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Search results 601 to 700 out of 1932 for Tat

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Type Details Score
Allele
Chrnb1<tm1Sjb> | MGI:3768925
 
Name: cholinergic receptor nicotinic beta 1 subunit; targeted mutation 1, Steven J Burden
Allele Type: Targeted
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Strain
MGI:5500182 | FVB/N-Tg(HIV)26Aln/PkltJ
Attribute String: coisogenic, mutant strain, transgenic
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Publication
1926769 | J:90297
First Author: Dickie P
Year: 1991
Journal: Virology
Title: HIV-associated nephropathy in transgenic mice expressing HIV-1 genes.
Volume: 185
Issue: 1
Pages: 109-19
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Publication
23389453 | J:195417
First Author: Sharma M
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.
Volume: 304
Issue: 8
Pages: F1127-36
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Publication
23678040 | J:200858
First Author: Rai P
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN.
Volume: 305
Issue: 3
Pages: F343-54
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Publication
26227493 | J:224439
 
First Author: Fan Y
Year: 2015
Journal: Nat Commun
Title: RTN1 mediates progression of kidney disease by inducing ER stress.
Volume: 6
Pages: 7841
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Publication
29608911 | J:273773
First Author: Bryant JL
Year: 2018
Journal: Exp Mol Pathol
Title: Renal aquaporin-4 associated pathology in TG-26 mice.
Volume: 104
Issue: 3
Pages: 239-249
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Publication
33382797 | J:299513
First Author: Barbe MF
Year: 2020
Journal: PLoS One
Title: A longitudinal characterization of sex-specific somatosensory and spatial memory deficits in HIV Tg26 heterozygous mice.
Volume: 15
Issue: 12
Pages: e0244725
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Publication
11706060 | J:72603
First Author: Lewis W
Year: 2001
Journal: Lab Invest
Title: Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.
Volume: 81
Issue: 11
Pages: 1527-36
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Publication
23325078 | J:202443
First Author: Mallipattu SK
Year: 2013
Journal: Kidney Int
Title: Expression of HIV transgene aggravates kidney injury in diabetic mice.
Volume: 83
Issue: 4
Pages: 626-34
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Publication
27799525 | J:238845
First Author: Carroll VA
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice.
Volume: 113
Issue: 46
Pages: 13168-13173
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Publication
20581056 | J:163393
First Author: Kumar D
Year: 2010
Journal: Am J Pathol
Title: HIV-associated nephropathy: role of mammalian target of rapamycin pathway.
Volume: 177
Issue: 2
Pages: 813-21
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Publication
22125642 | J:180952
First Author: Zhong Y
Year: 2011
Journal: PLoS One
Title: Novel retinoic acid receptor alpha agonists for treatment of kidney disease.
Volume: 6
Issue: 11
Pages: e27945
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Publication
23611955 | J:203570
First Author: Cheng K
Year: 2013
Journal: Exp Cell Res
Title: Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN).
Volume: 319
Issue: 13
Pages: 2073-80
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Publication
11988819 | J:136652
First Author: Mozes MM
Year: 2002
Journal: Eye (Lond)
Title: Congenital nuclear cataracts and uveitis in HIV-transgenic mice.
Volume: 16
Issue: 2
Pages: 177-84
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Publication
21698182 | J:174285
First Author: Leventhal JS
Year: 2011
Journal: PLoS One
Title: Renal HIV expression is unaffected by serum LPS levels in an HIV transgenic mouse model of LPS induced kidney injury.
Volume: 6
Issue: 6
Pages: e20688
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Publication
10886562 | J:130659
First Author: Barisoni L
Year: 2000
Journal: Kidney Int
Title: HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy.
Volume: 58
Issue: 1
Pages: 173-81
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Publication
24667548 | J:214149
First Author: Fan Y
Year: 2014
Journal: PLoS One
Title: Temporal profile of the renal transcriptome of HIV-1 transgenic mice during disease progression.
Volume: 9
Issue: 3
Pages: e93019
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Publication
1542649 | J:89477
First Author: Kopp JB
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.
Volume: 89
Issue: 5
Pages: 1577-81
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Publication
30999016 | J:278294
 
First Author: Putatunda R
Year: 2019
Journal: Brain Behav Immun
Title: Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice.
Volume: 80
Pages: 488-499
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Publication
26683666 | J:229681
First Author: Haque S
Year: 2016
Journal: Am J Pathol
Title: HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy.
Volume: 186
Issue: 2
Pages: 347-58
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Publication
12861038 | J:84552
First Author: Sutliff RL
Year: 2003
Journal: Lab Invest
Title: Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome.
Volume: 83
Issue: 7
Pages: 983-9
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Publication
34138902 | J:339886
First Author: Blessing NA
Year: 2021
Journal: PLoS One
Title: Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys.
Volume: 16
Issue: 6
Pages: e0253197
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Publication
31315440 | J:298015
First Author: Kearns AC
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Caspase-1 Activation Is Related With HIV-Associated Atherosclerosis in an HIV Transgenic Mouse Model and HIV Patient Cohort.
Volume: 39
Issue: 9
Pages: 1762-1775
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Publication
21993884 | J:180074
First Author: Salhan D
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.
Volume: 302
Issue: 1
Pages: F129-40
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Publication
30136611 | J:272455
First Author: Mondejar-Parreño G
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: HIV transgene expression impairs K+ channel function in the pulmonary vasculature.
Volume: 315
Issue: 5
Pages: L711-L723
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Publication
29572404 | J:291070
First Author: Embry AE
Year: 2018
Journal: J Am Soc Nephrol
Title: Similar Biophysical Abnormalities in Glomeruli and Podocytes from Two Distinct Models.
Volume: 29
Issue: 5
Pages: 1501-1512
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Publication
19092797 | J:162706
First Author: Chan KT
Year: 2009
Journal: Kidney Int
Title: Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus.
Volume: 75
Issue: 4
Pages: 366-72
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Publication
22579465 | J:301669
First Author: Yadav A
Year: 2012
Journal: Exp Mol Pathol
Title: Sirolimus modulates HIVAN phenotype through inhibition of epithelial mesenchymal transition.
Volume: 93
Issue: 1
Pages: 173-81
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Publication
22647636 | J:188436
First Author: Salhan D
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: HIV-induced kidney cell injury: role of ROS-induced downregulated vitamin D receptor.
Volume: 303
Issue: 4
Pages: F503-14
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Publication
10972678 | J:128808
First Author: Kajiyama W
Year: 2000
Journal: Kidney Int
Title: Glomerulosclerosis and viral gene expression in HIV-transgenic mice: role of nef.
Volume: 58
Issue: 3
Pages: 1148-59
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Publication
34531413 | J:359923
First Author: Bryant J
Year: 2021
Journal: Sci Rep
Title: 7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder.
Volume: 11
Issue: 1
Pages: 18519
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Publication
20015943 | J:301106
First Author: Yadav A
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: HIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation.
Volume: 298
Issue: 3
Pages: F734-44
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Allele
Tg(CD4-HIV)#gPjo | MGI:5008256
Name: transgene insertion #g, Paul Jolicoeur
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6369614 | B6(SJL)-Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj>/J
Attribute String: endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:7541260 | B6.Cg-Tc(HSA17)2Mdk App<em1Adiuj>/J
Attribute String: congenic, mutant strain, targeted mutation, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Tg(HIV)26Aln/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HIV)26Aln/Tg(HIV)26Aln
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Publication
1331097 | -
First Author: Anderson GL
Year: 1992
Journal: J Biol Chem
Title: The purification and characterization of arsenite oxidase from Alcaligenes faecalis, a molybdenum-containing hydroxylase.
Volume: 267
Issue: 33
Pages: 23674-82
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Publication
11763972 | -
First Author: Anantharaman V
Year: 2002
Journal: J Mol Microbiol Biotechnol
Title: SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases.
Volume: 4
Issue: 1
Pages: 71-5
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Protein Domain
IPR014067 | AioB/IdrB_ssu
Type: Family
Description: This entry represents a group of prokaryotic molybdopterin-containing oxidoreductases, including Arsenite oxidase subunit AioB from Alcaligenes faecalis and Iodate reductase subunit IdrB from Pseudomonas sp. AioB is the small subunit of an arsenite oxidase complex. It is a Rieske protein and appears to rely on the Tat (twin-arginine translocation) system to cross the membrane. Although this enzyme could run in the direction of arsenate reduction to arsenite in principle, the relevant biological function is arsenite oxidation for energy metabolism, not arsenic resistance [, ]. IdrB, a Rieske-type protein with a [2Fe-2S]-binding motif, is involved in iodate respiration [, ].
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Protein Domain
IPR034392 | TatSF1-like_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of Tat-SF1, which interacts with components of both the transcription and splicing machineries []. It has been shown to be a cofactor for human immunodeficiency virus-type 1 (HIV-1) Tat, which stimulates transcription elongation of HIV-1 through a series of events termed Tat transactivation [, ]. It contains two RNA recognition motifs (RRMs) and a highly acidic carboxyl-terminal half. Proteins containing this domain also include Cus2, a yeast homologue of human Tat-SF1. Cus2 interacts with U2 snRNA and Prp11, a subunit of the conserved splicing factor SF3a []. Like Tat-SF1, Cus2 contains two RRMs.
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Protein Domain
IPR034393 | TatSF1-like
Type: Family
Description: Tat-SF1 (HIV Tat-specific factor 1) interacts with components of both the transcription and splicing machineries []. It has been shown to be a cofactor for human immunodeficiency virus-type 1 (HIV-1) Tat, which stimulates transcription elongation of HIV-1 through a series of events termed Tat transactivation [, ]. It contains two RNA recognition motifs (RRMs) and a highly acidic carboxyl-terminal half. This entry also includes Cus2, a yeast homologue of human Tat-SF1. Cus2 interacts with U2 snRNA and Prp11, a subunit of the conserved splicing factor SF3a []. Like Tat-SF1, Cus2 contains two RRMs.
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Protein Domain
IPR044748 | Trm3/TARBP1_C
Type: Domain
Description: This entry represents the C-terminal methyltransferase domain of TARBP1 and Trm3 [].Yeast tRNA (guanosine(18)-2'-O)-methyltransferase Trm3 catalyses the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs []. Trm3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation [, ].
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Protein Domain
IPR023821 | rSAM_TatD-assoc
Type: Family
Description: Members of this family are radical SAM proteins found in about 5 percent of microbial genomes. A portion occur as gene fusions with, or adjacent to, members of the TatD family of hydrolases (). The TatD family may have several paralogs per genome, including TatD itself from E. coli (a soluble protein not actually part of the twin-arginine translocation complex), which appears to act in quality control for TAT, directing turnover of misfolded TAT substrates. The functions of TatD family hydrolases in general (other than TatD itself, which may be exceptional within its larger family), and of this radical SAM domain protein modeled here, are unknown.
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Publication
11133954 | -
First Author: Blaudeck N
Year: 2001
Journal: J Bacteriol
Title: Specificity of signal peptide recognition in tat-dependent bacterial protein translocation.
Volume: 183
Issue: 2
Pages: 604-10
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Publication
21282347 | -
First Author: Miller HB
Year: 2011
Journal: RNA
Title: Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing.
Volume: 17
Issue: 4
Pages: 665-74
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Publication
11780068 | -
First Author: Fong YW
Year: 2001
Journal: Nature
Title: Stimulatory effect of splicing factors on transcriptional elongation.
Volume: 414
Issue: 6866
Pages: 929-33
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Publication
9710584 | -
First Author: Yan D
Year: 1998
Journal: Mol Cell Biol
Title: CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif.
Volume: 18
Issue: 9
Pages: 5000-9
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Protein Domain
IPR003369 | TatA/B/E
Type: Family
Description: Translocation of proteins across the two membranes of Gram-negative bacteriacan be carried out via a number of routes. Most proteins marked for export carry a secretion signal at their N terminus, and are secreted by the general secretory pathway. The signal peptide is cleaved as they pass through the outer membrane. Other secretion systems include the type III system found in a select group of Gram-negative plant and animal pathogens, and the CagA system of Helicobacter pylori [].In some bacterial species, however, there exists a system that operates independently of the Sec pathway []. It selectively translocates periplasmic-bound molecules that are synthesised with, or are in close association with, "partner"proteins bearing an (S/T)RRXFLK twin arginine motif at the N terminus. The pathway is therefore termed the Twin-Arginine Translocation or TAT system. Surprisingly, the four components that make up the TAT system are structurally and mechanistically related to a pH-dependent import system in plant chloroplast thylakoid membranes []. Thegene products responsible for the Sec-independent pathway are called TatA,TatB, TatC and TatE.This entry represents the related TatA, TatB and TatE proteins.
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Protein Domain
IPR024905 | TatE
Type: Family
Description: Translocation of proteins across the two membranes of Gram-negative bacteriacan be carried out via a number of routes. Most proteins marked for export carry a secretion signal at their N terminus, and are secreted by the general secretory pathway. The signal peptide is cleaved as they pass through the outer membrane. Other secretion systems include the type III system found in a select group of Gram-negative plant and animal pathogens, and the CagA system of Helicobacter pylori [].In some bacterial species, however, there exists a system that operates independently of the Sec pathway []. It selectively translocates periplasmic-bound molecules that are synthesised with, or are in close association with, "partner"proteins bearing an (S/T)RRXFLK twin arginine motif at the N terminus. The pathway is therefore termed the Twin-Arginine Translocation or TAT system. Surprisingly, the four components that make up the TAT system are structurally and mechanistically related to a pH-dependent import system in plant chloroplast thylakoid membranes []. Thegene products responsible for the Sec-independent pathway are called TatA,TatB, TatC and TatE.TatE is highly related to TatA and these proteins appear to overlap in functionality []. Translocation occurred in single mutants of either TatA or TatE, though much less efficiently, but double mutants showed no detectable translocation.
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Protein Domain
IPR006312 | TatA/E
Type: Family
Description: Translocation of proteins across the two membranes of Gram-negative bacteriacan be carried out via a number of routes. Most proteins marked for export carry a secretion signal at their N terminus, and are secreted by the general secretory pathway. The signal peptide is cleaved as they pass through the outer membrane. Other secretion systems include the type III system found in a select group of Gram-negative plant and animal pathogens, and the CagA system of Helicobacter pylori [].In some bacterial species, however, there exists a system that operates independently of the Sec pathway []. It selectively translocates periplasmic-bound molecules that are synthesised with, or are in close association with, "partner"proteins bearing an (S/T)RRXFLK twin arginine motif at the N terminus. The pathway is therefore termed the Twin-Arginine Translocation or TAT system. Surprisingly, the four components that make up the TAT system are structurally and mechanistically related to a pH-dependent import system in plant chloroplast thylakoid membranes []. Thegene products responsible for the Sec-independent pathway are called TatA,TatB, TatC and TatE.TatA and TatE are highly related proteins and appear to overlap in functionality []. Translocation occurred in single mutants of either TatA or TatE, though much less efficiently, but double mutants showed no detectable translocation.
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Protein Domain
IPR008354 | Glc-Fru_OxRdtase_bac
Type: Family
Description: Glucose-fructose oxidoreductase (GFOR) catalyses the formation of D-gluconolactone and D-glucitol from D-glucose and D-fructose. It hasone tightly-bound NADP(H) per enzyme subunit, it exists as a homotetramer,and is one of the pivotal proteins in the sorbitol-gluconate pathway. It istargeted to the periplasm of the Gram-negative cell envelope, and belongs tothe GFO/IDH/MOCA superfamily. First discovered in Zymomonas mobilis, homologues have also been found in Caulobacter crescentus and Deinococcus radiodurans.GFOR is of great interest as its mechanism of secretion into the bacterialperiplasm differs from other precursor proteins of the Twin ArginineTranslocation (TAT) pathway []. Although it exhibits the consensus TAT signal motif (S/T-R-R-x-L-F-K) at its N terminus, unlike other TAT proteins that can be universally secreted across a number of Gram-negative microbes, GFOR is only translocated in Z. mobilis. However, replacing the Z. mobilis signal peptide with one from Escherichia coli restores this function. This observation has led to the suggestion that TAT-dependent precursors are optimally adapted only to their particular cognate secretion apparatus [].Recently, the crystal structure of Z. mobilis GFOR was resolved to 2.5A bymeans of X-ray crystallography. This revealed that the protein indeed exists as a homotetramer, and has 4 active sites. There are 2 distinct domains: a classical dinucleotide binding fold at the N terminus and a 9-stranded β-sheet at the C terminus. NADP(H) is bound to the N terminus of the first α-helix.
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Publication
10692587 | J:69173
First Author: Jimenez-Lara AM
Year: 2000
Journal: FEBS Lett
Title: Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family.
Volume: 468
Issue: 2-3
Pages: 203-10
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Publication
12801643 | J:83989
 
First Author: Legube G
Year: 2003
Journal: Gene
Title: Identification of a larger form of the histone acetyl transferase Tip60.
Volume: 310
Pages: 161-8
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Publication
28345588 | J:244889
 
First Author: Wang X
Year: 2017
Journal: Nat Commun
Title: Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF.
Volume: 8
Pages: 14091
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Publication
19011637 | J:142227
First Author: Liu XJ
Year: 2008
Journal: Nat Med
Title: Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex.
Volume: 14
Issue: 12
Pages: 1325-32
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Publication
16849638 | J:140454
First Author: Vidarsson G
Year: 2006
Journal: Blood
Title: FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis.
Volume: 108
Issue: 10
Pages: 3573-9
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Publication
20660762 | J:164406
First Author: Chiang PM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
Volume: 107
Issue: 37
Pages: 16320-4
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Publication
29378828 | J:261620
 
First Author: Collard R
Year: 2018
Journal: Mol Cell Biol
Title: Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using Models of Propionic Acidemia.
Volume: 38
Issue: 6
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Publication
33436632 | J:300870
First Author: Yan Z
Year: 2021
Journal: Nat Commun
Title: Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.
Volume: 12
Issue: 1
Pages: 308
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Publication
25189210 | J:217911
First Author: García-Caballero A
Year: 2014
Journal: Neuron
Title: The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity.
Volume: 83
Issue: 5
Pages: 1144-58
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Publication
30340616 | J:295635
First Author: Gadotti VM
Year: 2018
Journal: Mol Brain
Title: Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation.
Volume: 11
Issue: 1
Pages: 60
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Publication
22493483 | J:186211
First Author: Mallipattu SK
Year: 2012
Journal: J Biol Chem
Title: Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation.
Volume: 287
Issue: 23
Pages: 19122-35
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Publication
16120817 | J:170955
First Author: Barisoni L
Year: 2005
Journal: J Am Soc Nephrol
Title: The kd/kd mouse is a model of collapsing glomerulopathy.
Volume: 16
Issue: 10
Pages: 2847-51
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Publication
21221075 | J:169237
First Author: Bruggeman LA
Year: 2011
Journal: Lab Invest
Title: TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α.
Volume: 91
Issue: 3
Pages: 413-25
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Publication
10489260 | J:59490
First Author: Kojima N
Year: 1998
Journal: Learn Mem
Title: Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice.
Volume: 5
Issue: 6
Pages: 429-45
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Publication
21150871 | J:186881
First Author: Ratnam KK
Year: 2011
Journal: Kidney Int
Title: Role of the retinoic acid receptor-α in HIV-associated nephropathy.
Volume: 79
Issue: 6
Pages: 624-34
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Publication
21123730 | J:171180
First Author: Wyss HM
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Biophysical properties of normal and diseased renal glomeruli.
Volume: 300
Issue: 3
Pages: C397-405
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Publication
37629052 | J:339609
 
First Author: Alam MA
Year: 2023
Journal: Int J Mol Sci
Title: Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice.
Volume: 24
Issue: 16
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Publication
23340313 | J:194059
First Author: Leongson K
Year: 2013
Journal: Infect Immun
Title: Altered immune response differentially enhances susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in mice expressing the HIV-1 transgene.
Volume: 81
Issue: 4
Pages: 1100-13
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Publication
16785545 | J:134381
First Author: Lewandowski D
Year: 2006
Journal: J Immunol
Title: Altered CD4+ T cell phenotype and function determine the susceptibility to mucosal candidiasis in transgenic mice expressing HIV-1.
Volume: 177
Issue: 1
Pages: 479-91
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Publication
15351215 | J:131665
First Author: Hanna Z
Year: 2004
Journal: Virology
Title: In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice.
Volume: 327
Issue: 2
Pages: 273-86
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Publication
9987012 | J:55615
First Author: Lu YF
Year: 1999
Journal: Eur J Neurosci
Title: Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice.
Volume: 11
Issue: 1
Pages: 75-82
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Publication
25689250 | J:220539
First Author: Mallipattu SK
Year: 2015
Journal: J Clin Invest
Title: Krüppel-like factor 6 regulates mitochondrial function in the kidney.
Volume: 125
Issue: 3
Pages: 1347-61
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Publication
23874454 | J:204412
First Author: Johnstone DB
Year: 2013
Journal: PLoS One
Title: Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy.
Volume: 8
Issue: 7
Pages: e67839
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Publication
19553347 | J:152103
First Author: Arora S
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Human immunodeficiency virus downregulates podocyte apoE expression.
Volume: 297
Issue: 3
Pages: F653-61
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Publication
27335373 | J:280974
First Author: Raij L
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Podocyte injury: the role of proteinuria, urinary plasminogen, and oxidative stress.
Volume: 311
Issue: 6
Pages: F1308-F1317
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Publication
23806280 | J:203627
First Author: Cheng K
Year: 2013
Journal: Exp Cell Res
Title: Bone-derived mesenchymal stromal cells from HIV transgenic mice exhibit altered proliferation, differentiation capacity and paracrine functions along with impaired therapeutic potential in kidney injury.
Volume: 319
Issue: 14
Pages: 2266-74
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Publication
14983036 | J:88645
First Author: Gharavi AG
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3.
Volume: 101
Issue: 8
Pages: 2488-93
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Publication
27736906 | J:254208
First Author: Papeta N
Year: 2016
Journal: PLoS One
Title: Refinement of the HIVAN1 Susceptibility Locus on Chr. 3A1-A3 via Generation of Sub-Congenic Strains.
Volume: 11
Issue: 10
Pages: e0163860
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Publication
22406746 | J:183395
First Author: Jin Y
Year: 2012
Journal: Nat Med
Title: A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
Volume: 18
Issue: 4
Pages: 580-8
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Publication
17959719 | J:128926
First Author: Friese MB
Year: 2007
Journal: Development
Title: Synaptic differentiation is defective in mice lacking acetylcholine receptor beta-subunit tyrosine phosphorylation.
Volume: 134
Issue: 23
Pages: 4167-76
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Publication
22249313 | J:181932
First Author: Burnworth B
Year: 2012
Journal: Lab Invest
Title: SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus.
Volume: 92
Issue: 4
Pages: 499-510
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Publication
29463701 | J:259772
First Author: Raynaud-Messina B
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss.
Volume: 115
Issue: 11
Pages: E2556-E2565
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Publication
21292773 | J:170500
First Author: Bouchet J
Year: 2011
Journal: Blood
Title: Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.
Volume: 117
Issue: 13
Pages: 3559-68
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Strain
MGI:6164023 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, targeted mutation, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6508534 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Abca7<em2Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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•
•
•
•
Strain
MGI:6444738 | B6.Cg-Pilra<em1Adiuj> Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
•
•
•
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•
Strain
MGI:6444731 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Il1rap<em2Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: mutant strain, congenic, targeted mutation, endonuclease-mediated mutation
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•
Publication
38735056 | J:351102
First Author: Kotredes KP
Year: 2024
Journal: Alzheimers Dement
Title: Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology.
Volume: 20
Issue: 6
Pages: 4126-4146
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Publication
31177033 | J:351561
 
First Author: Chen Y
Year: 2019
Journal: J Neuroimmunol
Title: Oxymatrine can attenuate pathological deficits of Alzheimer's disease mice through regulation of neuroinflammation.
Volume: 334
Pages: 576978
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Strain
MGI:6369613 | B6(SJL)-Apoe<em2(APOE*)Adiuj> Tc(HSA17)1Mdk App<em1Adiuj>/AdiujJ
Attribute String: endonuclease-mediated mutation, mutant strain
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Allele
Tyr<em19Ove> | MGI:6416505
Name: tyrosinase; endonuclease-mediated mutation 19, Paul Overbeek
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Strain
MGI:7666003 | C57BL/6-Cd79b<tm1.1Rein>/J
Attribute String: targeted mutation, mutant strain
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•
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Genotype
Genotype
Symbol: Tg(CD4-HIV)F21380Pjo/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CD4-HIV)F26985Pjo/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CD4-HIV)F21388Pjo/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CD4-HIV)F21407Pjo/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CD4-HIV)F26990Pjo/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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