| Type |
Details |
Score |
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 2, Henry M Sucov |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 3, Henry M Sucov |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 1, Henry M Sucov |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 4, Henry M Sucov |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 1, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
TNNI3 interacting kinase; endonuclease-mediated mutation 2, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
troponin I, cardiac 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, Inducible, Recombinase, Reporter |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-CASQ2)1Mord/? Tg(Myh6-TNNI3K)#Dmar/? Tnni3k/Tnni3k |
| Background: |
involves: C57BL/6J * DBA/2J * SJL/J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnni3k/Tnni3k |
| Background: |
involves: C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-CASQ2)1Mord/? Tnni3k/Tnni3k |
| Background: |
involves: AKR/J * DBA/2J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lodder EM |
| Year: |
2012 |
| Journal: |
PLoS Genet |
| Title: |
Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. |
| Volume: |
8 |
| Issue: |
12 |
| Pages: |
e1003113 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wiltshire SA |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis. |
| Volume: |
186 |
| Issue: |
11 |
| Pages: |
6398-405 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Christopher Semsarian |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 4, Christopher Semsarian |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Robert Stehle |
| Allele Type: |
Transgenic |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 133, Jeffrey Robbins |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 121, Jeffrey Robbins |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-TNNI3*G203S)4Chs/? |
| Background: |
Not Specified |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-TNNI3*G203S)1Chs/? |
| Background: |
Not Specified |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-Tnni3*R146G)133Rbns/? |
| Background: |
Not Specified |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-Tnni3*L184)#Rste/? |
| Background: |
B6.Cg-Tg(Myh6-Tnni3*L184)#Rste |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-Tnni3*R146G)121Rbns/? |
| Background: |
Not Specified |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Myh6-CASQ2)1Mord/? Tnni3k/Tnni3k |
| Background: |
involves: AKR/J * DBA/2J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnni3k/Tnni3k A1cf/? |
| Background: |
involves: C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Douglas A Marchuk |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnni3k/Tnni3k A1cf/A1cf<+> |
| Background: |
involves: C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wheeler FC |
| Year: |
2005 |
| Journal: |
Mamm Genome |
| Title: |
QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. |
| Volume: |
16 |
| Issue: |
6 |
| Pages: |
414-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aly M |
| Year: |
2007 |
| Journal: |
Genes Immun |
| Title: |
Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
193-204 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Vincent M Christoffels |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Vincent M Christoffels |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 270, Anne Murphy |
| Allele Type: |
Transgenic |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Anne Murphy |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion r-0.25, Vincent M Christoffels |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramirez-Correa GA |
| Year: |
2015 |
| Journal: |
J Appl Physiol (1985) |
| Title: |
Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity. |
| Volume: |
118 |
| Issue: |
2 |
| Pages: |
212-23 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takimoto E |
| Year: |
2004 |
| Journal: |
Circ Res |
| Title: |
Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites. |
| Volume: |
94 |
| Issue: |
4 |
| Pages: |
496-504 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 354, Anne Murphy |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Norton N |
| Year: |
2021 |
| Journal: |
Front Cardiovasc Med |
| Title: |
Trpc6 Promotes Doxorubicin-Induced Cardiomyopathy in Male Mice With Pleiotropic Differences Between Males and Females. |
| Volume: |
8 |
|
| Pages: |
757784 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Habets PE |
| Year: |
2002 |
| Journal: |
Genes Dev |
| Title: |
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. |
| Volume: |
16 |
| Issue: |
10 |
| Pages: |
1234-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Horsthuis T |
| Year: |
2008 |
| Journal: |
Circ Res |
| Title: |
Distinct regulation of developmental and heart disease-induced atrial natriuretic factor expression by two separate distal sequences. |
| Volume: |
102 |
| Issue: |
7 |
| Pages: |
849-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
| Year: |
2001 |
|
| Title: |
LocusLink Collaboration |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators, MGI curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GO Central curators, GOA curators, Rhea curators |
| Year: |
2020 |
|
| Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
