Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 624 out of 624 for Pfkl

<< First < Previous | Next > Last >>

0.019s

Type

Details

Score

Allele

Pfkl<em1Smoc> | MGI:7291623

Name:	phosphofructokinase, liver, B-type; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Strain

MGI:6429346 | C57BL/6JSmoc-Pfkl<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

Strain

MGI:2174655 | STOCK Tg(Pfkl)224Yg/J

Attribute String:

mutant stock, transgenic

•

Genotype

Symbol:	Tg(Pfkl)224Yg/?
Background:	involves: BALB/cBy * C57BL/6 * DBA/2
Zygosity:	ot
Has Mutant Allele:	true

•

Publication

26194095 | J:224449

First Author:	Graham DB
Year:	2015
Journal:	Nat Commun
Title:	Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.
Volume:	6

Pages:	7838

•

Publication

10593569 | J:59587

First Author:	Shi JD
Year:	1999
Journal:	Autoimmunity
Title:	Chromosomal localization and complete genomic sequence of the murine autoimmune regulator gene (Aire).
Volume:	31
Issue:	1
Pages:	47-53

•

Publication

23395176 | J:198047

First Author:	Li MD
Year:	2013
Journal:	Cell Metab
Title:	O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.
Volume:	17
Issue:	2
Pages:	303-10

•

Publication

15361863 | -

First Author:	Jínek M
Year:	2004
Journal:	Nat Struct Mol Biol
Title:	The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.
Volume:	11
Issue:	10
Pages:	1001-7

•

Publication

20018868 | -

First Author:	Whelan SA
Year:	2010
Journal:	J Biol Chem
Title:	Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
Volume:	285
Issue:	8
Pages:	5204-11

•

Publication

22923583 | -

First Author:	Yi W
Year:	2012
Journal:	Science
Title:	Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Volume:	337
Issue:	6097
Pages:	975-80

•

Publication

22121020 | -

First Author:	Fujiki R
Year:	2011
Journal:	Nature
Title:	GlcNAcylation of histone H2B facilitates its monoubiquitination.
Volume:	480
Issue:	7378
Pages:	557-60

•

Protein Domain

IPR037919 | OGT

Type:

Family

Description:

The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; ) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) []; regulation of glycolysis by inhibiting PFKL activity []; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation []; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin []; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination []. It is a component of several complexes, including MLL5-L, NSL []and THAP1/THAP3-HCFC1-OGT [].This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [].

•

Publication

8812505 | J:34627

First Author:	Chen H
Year:	1996
Journal:	Genomics
Title:	Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter.
Volume:	35
Issue:	3
Pages:	620-4

•

Publication

9813288 | J:51070

First Author:	Peled-Kamar M
Year:	1998
Journal:	Brain Res
Title:	Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies.
Volume:	810
Issue:	1-2
Pages:	138-45

•

Publication

36469462 | J:351113

First Author:	Miyazawa H
Year:	2022
Journal:	Elife
Title:	Glycolytic flux-signaling controls mouse embryo mesoderm development.
Volume:	11

•

Publication

23353889 | J:194478

First Author:	Deplus R
Year:	2013
Journal:	EMBO J
Title:	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
Volume:	32
Issue:	5
Pages:	645-55

•

Publication

15063784 | J:91808

First Author:	Kazuki Y
Year:	2004
Journal:	Biochem Biophys Res Commun
Title:	Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.
Volume:	317
Issue:	2
Pages:	491-9

•

Publication

- | J:12512

First Author:	Threadgill DS
Year:	1989
Journal:	Cytogenet Cell Genet
Title:	Comparative mapping of HSA 21/MMU 16 homologs in the bovine.
Volume:	51

Pages:	1090-1091 (Abstr.)

•

Publication

20200153 | -

First Author:	Mazars R
Year:	2010
Journal:	J Biol Chem
Title:	The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
Volume:	285
Issue:	18
Pages:	13364-71

•

Protein

Q3TQV0

Organism:	Mus musculus/domesticus
Length:	182
Fragment?:	false

•

Protein

Q80XU6

Organism:	Mus musculus/domesticus
Length:	171
Fragment?:	false

•

Protein

Q8C676

Organism:	Mus musculus/domesticus
Length:	181
Fragment?:	false

•

Protein

Q8CGY8

Organism:	Mus musculus/domesticus
Length:	1046
Fragment?:	false

•

Publication

20018852 | -

First Author:	Cai Y
Year:	2010
Journal:	J Biol Chem
Title:	Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.
Volume:	285
Issue:	7
Pages:	4268-72

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do?searchOffset=600&searchTerm=Pfkl

MouseMine

Search our database by keyword

Examples

Search results 601 to 624 out of 624 for Pfkl

Categories

Hits by Pathway

Hits by Category

Hits by Strain