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Search results 601 to 689 out of 689 for Ptpn11

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Hits by Strain

Type Details Score
Publication
15650055 | J:98977
First Author: Jenkins BJ
Year: 2005
Journal: Blood
Title: The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.
Volume: 105
Issue: 9
Pages: 3512-20
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Strain
MGI:6331980 | STOCK Il6st<tm1Ern> Tirap<tm1.1Pjh>/MarpApb
Attribute String: targeted mutation, mutant stock
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Strain
MGI:5909087 | FVB/N-Tg(Myh7-Ptpn11*Q510E)#Krnz
Attribute String: coisogenic, mutant strain, transgenic
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Publication
25724491 | J:222124
First Author: Clay SA
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines.
Volume: 308
Issue: 9
Pages: H1086-95
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Genotype
Genotype
Symbol: Il6st/Il6st Stat3/Stat3<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6st/Il6st Stat1/Stat1
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ifnar2/Ifnar2 Il6st/Il6st
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6st/Il6st Tirap/Tirap
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh7-Ptpn11*Q510E)#Krnz/?
Background: FVB/N-Tg(Myh7-Ptpn11*Q510E)#Krnz
Zygosity: ot
Has Mutant Allele: true
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Publication
17082315 | J:143670
First Author: Jenkins BJ
Year: 2007
Journal: Blood
Title: Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.
Volume: 109
Issue: 6
Pages: 2380-8
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Publication
27373892 | J:324136
First Author: Ruwanpura SM
Year: 2016
Journal: Am J Respir Crit Care Med
Title: Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.
Volume: 194
Issue: 12
Pages: 1494-1505
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Strain
MGI:6332029 | STOCK Stat1<tm1Rds> Il6st<tm1Ern> Stat3<tm1Aki>/LudApb
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6332086 | B6.129-Il6st<tm1Ern> Tlr2<tm1Aki>/MarpApb
Attribute String: mutant strain, targeted mutation, congenic
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Publication
35588797 | J:327423
First Author: Zhang X
Year: 2022
Journal: Gastroenterology
Title: Induction of Fibroblast Growth Factor Receptor 4 by Helicobacter pylori via Signal Transducer and Activator of Transcription 3 With a Feedforward Activation Loop Involving Steroid Receptor Coactivator Signaling in Gastric Cancer.
Volume: 163
Issue: 3
Pages: 620-636.e9
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Strain
MGI:6332755 | B6.Cg-Il6st<tm1Ern> Stat3<tm1Dnl>/MarpApb
Attribute String: mutant strain, congenic, targeted mutation
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Publication
27893707 | J:243057
First Author: Miller A
Year: 2017
Journal: Oncogene
Title: Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma.
Volume: 36
Issue: 21
Pages: 3059-3066
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Genotype
Genotype
Symbol: Mapk1/Mapk1<+> Tg(Myh7-Ptpn11*Q79R)11Rbns/?
Background: involves: 129S2/SvPas * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapk3/Mapk3 Tg(Myh7-Ptpn11*Q79R)11Rbns/?
Background: involves: 129/Sv * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6st/Il6st Tg(Alb1-cre)7Gsc/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6/Il6 Il6st/Il6st
Background: involves: 129S1/Sv * 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6st/Il6st<+> Smad3/Smad3<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6st/Il6st Tg(RP11-H2112)5Trme/?
Background: involves: 129S1/Sv * C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6st/Il6st Tg(RP11-H2112)9Trme/?
Background: involves: 129S1/Sv * C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gkn2/Gkn2 Il6st/Il6st
Background: involves: 129S1/Sv * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
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Publication
29720585 | J:262915
First Author: Hyrenius-Wittsten A
Year: 2018
Journal: Nat Commun
Title: De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Volume: 9
Issue: 1
Pages: 1770
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Protein
P35235
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Publication
37272871 | J:340869
First Author: Millrine D
Year: 2023
Journal: J Immunol
Title: Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements.
Volume: 211
Issue: 2
Pages: 274-286
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Publication
19097069 | J:145736
First Author: Judd LM
Year: 2009
Journal: J Pathol
Title: Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression.
Volume: 217
Issue: 4
Pages: 552-62
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Publication
19109195 | J:142883
First Author: Nowell MA
Year: 2009
Journal: J Immunol
Title: Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Volume: 182
Issue: 1
Pages: 613-22
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Publication
17609432 | J:147013
First Author: Brender C
Year: 2007
Journal: Blood
Title: Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
Volume: 110
Issue: 7
Pages: 2528-36
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Publication
22268122 | J:183951
First Author: Ruwanpura SM
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice.
Volume: 302
Issue: 7
Pages: L627-39
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Publication
21297079 | J:190215
First Author: Ruwanpura SM
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice.
Volume: 45
Issue: 4
Pages: 720-30
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Publication
21148800 | J:168781
First Author: Greenhill CJ
Year: 2011
Journal: J Immunol
Title: IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.
Volume: 186
Issue: 2
Pages: 1199-208
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Publication
16143138 | J:103565
First Author: Howlett M
Year: 2005
Journal: Gastroenterology
Title: Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.
Volume: 129
Issue: 3
Pages: 1005-18
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Strain
MGI:6332186 | B6;129-Il6st<tm1Ern> Il10<tm1Cgn>/LudApb
Attribute String: mutant strain, targeted mutation
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Publication
16041381 | J:100160
First Author: Jenkins BJ
Year: 2005
Journal: Nat Med
Title: Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.
Volume: 11
Issue: 8
Pages: 845-52
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Publication
31481496 | J:280047
First Author: Balic JJ
Year: 2019
Journal: Cancer Res
Title: Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity.
Volume: 79
Issue: 20
Pages: 5272-5287
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Publication
29417587 | J:263948
First Author: Hill DG
Year: 2018
Journal: Int J Cancer
Title: Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.
Volume: 143
Issue: 1
Pages: 167-178
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Publication
26848037 | J:288464
 
First Author: Däbritz J
Year: 2016
Journal: Sci Rep
Title: Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells.
Volume: 6
Pages: 20584
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Publication
19121317 | J:146915
First Author: Howlett M
Year: 2009
Journal: Gastroenterology
Title: The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development.
Volume: 136
Issue: 3
Pages: 967-77
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Publication
35677533 | J:326621
 
First Author: Tran CP
Year: 2022
Journal: Oncotarget
Title: IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells.
Volume: 13
Pages: 785-799
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Publication
28911943 | J:257166
 
First Author: Roy R
Year: 2017
Journal: J Mol Cell Cardiol
Title: Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines.
Volume: 112
Pages: 83-90
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Strain
MGI:6332192 | STOCK Gpa33<tm1(cre)Ern> Il6st<tm1Ern> Pten<tm2Mak>/LudApb
Attribute String: mutant stock, targeted mutation
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Publication
19706403 | J:153094
First Author: Nakamura T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations.
Volume: 106
Issue: 36
Pages: 15436-41
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Publication
28481875 | J:248167
First Author: West AC
Year: 2017
Journal: Oncogene
Title: Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.
Volume: 36
Issue: 36
Pages: 5134-5144
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Publication
33181031 | J:323985
First Author: Saad MI
Year: 2021
Journal: Am J Respir Cell Mol Biol
Title: ADAM17 Deficiency Protects against Pulmonary Emphysema.
Volume: 64
Issue: 2
Pages: 183-195
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Publication
24480804 | J:212505
First Author: Schneeberger VE
Year: 2014
Journal: Carcinogenesis
Title: SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.
Volume: 35
Issue: 8
Pages: 1717-25
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Genotype
Genotype
Symbol: Tg(CAG-cat,-Ptpn11)1Rbns/? Tg(Tek-cre)12Flv/?
Background: involves: C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-PTPN11*E76K)#Jiwu/?
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-cat,-Ptpn11*Q510E)#Krnz/? Tg(Tek-cre)1Ywa/?
Background: involves: C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
25224413 | J:218683
First Author: Bejar R
Year: 2014
Journal: Blood
Title: TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.
Volume: 124
Issue: 17
Pages: 2705-12
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Publication
34625577 | J:312396
First Author: McNamara JT
Year: 2021
Journal: Sci Rep
Title: SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism.
Volume: 11
Issue: 1
Pages: 20006
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Publication
20007546 | J:157731
First Author: Caudell D
Year: 2010
Journal: Blood
Title: Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.
Volume: 115
Issue: 6
Pages: 1194-203
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Publication
28213521 | J:241654
First Author: Wills MK
Year: 2017
Journal: J Biol Chem
Title: Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors.
Volume: 292
Issue: 14
Pages: 5748-5759
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Publication
23948300 | J:202609
First Author: Putoczki TL
Year: 2013
Journal: Cancer Cell
Title: Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Volume: 24
Issue: 2
Pages: 257-71
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Publication
15976028 | J:99865
First Author: McLoughlin RM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.
Volume: 102
Issue: 27
Pages: 9589-94
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Publication
14755335 | J:87612
First Author: Sims NA
Year: 2004
Journal: J Clin Invest
Title: Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.
Volume: 113
Issue: 3
Pages: 379-89
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Publication
23853585 | J:213369
First Author: Carow B
Year: 2013
Journal: PLoS Pathog
Title: Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Volume: 9
Issue: 7
Pages: e1003442
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Publication
21710691 | J:175909
First Author: Kennedy CL
Year: 2011
Journal: J Pathol
Title: The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17.
Volume: 225
Issue: 2
Pages: 255-64
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Publication
18641358 | J:139226
First Author: Fielding CA
Year: 2008
Journal: J Immunol
Title: IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.
Volume: 181
Issue: 3
Pages: 2189-95
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Publication
18431520 | J:135184
First Author: Ernst M
Year: 2008
Journal: J Clin Invest
Title: STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.
Volume: 118
Issue: 5
Pages: 1727-38
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Publication
23321674 | J:194490
First Author: Thiem S
Year: 2013
Journal: J Clin Invest
Title: mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
Volume: 123
Issue: 2
Pages: 767-81
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Publication
29562203 | J:272415
First Author: O'Reilly LA
Year: 2018
Journal: Immunity
Title: Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Volume: 48
Issue: 3
Pages: 570-583.e8
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Publication
29282220 | J:261888
First Author: Deswaerte V
Year: 2018
Journal: Cancer Res
Title: Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism.
Volume: 78
Issue: 5
Pages: 1293-1307
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Publication
23079657 | J:192030
First Author: Tye H
Year: 2012
Journal: Cancer Cell
Title: STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.
Volume: 22
Issue: 4
Pages: 466-78
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Publication
24398427 | J:320713
First Author: Stuart E
Year: 2014
Journal: Mol Cancer Ther
Title: Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.
Volume: 13
Issue: 2
Pages: 468-74
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Publication
15761498 | J:97327
First Author: Klein C
Year: 2005
Journal: J Clin Invest
Title: The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
Volume: 115
Issue: 4
Pages: 860-9
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Publication
20530204 | J:163411
First Author: Sander LE
Year: 2010
Journal: J Exp Med
Title: Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.
Volume: 207
Issue: 7
Pages: 1453-64
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Publication
18216023 | J:135290
First Author: Dierssen U
Year: 2008
Journal: J Biol Chem
Title: Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration.
Volume: 283
Issue: 15
Pages: 9886-95
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Publication
20382701 | J:160377
First Author: Plum W
Year: 2010
Journal: Am J Pathol
Title: Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis.
Volume: 176
Issue: 5
Pages: 2236-46
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Publication
20585009 | J:178593
First Author: Hilfiker-Kleiner D
Year: 2010
Journal: Circulation
Title: Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.
Volume: 122
Issue: 2
Pages: 145-55
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Publication
17241879 | J:127268
First Author: Pietrangelo A
Year: 2007
Journal: Gastroenterology
Title: STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.
Volume: 132
Issue: 1
Pages: 294-300
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Publication
17641779 | J:123963
First Author: Nakamura T
Year: 2007
Journal: J Clin Invest
Title: Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
Volume: 117
Issue: 8
Pages: 2123-32
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Publication
35020406 | J:334058
First Author: Headland SE
Year: 2022
Journal: Sci Transl Med
Title: Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
Volume: 14
Issue: 627
Pages: eabf8188
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Publication
28170160 | J:239149
 
First Author: Alorro MG
Year: 2017
Journal: Genesis
Title: Generation of an inducible mouse model to reversibly silence Stat3.
Volume: 55
Issue: 4
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Publication
37957015 | J:342593
 
First Author: Thilakasiri P
Year: 2024
Journal: Life Sci Alliance
Title: Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3.
Volume: 7
Issue: 2
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Genotype
Genotype
Symbol: Mapk1/Mapk1<+> Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/? Tg(Tek-cre)12Flv/?
Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapk3/Mapk3<+> Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/? Tg(Tek-cre)12Flv/?
Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapk3/Mapk3 Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/? Tg(Tek-cre)12Flv/?
Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Publication
16906166 | J:112649
First Author: Stumhofer JS
Year: 2006
Journal: Nat Immunol
Title: Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Volume: 7
Issue: 9
Pages: 937-45
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Publication
17114459 | J:140695
First Author: El Kasmi KC
Year: 2006
Journal: J Immunol
Title: General nature of the STAT3-activated anti-inflammatory response.
Volume: 177
Issue: 11
Pages: 7880-8
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Publication
19185844 | J:144814
First Author: Bollrath J
Year: 2009
Journal: Cancer Cell
Title: gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
Volume: 15
Issue: 2
Pages: 91-102
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Publication
21515788 | J:173204
First Author: Haroon F
Year: 2011
Journal: J Immunol
Title: Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation.
Volume: 186
Issue: 11
Pages: 6521-31
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Publication
26974160 | J:234656
First Author: Menheniott TR
Year: 2016
Journal: J Clin Invest
Title: Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.
Volume: 126
Issue: 4
Pages: 1383-400
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Publication
25270258 | J:259053
First Author: Phesse TJ
Year: 2014
Journal: Sci Signal
Title: Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
Volume: 7
Issue: 345
Pages: ra92
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Publication
26837764 | J:231629
First Author: Thiem S
Year: 2016
Journal: Cancer Res
Title: Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.
Volume: 76
Issue: 8
Pages: 2277-87
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Publication
24069548 | J:202463
First Author: Li J
Year: 2013
Journal: JAKSTAT
Title: JAK-STAT and bone metabolism.
Volume: 2
Issue: 3
Pages: e23930
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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