|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 878 for Sf1

<< First    < Previous  |  Next >    Last >>
0.038s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Domain
IPR014014 | RNA_helicase_DEAD_Q_motif
Type: Domain
Description: RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). Besides these seven motifs, DEAD-box RNA helicases contain aconserved cluster of nine amino-acids (the Q motif) with an invariantglutamine located N-terminally of motif I. An additional highly conserved butisolated aromatic residue is also found upstream of these nine residues [].The Q motif is characteristic of and unique to DEAD box family of helicases.It is supposed to control ATP binding and hydrolysis, and therefore itrepresents a potential mechanism for regulating helicase activity.Several structural analyses of DEAD-box RNA helicases have been reported [, ]. The Q motif is located in close proximity to motif I. Theconserved glutamine and aromatic residues interact with the ADP molecule.Some proteins known to contain a Q motif:Eukaryotic initiation factor 4A (eIF4A). An ATP-dependent RNA helicasewhich is a subunit of the eIF4F complex involved in cap recognition andrequired for mRNA binding to ribosome.Various eukaryotic helicases involved in ribosome biogenesis (DBP3, DRS1,SPB4, MAK5, DBP6, DBP7, DBP9, DBP10).Eukaryotic DEAD-box proteins involved in pre-mRNA splicing (Prp5p, Prp28pand Sub2p).DEAD-box proteins required for mitochondrial genome expression (MSS116 andMRH4).Fungi ATP-dependent RNA helicase DHH1. It is required for decapping andturnover of mRNA.Fungi ATP-dependent RNA helicase DBP5. It is involved in nucleo-cytoplasmictransport of poly(A) RNA.Bacterial ATP-dependent RNA helicase rhlB. It is involved in the RNAdegradosome, a multi-enzyme complex important in RNA processing andmessenger RNA degradation.Bacterial cold-shock DEAD box protein A.This entry represents a region stretching from the conserved aromatic residue to one amino acid after the glutamine of the Q motif.
•
•
•
•
•
Protein Domain
IPR014759 | Helicase_SF3_ssRNA_vir
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). All of theproteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. Superfamily 3 consists of helicasesencoded mainly by small DNA viruses and some large nucleocytoplasmic DNAviruses [, ]. Small viruses are very dependent on the host-cell machinery toreplicate. SF3 helicase in small viruses is associated with an origin-bindingdomain. By pairing a domain that recognises the ori with a helicase, the viruscan bypass the host-cell-based regulation pathway and initiate its ownreplication. The protein binds to the viral ori leading to origin unwinding.Cellular replication proteins are then recruited to the ori and the viral DNAis replicated.In SF3 helicases the Walker A and Walker B motifs are separated by spacers ofrather uniform, and relatively short, length. In addition to the A and Bmotifs this family is characterised by a third motif (C) which resides betweenthe B motif and the C terminus of the conserved region. This motif consists ofan Asn residue preceded by a run of hydrophobic residues [].Several structures of SF3 helicases have been solved []. Theyall possess the same core alpha/beta fold, consisting of a five-strandedparallel beta sheet flanked on both sides by several alpha helices. Incontrast to SF1 and SF2 helicases, which have RecA-like core folds, the strandconnectivity within the alpha/beta core domain is that of AAA+ proteins [].The SF3 helicase proteins assemble into a hexameric ring.Some proteins known to contain an SF3 helicase domain are listed below:Polyomavirus large T antigen. It initiates DNA unwinding and replicationvia interactions with the viral origin of replication.Papillomavirus E1 protein. An ATP-dependent DNA helicase required forinitiation of viral DNA replication.Parvovirus Rep/NS1 protein, which is also required for the initiation ofviral replication.Poxviridae and other large DNA viruses D5 protein.Bacteriophage DNA primase/helicase protein.Bacterial prophage DNA primase/helicase protein.The entry represents the core alpha/beta fold of the SF3 helicase domain from predominantly single-stranded RNA viruses.
•
•
•
•
•
Protein Domain
IPR000605 | Helicase_SF3_ssDNA/RNA_vir
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). All of theproteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. Superfamily 3consists of helicasesencoded mainly by small DNA viruses and some large nucleocytoplasmic DNAviruses [, ]. Small viruses are very dependent on the host-cell machinery toreplicate. SF3 helicase in small viruses is associated with an origin-bindingdomain. By pairing a domain that recognises the ori with a helicase, the viruscan bypass the host-cell-based regulation pathway and initiate its ownreplication. The protein binds to the viral ori leading to origin unwinding.Cellular replication proteins are then recruited to the ori and the viral DNAis replicated.In SF3 helicases the Walker A and Walker B motifs are separated by spacers ofrather uniform, and relatively short, length. In addition to the A and Bmotifs this family is characterised by a third motif (C) which resides betweenthe B motif and the C terminus of the conserved region. This motif consists ofan Asn residue preceded by a run of hydrophobic residues [].Several structures of SF3 helicases have been solved []. Theyall possess the same core alpha/beta fold, consisting of a five-strandedparallel beta sheet flanked on both sides by several alpha helices. Incontrast to SF1 and SF2 helicases, which have RecA-like core folds, the strandconnectivity within the alpha/beta core domain is that of AAA+ proteins [].The SF3 helicase proteins assemble into a hexameric ring.Some proteins known to contain an SF3 helicase domain are listed below:Polyomavirus large T antigen. It initiates DNA unwinding and replicationvia interactions with the viral origin of replication.Papillomavirus E1 protein. An ATP-dependent DNA helicase required forinitiation of viral DNA replication.Parvovirus Rep/NS1 protein, which is also required for the initiation ofviral replication.Poxviridae and other large DNA viruses D5 protein.Bacteriophage DNA primase/helicase protein.Bacterial prophage DNA primase/helicase protein.The entry represents the core alpha/beta fold of the SF3 helicase domain found predominantly in DNA viruses.
•
•
•
•
•
Protein
Q924H9
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
•
•
•
•
•
Protein
E9PVX5
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
•
•
•
•
•
Protein
B2RT32
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
•
•
•
•
•
Protein
B7ZWH2
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: true
•
•
•
•
•
Protein
D3Z6T0
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
•
•
•
•
•
Protein
Q8BS67
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
•
•
•
•
•
Protein
Q3URT1
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: true
•
•
•
•
•
Protein
Q80YC3
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JGQ5
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JED3
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: true
•
•
•
•
•
Protein
F6SJP9
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
•
•
•
•
•
Protein
Q76MT2
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
•
•
•
•
•
Protein
Q8BVK1
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
•
•
•
•
•
Protein
E9Q9V7
Organism: Mus musculus/domesticus
Length: 936  
Fragment?: false
•
•
•
•
•
Protein
Q3U4M6
Organism: Mus musculus/domesticus
Length: 936  
Fragment?: false
•
•
•
•
•
Protein
A0A0N4SUI5
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
•
•
•
•
•
Protein
A0A087WQY5
Organism: Mus musculus/domesticus
Length: 1192  
Fragment?: true
•
•
•
•
•
Protein
B7ZWH3
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: true
•
•
•
•
•
Protein
A0A0A6YY15
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
•
•
•
•
•
Protein
Q9CRZ3
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
•
•
•
•
•
Protein
Q8CBU8
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
•
•
•
•
•
Protein
A0A1Y7VJD6
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: true
•
•
•
•
•
Protein
Q3URV3
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
•
•
•
•
•
Protein
G3UXI6
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
•
•
•
•
•
Protein
Q05CY3
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: true
•
•
•
•
•
Protein
Q8BIZ9
Organism: Mus musculus/domesticus
Length: 388  
Fragment?: false
•
•
•
•
•
Protein
G3UVU1
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
•
•
•
•
•
Protein
A0A140LJD7
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
•
•
•
•
•
Protein
Q6P8L5
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: true
•
•
•
•
•
Protein
A0JLR3
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: true
•
•
•
•
•
Protein
Q05BH3
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
•
•
•
•
•
Publication
2156730 | -
First Author: Gorbalenya AE
Year: 1990
Journal: FEBS Lett
Title: A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses.
Volume: 262
Issue: 1
Pages: 145-8
•
•
•
•
•
Publication
15718137 | -
First Author: Hickman AB
Year: 2005
Journal: Curr Opin Struct Biol
Title: Binding and unwinding: SF3 viral helicases.
Volume: 15
Issue: 1
Pages: 77-85
•
•
•
•
•
Protein
Q501J6
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
•
•
•
•
•
Protein
Q6ZPL9
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
•
•
•
•
•
Protein
Q9DBN9
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
•
•
•
•
•
Protein
Q61656
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
•
•
•
•
•
Protein
P60843
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
•
•
•
•
•
Protein
Q80Y44
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
•
•
•
•
•
Protein
P10630
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
•
•
•
•
•
Protein
Q9CWX9
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
•
•
•
•
•
Protein
Q8K4L0
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
•
•
•
•
•
Protein
Q3TFG3
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
•
•
•
•
•
Protein
Q3TU25
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
•
•
•
•
•
Protein
Q8BTS0
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
•
•
•
•
•
Protein
Q8CD14
Organism: Mus musculus/domesticus
Length: 909  
Fragment?: false
•
•
•
•
•
Protein
Q3TGK7
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
•
•
•
•
•
Protein
Q3TLL6
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
•
•
•
•
•
Protein
Q3V0Z8
Organism: Mus musculus/domesticus
Length: 690  
Fragment?: true
•
•
•
•
•
Protein
A0A0N4SVT1
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: true
•
•
•
•
•
Protein
Q810A4
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: true
•
•
•
•
•
Protein
Q52KC1
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
•
•
•
•
•
Protein
A0A338P6X5
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: true
•
•
•
•
•
Protein
Q7TMM1
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: true
•
•
•
•
•
Protein
Q8CFS2
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: true
•
•
•
•
•
Protein
F6QKD2
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
•
•
•
•
•
Protein
Q4FZL1
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
•
•
•
•
•
Protein
Q9CSI0
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: true
•
•
•
•
•
Protein
Q9CS87
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: true
•
•
•
•
•
Protein
A1L333
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
•
•
•
•
•
Protein
Q3UXC2
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
•
•
•
•
•
Protein
Q5U222
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: true
•
•
•
•
•
Protein
Q8BK20
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
•
•
•
•
•
Protein
Q8CD39
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
•
•
•
•
•
Protein
E9Q9T6
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
•
•
•
•
•
Protein
Q8C751
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: true
•
•
•
•
•
Protein
Q8BTU6
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
•
•
•
•
•
Protein
Q4VBG1
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
•
•
•
•
•
Protein
Q5F2A7
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
•
•
•
•
•
Protein
Q3U741
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
•
•
•
•
•
Protein
O08811
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
•
•
•
•
•
Protein
Q8K223
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
•
•
•
•
•
Protein
E9Q6K1
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
•
•
•
•
•
Protein
F6YA33
Organism: Mus musculus/domesticus
Length: 684  
Fragment?: true
•
•
•
•
•
Protein
Q3UKK7
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
•
•
•
•
•
Protein
Z4YL66
Organism: Mus musculus/domesticus
Length: 1141  
Fragment?: false
•
•
•
•
•
Protein
Q3TGP5
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
•
•
•
•
•
Protein
Q8BYH6
Organism: Mus musculus/domesticus
Length: 690  
Fragment?: false
•
•
•
•
•
Protein
Q8C6Y8
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
•
•
•
•
•
Protein
Q8BYF4
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: true
•
•
•
•
•
Protein
J3QMY1
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
•
•
•
•
•
Publication
15037234 | -
First Author: Iyer LM
Year: 2004
Journal: J Struct Biol
Title: Evolutionary history and higher order classification of AAA+ ATPases.
Volume: 146
Issue: 1-2
Pages: 11-31
•
•
•
•
•
Publication
11689653 | -
First Author: Iyer LM
Year: 2001
Journal: J Virol
Title: Common origin of four diverse families of large eukaryotic DNA viruses.
Volume: 75
Issue: 23
Pages: 11720-34
•
•
•
•
•
Protein
Q6PGC1
Organism: Mus musculus/domesticus
Length: 1365  
Fragment?: false
•
•
•
•
•
Protein
Q99MV5
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
•
•
•
•
•
Protein
Q75NR7
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
•
•
•
•
•
Protein
Q8R5F7
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
•
•
•
•
•
Protein
O70133
Organism: Mus musculus/domesticus
Length: 1380  
Fragment?: false
•
•
•
•
•
Protein
Q8CGS6
Organism: Mus musculus/domesticus
Length: 2544  
Fragment?: false
•
•
•
•
•
Protein
A2A4P0
Organism: Mus musculus/domesticus
Length: 1244  
Fragment?: false
•
•
•
•
•
Protein
Q9JIM3
Organism: Mus musculus/domesticus
Length: 1537  
Fragment?: false
•
•
•
•
•
Protein
Q99J87
Organism: Mus musculus/domesticus
Length: 678  
Fragment?: false
•
•
•
•
•
Protein
Q8VID5
Organism: Mus musculus/domesticus
Length: 982  
Fragment?: false
•
•
•
•
•
Protein
Q3TKT4
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
•
•
•
•
•
Protein
Q8BGE5
Organism: Mus musculus/domesticus
Length: 2021  
Fragment?: false
•
•
•
•
•
Protein
Q6DIC0
Organism: Mus musculus/domesticus
Length: 1577  
Fragment?: false
•
•
•
•
•
Protein
Q6NZP1
Organism: Mus musculus/domesticus
Length: 1069  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom