett |
| Title: |
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. |
| Volume: |
187 |
| Issue: |
1-2 |
| Pages: |
87-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fitzgerald DJ |
| Year: |
2004 |
| Journal: |
Environ Health Perspect |
| Title: |
Application of benzo(a)pyrene and coal tar tumor dose-response data to a modified benchmark dose method of guideline development. |
| Volume: |
112 |
| Issue: |
14 |
| Pages: |
1341-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fischer JM |
| Year: |
2005 |
| Journal: |
Mutat Res |
| Title: |
Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin. |
| Volume: |
588 |
| Issue: |
1 |
| Pages: |
35-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chakravarti D |
| Year: |
2008 |
| Journal: |
Mutat Res |
| Title: |
The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin. |
| Volume: |
649 |
| Issue: |
1-2 |
| Pages: |
161-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shahid M |
| Year: |
2008 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in mice. |
| Volume: |
295 |
| Issue: |
6 |
| Pages: |
F1836-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stenmark KR |
| Year: |
2009 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. |
| Volume: |
297 |
| Issue: |
6 |
| Pages: |
L1013-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernandez RA |
| Year: |
2015 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. |
| Volume: |
308 |
| Issue: |
8 |
| Pages: |
C581-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jia D |
| Year: |
2017 |
| Journal: |
Cardiovasc Res |
| Title: |
RAGE-mediated extracellular matrix proteins accumulation exacerbates HySu-induced pulmonary hypertension. |
| Volume: |
113 |
| Issue: |
6 |
| Pages: |
586-597 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hood KY |
| Year: |
2017 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension. |
| Volume: |
37 |
| Issue: |
7 |
| Pages: |
1361-1370 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Omura J |
| Year: |
2019 |
| Journal: |
Circ Res |
| Title: |
ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target. |
| Volume: |
125 |
| Issue: |
10 |
| Pages: |
884-906 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kurosawa R |
| Year: |
2019 |
| Journal: |
Circ Res |
| Title: |
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension. |
| Volume: |
125 |
| Issue: |
3 |
| Pages: |
309-327 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zawia A |
| Year: |
2021 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension. |
| Volume: |
41 |
| Issue: |
1 |
| Pages: |
430-445 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stading R |
| Year: |
2021 |
| Journal: |
Semin Cancer Biol |
| Title: |
Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. |
| Volume: |
76 |
|
| Pages: |
3-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dai J |
| Year: |
2018 |
| Journal: |
Cell Signal |
| Title: |
Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension. |
| Volume: |
51 |
|
| Pages: |
119-129 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamb JG |
| Year: |
1992 |
| Journal: |
FASEB J |
| Title: |
Cloning of mouse Ugtla-1 and rabbit UGT1A1 UDP glucuronosyltransferase cDNAs |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
A1671 (Abstr.) |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
924
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
893
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
924
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
924
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
950
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
891
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
973
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
931
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
684
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
891
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
891
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dumas SJ |
| Year: |
2018 |
| Journal: |
Circulation |
| Title: |
NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension. |
| Volume: |
137 |
| Issue: |
22 |
| Pages: |
2371-2389 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yaku A |
| Year: |
2022 |
| Journal: |
Circulation |
| Title: |
Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages. |
| Volume: |
146 |
| Issue: |
13 |
| Pages: |
1006-1022 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hashimoto R |
| Year: |
2020 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension. |
| Volume: |
318 |
| Issue: |
2 |
| Pages: |
L386-L401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Potus F |
| Year: |
2020 |
| Journal: |
Circulation |
| Title: |
Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension. |
| Volume: |
141 |
| Issue: |
24 |
| Pages: |
1986-2000 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li D |
| Year: |
2021 |
| Journal: |
Circulation |
| Title: |
ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. |
| Volume: |
143 |
| Issue: |
21 |
| Pages: |
2074-2090 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ye P |
| Year: |
2024 |
| Journal: |
Chin Med J (Engl) |
| Title: |
GRK2-YAP signaling is implicated in pulmonary arterial hypertension development. |
| Volume: |
137 |
| Issue: |
7 |
| Pages: |
846-858 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar S |
| Year: |
2012 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline. |
| Volume: |
302 |
| Issue: |
8 |
| Pages: |
H1655-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan K |
| Year: |
2019 |
| Journal: |
Circulation |
| Title: |
Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension. |
| Volume: |
139 |
| Issue: |
14 |
| Pages: |
1710-1724 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamanaka R |
| Year: |
2020 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension. |
| Volume: |
319 |
| Issue: |
5 |
| Pages: |
H1087-H1096 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dempsie Y |
| Year: |
2011 |
| Journal: |
Respir Res |
| Title: |
Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. |
| Volume: |
12 |
|
| Pages: |
159 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Savas U |
| Year: |
1997 |
| Journal: |
Arch Biochem Biophys |
| Title: |
Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1. |
| Volume: |
347 |
| Issue: |
2 |
| Pages: |
181-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu PP |
| Year: |
1998 |
| Journal: |
Chem Res Toxicol |
| Title: |
Structure, tumorigenicity, microsomal metabolism, and DNA binding of 7-Nitrodibenz[a,h]anthracene. |
| Volume: |
11 |
| Issue: |
8 |
| Pages: |
937-45 |
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•
•
•
•
|
| Publication |
| First Author: |
Lewtas J |
| Year: |
2007 |
| Journal: |
Mutat Res |
| Title: |
Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects. |
| Volume: |
636 |
| Issue: |
1-3 |
| Pages: |
95-133 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
West J |
| Year: |
2021 |
| Journal: |
Cells |
| Title: |
Overexpression of Msx1 in Mouse Lung Leads to Loss of Pulmonary Vessels Following Vascular Hypoxic Injury. |
| Volume: |
10 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu J |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
| Title: |
Hypoxia-Inducible Factor 2-Alpha Mediated Gene Sets Differentiate Pulmonary Arterial Hypertension. |
| Volume: |
9 |
|
| Pages: |
701247 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Brooks B |
| Year: |
1989 |
| Journal: |
Am J Hum Genet |
| Title: |
Localization of a gene required for the nuclear translocation of the dioxin receptor to human chromosome 1 and mouse chromosome 3 and a human RFLP with MspI |
| Volume: |
45 |
|
| Pages: |
A132 (Abstr.) |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Threadgill DW |
| Year: |
1989 |
| Journal: |
Cytogenet Cell Genet |
| Title: |
Syntenic assignment of HSA 9 and HSA 12 homologs in the bovine. Preliminary evidence for the role of fragile sites in mammalian genome evolution. |
| Volume: |
51 |
|
| Pages: |
1091 (Abstr.) |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
848
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
888
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
858
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
817
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
858
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
848
 |
| Fragment?: |
false |
|
•
•
•
•
•
|