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Search results 601 to 700 out of 868 for Plk1

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Hits by Strain

Type Details Score
Protein Domain
IPR007145 | MAP65_Ase1_PRC1
Type: Family
Description: This is a family of microtubule associated proteins, including MAP65 (MAP65-1/2/3/4/5/6/7/8/9) from Arabidopsis, Ase1 from yeast, and PRC1 from mammals.Ase1 is required for spindle elongation and stabilisation. It is cell cycle-regulated by anaphase promoting complex []. It is a potential Cdc28p substrate []. MAP65-1 plays a role in stabilising anti-parallel microtubules in the central spindle at anaphase to early cytokinesis. MAP65-1 is cell cycle regulated by phosphorylation [, , , , ].PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone []. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [, ]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [, , ]and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle [].
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Protein Domain
IPR039339 | Tex14
Type: Family
Description: TEX14 is an inactive serine/threonine-protein kinase because the active site aspartic acid residue has been replaced. It localizes to germ cell intercellular bridges during spermatogenesis. In germ cell cytokinesis a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel forms, unlike in somatic cells. This bridge does not form in TEX14 deficient mice and male mice are sterile []; female knockout mice are fertile []. TEX14 binds to CEP55, which is a stable component of the intercellular bridge, via a GPPX3Y motif and preventing proteins with a similar motif (such as ALIX and TSG101) from binding to CEP55 []. During mitosis, TEX14 is recruited to kinetochores by Plk1 and without TEX14, kinetochores are unable to bind other essential components leading to chromosome instability. Phosphorylation of TEX14 by Plk1 leads to its degradation, which is essential for metaphase-to-anaphase transition and chromosome segregation []. TEX14 contains ankyrin repeat-containing domains and a protein kinase domain.
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Protein
A0A0J9YVH0
Organism: Mus musculus/domesticus
Length: 1016  
Fragment?: true
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Protein Coding Gene
MGI:1924066 | Sdccag8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102722 | Pcnt
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97293 | Nedd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384917 | Cep290
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926137 | Sfi1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101834 | Tubg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107440 | Cep131
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921720 | Cep72
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1261794 | Haus4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922546 | Cep43
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107812 | Tubb5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923401 | Cep76
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918049 | Cep192
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385076 | Haus1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924386 | Cep78
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915725 | Ssna1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098824 | Odf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913546 | Haus2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2139083 | Cep152
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1925427 | Ninl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108084 | Cep250
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101783 | Plk4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384875 | Cdk5rap2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923389 | Haus6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2387633 | Haus3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2681869 | Cep135
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891414 | Cep41
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934606 | Alms1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919159 | Haus5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277958 | Pcm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923728 | Haus8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96960 | Rab8a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915551 | Cep57
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384878 | Cep164
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915371 | Cep70
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2158560 | Cep63
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920988 | Haus7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1350328 | Ofd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8K4E0
Organism: Mus musculus/domesticus
Length: 3251  
Fragment?: false
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Protein
Q6IRU7
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
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Protein
Q0VEJ0
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Protein
Q99NF3
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
Q66JX5
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
Q8CEE0
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
Q6IQY5
Organism: Mus musculus/domesticus
Length: 616  
Fragment?: false
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Protein
A2AUM9
Organism: Mus musculus/domesticus
Length: 1736  
Fragment?: false
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Protein
Q3UPP8
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
Q8K389
Organism: Mus musculus/domesticus
Length: 1822  
Fragment?: false
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Protein
Q62036
Organism: Mus musculus/domesticus
Length: 1060  
Fragment?: false
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Protein
P48725
Organism: Mus musculus/domesticus
Length: 2898  
Fragment?: false
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Protein
P55258
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q8QZX2
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q9CQS9
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
Q80Z25
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: false
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Protein
P33215
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
Q8BFT2
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q8BKT8
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
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Protein
Q9R0L6
Organism: Mus musculus/domesticus
Length: 2025  
Fragment?: false
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Protein
Q64702
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: false
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Protein
Q8BHX1
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q6ZQ12
Organism: Mus musculus/domesticus
Length: 1394  
Fragment?: false
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Protein
A3KGV1
Organism: Mus musculus/domesticus
Length: 830  
Fragment?: false
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Protein
Q5DU05
Organism: Mus musculus/domesticus
Length: 1446  
Fragment?: false
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Protein
Q9D3R3
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
Q6A078
Organism: Mus musculus/domesticus
Length: 2472  
Fragment?: false
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Protein
Q6P5D4
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
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Protein
Q9D786
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
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Protein
Q99L00
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
Q60952
Organism: Mus musculus/domesticus
Length: 2414  
Fragment?: false
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Protein
Q80UF4
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q9JJ94
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q3UZY0
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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Protein
P99024
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
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Protein
P83887
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
E9Q4Y4
Organism: Mus musculus/domesticus
Length: 2514  
Fragment?: false
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Protein
Q6NV99
Organism: Mus musculus/domesticus
Length: 933  
Fragment?: false
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Publication
35583996 | J:326291
First Author: Kopanja D
Year: 2022
Journal: Cancer Res
Title: Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer.
Volume: 82
Issue: 13
Pages: 2458-2471
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Publication
19833129 | J:154692
First Author: Dias SS
Year: 2009
Journal: FEBS Lett
Title: Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
Volume: 583
Issue: 22
Pages: 3543-8
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Publication
24996188 | J:213637
First Author: Lee S
Year: 2014
Journal: FEBS Lett
Title: Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.
Volume: 588
Issue: 17
Pages: 2844-50
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Protein
A0A0J9YUH4
Organism: Mus musculus/domesticus
Length: 1464  
Fragment?: true
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Protein
Q80XD5
Organism: Mus musculus/domesticus
Length: 1301  
Fragment?: false
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Protein
A0A0J9YTS1
Organism: Mus musculus/domesticus
Length: 1230  
Fragment?: true
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Protein
Q8CHD0
Organism: Mus musculus/domesticus
Length: 1481  
Fragment?: true
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Protein
F6WBA1
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
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Protein
A0A087WQC3
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
A0A087WQV6
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
Q9CVC4
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
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Protein
A0A087WR51
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
A0A087WQ89
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Publication
23574715 | -
First Author: Maier B
Year: 2013
Journal: Cell Cycle
Title: The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.
Volume: 12
Issue: 9
Pages: 1457-71
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Protein Coding Gene
MGI:2684927 | Cpap
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351660 | Csnk1e
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918898 | Optn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894678 | Aurka
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2178217 | Akap9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2141942 | Ccp110
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88311 | Ccnb2
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom