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Search results 601 to 700 out of 727 for Stat5b

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Type Details Score
Publication
16887981 | J:138395
First Author: Taylor DK
Year: 2006
Journal: J Immunol
Title: Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis.
Volume: 177
Issue: 4
Pages: 2216-23
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Allele
Stat5b<tm2Jni> | MGI:3577898
Name: signal transducer and activator of transcription 5B; targeted mutation 2, James N Ihle
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(Lck-Stat5b*)1Mafa/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Publication
22581861 | J:188874
First Author: Johnson K
Year: 2012
Journal: J Immunol
Title: IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.
Volume: 188
Issue: 12
Pages: 6084-92
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Publication
16192273 | -
First Author: Neculai D
Year: 2005
Journal: J Biol Chem
Title: Structure of the unphosphorylated STAT5a dimer.
Volume: 280
Issue: 49
Pages: 40782-7
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Publication
21276004 | -
 
First Author: Heltemes-Harris LM
Year: 2011
Journal: Ann N Y Acad Sci
Title: The role of STAT5 in the development, function, and transformation of B and T lymphocytes.
Volume: 1217
Pages: 18-31
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Protein Domain
IPR035886 | STAT5b_SH2
Type: Domain
Description: This entry represents the SH2 domain of STAT5b.STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR035858 | STAT5a/5b
Type: Family
Description: STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Publication
18495959 | J:142165
First Author: Spiegl N
Year: 2008
Journal: Blood
Title: Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Volume: 112
Issue: 9
Pages: 3762-71
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Publication
19047679 | J:145543
First Author: Nakayama J
Year: 2009
Journal: Blood
Title: BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
Volume: 113
Issue: 7
Pages: 1483-92
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Genotype
Genotype
Symbol: Tcf3/Tcf3 Tg(Lck-Stat5b*)1Mafa/?
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
11704849 | J:72631
First Author: Piazza F
Year: 2001
Journal: Oncogene
Title: The theory of APL.
Volume: 20
Issue: 49
Pages: 7216-22
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Publication
10817963 | J:62426
First Author: Takeda K
Year: 2000
Journal: Cytokine Growth Factor Rev
Title: STAT family of transcription factors in cytokine-mediated biological responses.
Volume: 11
Issue: 3
Pages: 199-207
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Protein Domain
IPR028819 | NCOA1
Type: Family
Description: Nuclear receptor coactivator 1 (NCOA1, also known as SRC-1) belongs to the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors []. These receptors can function as molecular switches [].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination [].
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Publication
17579030 | J:149422
First Author: Yu Q
Year: 2007
Journal: J Immunol
Title: Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection.
Volume: 179
Issue: 1
Pages: 126-31
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Publication
31628339 | J:282230
First Author: Wong JB
Year: 2019
Journal: Nat Commun
Title: B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Volume: 10
Issue: 1
Pages: 4768
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Publication
22623329 | J:188957
First Author: Zou T
Year: 2012
Journal: J Immunol
Title: Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
Volume: 189
Issue: 1
Pages: 28-32
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Publication
18195039 | J:132669
First Author: Nie L
Year: 2008
Journal: Mol Cell Biol
Title: Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals.
Volume: 28
Issue: 6
Pages: 2078-90
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Publication
19454668 | J:148869
First Author: Molinero LL
Year: 2009
Journal: J Immunol
Title: CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Volume: 182
Issue: 11
Pages: 6736-43
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Publication
24939936 | J:211775
First Author: Liu GJ
Year: 2014
Journal: Genes Dev
Title: Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.
Volume: 28
Issue: 12
Pages: 1337-50
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Genotype
Genotype
Symbol: Stat5a/Stat5a Stat5b/Stat5b
Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stat5a/Stat5a Stat5b/Stat5b
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
16219639 | J:103657
First Author: Sato N
Year: 2005
Journal: Int Immunol
Title: Physical and functional interactions between STAT3 and ZIP kinase.
Volume: 17
Issue: 12
Pages: 1543-52
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Publication
22730302 | J:199697
First Author: Chao HW
Year: 2012
Journal: Nucleic Acids Res
Title: NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.
Volume: 40
Issue: 17
Pages: 8484-98
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Publication
24412367 | J:208823
First Author: Ando T
Year: 2014
Journal: Cell Rep
Title: Critical role for mast cell Stat5 activity in skin inflammation.
Volume: 6
Issue: 2
Pages: 366-76
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Publication
28424246 | J:243973
First Author: Moffitt AB
Year: 2017
Journal: J Exp Med
Title: Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.
Volume: 214
Issue: 5
Pages: 1371-1386
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Publication
16177100 | J:118951
First Author: Litherland SA
Year: 2005
Journal: J Immunol
Title: Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Volume: 175
Issue: 7
Pages: 4561-5
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Publication
11257111 | J:68503
First Author: Pandolfi PP
Year: 2001
Journal: Hum Mol Genet
Title: Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.
Volume: 10
Issue: 7
Pages: 769-75
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Publication
12540601 | J:81610
First Author: Floyd ZE
Year: 2003
Journal: Diabetes
Title: STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation.
Volume: 52
Issue: 2
Pages: 308-14
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Protein
A0A1W2P7S6
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: true
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Publication
12138096 | -
First Author: Litterst CM
Year: 2002
Journal: J Biol Chem
Title: An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.
Volume: 277
Issue: 39
Pages: 36052-60
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Publication
9427757 | -
First Author: Kalkhoven E
Year: 1998
Journal: EMBO J
Title: Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor.
Volume: 17
Issue: 1
Pages: 232-43
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Publication
12954634 | -
First Author: Litterst CM
Year: 2003
Journal: J Biol Chem
Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.
Volume: 278
Issue: 46
Pages: 45340-51
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Publication
11773079 | -
First Author: Giraud S
Year: 2002
Journal: J Biol Chem
Title: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
Volume: 277
Issue: 10
Pages: 8004-11
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Publication
10449719 | -
First Author: Liu Z
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
Volume: 96
Issue: 17
Pages: 9485-90
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Publication
12529333 | -
First Author: Chauchereau A
Year: 2003
Journal: J Biol Chem
Title: Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
Volume: 278
Issue: 14
Pages: 12335-43
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Protein
A0A1W2P7D7
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
Q3U3A3
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Publication
21854393 | -
First Author: Niessen NA
Year: 2011
Journal: J Neurochem
Title: Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).
Volume: 119
Issue: 3
Pages: 579-93
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Protein Domain
IPR017426 | Nuclear_rcpt_coactivator
Type: Family
Description: This group represents the nuclear receptor coactivator family, also known as the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors []. These receptors can function as molecular switches [].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, ].
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Protein Domain
IPR010011 | NCO_DUF1518
Type: Domain
Description: This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3), also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors [, ].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, ].
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Publication
28369050 | J:260614
First Author: Katerndahl CDS
Year: 2017
Journal: Nat Immunol
Title: Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
Volume: 18
Issue: 6
Pages: 694-704
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Publication
34054809 | J:322578
 
First Author: Won HY
Year: 2021
Journal: Front Immunol
Title: The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation.
Volume: 12
Pages: 642856
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Publication
33277497 | J:300969
First Author: Tremblay CS
Year: 2020
Journal: Nat Commun
Title: Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Volume: 11
Issue: 1
Pages: 6211
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Publication
23836150 | J:205701
 
First Author: Nakajima K
Year: 2013
Journal: Nat Commun
Title: The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.
Volume: 4
Pages: 2112
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Publication
20065110 | J:159490
First Author: Li LX
Year: 2010
Journal: J Immunol
Title: A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness.
Volume: 184
Issue: 4
Pages: 1728-36
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Publication
25501905 | J:227943
First Author: Maekawa Y
Year: 2015
Journal: Nat Med
Title: Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.
Volume: 21
Issue: 1
Pages: 55-61
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Publication
12507421 | J:80975
First Author: Picard F
Year: 2002
Journal: Cell
Title: SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
Volume: 111
Issue: 7
Pages: 931-41
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Publication
10823921 | J:62724
First Author: Xu J
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development.
Volume: 97
Issue: 12
Pages: 6379-84
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Protein
A0A1W2P881
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Publication
9430642 | J:45674
First Author: Voegel JJ
Year: 1998
Journal: EMBO J
Title: The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
Volume: 17
Issue: 2
Pages: 507-19
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Publication
23226788 | -
First Author: Chang AK
Year: 2012
Journal: Oncol Lett
Title: The role of AIB1 in breast cancer.
Volume: 4
Issue: 4
Pages: 588-594
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Publication
11773439 | J:197519
First Author: Aoki N
Year: 2002
Journal: Mol Endocrinol
Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.
Volume: 16
Issue: 1
Pages: 58-69
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Publication
9009201 | J:64278
First Author: Liu X
Year: 1997
Journal: Genes Dev
Title: Stat5a is mandatory for adult mammary gland development and lactogenesis.
Volume: 11
Issue: 2
Pages: 179-86
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Publication
31817755 | J:287224
 
First Author: Kim EY
Year: 2019
Journal: Cells
Title: Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet.
Volume: 8
Issue: 12
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Publication
17950726 | J:141468
First Author: Wang J
Year: 2007
Journal: Exp Cell Res
Title: Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
Volume: 313
Issue: 20
Pages: 4120-9
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Publication
18199418 | J:131384
First Author: Burchill MA
Year: 2008
Journal: Immunity
Title: Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.
Volume: 28
Issue: 1
Pages: 112-21
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Publication
15887111 | J:124938
First Author: DiFedele LM
Year: 2005
Journal: Gastroenterology
Title: Tumor necrosis factor alpha blockade restores growth hormone signaling in murine colitis.
Volume: 128
Issue: 5
Pages: 1278-91
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Publication
17035345 | J:116067
First Author: Yagi J
Year: 2006
Journal: Int Immunol
Title: Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells.
Volume: 18
Issue: 12
Pages: 1681-90
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Publication
9751123 | J:112998
First Author: Liu X
Year: 1998
Journal: Cell Growth Differ
Title: Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b.
Volume: 9
Issue: 9
Pages: 795-803
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Publication
29654210 | J:261461
First Author: Fahl SP
Year: 2018
Journal: J Immunol
Title: c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint.
Volume: 200
Issue: 10
Pages: 3450-3463
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Publication
37389889 | J:358545
First Author: Zhou B
Year: 2023
Journal: Eur J Immunol
Title: Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
Volume: 53
Issue: 10
Pages: e2250226
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Publication
22999939 | J:196226
First Author: Jing X
Year: 2012
Journal: Cell Rep
Title: Crosstalk of humoral and cell-cell contact-mediated signals in postnatal body growth.
Volume: 2
Issue: 3
Pages: 652-65
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Publication
24341939 | J:217256
First Author: Gong Z
Year: 2014
Journal: Aging Cell
Title: Reductions in serum IGF-1 during aging impair health span.
Volume: 13
Issue: 3
Pages: 408-18
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Publication
27729410 | J:240474
First Author: Heinz RE
Year: 2016
Journal: Development
Title: Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis.
Volume: 143
Issue: 22
Pages: 4236-4248
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Publication
23169610 | J:312520
First Author: Lee C
Year: 2013
Journal: Drug Metab Dispos
Title: The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene.
Volume: 41
Issue: 2
Pages: 457-65
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Publication
11287618 | J:68832
First Author: Hoffmeyer A
Year: 2001
Journal: Mol Cell Biol
Title: Gadd45gamma is dispensable for normal mouse development and T-cell proliferation.
Volume: 21
Issue: 9
Pages: 3137-43
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Publication
25126749 | J:218982
First Author: Eto K
Year: 2014
Journal: PLoS One
Title: MafA is required for postnatal proliferation of pancreatic β-cells.
Volume: 9
Issue: 8
Pages: e104184
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Publication
11358384 | J:69191
First Author: Merghoub T
Year: 2001
Journal: Blood Cells Mol Dis
Title: Modeling acute promyelocytic leukemia in the mouse: new insights in the pathogenesis of human leukemias.
Volume: 27
Issue: 1
Pages: 231-48
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Publication
8943349 | J:36543
First Author: Meinke A
Year: 1996
Journal: Mol Cell Biol
Title: Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.
Volume: 16
Issue: 12
Pages: 6937-44
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Publication
10022878 | J:53081
First Author: John S
Year: 1999
Journal: Mol Cell Biol
Title: The significance of tetramerization in promoter recruitment by Stat5.
Volume: 19
Issue: 3
Pages: 1910-8
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Publication
11796490 | J:74981
First Author: González L
Year: 2002
Journal: Endocrinology
Title: Cytokine-inducible SH2 protein up-regulation is associated with desensitization of GH signaling in GHRH-transgenic mice.
Volume: 143
Issue: 2
Pages: 386-94
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Publication
26493931 | J:227919
First Author: Zhang F
Year: 2015
Journal: Toxicol Appl Pharmacol
Title: Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart.
Volume: 289
Issue: 3
Pages: 495-506
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Publication
26250110 | J:356929
First Author: Yoo KH
Year: 2015
Journal: Nucleic Acids Res
Title: Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.
Volume: 43
Issue: 18
Pages: 8774-89
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Publication
34535769 | J:312446
First Author: Heltemes-Harris LM
Year: 2021
Journal: Oncogene
Title: Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.
Volume: 40
Issue: 43
Pages: 6166-6179
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Publication
31123029 | J:358408
First Author: Maurer B
Year: 2020
Journal: Haematologica
Title: High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Volume: 105
Issue: 2
Pages: 435-447
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Protein
Q8C961
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
Q8CE59
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Publication
10713439 | -
First Author: Leo C
Year: 2000
Journal: Gene
Title: The SRC family of nuclear receptor coactivators.
Volume: 245
Issue: 1
Pages: 1-11
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•
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•
Publication
21606508 | J:172415
First Author: Moran AE
Year: 2011
Journal: J Exp Med
Title: T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Volume: 208
Issue: 6
Pages: 1279-89
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Publication
36316474 | J:333184
First Author: Lee RD
Year: 2022
Journal: Nat Immunol
Title: Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Volume: 23
Issue: 12
Pages: 1763-1776
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Publication
9292509 | J:43349
First Author: Feldman GM
Year: 1997
Journal: Blood
Title: STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression.
Volume: 90
Issue: 5
Pages: 1768-76
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Publication
16886906 | J:116529
First Author: Starzynski RR
Year: 2006
Journal: Biochem J
Title: STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide.
Volume: 400
Issue: 2
Pages: 367-75
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Publication
10752065 | J:62399
 
First Author: Waxman DJ
Year: 2000
Journal: Novartis Found Symp
Title: Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression.
Volume: 227
Pages: 61-74; discussion 75-81
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Publication
9742102 | J:50035
First Author: Verdier F
Year: 1998
Journal: Mol Cell Biol
Title: A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.
Volume: 18
Issue: 10
Pages: 5852-60
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Publication
10361113 | J:55735
First Author: Ilaria RL Jr
Year: 1999
Journal: Blood
Title: Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation.
Volume: 93
Issue: 12
Pages: 4154-66
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Publication
10454585 | J:56954
First Author: Matsumoto A
Year: 1999
Journal: Mol Cell Biol
Title: Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice.
Volume: 19
Issue: 9
Pages: 6396-407
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Publication
18347089 | J:138503
First Author: Hennighausen L
Year: 2008
Journal: Genes Dev
Title: Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.
Volume: 22
Issue: 6
Pages: 711-21
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Publication
19359380 | J:158162
First Author: Gevers EF
Year: 2009
Journal: Endocrinology
Title: Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.
Volume: 150
Issue: 8
Pages: 3627-36
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Publication
36989489 | J:338805
First Author: Tremblay CS
Year: 2023
Journal: Blood
Title: STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia.
Volume: 142
Issue: 3
Pages: 274-289
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Publication
12209125 | -
First Author: Levy DE
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Stats: transcriptional control and biological impact.
Volume: 3
Issue: 9
Pages: 651-62
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Publication
14668806 | -
First Author: Shuai K
Year: 2003
Journal: Nat Rev Immunol
Title: Regulation of JAK-STAT signalling in the immune system.
Volume: 3
Issue: 11
Pages: 900-11
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Publication
23977103 | -
First Author: Takakuma K
Year: 2013
Journal: PLoS One
Title: Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.
Volume: 8
Issue: 8
Pages: e71646
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Protein
Q8CBM5
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: true
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Publication
23791643 | J:207581
First Author: Han D
Year: 2013
Journal: Immunity
Title: Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.
Volume: 38
Issue: 6
Pages: 1211-22
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Publication
19494812 | J:150358
First Author: Pearce EL
Year: 2009
Journal: Nature
Title: Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Volume: 460
Issue: 7251
Pages: 103-7
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Protein
A2A5D3
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
A0A1W2P7C1
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: true
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Protein
A0A1W2P6K7
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
A2A5D4
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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