| Type |
Details |
Score |
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
270
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
269
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
460
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
207
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
967
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
279
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peche LY |
| Year: |
2012 |
| Journal: |
Cell Death Differ |
| Title: |
MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs. |
| Volume: |
19 |
| Issue: |
6 |
| Pages: |
926-36 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
MAGE-A genes are a subfamily of the melanoma antigen genes (MAGEs), whose expression is restricted to tumour cells of different origin and normal tissues of the human germline [, ].MAGEA2 may act by binding histone deacetylase (HDAC) and repressing p53-dependent apoptosis. In addition to its anti-apoptotic effect, MAGEA2 may have a role in the early progression to malignancy by interfering with PML (promyelocytic leukemia) tumour suppressor/p53 function []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Muscular LMNA-interacting protein (MLIP) is a muscle-enriched A-type Lamin-interacting protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localises with lamin A and C in the nuclear envelope. MLIP also co-localises with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pan WW |
| Year: |
2013 |
| Journal: |
Gene |
| Title: |
DAXX silencing suppresses mouse ovarian surface epithelial cell growth by inducing senescence and DNA damage. |
| Volume: |
526 |
| Issue: |
2 |
| Pages: |
287-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Evans JD |
| Year: |
2003 |
| Journal: |
J Virol |
| Title: |
Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation. |
| Volume: |
77 |
| Issue: |
9 |
| Pages: |
5295-304 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu J |
| Year: |
2005 |
| Journal: |
Cancer Cell |
| Title: |
A sumoylation site in PML/RARA is essential for leukemic transformation. |
| Volume: |
7 |
| Issue: |
2 |
| Pages: |
143-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei S |
| Year: |
2015 |
| Journal: |
Nat Med |
| Title: |
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. |
| Volume: |
21 |
| Issue: |
5 |
| Pages: |
457-66 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CTSG-RARA/PML)#Ley/? |
| Background: |
involves: C3H * C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CTSG-RARA/PML)2544Ley/? |
| Background: |
involves: C3H * C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pml/Pml<+> Tg(Mx1-cre)1Cgn/? |
| Background: |
involves: C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Croxton R |
| Year: |
2006 |
| Journal: |
Cancer Res |
| Title: |
Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB. |
| Volume: |
66 |
| Issue: |
18 |
| Pages: |
9026-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Howe K |
| Year: |
1998 |
| Journal: |
Genomics |
| Title: |
The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes. |
| Volume: |
47 |
| Issue: |
1 |
| Pages: |
92-100 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Le Goff P |
| Year: |
2004 |
| Journal: |
Exp Cell Res |
| Title: |
Intracellular trafficking of heat shock factor 2. |
| Volume: |
294 |
| Issue: |
2 |
| Pages: |
480-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogers RS |
| Year: |
2004 |
| Journal: |
Chromosoma |
| Title: |
SUMO modified proteins localize to the XY body of pachytene spermatocytes. |
| Volume: |
113 |
| Issue: |
5 |
| Pages: |
233-43 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma P |
| Year: |
2010 |
| Journal: |
J Cell Sci |
| Title: |
N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies. |
| Volume: |
123 |
| Issue: |
Pt 8 |
| Pages: |
1227-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fousteri MI |
| Year: |
2000 |
| Journal: |
EMBO J |
| Title: |
A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein. |
| Volume: |
19 |
| Issue: |
7 |
| Pages: |
1691-702 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the replication protein A (RPA) interacting protein. RPA is a single stranded DNA-binding protein involved in DNA replication, repair, and recombination []. After synthesis in thecytoplasm, RPA is transported into the nucleus mediated by RPA interacting protein [, ]. In humans, RPA interacting protein has several splice isoforms, including hRIPalpha, hRIPbeta, hRIPgamma, hRIPdelta1, hRIPdelta2, and hRIPdelta3. hRIPbeta transports RPA into the PML nuclear body and releases RPA upon UV irradiation []. It seems that the number of splice isoforms of RIPalpha is species-specific and has a tendency to increase in higher eukaryotes []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
SMC6 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination []. In humans, the complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
SMC5 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination [, ]. In humans, the SMC5-SMC6 complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) []. SMC5 is required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Drané P |
| Year: |
2010 |
| Journal: |
Genes Dev |
| Title: |
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. |
| Volume: |
24 |
| Issue: |
12 |
| Pages: |
1253-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Muromoto R |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation. |
| Volume: |
177 |
| Issue: |
2 |
| Pages: |
1160-70 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shin EJ |
| Year: |
2012 |
| Journal: |
EMBO Rep |
| Title: |
DeSUMOylating isopeptidase: a second class of SUMO protease. |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
339-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Piazza F |
| Year: |
2001 |
| Journal: |
Oncogene |
| Title: |
The theory of APL. |
| Volume: |
20 |
| Issue: |
49 |
| Pages: |
7216-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Giguère V |
| Year: |
1995 |
| Journal: |
Genomics |
| Title: |
The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9. |
| Volume: |
28 |
| Issue: |
3 |
| Pages: |
596-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Thé H |
| Year: |
2017 |
| Journal: |
Cancer Cell |
| Title: |
Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure. |
| Volume: |
32 |
| Issue: |
5 |
| Pages: |
552-560 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Potts PR |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. |
| Volume: |
25 |
| Issue: |
14 |
| Pages: |
3377-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Potts PR |
| Year: |
2007 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. |
| Volume: |
14 |
| Issue: |
7 |
| Pages: |
581-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Onoda F |
| Year: |
2004 |
| Journal: |
DNA Repair (Amst) |
| Title: |
SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. |
| Volume: |
3 |
| Issue: |
4 |
| Pages: |
429-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Taylor EM |
| Year: |
2008 |
| Journal: |
Mol Cell Biol |
| Title: |
Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. |
| Volume: |
28 |
| Issue: |
4 |
| Pages: |
1197-206 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nardella C |
| Year: |
2011 |
| Journal: |
Cancer Discov |
| Title: |
The APL paradigm and the "co-clinical trial" project. |
| Volume: |
1 |
| Issue: |
2 |
| Pages: |
108-16 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 15, Hugues de The |
| Allele Type: |
Transgenic |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 16, Hugues de The |
| Allele Type: |
Transgenic |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pml/Pml<+> Tg(CAG-cre/Esr1*)5Amc/? |
| Background: |
involves: BALB/cJ * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
106
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
93
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
107
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lakdawala SS |
| Year: |
2008 |
| Journal: |
J Virol |
| Title: |
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. |
| Volume: |
82 |
| Issue: |
17 |
| Pages: |
8362-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yondola MA |
| Year: |
2007 |
| Journal: |
J Virol |
| Title: |
The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha. |
| Volume: |
81 |
| Issue: |
8 |
| Pages: |
4264-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stracker TH |
| Year: |
2005 |
| Journal: |
J Virol |
| Title: |
Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. |
| Volume: |
79 |
| Issue: |
11 |
| Pages: |
6664-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boyer JL |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Genetic analysis of a potential zinc-binding domain of the adenovirus E4 34k protein. |
| Volume: |
275 |
| Issue: |
20 |
| Pages: |
14969-78 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Adenoviruses E4 is essential for DNA replication and late protein synthesis []. The adenovirus, early region 4 open reading frame 3 (E4 ORF3) protein is required for viral DNA replication during the interferon (IFN)-induced antiviral state [].The E4 ORF3 protein reorganises the promyelocytic leukemia (PML) protein nuclear bodies. These normally punctate structures are reorganised by E4 ORF3 into tracks that eventually surround viral replication centres. PML rearrangement is an evolutionarily conserved function of E4 ORF3 [].The product of adenovirus early region 4 (E4), open reading frame 6, is E4 34k. It modulates viral late gene expression, DNA replication, apoptosis, double strand break repair, and transformation through multiple interactions with components in infected and transformed cells [, ]. Conservation of several cysteine and histidine residues among E4 34k sequences suggests the presence of a zinc binding domain, which is important for its function []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
77
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki H |
| Year: |
2004 |
| Journal: |
Oncogene |
| Title: |
c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements. |
| Volume: |
23 |
| Issue: |
29 |
| Pages: |
5068-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deheuninck J |
| Year: |
2009 |
| Journal: |
Cell Res |
| Title: |
Ski and SnoN, potent negative regulators of TGF-beta signaling. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
47-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo K |
| Year: |
2004 |
| Journal: |
Curr Opin Genet Dev |
| Title: |
Ski and SnoN: negative regulators of TGF-beta signaling. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
65-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tecalco-Cruz AC |
| Year: |
2018 |
| Journal: |
Signal Transduct Target Ther |
| Title: |
Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease. |
| Volume: |
3 |
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| Pages: |
15 |
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| Publication |
| First Author: |
Zhao X |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. |
| Volume: |
102 |
| Issue: |
13 |
| Pages: |
4777-82 |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the SKI/SnoN family of proteins, which are the products of the oncogenic sno gene. This gene was identified based on its homology to v-ski, the transforming component of the Sloan-Kettering virus. Both Ski and SnoN are potent negative regulators of TGF-beta []. Overexpression of Ski or SnoN results in oncogenic transformation of avian fibroblasts; however it may also result in terminal differentiation and therefore the Ski/SnoN mechanism of action is thought to be complex [].These proteins do not have catalytic or DNA-binding activity and therefore function primarily through interaction with other proteins, acting as transcriptional cofactors. Despite their lack of DNA-binding ability, their primary function is related to transcriptional regulation, in particular the negative regulation of TGF-beta signalling [, ]. Ski/SnoN interact concurrently with co-Smad and R-Smad and in doing so block the ability of the Smad complexes to activate transcription of the TGF-beta target genes []. Binding of Ski/SnoN may additionally stabilise the Smad heteromer on DNA, therefore preventing further binding of active Smad complexes []. As Smad complexes critically mediate the inhibitory signals of TGF-beta in epithelial cells, high levels of SKI/SnoN may promote cell proliferation. They repress gene transcription recruiting diverse corepressors and histone deacetylases and stablish cross-regulatory mechanisms with TGF-beta/Smad pathway that control the magnitude and duration of TGF-beta signals. The alteration in regulatory processes may lead to disease development [].High levels of SnoN have been shown to stabilise p53 with a resultant increase in premature senescence. SnoN interacts with the PML protein and is then recruited to the PML nuclear bodies, resulting in stabilisation of p53 and premature senescence []. |
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| Publication |
| First Author: |
Gur I |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
e99503 |
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| Publication |
| First Author: |
Shiio Y |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. |
| Volume: |
26 |
| Issue: |
4 |
| Pages: |
1386-97 |
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| Publication |
| First Author: |
Nacerddine K |
| Year: |
2005 |
| Journal: |
Dev Cell |
| Title: |
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
769-79 |
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| Publication |
| First Author: |
Zhong S |
| Year: |
1999 |
| Journal: |
Nat Genet |
| Title: |
A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. |
| Volume: |
23 |
| Issue: |
3 |
| Pages: |
287-95 |
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| Publication |
| First Author: |
Lauver MD |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Antibody escape by polyomavirus capsid mutation facilitates neurovirulence. |
| Volume: |
9 |
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| Publication |
| First Author: |
Kitamura YI |
| Year: |
2005 |
| Journal: |
Cell Metab |
| Title: |
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. |
| Volume: |
2 |
| Issue: |
3 |
| Pages: |
153-63 |
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| Publication |
| First Author: |
He LZ |
| Year: |
2000 |
| Journal: |
Mol Cell |
| Title: |
Two critical hits for promyelocytic leukemia. |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
1131-41 |
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| Publication |
| First Author: |
Kenzel S |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase. |
| Volume: |
189 |
| Issue: |
9 |
| Pages: |
4582-91 |
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| Publication |
| First Author: |
Chen M |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
159 |
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| Publication |
| First Author: |
Kalathur M |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours. |
| Volume: |
6 |
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| Pages: |
7227 |
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| Publication |
| First Author: |
Sternsdorf T |
| Year: |
2006 |
| Journal: |
Cancer Cell |
| Title: |
Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
81-94 |
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