Type |
Details |
Score |
Publication |
First Author: |
Chen XQ |
Year: |
2023 |
Journal: |
Alzheimers Dement |
Title: |
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. |
Volume: |
19 |
Issue: |
5 |
Pages: |
2095-2116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pai EL |
Year: |
2020 |
Journal: |
Elife |
Title: |
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
2021 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Upregulation of Mir342 in Diet-Induced Obesity Mouse and the Hypothalamic Appetite Control. |
Volume: |
12 |
|
Pages: |
727915 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
136
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
136
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Risinger C |
Year: |
1993 |
Journal: |
J Biol Chem |
Title: |
Evolutionary conservation of synaptosome-associated protein 25 kDa (SNAP-25) shown by Drosophila and Torpedo cDNA clones. |
Volume: |
268 |
Issue: |
32 |
Pages: |
24408-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rizo J |
Year: |
2002 |
Journal: |
Nat Rev Neurosci |
Title: |
Snares and Munc18 in synaptic vesicle fusion. |
Volume: |
3 |
Issue: |
8 |
Pages: |
641-53 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in the SNAP-25 family members. SNAP-25 (synaptosome-associated protein 25kDa) proteins are components of SNARE complexes, which are proposed to account for the specificity of membrane fusion and todirectly execute fusion by forming a tight complex (the SNARE or corecomplex) that brings the synaptic vesicle and plasma membranestogether. The SNAREs constitute a large family of proteins thatare characterised by 60-residue sequences known as SNARE motifs (),which have a high propensity to form coiled coils and often precedecarboxy-terminal transmembrane regions. The synaptic core complex is formed by four SNARE motifs (two fromSNAP25 and one each from synaptobrevin and syntaxin 1) that areunstructured in isolation but form a parallel four-helix bundle onassembly. The crystal structure of the core complex revealedthat the helix bundle is highly twisted and contains several salt bridges onthe surface, as well as layers of interior hydrophobic residues.However, a polar layer in the centre of the complex is formed by threeglutamines (two from SNAP25 and one from syntaxin 1) and one arginine(from synaptobrevin) [].Members of the SNAP-25 family contain a cluster of cysteine residues that can be palmitoylated for membrane attachment []. |
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•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2003 |
Journal: |
Cell Mol Life Sci |
Title: |
The molecular machinery of synaptic vesicle exocytosis. |
Volume: |
60 |
Issue: |
5 |
Pages: |
942-60 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, transgenic, mutant stock |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaire J |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types. |
Volume: |
8 |
Issue: |
1 |
Pages: |
7182 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Snap25/Snap25<+> |
Background: |
B6.Cg-Snap25 Gt(ROSA)26Sor |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Park WJ |
Year: |
2008 |
Journal: |
Neurosci Lett |
Title: |
Leucine-rich glioma inactivated 3 associates with syntaxin 1. |
Volume: |
444 |
Issue: |
3 |
Pages: |
240-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hellwig S |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Role for Reelin in neurotransmitter release. |
Volume: |
31 |
Issue: |
7 |
Pages: |
2352-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller VM |
Year: |
2010 |
Journal: |
Brain Res |
Title: |
Sex effects of interleukin-6 deficiency on neuroinflammation in aged C57Bl/6 mice. |
Volume: |
1318 |
|
Pages: |
11-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Berkel AA |
Year: |
2021 |
Journal: |
J Neurochem |
Title: |
Loss of MUNC18-1 leads to retrograde transport defects in neurons. |
Volume: |
157 |
Issue: |
3 |
Pages: |
450-466 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andreyeva A |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. |
Volume: |
5 |
Issue: |
8 |
Pages: |
e12018 |
|
•
•
•
•
•
|
Publication |
First Author: |
Behrendorff N |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. |
Volume: |
286 |
Issue: |
34 |
Pages: |
29627-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ros O |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. |
Volume: |
14 |
Issue: |
6 |
Pages: |
e1007432 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sena RM |
Year: |
2021 |
Journal: |
Molecules |
Title: |
The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex. |
Volume: |
26 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson CE |
Year: |
2017 |
Journal: |
Chem Senses |
Title: |
Type III Cells in Anterior Taste Fields Are More Immunohistochemically Diverse Than Those of Posterior Taste Fields in Mice. |
Volume: |
42 |
Issue: |
9 |
Pages: |
759-767 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilhelmi I |
Year: |
2021 |
Journal: |
Mol Metab |
Title: |
The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells. |
Volume: |
45 |
|
Pages: |
101151 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quintero IB |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e73072 |
|
•
•
•
•
•
|
Publication |
First Author: |
Curtis LB |
Year: |
2008 |
Journal: |
J Comp Neurol |
Title: |
Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina. |
Volume: |
510 |
Issue: |
5 |
Pages: |
550-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gentil BJ |
Year: |
2014 |
Journal: |
J Neurochem |
Title: |
A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30. |
Volume: |
131 |
Issue: |
5 |
Pages: |
588-601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choe EA |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. |
Volume: |
27 |
Issue: |
35 |
Pages: |
9503-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheviet S |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis. |
Volume: |
119 |
Issue: |
Pt 14 |
Pages: |
2912-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang K |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14. |
Volume: |
20 |
Issue: |
17 |
Pages: |
3356-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barry J |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. |
Volume: |
126 |
Issue: |
Pt 9 |
Pages: |
2027-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jacky BP |
Year: |
2013 |
Journal: |
PLoS Pathog |
Title: |
Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A). |
Volume: |
9 |
Issue: |
5 |
Pages: |
e1003369 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foo LC |
Year: |
2013 |
Journal: |
Glia |
Title: |
Aldh1L1 is expressed by postnatal neural stem cells in vivo. |
Volume: |
61 |
Issue: |
9 |
Pages: |
1533-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dougherty JD |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Mouse transgenesis in a single locus with independent regulation for multiple fluorophores. |
Volume: |
7 |
Issue: |
7 |
Pages: |
e40511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buxton P |
Year: |
2003 |
Journal: |
Biochem J |
Title: |
Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. |
Volume: |
375 |
Issue: |
Pt 2 |
Pages: |
433-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adlard PA |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? |
Volume: |
30 |
Issue: |
5 |
Pages: |
1631-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sendin G |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Maturation of ribbon synapses in hair cells is driven by thyroid hormone. |
Volume: |
27 |
Issue: |
12 |
Pages: |
3163-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feringa FM |
Year: |
2023 |
Journal: |
J Neurosci |
Title: |
An Atypical, Staged Cell Death Pathway Induced by Depletion of SNARE-Proteins MUNC18-1 or Syntaxin-1. |
Volume: |
43 |
Issue: |
3 |
Pages: |
347-358 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li SK |
Year: |
2014 |
Journal: |
Diabetologia |
Title: |
Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell. |
Volume: |
57 |
Issue: |
4 |
Pages: |
809-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irfan M |
Year: |
2019 |
Journal: |
Neuroscience |
Title: |
SNAP-25 Puts SNAREs at Center Stage in Metabolic Disease. |
Volume: |
420 |
|
Pages: |
86-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Starcevic M |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). |
Volume: |
279 |
Issue: |
27 |
Pages: |
28393-401 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
206
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
210
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
161
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
210
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
221
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Shirafuji T |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance. |
Volume: |
38 |
Issue: |
2 |
Pages: |
278-290 |
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•
•
•
•
•
|
Publication |
First Author: |
Martin NA |
Year: |
2018 |
Journal: |
Front Immunol |
Title: |
Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice. |
Volume: |
9 |
|
Pages: |
490 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hontani Y |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Multicolor three-photon fluorescence imaging with single-wavelength excitation deep in mouse brain. |
Volume: |
7 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Biancolin AD |
Year: |
2020 |
Journal: |
Mol Metab |
Title: |
The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1. |
Volume: |
31 |
|
Pages: |
124-137 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fasshauer D |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. |
Volume: |
95 |
Issue: |
26 |
Pages: |
15781-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Setty SR |
Year: |
2007 |
Journal: |
Mol Biol Cell |
Title: |
BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. |
Volume: |
18 |
Issue: |
3 |
Pages: |
768-80 |
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•
•
•
•
|