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Search results 601 to 700 out of 897 for Rgs4

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4415971
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4827721
Age: embryonic day 14.5
Image: euxassay_011462_10
Specimen Label: euxassay_011462_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1679821
Stage: TS21
Assay Id: MGI:7645412
Age: embryonic day 13.5
Image: 3B
Note: At this stage expression was lost in the nodose-petrosal complex (gIX-X).
Specimen Label: 3B
Detected: false
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679816
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:7645412
Age: embryonic day 10.0
Image: 4A
Specimen Label: 4A
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7645412
Age: embryonic day 10.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 31
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GXD Expression
GXD Expression
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7645412
Age: embryonic day 10.5
Image: 6B
Note: Expression was downregulated but not extinguished.
Specimen Label: 6B
Detected: true
Specimen Num: 32
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GXD Expression
GXD Expression
 
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7645412
Age: embryonic day 10.5
Image: 6C
Specimen Label: 6C
Detected: true
Specimen Num: 33
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GXD Expression
GXD Expression
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7645412
Age: embryonic day 10.5
Image: 6D
Note: Expression was downregulated but not extinguished.
Specimen Label: 6D
Detected: true
Specimen Num: 34
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GXD Expression
GXD Expression
     
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1679822
Stage: TS22
Assay Id: MGI:7645412
Age: embryonic day 14.5
Specimen Label: not shown
Detected: false
Specimen Num: 38
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GXD Expression
GXD Expression
 
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3281321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7645412
Age: embryonic day 13.5
Note: Expressed strongly in pulmonary parasympathetic ganglion. Very few positive cells in ciliary ganglion.
Specimen Label: not shown
Detected: true
Specimen Num: 37
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GXD Expression
GXD Expression
   
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3281322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7645412
Age: embryonic day 14.5
Specimen Label: not shown
Detected: true
Specimen Num: 38
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Very strong
Sex: Female
Emaps: EMAPS:2991528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3639167
Age: postnatal day 49
Image: Mouse 384260 - Image 99234772
Note: Expression is frequently seen in the blood vessels of the uterus.
Specimen Label: Mouse 384260 - Image 99234772
Detected: true
Specimen Num: 64
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Very strong
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639167
Age: postnatal day 56
Image: Mouse 384262 - Image 99230411
Note: Expression is frequently seen in the brain.
Specimen Label: Mouse 384262 - Image 99230411
Detected: true
Specimen Num: 67
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Very strong
Sex: Male
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639167
Age: postnatal day 49
Image: Mouse 384254 - Image 99234404
Note: There is scattered expression in the granule layer.
Specimen Label: Mouse 384254 - Image 99234404
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Very strong
Sex: Female
Emaps: EMAPS:1796228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3639167
Age: postnatal day 49
Image: Mouse 384260 - Image 99234771
Note: Expression is frequently seen in the blood vessels of the ovary.
Specimen Label: Mouse 384260 - Image 99234771
Detected: true
Specimen Num: 63
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GXD Expression
GXD Expression
   
Probe: MGI:5001959
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542513
Age: embryonic day 15.5
Image: GUDMAP:8439
Specimen Label: GUDMAP:8439
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7782621
Assay Type: RNA in situ
Annotation Date: 2024-11-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3561128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7783419
Age: postnatal day 6
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3700621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7645412
Age: embryonic day 13.5
Image: 3E
Specimen Label: 3E
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
   
Probe: MGI:7782621
Assay Type: RNA in situ
Annotation Date: 2024-11-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3791728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7783419
Age: postnatal day 6
Specimen Label: 1B
Detected: true
Specimen Num: 1
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Publication
8917514 | J:36569
First Author: Chen CK
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling.
Volume: 93
Issue: 23
Pages: 12885-9
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Publication
31030617 | J:295230
First Author: Koch JN
Year: 2019
Journal: J Am Heart Assoc
Title: Regulator of G Protein Signaling 2 Facilitates Uterine Artery Adaptation During Pregnancy in Mice.
Volume: 8
Issue: 9
Pages: e010917
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Publication
39565858 | J:359070
First Author: Nielsen BE
Year: 2024
Journal: Sci Adv
Title: Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors.
Volume: 10
Issue: 47
Pages: eadp6301
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Publication
10203790 | J:54103
First Author: De Vries L
Year: 1999
Journal: Trends Cell Biol
Title: RGS proteins: more than just GAPs for heterotrimeric G proteins.
Volume: 9
Issue: 4
Pages: 138-44
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Publication
15238534 | J:91132
First Author: Bilger A
Year: 2004
Journal: Genetics
Title: A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.
Volume: 167
Issue: 2
Pages: 859-66
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Publication
21541283 | J:172381
First Author: Osterberg N
Year: 2011
Journal: PLoS One
Title: Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.
Volume: 6
Issue: 4
Pages: e19239
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Publication
33386618 | J:351810
First Author: Morales L
Year: 2021
Journal: J Comp Neurol
Title: A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala.
Volume: 529
Issue: 10
Pages: 2418-2449
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19302145 | J:147117
First Author: Cheng TW
Year: 2009
Journal: Eur J Neurosci
Title: Secreted TARSH regulates olfactory mitral cell dendritic complexity.
Volume: 29
Issue: 6
Pages: 1083-95
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Publication
11342430 | J:69278
First Author: Nagata Y
Year: 2001
Journal: Blood
Title: A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.
Volume: 97
Issue: 10
Pages: 3051-60
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Publication
16860307 | J:119269
First Author: Caqueret A
Year: 2006
Journal: Dev Biol
Title: Laminar organization of the early developing anterior hypothalamus.
Volume: 298
Issue: 1
Pages: 95-106
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Publication
23968836 | J:199782
First Author: Ha S
Year: 2015
Journal: Cereb Cortex
Title: A forward genetic screen in mice identifies mutants with abnormal cortical patterning.
Volume: 25
Issue: 1
Pages: 167-79
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Publication
28467908 | J:254511
First Author: Inoue K
Year: 2017
Journal: Cell Rep
Title: The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development.
Volume: 19
Issue: 5
Pages: 949-956
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Publication
28433741 | J:259070
 
First Author: Tischfield DJ
Year: 2017
Journal: Neurobiol Dis
Title: Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.
Volume: 103
Pages: 174-183
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Publication
24893171 | J:218509
First Author: Kim HJ
Year: 2014
Journal: PLoS One
Title: Patterns of gene expression associated with Pten deficiency in the developing inner ear.
Volume: 9
Issue: 6
Pages: e97544
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Publication
22577142 | J:316188
First Author: Lee MJ
Year: 2012
Journal: J Biol Chem
Title: Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes.
Volume: 287
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Pages: 24043-52
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21821099 | J:184660
 
First Author: Kvajo M
Year: 2012
Journal: Neuroscience
Title: Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.
Volume: 211
Pages: 136-64
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Publication
36521641 | J:332291
 
First Author: Song H
Year: 2022
Journal: Dev Biol
Title: Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development.
Volume: 494
Pages: 71-84
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Publication
17239249 | J:160656
 
First Author: Eng SR
Year: 2007
Journal: Neural Dev
Title: POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia.
Volume: 2
Pages: 3
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Publication
35793630 | J:326542
First Author: van de Haar LL
Year: 2022
Journal: Cell Rep
Title: Molecular signatures and cellular diversity during mouse habenula development.
Volume: 40
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Pages: 111029
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21858141 | J:177585
First Author: Hesse K
Year: 2011
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Title: AP-2δ is a crucial transcriptional regulator of the posterior midbrain.
Volume: 6
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First Author: Chambers D
Year: 2009
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Title: Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain.
Volume: 4
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30917309 | J:283226
First Author: Desiderio S
Year: 2019
Journal: Cell Rep
Title: Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.
Volume: 26
Issue: 13
Pages: 3522-3536.e5
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10051400 | J:52606
First Author: Eddleston J
Year: 1999
Journal: Genomics
Title: Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).
Volume: 56
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31597102 | J:286533
First Author: Tenney AP
Year: 2019
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34994686 | J:317827
   
First Author: Sawai A
Year: 2022
Journal: Elife
Title: PRC1 sustains the integrity of neural fate in the absence of PRC2 function.
Volume: 11
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Publication
39106860 | J:353339
First Author: Butts JC
Year: 2024
Journal: Dev Cell
Title: A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain.
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First Author: Gerl K
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Title: Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
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First Author: Sierra DA
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Journal: Genomics
Title: Evolution of the regulators of G-protein signaling multigene family in mouse and human.
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19799774 | J:157314
First Author: Ling KH
Year: 2009
Journal: Genome Biol
Title: Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Volume: 10
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37298722 | J:336866
 
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Year: 2023
Journal: Int J Mol Sci
Title: The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.
Volume: 24
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First Author: Deltagen Inc
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Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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First Author: Allen Institute for Brain Science
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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First Author: Mouse Genome Informatics Group
Year: 2003
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
15661377 | J:95566
First Author: Tervonen T
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse.
Volume: 133
Issue: 1
Pages: 162-5
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Publication
24421355 | J:219909
First Author: Chen IS
Year: 2014
Journal: J Physiol
Title: RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
Volume: 592
Issue: 6
Pages: 1237-48
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Publication
33067534 | J:299003
First Author: Hu L
Year: 2020
Journal: Sci Rep
Title: SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells.
Volume: 10
Issue: 1
Pages: 17581
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Publication
10487771 | J:133939
First Author: Rogers JH
Year: 1999
Journal: J Clin Invest
Title: RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.
Volume: 104
Issue: 5
Pages: 567-76
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Transgene
MGI:3767841 | Tg(Rgs4-EGFP)4Lvt
Type: transgene
Organism: mouse, laboratory
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Publication
11162127 | J:127759
First Author: Rogers JH
Year: 2001
Journal: J Mol Cell Cardiol
Title: RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice.
Volume: 33
Issue: 2
Pages: 209-18
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Allele
Tg(Rgs4-EGFP)4Lvt | MGI:3767843
Name: transgene insertion 4, Pat Levitt
Allele Type: Transgenic
Attribute String: Reporter
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Publication
16989953 | J:128690
First Author: Ebert PJ
Year: 2006
Journal: Neuroscience
Title: Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. II. Subcortical regions.
Volume: 142
Issue: 4
Pages: 1163-81
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Publication
9108480 | -
First Author: Tesmer JJ
Year: 1997
Journal: Cell
Title: Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Volume: 89
Issue: 2
Pages: 251-61
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Allele
Rgs4<tm1.1Jbr> | MGI:3580388
Name: regulator of G-protein signaling 4; targeted mutation 1, Jean-Francois Brunet
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tg(Rgs4-EGFP)HS100Gsat | MGI:4847379
Name: transgene insertion HS100, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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HT Experiment
E-GEOD-33372 | Transcription profiling by array of mouse hypothalamus mutant for WFS1
Series Id: GSE33372
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:4834822 | STOCK Rgs4<tm1.1Jbr>/Orl
Attribute String: targeted mutation, mutant stock
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Strain
MGI:5003755 | STOCK Tg(Rgs4-EGFP)HS100Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Rgs4/Rgs4
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR034953 | RGS_RGS4
Type: Domain
Description: RGS4 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS4 is expressed widely in brain and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling []. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia [, , ]. RGS4 also is up-regulated in the failing human heart []. RGS4 interacts with many binding partners outside of GPCR pathways, including PIP, calcium/CaM, PA and 14-3-3 [, ].The RGS (Regulator of G-protein Signalling) domain is an essential part of the RGS4 protein.
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Strain
MGI:3767847 | B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
Attribute String: transgenic, mutant strain, congenic
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Genotype
Genotype
Symbol: Tg(Rgs4-EGFP)4Lvt/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
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