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Search results 601 to 700 out of 8636 for Pml

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Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 967  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Publication
First Author: Peche LY
Year: 2012
Journal: Cell Death Differ
Title: MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs.
Volume: 19
Issue: 6
Pages: 926-36
Protein Domain
Type: Family
Description: MAGE-A genes are a subfamily of the melanoma antigen genes (MAGEs), whose expression is restricted to tumour cells of different origin and normal tissues of the human germline [, ].MAGEA2 may act by binding histone deacetylase (HDAC) and repressing p53-dependent apoptosis. In addition to its anti-apoptotic effect, MAGEA2 may have a role in the early progression to malignancy by interfering with PML (promyelocytic leukemia) tumour suppressor/p53 function [].
Protein Domain
Type: Family
Description: Muscular LMNA-interacting protein (MLIP) is a muscle-enriched A-type Lamin-interacting protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localises with lamin A and C in the nuclear envelope. MLIP also co-localises with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP [].
Publication
First Author: Pan WW
Year: 2013
Journal: Gene
Title: DAXX silencing suppresses mouse ovarian surface epithelial cell growth by inducing senescence and DNA damage.
Volume: 526
Issue: 2
Pages: 287-94
Publication
First Author: Evans JD
Year: 2003
Journal: J Virol
Title: Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.
Volume: 77
Issue: 9
Pages: 5295-304
Publication
First Author: Zhu J
Year: 2005
Journal: Cancer Cell
Title: A sumoylation site in PML/RARA is essential for leukemic transformation.
Volume: 7
Issue: 2
Pages: 143-53
Publication
First Author: Wei S
Year: 2015
Journal: Nat Med
Title: Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Volume: 21
Issue: 5
Pages: 457-66
Genotype
Symbol: Tg(CTSG-RARA/PML)#Ley/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(CTSG-RARA/PML)2544Ley/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Pml/Pml<+> Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Croxton R
Year: 2006
Journal: Cancer Res
Title: Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
Volume: 66
Issue: 18
Pages: 9026-35
Publication
First Author: Howe K
Year: 1998
Journal: Genomics
Title: The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes.
Volume: 47
Issue: 1
Pages: 92-100
Publication
First Author: Le Goff P
Year: 2004
Journal: Exp Cell Res
Title: Intracellular trafficking of heat shock factor 2.
Volume: 294
Issue: 2
Pages: 480-93
Publication
First Author: Rogers RS
Year: 2004
Journal: Chromosoma
Title: SUMO modified proteins localize to the XY body of pachytene spermatocytes.
Volume: 113
Issue: 5
Pages: 233-43
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sharma P
Year: 2010
Journal: J Cell Sci
Title: N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies.
Volume: 123
Issue: Pt 8
Pages: 1227-34
Publication
First Author: Fousteri MI
Year: 2000
Journal: EMBO J
Title: A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein.
Volume: 19
Issue: 7
Pages: 1691-702
Protein Domain
Type: Family
Description: This entry represents the replication protein A (RPA) interacting protein. RPA is a single stranded DNA-binding protein involved in DNA replication, repair, and recombination []. After synthesis in thecytoplasm, RPA is transported into the nucleus mediated by RPA interacting protein [, ]. In humans, RPA interacting protein has several splice isoforms, including hRIPalpha, hRIPbeta, hRIPgamma, hRIPdelta1, hRIPdelta2, and hRIPdelta3. hRIPbeta transports RPA into the PML nuclear body and releases RPA upon UV irradiation []. It seems that the number of splice isoforms of RIPalpha is species-specific and has a tendency to increase in higher eukaryotes [].
Protein Domain
Type: Family
Description: This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon [].
Protein Domain
Type: Family
Description: SMC6 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination []. In humans, the complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) [].
Protein Domain
Type: Family
Description: SMC5 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination [, ]. In humans, the SMC5-SMC6 complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) []. SMC5 is required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 [].
Publication
First Author: Drané P
Year: 2010
Journal: Genes Dev
Title: The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Volume: 24
Issue: 12
Pages: 1253-65
Publication
First Author: Muromoto R
Year: 2006
Journal: J Immunol
Title: Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.
Volume: 177
Issue: 2
Pages: 1160-70
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Shin EJ
Year: 2012
Journal: EMBO Rep
Title: DeSUMOylating isopeptidase: a second class of SUMO protease.
Volume: 13
Issue: 4
Pages: 339-46
Publication
First Author: Piazza F
Year: 2001
Journal: Oncogene
Title: The theory of APL.
Volume: 20
Issue: 49
Pages: 7216-22
Publication
First Author: Giguère V
Year: 1995
Journal: Genomics
Title: The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.
Volume: 28
Issue: 3
Pages: 596-8
Publication
First Author: de Thé H
Year: 2017
Journal: Cancer Cell
Title: Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure.
Volume: 32
Issue: 5
Pages: 552-560
Publication
First Author: Potts PR
Year: 2006
Journal: EMBO J
Title: Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.
Volume: 25
Issue: 14
Pages: 3377-88
Publication
First Author: Potts PR
Year: 2007
Journal: Nat Struct Mol Biol
Title: The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.
Volume: 14
Issue: 7
Pages: 581-90
Publication
First Author: Onoda F
Year: 2004
Journal: DNA Repair (Amst)
Title: SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae.
Volume: 3
Issue: 4
Pages: 429-39
Publication
First Author: Taylor EM
Year: 2008
Journal: Mol Cell Biol
Title: Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Volume: 28
Issue: 4
Pages: 1197-206
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nardella C
Year: 2011
Journal: Cancer Discov
Title: The APL paradigm and the "co-clinical trial" project.
Volume: 1
Issue: 2
Pages: 108-16
Allele
Name: transgene insertion 15, Hugues de The
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 16, Hugues de The
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Pml/Pml<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: BALB/cJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
Publication
First Author: Lakdawala SS
Year: 2008
Journal: J Virol
Title: Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Volume: 82
Issue: 17
Pages: 8362-72
Publication
First Author: Yondola MA
Year: 2007
Journal: J Virol
Title: The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha.
Volume: 81
Issue: 8
Pages: 4264-71
Publication
First Author: Stracker TH
Year: 2005
Journal: J Virol
Title: Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins.
Volume: 79
Issue: 11
Pages: 6664-73
Publication
First Author: Boyer JL
Year: 2000
Journal: J Biol Chem
Title: Genetic analysis of a potential zinc-binding domain of the adenovirus E4 34k protein.
Volume: 275
Issue: 20
Pages: 14969-78
Protein Domain
Type: Family
Description: Adenoviruses E4 is essential for DNA replication and late protein synthesis []. The adenovirus, early region 4 open reading frame 3 (E4 ORF3) protein is required for viral DNA replication during the interferon (IFN)-induced antiviral state [].The E4 ORF3 protein reorganises the promyelocytic leukemia (PML) protein nuclear bodies. These normally punctate structures are reorganised by E4 ORF3 into tracks that eventually surround viral replication centres. PML rearrangement is an evolutionarily conserved function of E4 ORF3 [].The product of adenovirus early region 4 (E4), open reading frame 6, is E4 34k. It modulates viral late gene expression, DNA replication, apoptosis, double strand break repair, and transformation through multiple interactions with components in infected and transformed cells [, ]. Conservation of several cysteine and histidine residues among E4 34k sequences suggests the presence of a zinc binding domain, which is important for its function [].
Protein
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
Publication
First Author: Suzuki H
Year: 2004
Journal: Oncogene
Title: c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.
Volume: 23
Issue: 29
Pages: 5068-76
Publication
First Author: Deheuninck J
Year: 2009
Journal: Cell Res
Title: Ski and SnoN, potent negative regulators of TGF-beta signaling.
Volume: 19
Issue: 1
Pages: 47-57
Publication
First Author: Luo K
Year: 2004
Journal: Curr Opin Genet Dev
Title: Ski and SnoN: negative regulators of TGF-beta signaling.
Volume: 14
Issue: 1
Pages: 65-70
Publication  
First Author: Tecalco-Cruz AC
Year: 2018
Journal: Signal Transduct Target Ther
Title: Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease.
Volume: 3
Pages: 15
Publication
First Author: Zhao X
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.
Volume: 102
Issue: 13
Pages: 4777-82
Protein Domain
Type: Family
Description: This entry represents the SKI/SnoN family of proteins, which are the products of the oncogenic sno gene. This gene was identified based on its homology to v-ski, the transforming component of the Sloan-Kettering virus. Both Ski and SnoN are potent negative regulators of TGF-beta []. Overexpression of Ski or SnoN results in oncogenic transformation of avian fibroblasts; however it may also result in terminal differentiation and therefore the Ski/SnoN mechanism of action is thought to be complex [].These proteins do not have catalytic or DNA-binding activity and therefore function primarily through interaction with other proteins, acting as transcriptional cofactors. Despite their lack of DNA-binding ability, their primary function is related to transcriptional regulation, in particular the negative regulation of TGF-beta signalling [, ]. Ski/SnoN interact concurrently with co-Smad and R-Smad and in doing so block the ability of the Smad complexes to activate transcription of the TGF-beta target genes []. Binding of Ski/SnoN may additionally stabilise the Smad heteromer on DNA, therefore preventing further binding of active Smad complexes []. As Smad complexes critically mediate the inhibitory signals of TGF-beta in epithelial cells, high levels of SKI/SnoN may promote cell proliferation. They repress gene transcription recruiting diverse corepressors and histone deacetylases and stablish cross-regulatory mechanisms with TGF-beta/Smad pathway that control the magnitude and duration of TGF-beta signals. The alteration in regulatory processes may lead to disease development [].High levels of SnoN have been shown to stabilise p53 with a resultant increase in premature senescence. SnoN interacts with the PML protein and is then recruited to the PML nuclear bodies, resulting in stabilisation of p53 and premature senescence [].
Publication
First Author: Gur I
Year: 2014
Journal: PLoS One
Title: Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
Volume: 9
Issue: 6
Pages: e99503
Publication
First Author: Shiio Y
Year: 2006
Journal: Mol Cell Biol
Title: Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.
Volume: 26
Issue: 4
Pages: 1386-97
Publication
First Author: Nacerddine K
Year: 2005
Journal: Dev Cell
Title: The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.
Volume: 9
Issue: 6
Pages: 769-79
Publication
First Author: Zhong S
Year: 1999
Journal: Nat Genet
Title: A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
Volume: 23
Issue: 3
Pages: 287-95
Publication    
First Author: Lauver MD
Year: 2020
Journal: Elife
Title: Antibody escape by polyomavirus capsid mutation facilitates neurovirulence.
Volume: 9
Publication
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
Publication
First Author: He LZ
Year: 2000
Journal: Mol Cell
Title: Two critical hits for promyelocytic leukemia.
Volume: 6
Issue: 5
Pages: 1131-41
Publication
First Author: Kenzel S
Year: 2012
Journal: J Immunol
Title: Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.
Volume: 189
Issue: 9
Pages: 4582-91
Publication
First Author: Chen M
Year: 2018
Journal: Nat Commun
Title: Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.
Volume: 9
Issue: 1
Pages: 159
Publication  
First Author: Kalathur M
Year: 2015
Journal: Nat Commun
Title: A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.
Volume: 6
Pages: 7227
Publication
First Author: Sternsdorf T
Year: 2006
Journal: Cancer Cell
Title: Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.
Volume: 9
Issue: 2
Pages: 81-94