|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 867 for Pak1

0.017s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
UniProt Feature
Begin: 467
Description: Phosphothreonine; by PAK1
Type: modified residue
End: 467
UniProt Feature
Begin: 101
Description: Phosphoserine; by PAK1
Type: modified residue
End: 101
UniProt Feature
Begin: 128
Description: Phosphoserine; by PAK1
Type: modified residue
End: 128
UniProt Feature
Begin: 65
Description: Phosphoserine; by PAK1
Type: modified residue
End: 65
Publication
First Author: Ijuin T
Year: 2012
Journal: Mol Cell Biol
Title: Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.
Volume: 32
Issue: 17
Pages: 3570-84
Publication
First Author: Zhou Z
Year: 2009
Journal: Neuropharmacology
Title: A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function.
Volume: 56
Issue: 1
Pages: 81-9
Publication
First Author: Burbelo PD
Year: 1995
Journal: J Biol Chem
Title: A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
Volume: 270
Issue: 49
Pages: 29071-4
Publication
First Author: Wang Z
Year: 2010
Journal: Oncogene
Title: Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo.
Volume: 29
Issue: 23
Pages: 3362-73
Publication
First Author: Goto H
Year: 2002
Journal: Genes Cells
Title: Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK).
Volume: 7
Issue: 2
Pages: 91-7
Publication
First Author: Mayhew MW
Year: 2007
Journal: J Cell Sci
Title: Identification of phosphorylation sites in betaPIX and PAK1.
Volume: 120
Issue: Pt 22
Pages: 3911-8
Publication
First Author: Nola S
Year: 2008
Journal: Hum Mol Genet
Title: Scrib regulates PAK activity during the cell migration process.
Volume: 17
Issue: 22
Pages: 3552-65
Publication
First Author: Kreis P
Year: 2008
Journal: J Neurochem
Title: The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.
Volume: 106
Issue: 3
Pages: 1184-97
Publication  
First Author: Martin K
Year: 2016
Journal: Nat Commun
Title: PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.
Volume: 7
Pages: 12502
Publication
First Author: Dorrance AM
Year: 2013
Journal: Blood
Title: The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.
Volume: 121
Issue: 13
Pages: 2474-82
Publication
First Author: Hayashi ML
Year: 2004
Journal: Neuron
Title: Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.
Volume: 42
Issue: 5
Pages: 773-87
Publication
First Author: Wu Y
Year: 2005
Journal: J Cell Sci
Title: A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.
Volume: 118
Issue: Pt 3
Pages: 539-53
Publication
First Author: Li X
Year: 2003
Journal: Mol Cell Biol
Title: Targeted disruption of the gene for the PAK5 kinase in mice.
Volume: 23
Issue: 20
Pages: 7134-42
Publication
First Author: Smith TK
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity.
Volume: 105
Issue: 24
Pages: 8298-303
Publication
First Author: Vignal E
Year: 2000
Journal: J Biol Chem
Title: Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.
Volume: 275
Issue: 46
Pages: 36457-64
Publication
First Author: Kang T
Year: 2019
Journal: Mol Cells
Title: Loss of ϐPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts.
Volume: 42
Issue: 8
Pages: 589-596
Publication
First Author: Mikawa T
Year: 2014
Journal: J Cell Biol
Title: Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.
Volume: 204
Issue: 5
Pages: 729-45
Publication
First Author: Osada S
Year: 1997
Journal: Oncogene
Title: YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways.
Volume: 14
Issue: 17
Pages: 2047-57
Publication
First Author: Dolan BM
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Volume: 110
Issue: 14
Pages: 5671-6
Publication  
First Author: Bongmba OY
Year: 2011
Journal: Brain Res
Title: Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.
Volume: 1399
Pages: 79-95
Publication
First Author: Walmsley MJ
Year: 2003
Journal: Science
Title: Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling.
Volume: 302
Issue: 5644
Pages: 459-62
Publication
First Author: Radu M
Year: 2015
Journal: Mol Cell Biol
Title: p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.
Volume: 35
Issue: 23
Pages: 3990-4005
Publication
First Author: Staser K
Year: 2013
Journal: Exp Hematol
Title: A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
Volume: 41
Issue: 1
Pages: 56-66.e2
Publication
First Author: Wu PR
Year: 2023
Journal: Cell Death Dis
Title: Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation.
Volume: 14
Issue: 1
Pages: 52
Publication
First Author: Hu B
Year: 2024
Journal: Brain
Title: PAK2 is necessary for myelination in the peripheral nervous system.
Volume: 147
Issue: 5
Pages: 1809-1821
Publication
First Author: Ryan XP
Year: 2005
Journal: Neuron
Title: The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology.
Volume: 47
Issue: 1
Pages: 85-100
Publication
First Author: Hu B
Year: 2016
Journal: PLoS Genet
Title: Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.
Volume: 12
Issue: 9
Pages: e1006290
Publication
First Author: Gustafsson K
Year: 2013
Journal: Exp Cell Res
Title: The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity.
Volume: 319
Issue: 12
Pages: 1852-64
Publication
First Author: Zeng C
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC1/Cdc42 Small GTPase phosphorylation and activation.
Volume: 311
Issue: 4
Pages: E772-E780
Publication
First Author: Hada K
Year: 2021
Journal: Mol Brain
Title: Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
Volume: 14
Issue: 1
Pages: 21
Publication
First Author: Swiercz JM
Year: 2002
Journal: Neuron
Title: Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.
Volume: 35
Issue: 1
Pages: 51-63
Publication
First Author: Jacinto E
Year: 2004
Journal: Nat Cell Biol
Title: Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Volume: 6
Issue: 11
Pages: 1122-8
Publication
First Author: Kepner EM
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.
Volume: 301
Issue: 6
Pages: E1072-80
Publication
First Author: Carothers AM
Year: 2006
Journal: Exp Cell Res
Title: Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.
Volume: 312
Issue: 4
Pages: 387-400
Publication
First Author: Mokalled MH
Year: 2010
Journal: Development
Title: Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development.
Volume: 137
Issue: 14
Pages: 2365-74
Publication
First Author: Chen Y
Year: 2008
Journal: Dev Biol
Title: Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.
Volume: 324
Issue: 1
Pages: 161-76
Publication
First Author: Fan M
Year: 2022
Journal: Biol Psychiatry
Title: JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice.
Volume: 92
Issue: 10
Pages: 800-814
Publication
First Author: Cook D
Year: 2011
Journal: PLoS One
Title: Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.
Volume: 6
Issue: 10
Pages: e26120
Publication  
First Author: Zhu C
Year: 2018
Journal: Front Mol Neurosci
Title: Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.
Volume: 11
Pages: 362
Publication
First Author: Fuerst PG
Year: 2009
Journal: Neuron
Title: DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
Volume: 64
Issue: 4
Pages: 484-97
Publication
First Author: Lo HF
Year: 2017
Journal: J Pathol
Title: Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion.
Volume: 241
Issue: 3
Pages: 324-336
Publication
First Author: Ingram DA
Year: 2001
Journal: J Exp Med
Title: Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro.
Volume: 194
Issue: 1
Pages: 57-69
Publication
First Author: Pontoriero GF
Year: 2008
Journal: Dev Dyn
Title: Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
Volume: 237
Issue: 3
Pages: 602-17
Publication
First Author: Jiang XS
Year: 2010
Journal: Hum Mol Genet
Title: Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.
Volume: 19
Issue: 7
Pages: 1347-57
Publication
First Author: Rosário M
Year: 2012
Journal: Genes Dev
Title: Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Volume: 26
Issue: 15
Pages: 1743-57
Publication
First Author: Wang X
Year: 2007
Journal: Mol Cell Biol
Title: Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.
Volume: 27
Issue: 22
Pages: 7935-46
Publication
First Author: Grimsley-Myers CM
Year: 2009
Journal: J Neurosci
Title: The small GTPase Rac1 regulates auditory hair cell morphogenesis.
Volume: 29
Issue: 50
Pages: 15859-69
Publication
First Author: Piccand J
Year: 2014
Journal: Diabetes
Title: Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.
Volume: 63
Issue: 1
Pages: 203-15
Publication
First Author: Yang CY
Year: 2019
Journal: J Neurosci
Title: Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Volume: 39
Issue: 25
Pages: 4959-4975
Publication
First Author: Sipe CW
Year: 2013
Journal: Development
Title: Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.
Volume: 140
Issue: 8
Pages: 1785-95
Publication
First Author: Kaji K
Year: 2007
Journal: Development
Title: Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
Volume: 134
Issue: 6
Pages: 1123-32
Publication
First Author: Landin Malt A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.
Volume: 116
Issue: 11
Pages: 4999-5008
Publication
First Author: Zhang M
Year: 2019
Journal: Theranostics
Title: Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.
Volume: 9
Issue: 17
Pages: 5065-5084
Publication  
First Author: Lo Giudice Q
Year: 2019
Journal: Development
Title: Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons.
Volume: 146
Issue: 17
Publication
First Author: Longatti A
Year: 2021
Journal: Mol Neurobiol
Title: Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
Volume: 58
Issue: 12
Pages: 6092-6110
Publication
First Author: Singh S
Year: 2007
Journal: Birth Defects Res A Clin Mol Teratol
Title: Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.
Volume: 79
Issue: 1
Pages: 35-44
Publication
First Author: Tu Z
Year: 2016
Journal: Cell Death Differ
Title: Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.
Volume: 23
Issue: 1
Pages: 169-81
Publication  
First Author: Teo ZL
Year: 2014
Journal: Exp Eye Res
Title: Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.
Volume: 121
Pages: 130-42
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Munton RP
Year: 2007
Journal: Mol Cell Proteomics
Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Volume: 6
Issue: 2
Pages: 283-93
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication  
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles