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Search results 601 to 700 out of 31756 for Set

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kiyosawa H
Year: 2003
Journal: Genome Res
Title: Antisense transcripts with FANTOM2 clone set and their implications for gene regulation.
Volume: 13
Issue: 6B
Pages: 1324-34
Publication
First Author: Guo L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis.
Volume: 107
Issue: 43
Pages: 18557-62
Publication
First Author: Schotta G
Year: 2008
Journal: Genes Dev
Title: A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Volume: 22
Issue: 15
Pages: 2048-61
Publication
First Author: Faundes V
Year: 2018
Journal: Am J Hum Genet
Title: Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.
Volume: 102
Issue: 1
Pages: 175-187
Publication
First Author: Stessman HA
Year: 2017
Journal: Nat Genet
Title: Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.
Volume: 49
Issue: 4
Pages: 515-526
Publication
First Author: Viotti M
Year: 2018
Journal: J Cell Biol
Title: SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.
Volume: 217
Issue: 2
Pages: 763-777
Publication
First Author: Yang H
Year: 2008
Journal: J Biol Chem
Title: Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
Volume: 283
Issue: 18
Pages: 12085-92
Protein Domain
Type: Domain
Description: This entry represents the SET domain found in KMT2E.The protein known as histone-lysine N-methyltransferase 2E (KMT2E, mixed-lineage leukemia 5 or MLL5) has been shown to lack key residues and an essential loop in the the SET-I subdomain required for binding substrate and cofactors []. MLL5 had been thought to be specific for mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2; which are specific tags for epigenetic transcriptional activation), and a component of an MLL5 complex, but the paper describing this alleged complex has been retracted by the authors []. MLL5 mediates hematopoietic cell homeostasis, spermatogenesis, cell cycle progression, and survival [, ]. It is recruited to gene-rich euchromatic regions via the interaction of its plant homeodomain finger with the histone mark H3K4me3 []. Overexpression of the MLL5 gene induced cell cycle arrest in G(1) phase [].
Protein Domain
Type: Domain
Description: Post-translational modification of the core histones H2A, H2B, H3 and H4 play an important part in chromatin biology. Histone H4 lysine 20 methylation (H4K20me) is critical for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction []. Suv4-20 family members are a group of histone H4K20 methyltransferases that play an important role in epigenetic regulation. Lower eukaryotes have a single Suv4-20, while mammals have two closely related Suv4-20 paralogs, SUV420H1 and SUV420H2 []. In mammals H4K20me2 is generated primarily by SUV420H1/KMT5B (which can also produce H4K20me3), while H4K20me3 is mostly generated by SUV420H2/KMT5C [].This entry represents the SET domain found in KMT5C (also known as SUV420H2). KMT5C acts as an upstream epigenetic regulator of epithelial/mesenchymal state control [].
Protein Domain
Type: Domain
Description: Post-translational modification of the core histones H2A, H2B, H3 and H4 play an important part in chromatin biology. Histone H4 lysine 20 methylation (H4K20me) is critical for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction []. Suv4-20 family members are a group of histone H4K20 methyltransferases that play an important role in epigenetic regulation. Lower eukaryotes have a single Suv4-20, while mammals have two closely related Suv4-20 paralogs, SUV420H1 and SUV420H2 []. In mammals H4K20me2 is generated primarily by SUV420H1/KMT5B (which can also produce H4K20me3), while H4K20me3 is mostly generated by SUV420H2/KMT5C [].This entry represents the SET domain found in Suv4-20 from lower eukaryotes [].
Protein Domain
Type: Domain
Description: Post-translational modification of the core histones H2A, H2B, H3 and H4 play an important part in chromatin biology. Histone H4 lysine 20 methylation (H4K20me) is critical for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction []. Suv4-20 family members are a group of histone H4K20 methyltransferases that play an important role in epigenetic regulation. Lower eukaryotes have a single Suv4-20, while mammals have two closely related Suv4-20 paralogs, SUV420H1 and SUV420H2 []. In mammals H4K20me2 is generated primarily by SUV420H1/KMT5B (which can also produce H4K20me3), while H4K20me3 is mostly generated by SUV420H2/KMT5C [].This entry represents the SET domain found in KMT5B (also known as SUV420H1). Suv420h1 knockout mice die perinatally and show overall growth retardation []. In humans KMT5B may affect neurodevelopment and has been linked to Mental retardation, autosomal dominant 51 [, ].
Allele
Name: SET domain containing 2; targeted mutation 1, Zhu Chen
Allele Type: Targeted
Attribute String: Null/knockout
Protein
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
Publication
First Author: Gestreau C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Task2 potassium channels set central respiratory CO2 and O2 sensitivity.
Volume: 107
Issue: 5
Pages: 2325-30
Publication
First Author: Rudnick A
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Pancreatic beta cells express a diverse set of homeobox genes.
Volume: 91
Issue: 25
Pages: 12203-7
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
Publication
First Author: Zhou Y
Year: 2018
Journal: Haematologica
Title: Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.
Volume: 103
Issue: 7
Pages: 1110-1123
Publication
First Author: Venkatesh S
Year: 2012
Journal: Nature
Title: Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.
Volume: 489
Issue: 7416
Pages: 452-5
Publication  
First Author: Zhang Y
Year: 2017
Journal: Sci Rep
Title: Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.
Volume: 7
Pages: 43906
Publication
First Author: Tlemsani C
Year: 2016
Journal: J Med Genet
Title: SETD2 and DNMT3A screen in the Sotos-like syndrome French cohort.
Volume: 53
Issue: 11
Pages: 743-751
Publication
First Author: Zhu X
Year: 2014
Journal: Nat Genet
Title: Identification of functional cooperative mutations of SETD2 in human acute leukemia.
Volume: 46
Issue: 3
Pages: 287-93
Publication  
First Author: Mar BG
Year: 2014
Journal: Nat Commun
Title: Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.
Volume: 5
Pages: 3469
Publication
First Author: Dalgliesh GL
Year: 2010
Journal: Nature
Title: Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
Volume: 463
Issue: 7279
Pages: 360-3
Publication
First Author: Grini PE
Year: 2009
Journal: PLoS One
Title: The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis.
Volume: 4
Issue: 11
Pages: e7817
Protein Domain
Type: Domain
Description: This entry represents the SET domain found in SETD2 from animals, ASHH2 from plants and Set2 from fungi. Proteins containing this domain are a group of histone methyltransferases that methylates histone H3 to form H3K36me [, ].Yeast Set2 is involved in transcription elongation as well as in transcription repression []. The methyltransferase activity of budding yeast Set2 requires the recruitment to the RNA polymerase II, which is CTK1 dependent [, , , , , , ]. Plant ASHH2 is required for the correct expression of genes essential to reproductive development [].SETD2 acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate [, ]. SETD2 is also required for DNA double-strand break repair and activation of the p53-mediated checkpoint []. SETD2-inactivation has been linked to tumour development []. SETD2 also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy []. Moreover, SETD2 is also involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription [].SETD2 has been linked to several human diseases, including Renal cell carcinoma (RCC) [], Luscan-Lumish syndrome (LLS) [], Leukemia, acute lymphoblastic (ALL) []and Leukemia, acute myelogenous (AML) [, ].
Publication
First Author: Kumar S
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Identification of a set of genes with developmentally down-regulated expression in the mouse brain.
Volume: 185
Issue: 3
Pages: 1155-61
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
Publication
First Author: Mar BG
Year: 2017
Journal: Blood
Title: SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
Volume: 130
Issue: 24
Pages: 2631-2641
Publication
First Author: Lawson KA
Year: 2013
Journal: FEBS Lett
Title: ESET histone methyltransferase regulates osteoblastic differentiation of mesenchymal stem cells during postnatal bone development.
Volume: 587
Issue: 24
Pages: 3961-7
Publication
First Author: Abe H
Year: 2022
Journal: Nat Commun
Title: Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.
Volume: 13
Issue: 1
Pages: 7212
Publication
First Author: Cheng EC
Year: 2021
Journal: Cell Rep
Title: The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis.
Volume: 34
Issue: 1
Pages: 108575
Publication
First Author: Hamm JP
Year: 2020
Journal: Biol Psychiatry
Title: Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a(+/-) Mice.
Volume: 88
Issue: 3
Pages: 215-223
Publication
First Author: Chiang YC
Year: 2018
Journal: Cancer Res
Title: SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.
Volume: 78
Issue: 12
Pages: 3135-3146
Publication  
First Author: Liu M
Year: 2021
Journal: Redox Biol
Title: The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis.
Volume: 43
Pages: 102004
Publication
First Author: Clifton NE
Year: 2022
Journal: Hum Mol Genet
Title: Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function.
Volume: 31
Issue: 18
Pages: 3095-3106
Publication
First Author: Karras P
Year: 2019
Journal: Cancer Cell
Title: p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Volume: 35
Issue: 1
Pages: 46-63.e10
Publication
First Author: Ozga AJ
Year: 2022
Journal: Immunity
Title: CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection.
Volume: 55
Issue: 1
Pages: 82-97.e8
Publication      
First Author: Ruggiero A
Year: 2024
Journal: Neuron
Title: NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics.
Publication
First Author: Huang JL
Year: 2024
Journal: Nat Metab
Title: Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice.
Volume: 6
Issue: 1
Pages: 61-77
Publication
First Author: Liu Z
Year: 2008
Journal: Mol Cell
Title: Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.
Volume: 29
Issue: 6
Pages: 665-78
Publication
First Author: Tanaka T
Year: 2023
Journal: Nat Immunol
Title: Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway.
Volume: 24
Issue: 3
Pages: 439-451
Publication
First Author: Brenner DS
Year: 2014
Journal: Pain
Title: A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
Volume: 155
Issue: 10
Pages: 2124-33
Publication
First Author: Barth JL
Year: 2010
Journal: Dev Dyn
Title: Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis.
Volume: 239
Issue: 7
Pages: 2024-33
Publication
First Author: Nofsinger RR
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis.
Volume: 105
Issue: 50
Pages: 20021-6
Publication
First Author: Verneuil J
Year: 2020
Journal: PLoS Biol
Title: The M-current works in tandem with the persistent sodium current to set the speed of locomotion.
Volume: 18
Issue: 11
Pages: e3000738
Publication
First Author: Davis RC
Year: 2005
Journal: Genomics
Title: A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background.
Volume: 86
Issue: 3
Pages: 259-70
Publication
First Author: Davis RC
Year: 2007
Journal: Genomics
Title: A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background.
Volume: 90
Issue: 3
Pages: 306-13
Publication
First Author: De S
Year: 2010
Journal: Physiol Genomics
Title: Disease and phenotype gene set analysis of disease-based gene expression in mouse and human.
Volume: 42A
Issue: 2
Pages: 162-7
MP Term
Protein
Organism: Mus musculus/domesticus
Length: 2537  
Fragment?: false
Publication
First Author: Nishimura M
Year: 1995
Journal: Mamm Genome
Title: The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile.
Volume: 6
Issue: 12
Pages: 850-7
Publication
First Author: Huang N
Year: 1998
Journal: EMBO J
Title: Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators.
Volume: 17
Issue: 12
Pages: 3398-412
Allele
Name: SET nuclear oncogene; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Powlesland AS
Year: 2006
Journal: J Biol Chem
Title: Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins.
Volume: 281
Issue: 29
Pages: 20440-9
Publication
First Author: Casten KS
Year: 2011
Journal: Behav Neurosci
Title: Discrimination learning and attentional set formation in a mouse model of Fragile X.
Volume: 125
Issue: 3
Pages: 473-9
Publication  
First Author: Zamorano C
Year: 2018
Journal: Neuroscience
Title: Memory Retrieval Re-Activates Erk1/2 Signaling in the Same Set of CA1 Neurons Recruited During Conditioning.
Volume: 370
Pages: 101-111
Publication  
First Author: Banerjee K
Year: 2023
Journal: J Clin Invest
Title: SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations.
Volume: 133
Issue: 18
Publication
First Author: Shibata T
Year: 2011
Journal: Int Immunol
Title: Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes.
Volume: 23
Issue: 8
Pages: 503-10
Publication
First Author: Chen CT
Year: 2014
Journal: Curr Biol
Title: A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.
Volume: 24
Issue: 19
Pages: 2327-2334
Publication
First Author: Holmen SL
Year: 2002
Journal: J Biol Chem
Title: A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.
Volume: 277
Issue: 38
Pages: 34727-35
Publication  
First Author: Ruggiero T
Year: 2007
Journal: BMC Mol Biol
Title: Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling.
Volume: 8
Pages: 28
Publication
First Author: Lau LF
Year: 1985
Journal: EMBO J
Title: Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
Volume: 4
Issue: 12
Pages: 3145-51
Publication
First Author: Krouwels IM
Year: 2005
Journal: J Cell Biol
Title: A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain.
Volume: 170
Issue: 4
Pages: 537-49
Publication
First Author: Joshi A
Year: 2013
Journal: Exp Hematol
Title: Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.
Volume: 41
Issue: 4
Pages: 354-66.e14
Publication
First Author: Avet C
Year: 2018
Journal: PLoS One
Title: GnRH regulates the expression of its receptor accessory protein SET in pituitary gonadotropes.
Volume: 13
Issue: 7
Pages: e0201494
Publication
First Author: Chirn GW
Year: 2015
Journal: PLoS Genet
Title: Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.
Volume: 11
Issue: 11
Pages: e1005652
Publication
First Author: Bennett D
Year: 1975
Journal: Genet Res
Title: Observations on a set of radiation-induced dominant T-like mutations in the mouse.
Volume: 26
Issue: 1
Pages: 95-108
Publication
First Author: Kotas ME
Year: 2021
Journal: Mucosal Immunol
Title: CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
Volume: 14
Issue: 6
Pages: 1295-1305
Publication
First Author: Boulay AC
Year: 2015
Journal: J Neurosci
Title: Immune quiescence of the brain is set by astroglial connexin 43.
Volume: 35
Issue: 10
Pages: 4427-39
Publication
First Author: Eggers ED
Year: 2006
Journal: J Neurosci
Title: Receptor and transmitter release properties set the time course of retinal inhibition.
Volume: 26
Issue: 37
Pages: 9413-25
Publication
First Author: Liu Y
Year: 2018
Journal: Nature
Title: Touch and tactile neuropathic pain sensitivity are set by corticospinal projections.
Volume: 561
Issue: 7724
Pages: 547-550
Publication
First Author: Vaiman D
Year: 1994
Journal: Mamm Genome
Title: A set of 99 cattle microsatellites: characterization, synteny mapping, and polymorphism.
Volume: 5
Issue: 5
Pages: 288-97
Publication
First Author: Wu C
Year: 2008
Journal: PLoS Genet
Title: Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
Volume: 4
Issue: 5
Pages: e1000070
Publication  
First Author: Keniry A
Year: 2016
Journal: Epigenetics Chromatin
Title: Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing.
Volume: 9
Pages: 16
Publication
First Author: Rao H
Year: 2021
Journal: Cancer Res
Title: Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma.
Volume: 81
Issue: 13
Pages: 3554-3567
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sarai N
Year: 2013
Journal: EMBO J
Title: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Volume: 32
Issue: 17
Pages: 2392-406
Publication  
First Author: Kotturi MF
Year: 2010
Journal: Immunome Res
Title: Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage.
Volume: 6
Pages: 4
Publication
First Author: Stathopoulou C
Year: 2017
Journal: PLoS One
Title: Long non-coding RNA SeT and miR-155 regulate the Tnfα gene allelic expression profile.
Volume: 12
Issue: 9
Pages: e0184788
Publication  
First Author: Peirce JL
Year: 2004
Journal: BMC Genet
Title: A new set of BXD recombinant inbred lines from advanced intercross populations in mice.
Volume: 5
Pages: 7
Protein
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2588  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhou J
Year: 2023
Journal: J Neurosci
Title: The Orienting Reflex Reveals Behavioral States Set by Demanding Contexts: Role of the Superior Colliculus.
Volume: 43
Issue: 10
Pages: 1778-1796
Allele  
Name: low set ears
Allele Type: Spontaneous
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat