|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 763 for Tcf4

0.027s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
GXD Expression  
Probe: MGI:6382931
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7543402
Age: embryonic day 18.5
Note: Numbers of expressing cells resembled those of control.
Specimen Label: Tcf4 ko not shown
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2674976
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7543403
Age: embryonic day 18.5
Note: Numbers of expressing cells resembled those of control.
Specimen Label: Tcf4 ko not shown
Detected: true
Specimen Num: 2
Publication
First Author: Li L
Year: 2020
Journal: Int J Cancer
Title: UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.
Volume: 147
Issue: 8
Pages: 2239-2252
Publication  
First Author: Hrckulak D
Year: 2018
Journal: Genes (Basel)
Title: Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells.
Volume: 9
Issue: 9
Publication
First Author: Brinkmeier ML
Year: 2007
Journal: Dev Biol
Title: TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.
Volume: 311
Issue: 2
Pages: 396-407
Publication
First Author: van Es JH
Year: 2012
Journal: Mol Cell Biol
Title: A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.
Volume: 32
Issue: 10
Pages: 1918-27
Publication
First Author: D'Rozario M
Year: 2016
Journal: Cell Rep
Title: Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.
Volume: 15
Issue: 2
Pages: 386-97
Publication
First Author: Saegusa M
Year: 2012
Journal: Lab Invest
Title: Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas.
Volume: 92
Issue: 4
Pages: 511-21
Publication
First Author: Greb-Markiewicz B
Year: 2019
Journal: Sci Rep
Title: The subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals.
Volume: 9
Issue: 1
Pages: 15629
Interaction Experiment
Description: Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.
Publication
First Author: Sepp M
Year: 2012
Journal: Hum Mol Genet
Title: Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.
Volume: 21
Issue: 13
Pages: 2873-88
Publication
First Author: Hu MC
Year: 2005
Journal: Development
Title: Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription.
Volume: 132
Issue: 1
Pages: 215-25
GXD Expression
Probe: MGI:7576988
Assay Type: RNA in situ
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7577013
Age: embryonic day 13.5
Image: 6F
Note: The expression pattern of Tcf4 and Tcf3 were mutually exclusive.
Specimen Label: 6F
Detected: true
Specimen Num: 2
Publication
First Author: Miller KA
Year: 2007
Journal: Dev Biol
Title: A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells.
Volume: 311
Issue: 2
Pages: 665-78
Publication
First Author: Omer CA
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Identification of Tcf4 residues involved in high-affinity beta-catenin binding.
Volume: 256
Issue: 3
Pages: 584-90
GXD Expression
Probe: MGI:2676495
Assay Type: RNA in situ
Annotation Date: 2003-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1628514
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:2676620
Age: embryonic day 9.0
Image: 7H
Note: Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains.
Specimen Label: 7H
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:2676496
Assay Type: RNA in situ
Annotation Date: 2003-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1628513
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:2676621
Age: embryonic day 9.0
Image: 7L
Note: Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains.
Specimen Label: 7L
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:2676495
Assay Type: RNA in situ
Annotation Date: 2003-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1651914
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:2676620
Age: embryonic day 9.0
Image: 7H
Note: Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains.
Specimen Label: 7H
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:2676496
Assay Type: RNA in situ
Annotation Date: 2003-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614413
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:2676621
Age: embryonic day 9.0
Image: 7L
Note: Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains.
Specimen Label: 7L
Detected: true
Specimen Num: 1
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
GXD Expression
Probe: MGI:2676494
Assay Type: RNA in situ
Annotation Date: 2003-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614014
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:2676619
Age: embryonic day 9.0
Image: 7D
Note: Ventral to dorsal expansionl in diencephalic and midbrain primordia. Expression extended dorsally, overlapping Dbx1 and Tcf4 domains; also strongly expressed just posterior to the midbrain-hindbrain isthmus.
Specimen Label: 7D
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:7576988
Assay Type: RNA in situ
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7577013
Age: embryonic day 13.5
Image: 6E
Note: The expression pattern of Tcf4 and Tcf3 were mutually exclusive. An expansion in the expression domain was seen, compared with the control.
Specimen Label: 6E
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:2676494
Assay Type: RNA in situ
Annotation Date: 2003-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1651414
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:2676619
Age: embryonic day 9.0
Image: 7D
Note: Ventral to dorsal expansionl in diencephalic and midbrain primordia. Expression extended dorsally, overlapping Dbx1 and Tcf4 domains; also strongly expressed just posterior to the midbrain-hindbrain isthmus.
Specimen Label: 7D
Detected: true
Specimen Num: 4
Allele
Name: transcription factor 4; targeted mutation 1, Yuan Zhuang
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: transcription factor 4; targeted mutation 1, Dan Holmberg
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: transcription factor 4; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: transcription factor 4; endonuclease-mediated mutation 1, Benjamin D Philpot
Allele Type: Endonuclease-mediated
Attribute String: Dominant negative
Allele
Name: transcription factor 4; endonuclease-mediated mutation 2, Benjamin D Philpot
Allele Type: Endonuclease-mediated
Attribute String: Dominant negative
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
Genotype
Symbol: Tcf4/Tcf4<+> Tmem163/Tmem163<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
DO Term
Genotype
Symbol: Tcf4/Tcf4<+> Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tcf4/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tcf4/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tcf4/Tcf4<+>
Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Tcf4/Tcf4<+>
Background: involves: C57BL/6N
Zygosity: ht
Has Mutant Allele: true
Publication  
First Author: Brzózka MM
Year: 2016
Journal: Neuroscience
Title: OSO paradigm--A rapid behavioral screening method for acute psychosocial stress reactivity in mice.
Volume: 314
Pages: 1-11
Allele
Name: transgene insertion 1, Moritz J Rossner
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
HT Experiment
Series Id: GSE32511
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Strain
Attribute String: congenic, mutant strain, transgenic
Genotype
Symbol: Tg(Thy1-Tcf4)1Mjro/?
Background: involves: C57BL/6N * FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-Tcf4)1Mjro/?
Background: B6N.FVB-Tg(Thy1-Tcf4)1Mjro
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Sampson EM
Year: 2001
Journal: EMBO J
Title: Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
Volume: 20
Issue: 16
Pages: 4500-11
Publication
First Author: Lemercier C
Year: 2000
Journal: Mol Cell Biol
Title: Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.
Volume: 20
Issue: 18
Pages: 6627-37
Publication
First Author: Escamilla-Powers JR
Year: 2010
Journal: J Biol Chem
Title: The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.
Volume: 285
Issue: 7
Pages: 4847-58
Protein Domain
Type: Family
Description: HMG box-containing protein 1 (HBP1) is a high mobility group (HMG) box transcription factor that negatively regulates the Wnt-beta-catenin pathway []and is involved in histone H1(0) gene expression []. It binds the transcription factor TCF4 and prevents it from binding to its target genes, including c-MYC and CYCLIN D []. It acts as a tumour suppressor and an important effector in oncogene-induced premature senescence [].
HT Experiment
Series Id: GSE57324
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
Publication
First Author: Dahle Ø
Year: 2003
Journal: Eur J Biochem
Title: Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.
Volume: 270
Issue: 6
Pages: 1338-48
Publication
First Author: Yamamoto H
Year: 2003
Journal: EMBO J
Title: Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.
Volume: 22
Issue: 9
Pages: 2047-59
Publication
First Author: Subramanian L
Year: 2003
Journal: J Biol Chem
Title: A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.
Volume: 278
Issue: 11
Pages: 9134-41
Publication
First Author: Ihara M
Year: 2005
Journal: Mol Cell Biol
Title: SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.
Volume: 25
Issue: 9
Pages: 3506-18
Publication
First Author: Danielsen JR
Year: 2012
Journal: J Cell Biol
Title: DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.
Volume: 197
Issue: 2
Pages: 179-87
Protein Domain
Type: Family
Description: SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability []. PIAS4 is an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilising the interaction between Ubc9 and the substrate, and is a SUMO-tethering factor []. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. It mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations [, , , , ].
Publication
First Author: Roose J
Year: 1999
Journal: Science
Title: Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Volume: 285
Issue: 5435
Pages: 1923-6
HT Experiment
Series Id: GSE56461
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Shinbo Y
Year: 2006
Journal: Cell Death Differ
Title: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.
Volume: 13
Issue: 1
Pages: 96-108
Publication
First Author: Villanueva CJ
Year: 2011
Journal: Cell Metab
Title: TLE3 is a dual-function transcriptional coregulator of adipogenesis.
Volume: 13
Issue: 4
Pages: 413-427
Publication
First Author: Batlle E
Year: 2005
Journal: Nature
Title: EphB receptor activity suppresses colorectal cancer progression.
Volume: 435
Issue: 7045
Pages: 1126-30