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Search results 601 to 670 out of 670 for Prdm16

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:7581887
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7581990
Age: embryonic day 15.5
Image: 1B E15.5
Note: Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen Label: 1B E15.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7581887
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759724
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7581990
Age: embryonic day 16.5
Image: 1B E16.5
Note: Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen Label: 1B E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7581887
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7581990
Age: embryonic day 18.5
Image: 1B E18.5
Note: Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen Label: 1B E18.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:7581887
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7581990
Age: postnatal day 0
Image: 1B P0
Note: Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen Label: 1B P0
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7581887
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7581990
Age: postnatal day 3
Image: 1B P3
Note: Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen Label: 1B P3
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:7581887
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7581990
Age: postnatal day 7
Image: 1B P7
Note: Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen Label: 1B P7
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:7384695
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1617720
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7384935
Age: embryonic day 12.5
Image: 2I
Note: Expression in mesenchyme lateral to epaxial myotome, colocalized with Prdm16 expression.
Specimen Label: 2I
Detected: true
Specimen Num: 9
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Allele
Prdm16<em1Smoc> | MGI:7291788
Name: PR domain containing 16; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
30462309 | -
     
First Author: Ivanochko D
Year: 2018
Journal: Nucleic Acids Res
Title: Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
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Publication
26876562 | J:233027
First Author: Svensson KJ
Year: 2016
Journal: Cell Metab
Title: A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.
Volume: 23
Issue: 3
Pages: 454-66
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Strain
MGI:6476076 | C57BL/6JSmoc-Prdm16<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Prdm16<tm1.1Bjo> | MGI:7541323
Name: PR domain containing 16; targeted mutation 1.1, Bryan C Bjork
Allele Type: Targeted
Attribute String: Conditional ready, Reporter
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Protein Domain
IPR044410 | PRDM16_PR-SET
Type: Domain
Description: This entry represents the PR/SET domain found in PR domain zinc finger protein 16 (PRDM16, also known as MEL1). PRDM16 and PRDM3 share protein sequences similarities and have functions in hematopoietic and neuronal stem cells and in adipose tissue differentiation. They also act as oncoproteins (Mel1 and Evi1) involved in translocation-induced leukemia. PRDM3 and PRDM16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity [, , ].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes [].
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Protein Domain
IPR044411 | PRDM3_PR-SET
Type: Domain
Description: This entry represents the PR/SET domain found in PR domain zinc finger protein 3 (PRDM3, also known as MECOM or EVI-1). PRDM3 and PRDM16 share protein sequences similarities and have functions in hematopoietic and neuronal stem cells and in adipose tissue differentiation. They also act as oncoproteins (Mel1 and Evi1) involved in translocation-induced leukemia. PRDM3 and PRDM16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes [].
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HT Experiment
GSE250363 | PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiations and Function [bulk RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE250365 | PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiations and Function [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-MTAB-1704 | RNA-seq of coding RNA of brown adipose tissue from Ehmt1flox/flox control mice, Ehmt1Myf5 Knockout mice and Ehmt1adipo knockout mice to study the role of euchromatic histone-lysine N-methyltransferase 1 (EHMT1)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
25205686 | J:217555
First Author: Choi MC
Year: 2014
Journal: EMBO Rep
Title: HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.
Volume: 15
Issue: 11
Pages: 1175-83
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Publication
29131158 | J:251812
First Author: Ikeda K
Year: 2017
Journal: Nat Med
Title: UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.
Volume: 23
Issue: 12
Pages: 1454-1465
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Publication
24995979 | J:214637
First Author: Kong X
Year: 2014
Journal: Cell
Title: IRF4 is a key thermogenic transcriptional partner of PGC-1α.
Volume: 158
Issue: 1
Pages: 69-83
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Publication
34824202 | J:317394
First Author: Li F
Year: 2021
Journal: Nat Commun
Title: Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat.
Volume: 12
Issue: 1
Pages: 6838
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Publication
23217260 | J:195099
First Author: Derecka M
Year: 2012
Journal: Cell Metab
Title: Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.
Volume: 16
Issue: 6
Pages: 814-24
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Publication
22863012 | J:187882
First Author: Qiang L
Year: 2012
Journal: Cell
Title: Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Volume: 150
Issue: 3
Pages: 620-32
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Publication
28535373 | J:284020
First Author: An Y
Year: 2017
Journal: Dev Cell
Title: A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.
Volume: 41
Issue: 4
Pages: 382-391.e5
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Publication
24709624 | J:214781
First Author: Long JZ
Year: 2014
Journal: Cell Metab
Title: A smooth muscle-like origin for beige adipocytes.
Volume: 19
Issue: 5
Pages: 810-20
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Publication
27238639 | J:249880
First Author: Shao M
Year: 2016
Journal: Cell Metab
Title: Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.
Volume: 23
Issue: 6
Pages: 1167-1184
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Publication
31010955 | J:277362
First Author: Shuai L
Year: 2019
Journal: Diabetes
Title: SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue.
Volume: 68
Issue: 7
Pages: 1449-1461
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Publication
24356587 | J:241741
First Author: Feuermann Y
Year: 2013
Journal: RNA Biol
Title: MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
Volume: 10
Issue: 12
Pages: 1807-14
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Publication
27566776 | J:235661
First Author: Zeng X
Year: 2016
Journal: Genes Dev
Title: Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.
Volume: 30
Issue: 16
Pages: 1822-36
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Publication
22405073 | J:182671
First Author: Ortega-Molina A
Year: 2012
Journal: Cell Metab
Title: Pten positively regulates brown adipose function, energy expenditure, and longevity.
Volume: 15
Issue: 3
Pages: 382-94
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Publication
23978475 | J:222765
First Author: Thoren LA
Year: 2013
Journal: Stem Cell Res
Title: PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells.
Volume: 11
Issue: 3
Pages: 1129-36
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Publication
32449550 | J:303929
First Author: Ye B
Year: 2020
Journal: EMBO J
Title: The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
Volume: 39
Issue: 13
Pages: e103786
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Publication
28186086 | J:249898
First Author: Ng Y
Year: 2017
Journal: Exp Mol Med
Title: HOXC10 suppresses browning of white adipose tissues.
Volume: 49
Issue: 2
Pages: e292
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Publication
18483216 | J:134769
First Author: Farmer SR
Year: 2008
Journal: Genes Dev
Title: Molecular determinants of brown adipocyte formation and function.
Volume: 22
Issue: 10
Pages: 1269-75
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Publication
24449206 | J:225252
First Author: De Sousa M
Year: 2014
Journal: Stem Cells
Title: p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells.
Volume: 32
Issue: 5
Pages: 1323-36
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Publication
25187367 | J:247170
First Author: Kong X
Year: 2015
Journal: Diabetes
Title: Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue.
Volume: 64
Issue: 2
Pages: 393-404
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Publication
29574003 | J:265900
 
First Author: Higa R
Year: 2018
Journal: Mol Cell Endocrinol
Title: CD105 maintains the thermogenic program of beige adipocytes by regulating Smad2 signaling.
Volume: 474
Pages: 184-193
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Publication
37925548 | J:342362
First Author: Huang X
Year: 2023
Journal: Nat Commun
Title: Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.
Volume: 14
Issue: 1
Pages: 7102
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HT Experiment
E-GEOD-22693 | Regulation of gene expression program by Fsp27 in white and brown adipose tissue
Series Id: GSE22693
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
25038826 | J:226881
First Author: Bi P
Year: 2014
Journal: Nat Med
Title: Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
Volume: 20
Issue: 8
Pages: 911-8
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Publication
21743466 | J:174421
First Author: Sun L
Year: 2011
Journal: Nat Cell Biol
Title: Mir193b-365 is essential for brown fat differentiation.
Volume: 13
Issue: 8
Pages: 958-65
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Publication
25424999 | J:218795
First Author: Lau P
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
Volume: 308
Issue: 2
Pages: E159-71
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Publication
20471959 | J:162429
First Author: Waldén TB
Year: 2010
Journal: Biochem Biophys Res Commun
Title: PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte.
Volume: 397
Issue: 2
Pages: 146-51
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Publication
23874225 | J:199296
First Author: Liu W
Year: 2013
Journal: PLoS Genet
Title: miR-133a regulates adipocyte browning in vivo.
Volume: 9
Issue: 7
Pages: e1003626
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Publication
37154385 | J:359639
First Author: Chae SA
Year: 2023
Journal: J Physiol
Title: Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling.
Volume: 601
Issue: 12
Pages: 2371-2389
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Publication
24722250 | J:229875
First Author: Chou CF
Year: 2014
Journal: Diabetes
Title: KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression.
Volume: 63
Issue: 9
Pages: 2949-61
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Publication
24642257 | J:219123
First Author: Zhou Y
Year: 2014
Journal: Biochem Biophys Res Commun
Title: The formation of brown adipose tissue induced by transgenic over-expression of PPARγ2.
Volume: 446
Issue: 4
Pages: 959-64
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Publication
29358218 | J:262883
     
First Author: Li Q
Year: 2018
Journal: Mol Cell Biol
Title: TCF7/TCF1 feedback controls osteocalcin signaling in brown adipocytes independent of canonical WNT/β-catenin pathway.
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Publication
31352005 | J:293627
 
First Author: Sun W
Year: 2019
Journal: Mol Metab
Title: Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway.
Volume: 28
Pages: 48-57
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Publication
34056831 | J:340200
First Author: Bast-Habersbrunner A
Year: 2021
Journal: EMBO Rep
Title: LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis.
Volume: 22
Issue: 7
Pages: e51289
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Publication
38187557 | J:361039
     
First Author: He H
Year: 2023
Journal: bioRxiv
Title: PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function.
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Publication
33252251 | J:303183
First Author: Auclair M
Year: 2021
Journal: Am J Physiol Endocrinol Metab
Title: Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.
Volume: 320
Issue: 2
Pages: E219-E233
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Publication
34846543 | J:322750
First Author: Kirschner KM
Year: 2022
Journal: Diabetologia
Title: Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet.
Volume: 65
Issue: 3
Pages: 528-540
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Publication
29237539 | J:278211
 
First Author: Rabhi N
Year: 2018
Journal: Mol Metab
Title: Cdkn2a deficiency promotes adipose tissue browning.
Volume: 8
Pages: 65-76
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Publication
18719589 | J:138822
First Author: Tseng YH
Year: 2008
Journal: Nature
Title: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Volume: 454
Issue: 7207
Pages: 1000-4
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Publication
30327824 | J:273048
First Author: Sevillano J
Year: 2019
Journal: Diabetologia
Title: Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice.
Volume: 62
Issue: 1
Pages: 123-135
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Publication
23717545 | J:200834
First Author: Ringholm S
Year: 2013
Journal: PLoS One
Title: PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue.
Volume: 8
Issue: 5
Pages: e64123
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Publication
36451857 | J:334221
First Author: Shen H
Year: 2022
Journal: Theranostics
Title: SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex.
Volume: 12
Issue: 18
Pages: 7699-7716
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Publication
23977283 | J:204430
First Author: Choi HR
Year: 2013
Journal: PLoS One
Title: Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase.
Volume: 8
Issue: 8
Pages: e72340
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Publication
28288167 | J:245555
First Author: Kodo K
Year: 2017
Journal: PLoS One
Title: Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice.
Volume: 12
Issue: 3
Pages: e0173661
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Publication
24095733 | J:277873
First Author: Wu H
Year: 2013
Journal: Cell Rep
Title: Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.
Volume: 5
Issue: 1
Pages: 13-20
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Publication
32290321 | -
 
First Author: Casamassimi A
Year: 2020
Journal: Int J Mol Sci
Title: Multifaceted Role of PRDM Proteins in Human Cancer.
Volume: 21
Issue: 7
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Publication
20649970 | J:162769
 
First Author: Li D
Year: 2010
Journal: BMC Genomics
Title: Regulation of gene expression by FSP27 in white and brown adipose tissue.
Volume: 11
Pages: 446
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Protein
Q8BNF5
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Publication
15368895 | J:92575
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 3
Pages: 205-18
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:109762
     
First Author: Mouse Genome Informatics and VEGA Genome Database Project
Year: 2006
Journal: Database Release
Title: Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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