|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 773 for Traf3

<< First    < Previous  |  Next >    Last >>
0.051s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Traf3ip3<tm1a(KOMP)Wtsi> | MGI:4363678
Name: TRAF3 interacting protein 3; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Traf3ip3<tm1e(KOMP)Wtsi> | MGI:4364596
Name: TRAF3 interacting protein 3; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Traf3ip2<tm1a(EUCOMM)Wtsi> | MGI:4432269
Name: TRAF3 interacting protein 2; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Traf3ip2<tm1e(EUCOMM)Wtsi> | MGI:4434037
Name: TRAF3 interacting protein 2; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Strain
MGI:4820867 | A.KOR-Traf3ip2<adjm>
Attribute String: spontaneous mutation, mutant strain, congenic
•
•
•
•
•
Strain
MGI:4820866 | KOR-Traf3ip2<adjm>
Attribute String: coisogenic, mutant strain, spontaneous mutation
•
•
•
•
•
Strain
MGI:4820869 | C.KOR-Traf3ip2<adjm>
Attribute String: spontaneous mutation, mutant strain, congenic
•
•
•
•
•
Strain
MGI:4820868 | B6.KOR-Traf3ip2<adjm>
Attribute String: congenic, mutant strain, spontaneous mutation
•
•
•
•
•
Strain
MGI:6144515 | C.KOR1-Traf3ip2<adjm>/StmRbrc
Attribute String: mutant strain, congenic, spontaneous mutation
•
•
•
•
•
Strain
MGI:6144531 | A.KOR1-Traf3ip2<adjm>/StmRbrc
Attribute String: mutant strain, congenic, spontaneous mutation
•
•
•
•
•
Strain
MGI:4820870 | AK.KOR-Traf3ip2<adjm>
Attribute String: congenic, mutant strain, spontaneous mutation
•
•
•
•
•
Strain
MGI:6144495 | B6;KOR1-Traf3ip2<adjm>/StmRbrc
Attribute String: mutant stock, targeted mutation
•
•
•
•
•
Allele
Traf3ip2<Gt(IST13832B10)Tigm> | MGI:5186890
 
Name: TRAF3 interacting protein 2; gene trap IST13832B10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST13900D5)Tigm> | MGI:5195442
 
Name: TRAF3 interacting protein 2; gene trap IST13900D5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST14206G3)Tigm> | MGI:5213609
 
Name: TRAF3 interacting protein 2; gene trap IST14206G3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST14172G9)Tigm> | MGI:5214187
 
Name: TRAF3 interacting protein 2; gene trap IST14172G9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST14219G5)Tigm> | MGI:5216985
 
Name: TRAF3 interacting protein 2; gene trap IST14219G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip1<Gt(IST14437C6)Tigm> | MGI:5232150
 
Name: TRAF3 interacting protein 1; gene trap IST14437C6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST14582B8)Tigm> | MGI:5243324
 
Name: TRAF3 interacting protein 2; gene trap IST14582B8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST14781A4)Tigm> | MGI:5258895
 
Name: TRAF3 interacting protein 2; gene trap IST14781A4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip2<Gt(IST15080F5)Tigm> | MGI:5281330
 
Name: TRAF3 interacting protein 2; gene trap IST15080F5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Traf3ip1<tm1a(EUCOMM)Hmgu> | MGI:5436877
Name: TRAF3 interacting protein 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Traf3ip1<tm1e(EUCOMM)Hmgu> | MGI:5438919
Name: TRAF3 interacting protein 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Traf3ip3<tm1b(KOMP)Wtsi> | MGI:5795737
Name: TRAF3 interacting protein 3; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Traf3ip3<tm1c(KOMP)Wtsi> | MGI:5795738
Name: TRAF3 interacting protein 3; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
•
•
•
•
•
Allele
Traf3ip1<em1(IMPC)Bay> | MGI:6358077
Name: TRAF3 interacting protein 1; endonuclease-mediated mutation 1, Baylor College of Medicine
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: involves: 129/Sv * BALB/c
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: either: B6.129-Traf3ip2 or (involves: 129) or (involves: 129 * BALB/c)
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: KOR-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: C.KOR-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: B6.KOR-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: AK.KOR-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: A.KOR-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip1/Traf3ip1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: C.129-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: B6.129-Traf3ip2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
30962593 | J:282323
First Author: Majumder S
Year: 2019
Journal: Nat Immunol
Title: IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.
Volume: 20
Issue: 5
Pages: 534-545
•
•
•
•
•
Publication
25888259 | J:229778
First Author: Reynolds JM
Year: 2015
Journal: Immunity
Title: Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
Volume: 42
Issue: 4
Pages: 692-703
•
•
•
•
•
Publication
29563620 | J:282433
First Author: Herjan T
Year: 2018
Journal: Nat Immunol
Title: IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.
Volume: 19
Issue: 4
Pages: 354-365
•
•
•
•
•
Publication
30579117 | -
 
First Author: Wen J
Year: 2019
Journal: Mol Immunol
Title: USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells.
Volume: 106
Pages: 53-62
•
•
•
•
•
Publication
23150880 | -
First Author: Zhang P
Year: 2012
Journal: Sci Signal
Title: Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5.
Volume: 5
Issue: 250
Pages: ra81
•
•
•
•
•
Publication
14572659 | -
First Author: Dadgostar H
Year: 2003
Journal: FEBS Lett
Title: T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1).
Volume: 553
Issue: 3
Pages: 403-7
•
•
•
•
•
Publication
21982598 | J:177650
First Author: Chang SH
Year: 2011
Journal: Immunity
Title: Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.
Volume: 35
Issue: 4
Pages: 611-21
•
•
•
•
•
Publication
26431948 | J:233769
First Author: Lee JS
Year: 2015
Journal: Immunity
Title: Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.
Volume: 43
Issue: 4
Pages: 727-38
•
•
•
•
•
Publication
29070673 | J:251136
First Author: Zepp JA
Year: 2017
Journal: J Immunol
Title: IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Volume: 199
Issue: 11
Pages: 3849-3857
•
•
•
•
•
Publication
37725983 | J:341717
First Author: Taylor TC
Year: 2023
Journal: Cell Host Microbe
Title: IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.
Volume: 31
Issue: 10
Pages: 1700-1713.e4
•
•
•
•
•
Publication
28561022 | J:250338
 
First Author: Wang C
Year: 2017
Journal: Nat Commun
Title: IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.
Volume: 8
Pages: 15508
•
•
•
•
•
Publication
33723527 | J:304178
First Author: Lin X
Year: 2021
Journal: iScience
Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.
Volume: 24
Issue: 4
Pages: 102293
•
•
•
•
•
Publication
12459498 | J:113967
First Author: Kanamori M
Year: 2002
Journal: FEBS Lett
Title: NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6.
Volume: 532
Issue: 1-2
Pages: 241-6
•
•
•
•
•
Publication
29101209 | J:260574
 
First Author: Verma AH
Year: 2017
Journal: Sci Immunol
Title: Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.
Volume: 2
Issue: 17
•
•
•
•
•
Publication
31511356 | J:280270
First Author: Claudio E
Year: 2019
Journal: J Immunol
Title: IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology.
Volume: 203
Issue: 8
Pages: 2319-2327
•
•
•
•
•
Strain
MGI:7853391 | C57BL/6NTac-Traf3ip3<tm1a(KOMP)Wtsi>/WtsiH
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:6347635 | C57BL/6N-Traf3ip3<tm1a(KOMP)Wtsi>/Mmucd
Attribute String: mutant strain, coisogenic, targeted mutation
•
•
•
•
•
Strain
MGI:6335663 | C57BL/6NTac-Traf3ip3<tm1a(KOMP)Wtsi>/Wtsi
Attribute String: coisogenic, mutant strain, targeted mutation
•
•
•
•
•
Strain
MGI:5781480 | C57BL/6N-Traf3ip3<tm1a(KOMP)Wtsi>/Wtsi
Attribute String: coisogenic, targeted mutation
•
•
•
•
•
Strain
MGI:6866280 | C57BL/6N-Traf3ip1<em1(IMPC)Bay>/Mmmh
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:6731187 | C57BL/6N-Traf3ip1<em1(IMPC)Bay>/BayMmucd
Attribute String: coisogenic, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Cd40/Cd40 Traf3ip2/Traf3ip2
Background: involves: 129 * 129P2/OlaHsd * BALB/c
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip3/Traf3ip3
Background: C57BL/6N-Traf3ip3/Wtsi
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip3/Traf3ip3
Background: involves: BALB/cJ * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip1/Traf3ip1
Background: C57BL/6N-Traf3ip1/BayMmucd
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
27956525 | J:252186
First Author: Huang J
Year: 2017
Journal: J Immunol
Title: IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis.
Volume: 198
Issue: 2
Pages: 669-680
•
•
•
•
•
Publication
31239234 | J:298428
First Author: Lindstrom SI
Year: 2019
Journal: J Diabetes Complications
Title: Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.
Volume: 33
Issue: 9
Pages: 668-674
•
•
•
•
•
Publication
23355738 | J:193470
First Author: Zhang B
Year: 2013
Journal: J Immunol
Title: Crystal structure of IL-17 receptor B SEFIR domain.
Volume: 190
Issue: 5
Pages: 2320-6
•
•
•
•
•
Genotype
Genotype
Symbol: Fcgr2b/Fcgr2b Traf3ip2/Traf3ip2
Background: involves: 129 * 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip1/Traf3ip1<+>
Background: C57BL/6N-Traf3ip1/BayMmucd
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Ptch1/Ptch1<+> Traf3ip1/Traf3ip1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
30578323 | J:273043
First Author: Chen X
Year: 2019
Journal: J Exp Med
Title: IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells.
Volume: 216
Issue: 1
Pages: 195-214
•
•
•
•
•
Publication
20554964 | J:161934
First Author: Ho AW
Year: 2010
Journal: J Immunol
Title: IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.
Volume: 185
Issue: 2
Pages: 1063-70
•
•
•
•
•
Publication
21822257 | J:176466
First Author: Bulek K
Year: 2011
Journal: Nat Immunol
Title: The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.
Volume: 12
Issue: 9
Pages: 844-52
•
•
•
•
•
Publication
23453926 | J:201237
 
First Author: Valente AJ
Year: 2013
Journal: Free Radic Biol Med
Title: Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling.
Volume: 60
Pages: 125-35
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2 Tnfsf13b/Tnfsf13b
Background: involves: 129 * 129S2/SvPas * BALB/c
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Traf3ip2/Traf3ip2 Tg(CD19-cre/ERT2)1Cgn/?
Background: involves: 129/Sv * BALB/c
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Fcgr2b/Fcgr2b Traf3ip2/Traf3ip2<+>
Background: involves: 129 * 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Fcgr2b/Fcgr2b Traf3ip2/Traf3ip2<+>
Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
10903733 | -
First Author: Hatzoglou A
Year: 2000
Journal: J Immunol
Title: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.
Volume: 165
Issue: 3
Pages: 1322-30
•
•
•
•
•
Publication
21822258 | J:176465
First Author: Sun D
Year: 2011
Journal: Nat Immunol
Title: Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
Volume: 12
Issue: 9
Pages: 853-60
•
•
•
•
•
Publication
20139273 | J:159641
First Author: Xie S
Year: 2010
Journal: J Immunol
Title: IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.
Volume: 184
Issue: 5
Pages: 2289-96
•
•
•
•
•
Publication
9825865 | J:50810
First Author: Manova K
Year: 1998
Journal: Dev Dyn
Title: Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice.
Volume: 213
Issue: 3
Pages: 293-308
•
•
•
•
•
Strain
MGI:5617719 | B6.129-Tcrb<tm1Mom> Traf3ip2<tm1.1Lix> Tcrd<tm1Mom>
Attribute String: targeted mutation, mutant strain, congenic
•
•
•
•
•
Genotype
Genotype
Symbol: Tcrb/Tcrb Tcrd/Tcrd Traf3ip2/Traf3ip2
Background: B6.129-Tcrb Traf3ip2 Tcrd
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Fcgr2b/Fcgr2b Traf3ip2/Traf3ip2 Cd79a/Cd79a<+>
Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cd4-cre)1Cwi/? Traf3ip3/Traf3ip3
Background: involves: C57BL/6 * C57BL/6N * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
21307337 | J:183002
First Author: Keady BT
Year: 2011
Journal: Mol Biol Cell
Title: IFT20 is required for opsin trafficking and photoreceptor outer segment development.
Volume: 22
Issue: 7
Pages: 921-30
•
•
•
•
•
Publication
25443296 | J:217382
First Author: Liew GM
Year: 2014
Journal: Dev Cell
Title: The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
Volume: 31
Issue: 3
Pages: 265-78
•
•
•
•
•
Publication
22851696 | J:189138
First Author: Qu F
Year: 2012
Journal: Mol Cell Biol
Title: TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.
Volume: 32
Issue: 19
Pages: 3925-37
•
•
•
•
•
Publication
15585864 | -
First Author: Ni CZ
Year: 2004
Journal: J Immunol
Title: Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.
Volume: 173
Issue: 12
Pages: 7394-400
•
•
•
•
•
Protein Domain
IPR037304 | TRAF3_MATH
Type: Domain
Description: Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling []. It is a critical regulator of both innate and adaptive immune responses []. TRAF3 plays a role in the regulation of B-cell survival [], in the regulation of antiviral responses [], and in T-cell dependent immune responses []. It is required for normal antibody isotype switching from IgM to IgG []. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [].TRAF3 contains a RING finger domain, five zinc finger domains, and a TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [].
•
•
•
•
•
Protein Domain
IPR041476 | TRAF3IP1_C
Type: Domain
Description: TRAF3IP1, also known as MIP-T3, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved [].
•
•
•
•
•
Protein
A0A087WQD8
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
•
•
•
•
•
Publication
10791955 | -
First Author: Ling L
Year: 2000
Journal: J Biol Chem
Title: MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.
Volume: 275
Issue: 31
Pages: 23852-60
•
•
•
•
•
Protein Domain
IPR018799 | TRAF3IP1
Type: Family
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].
•
•
•
•
•
Publication
19253336 | J:154656
First Author: Follit JA
Year: 2009
Journal: Cell Motil Cytoskeleton
Title: Characterization of mouse IFT complex B.
Volume: 66
Issue: 8
Pages: 457-68
•
•
•
•
•
Publication
24596149 | J:215956
 
First Author: Ishikawa H
Year: 2014
Journal: Elife
Title: TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.
Volume: 3
Pages: e01566
•
•
•
•
•
Publication
26980730 | J:234200
First Author: Katoh Y
Year: 2016
Journal: J Biol Chem
Title: Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
Volume: 291
Issue: 21
Pages: 10962-75
•
•
•
•
•
Publication
12812986 | -
First Author: Morris JA
Year: 2003
Journal: Hum Mol Genet
Title: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Volume: 12
Issue: 13
Pages: 1591-608
•
•
•
•
•
Publication
12935900 | -
First Author: Niu Y
Year: 2003
Journal: FEBS Lett
Title: MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation.
Volume: 550
Issue: 1-3
Pages: 139-43
•
•
•
•
•
Protein Domain
IPR042576 | TRAF3IP1_N_sf
Type: Homologous_superfamily
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].This superfamily represents the N-terminal domain of TRAF3-interacting protein 1.
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom