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Search results 601 to 700 out of 746 for Syk

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Type Details Score
Publication
9794398 | J:74974
First Author: Kadlecek TA
Year: 1998
Journal: J Immunol
Title: Differential requirements for ZAP-70 in TCR signaling and T cell development.
Volume: 161
Issue: 9
Pages: 4688-94
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Publication
17056522 | J:140531
First Author: Gustin SE
Year: 2006
Journal: J Immunol
Title: Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.
Volume: 177
Issue: 9
Pages: 5980-9
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Publication
20400514 | J:164469
First Author: Daniel JL
Year: 2010
Journal: J Biol Chem
Title: Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.
Volume: 285
Issue: 23
Pages: 17282-91
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Publication
20851882 | J:167020
First Author: Adapala NS
Year: 2010
Journal: J Biol Chem
Title: The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.
Volume: 285
Issue: 47
Pages: 36745-58
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Publication
21967979 | J:178858
First Author: Buitrago L
Year: 2011
Journal: Blood
Title: Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling.
Volume: 118
Issue: 20
Pages: 5631-40
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Publication
19502385 | J:171490
First Author: Parti RP
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.
Volume: 42
Issue: 4
Pages: 415-23
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Publication
19786542 | J:153823
First Author: McPherson VA
Year: 2009
Journal: J Immunol
Title: SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells.
Volume: 183
Issue: 8
Pages: 4940-7
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Publication
32358018 | J:294654
First Author: Yoshida K
Year: 2020
Journal: J Immunol
Title: Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.
Volume: 204
Issue: 12
Pages: 3077-3085
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Publication
10700474 | J:61130
First Author: Xu S
Year: 2000
Journal: Int Immunol
Title: B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice.
Volume: 12
Issue: 3
Pages: 397-404
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Publication
28348271 | J:247739
First Author: Mokada-Gopal L
Year: 2017
Journal: J Immunol
Title: Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis.
Volume: 198
Issue: 9
Pages: 3737-3745
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Publication
30686754 | J:294965
 
First Author: Lee JS
Year: 2019
Journal: EBioMedicine
Title: Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation.
Volume: 40
Pages: 184-197
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Publication
20944008 | J:165625
First Author: Samayawardhena LA
Year: 2010
Journal: J Immunol
Title: PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.
Volume: 185
Issue: 10
Pages: 5993-6002
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Publication
26184912 | J:258579
First Author: Carter MJ
Year: 2016
Journal: Cell Death Differ
Title: BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.
Volume: 23
Issue: 2
Pages: 303-12
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Publication
21108475 | J:174574
First Author: Smrz D
Year: 2010
Journal: Eur J Immunol
Title: TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release.
Volume: 40
Issue: 12
Pages: 3557-69
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Publication
20497953 | J:161303
First Author: Karman J
Year: 2010
Journal: Int Immunol
Title: Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
Volume: 22
Issue: 7
Pages: 593-603
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Publication
10688901 | J:80920
First Author: Hayashi K
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells.
Volume: 97
Issue: 6
Pages: 2755-60
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Publication
25151118 | J:220104
 
First Author: Matté A
Year: 2014
Journal: Free Radic Biol Med
Title: The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence.
Volume: 76
Pages: 80-8
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Publication
26282541 | J:226419
First Author: Alshehri OM
Year: 2015
Journal: Blood
Title: Fibrin activates GPVI in human and mouse platelets.
Volume: 126
Issue: 13
Pages: 1601-8
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Publication
23149425 | J:219059
First Author: Back SH
Year: 2013
Journal: Cell Mol Life Sci
Title: TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
Volume: 70
Issue: 7
Pages: 1269-84
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Publication
24106269 | J:204983
First Author: Kim S
Year: 2013
Journal: J Biol Chem
Title: RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation.
Volume: 288
Issue: 47
Pages: 34230-8
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Publication
28948613 | J:258225
First Author: Purvis HA
Year: 2018
Journal: Eur J Immunol
Title: Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.
Volume: 48
Issue: 2
Pages: 306-315
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Publication
30139951 | J:278018
First Author: Clarke F
Year: 2018
Journal: Sci Rep
Title: The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Volume: 8
Issue: 1
Pages: 12692
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Publication
14739220 | J:90287
First Author: Li TT
Year: 2004
Journal: Blood
Title: Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen.
Volume: 103
Issue: 9
Pages: 3396-402
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Publication
20732300 | J:165978
First Author: Chiba N
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Functional roles of Cot/Tpl2 in mast cell responses to lipopolysaccharide and FcεRI-clustering.
Volume: 402
Issue: 1
Pages: 1-6
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Publication
23264598 | J:194599
First Author: Zhi H
Year: 2013
Journal: Blood
Title: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.
Volume: 121
Issue: 10
Pages: 1858-67
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Publication
39281679 | J:359146
 
First Author: Miao J
Year: 2024
Journal: Front Immunol
Title: hFcγRIIa: a double-edged sword in osteoclastogenesis and bone balance in transgenic mice.
Volume: 15
Pages: 1425670
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Publication
31262710 | J:289298
 
First Author: Wang C
Year: 2019
Journal: EBioMedicine
Title: Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.
Volume: 45
Pages: 578-587
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Publication
23280426 | J:193839
First Author: Lechouane F
Year: 2013
Journal: Eur J Immunol
Title: B-cell receptor signal strength influences terminal differentiation.
Volume: 43
Issue: 3
Pages: 619-28
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Publication
22109549 | J:180445
First Author: Malik AF
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.
Volume: 108
Issue: 50
Pages: 20095-100
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Publication
31010852 | J:275425
First Author: Tam JM
Year: 2019
Journal: J Immunol
Title: Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans.
Volume: 202
Issue: 11
Pages: 3256-3266
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Publication
29668708 | J:262049
First Author: Kaisar MMM
Year: 2018
Journal: PLoS Biol
Title: Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.
Volume: 16
Issue: 4
Pages: e2005504
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Publication
33560379 | J:302300
First Author: Walsh TG
Year: 2021
Journal: Blood Adv
Title: Loss of the exocyst complex component EXOC3 promotes hemostasis and accelerates arterial thrombosis.
Volume: 5
Issue: 3
Pages: 674-686
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Publication
32334108 | J:289412
 
First Author: Schweig JE
Year: 2020
Journal: Neurosci Lett
Title: Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures.
Volume: 729
Pages: 134992
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Publication
26619766 | J:339018
First Author: Vandenbriele C
Year: 2016
Journal: Platelets
Title: Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.
Volume: 27
Issue: 4
Pages: 365-72
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Publication
19889639 | J:158297
First Author: Seyrantepe V
Year: 2010
Journal: J Biol Chem
Title: Regulation of phagocytosis in macrophages by neuraminidase 1.
Volume: 285
Issue: 1
Pages: 206-15
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Publication
32941658 | J:304610
First Author: Wolf AJ
Year: 2021
Journal: J Leukoc Biol
Title: Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes.
Volume: 109
Issue: 1
Pages: 161-172
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Publication
28298521 | J:247732
First Author: Kottom TJ
Year: 2017
Journal: J Immunol
Title: The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection.
Volume: 198
Issue: 9
Pages: 3515-3525
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Publication
23315163 | J:195429
First Author: McMillan SJ
Year: 2013
Journal: Blood
Title: Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.
Volume: 121
Issue: 11
Pages: 2084-94
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Publication
29146750 | J:283404
First Author: Gotru SK
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.
Volume: 38
Issue: 2
Pages: 344-352
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Publication
25520375 | J:234144
First Author: Musumeci L
Year: 2015
Journal: Circulation
Title: Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.
Volume: 131
Issue: 7
Pages: 656-68
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Publication
27807193 | J:269074
First Author: Vermeren S
Year: 2016
Journal: J Immunol
Title: PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.
Volume: 197
Issue: 12
Pages: 4771-4779
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Publication
28336561 | J:263672
First Author: Smith CW
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.
Volume: 37
Issue: 5
Pages: 823-835
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Publication
11551923 | J:72778
First Author: Otipoby KL
Year: 2001
Journal: J Biol Chem
Title: CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.
Volume: 276
Issue: 47
Pages: 44315-22
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Publication
11606584 | J:73459
First Author: Rodriguez R
Year: 2001
Journal: J Biol Chem
Title: Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
Volume: 276
Issue: 51
Pages: 47982-92
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Publication
10781838 | J:62319
First Author: Ulivieri C
Year: 2000
Journal: Mol Immunol
Title: Restoration of thymic development in an Lck(-/-) thymoma overexpressing ZAP-70.
Volume: 37
Issue: 1-2
Pages: 85-90
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Publication
7525568 | J:38403
First Author: Burg DL
Year: 1994
Journal: J Biol Chem
Title: Interactions of Lyn with the antigen receptor during B cell activation.
Volume: 269
Issue: 45
Pages: 28136-42
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Publication
9042338 | J:38286
First Author: Furlong MT
Year: 1997
Journal: Biochim Biophys Acta
Title: Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk.
Volume: 1355
Issue: 2
Pages: 177-90
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Publication
9143687 | J:40174
 
First Author: Daëron M
Year: 1997
Journal: Annu Rev Immunol
Title: Fc receptor biology.
Volume: 15
Pages: 203-34
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Publication
14757742 | J:90893
First Author: Kettner A
Year: 2004
Journal: J Exp Med
Title: WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.
Volume: 199
Issue: 3
Pages: 357-68
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Publication
16728400 | J:116452
First Author: Wilkinson B
Year: 2006
Journal: J Biol Chem
Title: Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia.
Volume: 281
Issue: 30
Pages: 20842-50
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Publication
16339538 | J:122240
First Author: Lee Y
Year: 2005
Journal: J Immunol
Title: Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement.
Volume: 175
Issue: 12
Pages: 8011-23
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Publication
17688077 | J:126670
First Author: Uckun FM
Year: 2007
Journal: Arzneimittelforschung
Title: Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis.
Volume: 57
Issue: 6
Pages: 320-9
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Publication
17092301 | J:135919
First Author: Hughan SC
Year: 2007
Journal: J Thromb Haemost
Title: Differential regulation of adapter proteins Dok2 and Dok1 in platelets, leading to an association of Dok2 with integrin alphaIIbbeta3.
Volume: 5
Issue: 2
Pages: 387-94
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Publication
17182584 | J:141925
First Author: Kitaura J
Year: 2007
Journal: J Immunol
Title: Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice.
Volume: 178
Issue: 1
Pages: 455-62
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Publication
19017976 | J:142383
First Author: Radhakrishnan S
Year: 2008
Journal: J Immunol
Title: TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.
Volume: 181
Issue: 11
Pages: 7863-72
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Publication
17237371 | J:143665
First Author: Osman MS
Year: 2007
Journal: J Immunol
Title: Activating Ly-49 receptors regulate LFA-1-mediated adhesion by NK cells.
Volume: 178
Issue: 3
Pages: 1261-7
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Publication
19155486 | J:144329
First Author: Marjon KD
Year: 2009
Journal: J Immunol
Title: Macrophages activated by C-reactive protein through Fc gamma RI transfer suppression of immune thrombocytopenia.
Volume: 182
Issue: 3
Pages: 1397-403
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Publication
17911602 | J:153034
First Author: Dráberová L
Year: 2007
Journal: J Immunol
Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.
Volume: 179
Issue: 8
Pages: 5169-80
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Publication
19617348 | J:156365
First Author: Srivastava V
Year: 2009
Journal: J Biol Chem
Title: Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infection.
Volume: 284
Issue: 38
Pages: 25532-41
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Publication
20360401 | J:162444
First Author: Lin JS
Year: 2010
Journal: J Leukoc Biol
Title: Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast.
Volume: 88
Issue: 1
Pages: 95-106
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Publication
22784989 | J:188159
First Author: Kim Y
Year: 2013
Journal: Mol Immunol
Title: DNA methyl transferase I acts as a negative regulator of allergic skin inflammation.
Volume: 53
Issue: 1-2
Pages: 1-14
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Publication
23728778 | J:200519
First Author: Uhde M
Year: 2013
Journal: Int Immunol
Title: Differential regulation of marginal zone and follicular B cell responses by CD83.
Volume: 25
Issue: 9
Pages: 507-20
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Publication
25656801 | J:231507
First Author: Garcia-Vilas JA
Year: 2015
Journal: Mol Immunol
Title: Damnacanthal inhibits IgE receptor-mediated activation of mast cells.
Volume: 65
Issue: 1
Pages: 86-93
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Publication
26432261 | J:233767
First Author: Karnam A
Year: 2015
Journal: Mol Immunol
Title: Sonic hedgehog-responsive lipoxygenases and cyclooxygenase-2 modulate Dectin-1-induced inflammatory cytokines.
Volume: 68
Issue: 2 Pt A
Pages: 280-9
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Publication
28646116 | J:244428
First Author: Havranek O
Year: 2017
Journal: Blood
Title: Tonic B-cell receptor signaling in diffuse large B-cell lymphoma.
Volume: 130
Issue: 8
Pages: 995-1006
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Publication
28705934 | J:245554
First Author: Badolia R
Year: 2017
Journal: J Biol Chem
Title: Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets.
Volume: 292
Issue: 35
Pages: 14516-14531
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Publication
26132276 | J:247152
First Author: Huang JH
Year: 2015
Journal: PLoS Pathog
Title: CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway.
Volume: 11
Issue: 7
Pages: e1004985
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Publication
28506889 | J:257977
 
First Author: Sambandam Y
Year: 2017
Journal: Bone
Title: NFAM1 signaling enhances osteoclast formation and bone resorption activity in Paget's disease of bone.
Volume: 101
Pages: 236-244
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Publication
29386516 | J:260185
First Author: Oda Y
Year: 2018
Journal: Sci Rep
Title: The effect of PU.1 knockdown on gene expression and function of mast cells.
Volume: 8
Issue: 1
Pages: 2005
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Publication
29355515 | J:261106
First Author: Kim JW
Year: 2018
Journal: Am J Pathol
Title: Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1β in Mice.
Volume: 188
Issue: 4
Pages: 967-980
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Publication
10627520 | J:265954
First Author: Caldwell RG
Year: 2000
Journal: J Virol
Title: Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice.
Volume: 74
Issue: 3
Pages: 1101-13
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Publication
29401630 | J:273837
First Author: Jia Y
Year: 2018
Journal: FASEB J
Title: Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase.
Volume: 32
Issue: 6
Pages: 3398-3410
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Publication
31145900 | J:277426
 
First Author: Loureiro CA
Year: 2019
Journal: Arch Biochem Biophys
Title: Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3.
Volume: 669
Pages: 61-70
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Publication
33037139 | J:304064
First Author: Prestes EB
Year: 2020
Journal: J Immunol
Title: Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis.
Volume: 205
Issue: 10
Pages: 2795-2805
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Publication
34193612 | J:330070
 
First Author: Scherlinger M
Year: 2021
Journal: Sci Transl Med
Title: Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis.
Volume: 13
Issue: 600
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Publication
30559741 | J:313190
 
First Author: Huang JH
Year: 2018
Journal: Front Immunol
Title: NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages.
Volume: 9
Pages: 2761
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Publication
22921586 | J:312801
First Author: Schweneker K
Year: 2013
Journal: Immunobiology
Title: The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.
Volume: 218
Issue: 4
Pages: 664-73
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Publication
23341451 | J:318142
First Author: Manne BK
Year: 2013
Journal: J Biol Chem
Title: Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2).
Volume: 288
Issue: 11
Pages: 7717-7726
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Publication
28943410 | J:318463
 
First Author: Gowert NS
Year: 2017
Journal: Cell Signal
Title: Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.
Volume: 40
Pages: 210-221
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Publication
29459869 | J:318498
 
First Author: Liu J
Year: 2018
Journal: Front Immunol
Title: Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis.
Volume: 9
Pages: 160
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Protein
P43404
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
E9PWE9
Organism: Mus musculus/domesticus
Length: 583  
Fragment?: false
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Protein
Q6P1E0
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q3UPF7
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q60819
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Publication
7659156 | -
First Author: Hatada MH
Year: 1995
Journal: Nature
Title: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.
Volume: 377
Issue: 6544
Pages: 32-8
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Protein Domain
IPR023420 | Kinase_SYK/ZAP-70_inter-SH2_sf
Type: Homologous_superfamily
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].SYK is a positive effector of B-cell antigen receptor (BCR) stimulated responses [, ]. ZAP-70 plays a role in T-cell development and lymphocyte activation. It is essential for TCR-mediated IL-2 production [, ].The N-terminal region of ZAP-70 consists of two SH2 domains that are connected by an helical region. The overall fold is Y shaped, with the intervening residues forming the stem []. This superfamily represents the inter-SH2 domain found in ZAP-70 and SYK kinases.
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Publication
21746961 | J:177211
First Author: Lee JH
Year: 2011
Journal: J Immunol
Title: The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Volume: 187
Issue: 4
Pages: 1807-15
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Publication
10547366 | J:59037
 
First Author: Suen PW
Year: 1999
Journal: J Cell Sci
Title: Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
Volume: 112 ( Pt 22)
Pages: 4067-78
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Publication
11509585 | J:71174
First Author: Hasegawa M
Year: 2001
Journal: J Immunol
Title: A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
Volume: 167
Issue: 5
Pages: 2469-78
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Publication
16038788 | J:100134
First Author: Mortaz E
Year: 2005
Journal: Exp Hematol
Title: Mast cell activation is differentially affected by heat shock.
Volume: 33
Issue: 8
Pages: 944-52
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Publication
31993060 | J:297722
 
First Author: Draberova L
Year: 2019
Journal: Front Immunol
Title: Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.
Volume: 10
Pages: 3068
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Publication
30951849 | J:283618
 
First Author: Teter B
Year: 2019
Journal: Neurobiol Dis
Title: Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis.
Volume: 127
Pages: 432-448
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Publication
15699129 | J:96557
First Author: Okazawa H
Year: 2005
Journal: J Immunol
Title: Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system.
Volume: 174
Issue: 4
Pages: 2004-11
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Publication
35605249 | J:327047
First Author: Ikeda M
Year: 2022
Journal: Blood Adv
Title: Latent membrane proteins from EBV differentially target cellular pathways to accelerate MYC-induced lymphomagenesis.
Volume: 6
Issue: 14
Pages: 4283-4296
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Publication
25331948 | J:338736
First Author: Paris D
Year: 2014
Journal: J Biol Chem
Title: The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.
Volume: 289
Issue: 49
Pages: 33927-44
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Publication
29587871 | J:265880
First Author: Zhong L
Year: 2018
Journal: Mol Neurodegener
Title: Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Volume: 13
Issue: 1
Pages: 15
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Publication
10938113 | J:63932
First Author: Moores SL
Year: 2000
Journal: Mol Cell Biol
Title: Vav family proteins couple to diverse cell surface receptors.
Volume: 20
Issue: 17
Pages: 6364-73
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Publication
9429890 | J:44757
First Author: Altin JG
Year: 1997
Journal: Immunol Cell Biol
Title: The role of CD45 and CD45-associated molecules in T cell activation.
Volume: 75
Issue: 5
Pages: 430-45
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Publication
12072546 | J:77152
First Author: Prakash O
Year: 2002
Journal: J Natl Cancer Inst
Title: Tumorigenesis and aberrant signaling in transgenic mice expressing the human herpesvirus-8 K1 gene.
Volume: 94
Issue: 12
Pages: 926-35
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