Type |
Details |
Score |
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382931 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-10-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7543402 |
Age: |
embryonic day 18.5 |
|
Note: |
Numbers of expressing cells resembled those of control. |
Specimen Label: |
Tcf4 ko not shown |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2674976 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-10-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7543403 |
Age: |
embryonic day 18.5 |
|
Note: |
Numbers of expressing cells resembled those of control. |
Specimen Label: |
Tcf4 ko not shown |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2020 |
Journal: |
Int J Cancer |
Title: |
UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling. |
Volume: |
147 |
Issue: |
8 |
Pages: |
2239-2252 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hrckulak D |
Year: |
2018 |
Journal: |
Genes (Basel) |
Title: |
Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells. |
Volume: |
9 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkmeier ML |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. |
Volume: |
311 |
Issue: |
2 |
Pages: |
396-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Es JH |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. |
Volume: |
32 |
Issue: |
10 |
Pages: |
1918-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'Rozario M |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons. |
Volume: |
15 |
Issue: |
2 |
Pages: |
386-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saegusa M |
Year: |
2012 |
Journal: |
Lab Invest |
Title: |
Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas. |
Volume: |
92 |
Issue: |
4 |
Pages: |
511-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Greb-Markiewicz B |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
The subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals. |
Volume: |
9 |
Issue: |
1 |
Pages: |
15629 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. |
|
•
•
•
•
•
|
Publication |
First Author: |
Sepp M |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects. |
Volume: |
21 |
Issue: |
13 |
Pages: |
2873-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu MC |
Year: |
2005 |
Journal: |
Development |
Title: |
Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. |
Volume: |
132 |
Issue: |
1 |
Pages: |
215-25 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7576988 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-01-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7577013 |
Age: |
embryonic day 13.5 |
Image: |
6F |
Note: |
The expression pattern of Tcf4 and Tcf3 were mutually exclusive. |
Specimen Label: |
6F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller KA |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells. |
Volume: |
311 |
Issue: |
2 |
Pages: |
665-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Omer CA |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Identification of Tcf4 residues involved in high-affinity beta-catenin binding. |
Volume: |
256 |
Issue: |
3 |
Pages: |
584-90 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2676495 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1628514 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:2676620 |
Age: |
embryonic day 9.0 |
Image: |
7H |
Note: |
Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2676496 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1628513 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:2676621 |
Age: |
embryonic day 9.0 |
Image: |
7L |
Note: |
Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains. |
Specimen Label: |
7L |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2676495 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1651914 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:2676620 |
Age: |
embryonic day 9.0 |
Image: |
7H |
Note: |
Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2676496 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1614413 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:2676621 |
Age: |
embryonic day 9.0 |
Image: |
7L |
Note: |
Expression detected in alar plates of caudal diencephalon and anterior midbrain, overlapping Tcf4 and Dbx1 domains. |
Specimen Label: |
7L |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2676494 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1614014 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:2676619 |
Age: |
embryonic day 9.0 |
Image: |
7D |
Note: |
Ventral to dorsal expansionl in diencephalic and midbrain primordia. Expression extended dorsally, overlapping Dbx1 and Tcf4 domains; also strongly expressed just posterior to the midbrain-hindbrain isthmus. |
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7576988 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-01-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7577013 |
Age: |
embryonic day 13.5 |
Image: |
6E |
Note: |
The expression pattern of Tcf4 and Tcf3 were mutually exclusive. An expansion in the expression domain was seen, compared with the control. |
Specimen Label: |
6E |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2676494 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1651414 |
Pattern: |
Regionally restricted |
Stage: |
TS14 |
Assay Id: |
MGI:2676619 |
Age: |
embryonic day 9.0 |
Image: |
7D |
Note: |
Ventral to dorsal expansionl in diencephalic and midbrain primordia. Expression extended dorsally, overlapping Dbx1 and Tcf4 domains; also strongly expressed just posterior to the midbrain-hindbrain isthmus. |
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 4; targeted mutation 1, Yuan Zhuang |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 4; targeted mutation 1, Dan Holmberg |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 4; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 4; endonuclease-mediated mutation 1, Benjamin D Philpot |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Dominant negative |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 4; endonuclease-mediated mutation 2, Benjamin D Philpot |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Dominant negative |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
459
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
605
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
447
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
317
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
299
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
455
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
288
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf4/Tcf4<+> Tmem163/Tmem163<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf4/Tcf4<+> Tg(Nes-cre)1Kln/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf4/? |
Background: |
involves: C57BL/6 * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf4/? |
Background: |
involves: C57BL/6 * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Tcf4/Tcf4<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Tcf4/Tcf4<+> |
Background: |
involves: C57BL/6N |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Brzózka MM |
Year: |
2016 |
Journal: |
Neuroscience |
Title: |
OSO paradigm--A rapid behavioral screening method for acute psychosocial stress reactivity in mice. |
Volume: |
314 |
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Pages: |
1-11 |
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Allele |
Name: |
transgene insertion 1, Moritz J Rossner |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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HT Experiment |
Series Id: |
GSE32511 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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Genotype |
Symbol: |
Tg(Thy1-Tcf4)1Mjro/? |
Background: |
involves: C57BL/6N * FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
•
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Genotype |
Symbol: |
Tg(Thy1-Tcf4)1Mjro/? |
Background: |
B6N.FVB-Tg(Thy1-Tcf4)1Mjro |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
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Publication |
First Author: |
Sampson EM |
Year: |
2001 |
Journal: |
EMBO J |
Title: |
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. |
Volume: |
20 |
Issue: |
16 |
Pages: |
4500-11 |
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Publication |
First Author: |
Lemercier C |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. |
Volume: |
20 |
Issue: |
18 |
Pages: |
6627-37 |
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Publication |
First Author: |
Escamilla-Powers JR |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity. |
Volume: |
285 |
Issue: |
7 |
Pages: |
4847-58 |
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Protein Domain |
Type: |
Family |
Description: |
HMG box-containing protein 1 (HBP1) is a high mobility group (HMG) box transcription factor that negatively regulates the Wnt-beta-catenin pathway []and is involved in histone H1(0) gene expression []. It binds the transcription factor TCF4 and prevents it from binding to its target genes, including c-MYC and CYCLIN D []. It acts as a tumour suppressor and an important effector in oncogene-induced premature senescence []. |
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HT Experiment |
Series Id: |
GSE57324 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
71
 |
Fragment?: |
true |
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Publication |
First Author: |
Dahle Ø |
Year: |
2003 |
Journal: |
Eur J Biochem |
Title: |
Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner. |
Volume: |
270 |
Issue: |
6 |
Pages: |
1338-48 |
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Publication |
First Author: |
Yamamoto H |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. |
Volume: |
22 |
Issue: |
9 |
Pages: |
2047-59 |
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Publication |
First Author: |
Subramanian L |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3. |
Volume: |
278 |
Issue: |
11 |
Pages: |
9134-41 |
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Publication |
First Author: |
Ihara M |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4. |
Volume: |
25 |
Issue: |
9 |
Pages: |
3506-18 |
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Publication |
First Author: |
Danielsen JR |
Year: |
2012 |
Journal: |
J Cell Biol |
Title: |
DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. |
Volume: |
197 |
Issue: |
2 |
Pages: |
179-87 |
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Protein Domain |
Type: |
Family |
Description: |
SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability []. PIAS4 is an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilising the interaction between Ubc9 and the substrate, and is a SUMO-tethering factor []. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. It mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations [, , , , ]. |
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Publication |
First Author: |
Roose J |
Year: |
1999 |
Journal: |
Science |
Title: |
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. |
Volume: |
285 |
Issue: |
5435 |
Pages: |
1923-6 |
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HT Experiment |
Series Id: |
GSE56461 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Publication |
First Author: |
Shinbo Y |
Year: |
2006 |
Journal: |
Cell Death Differ |
Title: |
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. |
Volume: |
13 |
Issue: |
1 |
Pages: |
96-108 |
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Publication |
First Author: |
Villanueva CJ |
Year: |
2011 |
Journal: |
Cell Metab |
Title: |
TLE3 is a dual-function transcriptional coregulator of adipogenesis. |
Volume: |
13 |
Issue: |
4 |
Pages: |
413-427 |
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Publication |
First Author: |
Batlle E |
Year: |
2005 |
Journal: |
Nature |
Title: |
EphB receptor activity suppresses colorectal cancer progression. |
Volume: |
435 |
Issue: |
7045 |
Pages: |
1126-30 |
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