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Search results 601 to 648 out of 648 for Thra

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Type

Details

Score

Publication

12466851 | J:80000

First Author:	Okazaki Y
Year:	2002
Journal:	Nature
Title:	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume:	420
Issue:	6915
Pages:	563-73

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Publication

- | J:164563

First Author:	The Gene Ontology Consortium
Year:	2010

Title:	Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

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Publication

- | J:75000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Mouse Genome Informatics Computational Sequence to Gene Associations

•

Publication

- | J:157972

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2010
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).

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Publication

- | J:161428

First Author:	Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year:	2010

Title:	Annotation inferences using phylogenetic trees

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Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

•

Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

•

Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

•

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

7003595 | -

First Author:	Katinka M
Year:	1980
Journal:	Proc Natl Acad Sci U S A
Title:	Nucleotide sequence of the thrA gene of Escherichia coli.
Volume:	77
Issue:	10
Pages:	5730-3

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DO Term

DOID:0070128 | congenital nongoitrous hypothyroidism 6

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Publication

6298218 | -

First Author:	Zakin MM
Year:	1983
Journal:	J Biol Chem
Title:	Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase ii-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I-homoserine dehydrogenase I, derive from a common ancestor.
Volume:	258
Issue:	5
Pages:	3028-31

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Allele

Tg(Thra-EGFP)KL340Gsat | MGI:4847490

Name:	transgene insertion KL340, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

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Publication

8423151 | -

First Author:	Omori K
Year:	1993
Journal:	J Bacteriol
Title:	Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase I.
Volume:	175
Issue:	3
Pages:	785-94

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Publication

11888289 | -

First Author:	James CL
Year:	2002
Journal:	Biochemistry
Title:	Production and characterization of bifunctional enzymes. Domain swapping to produce new bifunctional enzymes in the aspartate pathway.
Volume:	41
Issue:	11
Pages:	3720-5

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Publication

16525757 | -

First Author:	Azevedo RA
Year:	2006
Journal:	Amino Acids
Title:	The aspartic acid metabolic pathway, an exciting and essential pathway in plants.
Volume:	30
Issue:	2
Pages:	143-62

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Publication

7846152 | -

First Author:	Muehlbauer GJ
Year:	1994
Journal:	Plant Physiol
Title:	Molecular genetics of the maize (Zea mays L.) aspartate kinase-homoserine dehydrogenase gene family.
Volume:	106
Issue:	4
Pages:	1303-12

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Protein Domain

IPR041743 | AK-HSDH_N

Type:

Domain

Description:

This entry includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK-homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-HSDHI, ThrA and E. coli AKII-HSDHII, MetL) and higher plants (Z. mays AK-HSDH). AK and HSDH are the first and third enzymes in the biosynthetic pathway of the aspartate family of amino acids. AK catalyzes the phosphorylation of Asp to P-aspartyl phosphate. HSDH catalyzes the NADPH-dependent conversion of Asp 3-semialdehyde to homoserine. ThrA and MetL are involved in threonine and methionine biosynthesis, respectively. In E. coli, ThrA is subject to allosteric regulation by the end product L-threonine and the native enzyme is reported to be tetrameric. As with bacteria, plant AK and HSDH are feedback inhibited by pathway end products. Maize AK-HSDH is a Thr-sensitive 180kDa enzyme. Arabidopsis AK-HSDH is an alanine-activated, threonine-sensitive enzyme whose ACT domains, located C-terminal to the AK catalytic domain, were shown to be involved in allosteric activation [, , , , , , , ].

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Allele

Thra<tm2Ven> | MGI:2654864

Name:	thyroid hormone receptor alpha; targeted mutation 2, Bjorn Vennstrom
Allele Type:	Targeted
Attribute String:	Null/knockout

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Strain

MGI:5004061 | STOCK Tg(Thra-EGFP)KL340Gsat/Mmucd

Attribute String:

mutant stock, transgenic

•

Allele

Thra<tm1Ffla> | MGI:3758914

Name:	thyroid hormone receptor alpha; targeted mutation 1, Frederic Flamant
Allele Type:	Targeted
Attribute String:	Conditional ready, Dominant negative

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HT Experiment

GSE272299 | RNA-seq of laser-captured dissected endometrium of WT and Thra1 PV/+ mice


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Strain

MGI:4835205 | C;129P2-Thra<tm2Ven>/Kctt

Attribute String:

targeted mutation, mutant stock

•

Genotype

Symbol:	Thra/Thra
Background:	involves: 129P2/OlaHsd * C57BL/6NCrl
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Thra/Thra
Background:	involves: 129P2/OlaHsd * BALB/c * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Thra/Thra<+>
Background:	involves: 129P2/OlaHsd * BALB/c
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Thra/Thra
Background:	involves: 129P2/OlaHsd * BALB/c
Zygosity:	hm
Has Mutant Allele:	true

•

Publication

12435751 | -

First Author:	Paris S
Year:	2003
Journal:	J Biol Chem
Title:	Mechanism of control of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase by threonine.
Volume:	278
Issue:	7
Pages:	5361-6

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Publication

16216875 | -

First Author:	Curien G
Year:	2005
Journal:	J Biol Chem
Title:	Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity.
Volume:	280
Issue:	50
Pages:	41178-83

•

Publication

31628250 | J:281571

First Author:	Krieger TG
Year:	2019
Journal:	Proc Natl Acad Sci U S A
Title:	Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development.
Volume:	116
Issue:	45
Pages:	22754-22763

•

Publication

35996586 | J:330804

First Author:	Ali M
Year:	2022
Journal:	iScience
Title:	Transcriptional responses to injury of regenerative lung alveolar epithelium.
Volume:	25
Issue:	8
Pages:	104843

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Genotype

Symbol:	Thra/Thra<+> Tg(Sycp1-cre)4Min/?
Background:	involves: 129/Sv * C57BL/6 * DBA/2
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

29625991 | J:264811

First Author:	Aguayo-Mazzucato C
Year:	2018
Journal:	Diabetes
Title:	T₃ Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.
Volume:	67
Issue:	7
Pages:	1322-1331

•

Publication

39890871 | J:361627

First Author:	Edmondson E
Year:	2025
Journal:	Sci Rep
Title:	TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility.
Volume:	15
Issue:	1
Pages:	3892

•

Genotype

Symbol:	Thra/Thra Thrb/Thrb
Background:	involves: 129P2/OlaHsd * BALB/c * C57BL/6J
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Thra/Thra<+> Thrb/Thrb
Background:	involves: 129P2/OlaHsd * BALB/c * C57BL/6J
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Tg(CAG-cre/Esr1*)5Amc/? Thra/Thra<+>
Background:	involves: 129/Sv * C57BL/6 * CBA
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Tg(Nes-cre)1Kln/? Thra/Thra<+>
Background:	involves: 129 * C57BL/6 * SJL
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

28428265 | J:250132

First Author:	Ma H
Year:	2017
Journal:	FASEB J
Title:	Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.
Volume:	31
Issue:	8
Pages:	3425-3438

•

Publication

17229929 | J:121945

First Author:	Sridharan S
Year:	2007
Journal:	Biol Reprod
Title:	Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice.
Volume:	76
Issue:	5
Pages:	804-12

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Publication

22507269 | J:210502

First Author:	Kim WG
Year:	2013
Journal:	Biochim Biophys Acta
Title:	Thyroid hormone receptors and cancer.
Volume:	1830
Issue:	7
Pages:	3928-36

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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