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Search results 601 to 700 out of 721 for Tsc1

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Type Details Score
Interaction Experiment
Yasui S (2007)
Description: The TSC1 gene product hamartin interacts with NADE.
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Publication
30527742 | J:273019
First Author: Wu R
Year: 2019
Journal: Cell Metab
Title: The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex.
Volume: 29
Issue: 3
Pages: 653-667.e6
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Interaction Experiment
Lamb RF (2000)
Description: The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.
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Publication
9580671 | -
First Author: van Slegtenhorst M
Year: 1998
Journal: Hum Mol Genet
Title: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.
Volume: 7
Issue: 6
Pages: 1053-7
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Allele
Tsc1<tm1Smoc> | MGI:7293013
Name: TSC complex subunit 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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DO Term
DOID:0080324 | tuberous sclerosis 1
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HT Experiment
E-MTAB-1487 | Transcription profiling by array of mice overexpressing a transgenic mutant human TDP-43 (hTDP-43) gene and wild-type mice to study TDP-43 mutations in relation to amyotrophic lateral sclerosis
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE230175 | Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis.
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
16464865 | -
First Author: Chong-Kopera H
Year: 2006
Journal: J Biol Chem
Title: TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.
Volume: 281
Issue: 13
Pages: 8313-6
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HT Experiment
E-GEOD-74893 | Regulation of PERK-eIF2alpha Signaling by Tuberous Sclerosis Complex-1 Controls Homeostasis and Survival of Myelinating Oligodendrocytes
Series Id: GSE74893
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:6476552 | C57BL/6JSmoc-Tsc1<tm1Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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HT Experiment
GSE156891 | RNAseq analysis of gene expression profiles in a mouse model of tuberous sclerosis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q8BQP0
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein Domain
IPR007483 | Hamartin
Type: Family
Description: This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein . Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation in either TSC1 or TSC2 tumour suppressor genes. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin .
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Publication
15388229 | J:94922
First Author: Muto E
Year: 2004
Journal: Biochimie
Title: Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.
Volume: 86
Issue: 8
Pages: 523-31
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Publication
26039994 | -
First Author: Shathasivam P
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.
Volume: 112
Issue: 23
Pages: E3000-9
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Publication
16054033 | -
First Author: Teleman AA
Year: 2005
Journal: Dev Cell
Title: Drosophila Melted modulates FOXO and TOR activity.
Volume: 9
Issue: 2
Pages: 271-81
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Protein Domain
IPR039888 | Melted-like
Type: Family
Description: This entry includes protein melted from fruit flies and its homologues. They contain a single C-terminal PH domain that is required for membrane targeting. Melted interacts with both Tsc1 and FOXO and can recruit them to the cell membrane []. In vertebrates the melted protein homologue, veph, is expressed in the developing central nervous system []. The human homologue VEPH1 (ventricular zone-expressed PH domain-containing protein homologue 1) has been shown to inhibit TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI [].
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Protein
Q9EP53
Organism: Mus musculus/domesticus
Length: 1161  
Fragment?: false
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Protein
F2Z3X2
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
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Protein
F2Z3W0
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Publication
7558029 | J:27400
First Author: Xu L
Year: 1995
Journal: Genomics
Title: Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues.
Volume: 27
Issue: 3
Pages: 475-80
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Protein Domain
IPR003913 | Tuberin
Type: Family
Description: Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by a mutation in either the TSC1 or TSC2 tumour suppressor genes. The disease ischaracterised by hamartomas in one or more organs (including brain, skin,heart and kidney) giving rise to a broad phenotypic spectrum (including seizures, mental retardation, renal dysfunction and dermatological abnormalities. TSC2 encodes tuberin, a putative GTPase activatingprotein for rap1 and rab5. The TSC1 gene was recently identified and codesfor hamartin, a novel protein with no significant similarity to tuberin orany other known vertebrate protein []. Hamartin and tuberin have been shown to associate physically in vivo, their interaction being mediated by predicted coiled-coil domains. It is thought that hamartin and tuberin function in the same complex, rather than in separate pathways.Moreover, because oligomerisation of the hamartin C-terminal coiled coildomain is inhibited by the presence of tuberin, it is possible that tuberinacts as a chaperone, preventing hamartin self-aggregation [].Tuberin is a widely expressed 1784-amino-acid protein. Expression of the wild-type gene in TSC2 mutant tumour cells inhibits proliferation andtumorigenicity. This "suppressor"activity is encoded by a functionaldomain in the C terminus that shares similarity with the GTPase activatingprotein Rap1GAP []. It is thought that tuberin functions as a Rab5GAP in vivo to negatively regulate Rab5-GTP activity in endocytosis []. It also acts as a GTPase-activating protein (GAP) for the small GTPase RheB, a direct activator of the protein kinase activity of mTORC1 [, ].
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Publication
15340059 | -
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
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Publication
12271141 | -
First Author: Tee AR
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Volume: 99
Issue: 21
Pages: 13571-6
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Publication
11030407 | J:64752
First Author: Cheadle JP
Year: 2000
Journal: Hum Genet
Title: Molecular genetic advances in tuberous sclerosis.
Volume: 107
Issue: 2
Pages: 97-114
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Publication
37293130 | J:346335
 
First Author: Chalkiadaki K
Year: 2023
Journal: Front Cell Dev Biol
Title: Reversal of memory and autism-related phenotypes in Tsc2(+/-) mice via inhibition of Nlgn1.
Volume: 11
Pages: 1205112
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Publication
20062052 | J:156683
First Author: Nie D
Year: 2010
Journal: Nat Neurosci
Title: Tsc2-Rheb signaling regulates EphA-mediated axon guidance.
Volume: 13
Issue: 2
Pages: 163-72
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Publication
34253722 | J:307919
First Author: Alesi N
Year: 2021
Journal: Nat Commun
Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Volume: 12
Issue: 1
Pages: 4245
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Publication
25880340 | J:222712
 
First Author: Sugiura H
Year: 2015
Journal: Nat Commun
Title: Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.
Volume: 6
Pages: 6842
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Publication
36640300 | J:333114
First Author: Lee MC
Year: 2023
Journal: Cell Rep
Title: A multiplexed in vivo approach to identify driver genes in small cell lung cancer.
Volume: 42
Issue: 1
Pages: 111990
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Publication
33215753 | J:302301
First Author: Ko CJ
Year: 2021
Journal: EMBO J
Title: The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses.
Volume: 40
Issue: 2
Pages: e104532
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Publication
33910008 | J:337368
First Author: Hooshmandi M
Year: 2021
Journal: Cell Rep
Title: 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors.
Volume: 35
Issue: 4
Pages: 109036
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Publication
38195686 | J:351179
First Author: Alesi N
Year: 2024
Journal: Nat Commun
Title: TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex.
Volume: 15
Issue: 1
Pages: 406
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Publication
38107199 | J:350855
First Author: Riley VA
Year: 2023
Journal: iScience
Title: Tsc2 coordinates neuroprogenitor differentiation.
Volume: 26
Issue: 12
Pages: 108442
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Publication
39261456 | J:358813
First Author: Jiang X
Year: 2024
Journal: Nat Commun
Title: Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Volume: 15
Issue: 1
Pages: 7948
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Publication
15563020 | J:95490
First Author: Scheidenhelm DK
Year: 2004
Journal: J Child Neurol
Title: Mouse models of tuberous sclerosis complex.
Volume: 19
Issue: 9
Pages: 726-33
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Publication
17052453 | J:114397
First Author: Zhang HH
Year: 2006
Journal: Mol Cell
Title: S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.
Volume: 24
Issue: 2
Pages: 185-97
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Publication
15851026 | J:120197
First Author: Ma L
Year: 2005
Journal: Cell
Title: Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Volume: 121
Issue: 2
Pages: 179-93
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Publication
23955302 | J:201593
First Author: Zhang J
Year: 2013
Journal: Nat Cell Biol
Title: A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Volume: 15
Issue: 10
Pages: 1186-96
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Publication
35294228 | J:322875
First Author: Lee Y
Year: 2022
Journal: Sci Adv
Title: Hematopoietic stem cells temporally transition to thrombopoietin dependence in the fetal liver.
Volume: 8
Issue: 11
Pages: eabm7688
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Protein
Q3UI96
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
A0A2I3BPE9
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
Q3UG84
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
Q3TBX9
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: true
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Publication
9045618 | -
First Author: Xiao GH
Year: 1997
Journal: J Biol Chem
Title: The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
Volume: 272
Issue: 10
Pages: 6097-100
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Publication
15988001 | J:99368
First Author: Sofer A
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of mTOR and cell growth in response to energy stress by REDD1.
Volume: 25
Issue: 14
Pages: 5834-45
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Publication
25157160 | J:216395
First Author: Li Z
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway.
Volume: 111
Issue: 36
Pages: 13163-8
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Publication
10491404 | J:57631
First Author: Onda H
Year: 1999
Journal: J Clin Invest
Title: Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background.
Volume: 104
Issue: 6
Pages: 687-95
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Publication
23386687 | J:205463
First Author: Guo Y
Year: 2013
Journal: Mol Cancer Res
Title: Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis.
Volume: 11
Issue: 5
Pages: 467-73
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Publication
15972957 | J:99509
First Author: Mak BC
Year: 2005
Journal: Am J Pathol
Title: Aberrant beta-catenin signaling in tuberous sclerosis.
Volume: 167
Issue: 1
Pages: 107-16
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Publication
29364507 | J:263225
First Author: Saré RM
Year: 2018
Journal: J Neurochem
Title: Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin.
Volume: 145
Issue: 5
Pages: 417-425
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Publication
15578690 | J:95229
First Author: Lee L
Year: 2005
Journal: Genes Chromosomes Cancer
Title: Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models.
Volume: 42
Issue: 3
Pages: 213-27
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Publication
20159776 | J:159339
First Author: Cao J
Year: 2010
Journal: Hum Mol Genet
Title: Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice.
Volume: 19
Issue: 10
Pages: 1908-20
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Publication
32303566 | J:288768
 
First Author: Saré RM
Year: 2020
Journal: eNeuro
Title: Sex-Selective Effects on Behavior in a Mouse Model of Tuberous Sclerosis Complex.
Volume: 7
Issue: 2
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Publication
30928642 | J:282236
 
First Author: Okamoto SI
Year: 2019
Journal: Neurobiol Dis
Title: NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.
Volume: 127
Pages: 390-397
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Publication
22363765 | J:252088
First Author: Auricchio N
Year: 2012
Journal: PLoS One
Title: Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).
Volume: 7
Issue: 2
Pages: e31900
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Publication
19602587 | J:150957
First Author: Huang J
Year: 2009
Journal: Cancer Res
Title: Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
Volume: 69
Issue: 15
Pages: 6107-14
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Publication
19527517 | J:157342
 
First Author: Pollizzi K
Year: 2009
Journal: Mol Cancer
Title: Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.
Volume: 8
Pages: 38
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Publication
16390268 | J:107438
First Author: Brown AB
Year: 2005
Journal: Hum Gene Ther
Title: Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Volume: 16
Issue: 12
Pages: 1367-76
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Publication
22752306 | J:187405
First Author: Yuan E
Year: 2012
Journal: Hum Mol Genet
Title: Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features.
Volume: 21
Issue: 19
Pages: 4286-300
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Publication
27768862 | J:238741
First Author: Ren S
Year: 2016
Journal: Am J Pathol
Title: Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.
Volume: 186
Issue: 12
Pages: 3261-3272
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Publication
34806651 | J:316405
 
First Author: Thomas A
Year: 2021
Journal: JCI Insight
Title: Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice.
Volume: 6
Issue: 22
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Publication
29501742 | J:273677
First Author: Li H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.
Volume: 498
Issue: 1
Pages: 234-239
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Publication
23359422 | J:195049
First Author: Fu C
Year: 2013
Journal: Genesis
Title: Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.
Volume: 51
Issue: 4
Pages: 284-92
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Publication
23123587 | J:197492
 
First Author: Reith RM
Year: 2013
Journal: Neurobiol Dis
Title: Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex.
Volume: 51
Pages: 93-103
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Publication
25613864 | J:220337
First Author: Rozas NS
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.
Volume: 457
Issue: 4
Pages: 635-9
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Publication
32588887 | J:294610
First Author: Kapfhamer D
Year: 2020
Journal: Hum Mol Genet
Title: Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
Volume: 29
Issue: 14
Pages: 2395-2407
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Publication
29635516 | J:262779
First Author: McKenna J 3rd
Year: 2018
Journal: Hum Mol Genet
Title: Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.
Volume: 27
Issue: 12
Pages: 2113-2124
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Publication
22532572 | J:185369
First Author: Way SW
Year: 2012
Journal: Hum Mol Genet
Title: The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.
Volume: 21
Issue: 14
Pages: 3226-36
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Publication
31636454 | J:291719
First Author: Chen CJ
Year: 2019
Journal: Nat Med
Title: Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.
Volume: 25
Issue: 11
Pages: 1684-1690
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Publication
23820898 | J:221228
First Author: Prizant H
Year: 2013
Journal: Mol Endocrinol
Title: Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.
Volume: 27
Issue: 9
Pages: 1403-14
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Publication
26693177 | J:239993
 
First Author: Crowell B
Year: 2015
Journal: eNeuro
Title: Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).
Volume: 2
Issue: 6
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Publication
18806760 | J:158108
First Author: Maiuri MC
Year: 2009
Journal: Cell Death Differ
Title: Control of autophagy by oncogenes and tumor suppressor genes.
Volume: 16
Issue: 1
Pages: 87-93
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Publication
23049074 | J:191137
First Author: Carson RP
Year: 2013
Journal: Hum Mol Genet
Title: Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.
Volume: 22
Issue: 1
Pages: 140-52
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Publication
39365820 | J:357549
First Author: Stransky LA
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned.
Volume: 121
Issue: 41
Pages: e2408549121
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Publication
24707048 | J:208865
First Author: Clifford MA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: EphA7 signaling guides cortical dendritic development and spine maturation.
Volume: 111
Issue: 13
Pages: 4994-9
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Publication
31078684 | J:288652
 
First Author: Short B
Year: 2019
Journal: Neurobiol Dis
Title: Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex.
Volume: 129
Pages: 93-101
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Publication
29509898 | J:261762
First Author: Ogórek B
Year: 2018
Journal: Hum Mol Genet
Title: TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.
Volume: 27
Issue: 9
Pages: 1654-1663
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Publication
19738049 | J:152687
First Author: Bhatia B
Year: 2009
Journal: Cancer Res
Title: Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
Volume: 69
Issue: 18
Pages: 7224-34
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Publication
20038814 | J:156692
First Author: Ma J
Year: 2010
Journal: J Clin Invest
Title: Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.
Volume: 120
Issue: 1
Pages: 103-14
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Publication
33664851 | J:322079
First Author: Lou P
Year: 2021
Journal: Theranostics
Title: MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways.
Volume: 11
Issue: 8
Pages: 3607-3623
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Publication
26883642 | J:271810
First Author: Krityakiarana W
Year: 2016
Journal: Neurochem Res
Title: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration.
Volume: 41
Issue: 1-2
Pages: 431-49
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Publication
24961618 | J:271813
First Author: Espinosa-Jeffrey A
Year: 2013
Journal: Brain Sci
Title: White matter loss in a mouse model of periventricular leukomalacia is rescued by trophic factors.
Volume: 3
Issue: 4
Pages: 1461-82
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Publication
10827137 | J:62413
First Author: Pasumarthi KB
Year: 2000
Journal: Circ Res
Title: Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene.
Volume: 86
Issue: 10
Pages: 1069-77
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Publication
10029074 | J:52822
First Author: Satake N
Year: 1999
Journal: Cancer Res
Title: Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.
Volume: 59
Issue: 4
Pages: 849-55
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Publication
15150095 | J:90253
First Author: El-Hashemite N
Year: 2004
Journal: Cancer Res
Title: Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment.
Volume: 64
Issue: 10
Pages: 3436-43
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Publication
17290308 | J:120746
First Author: Zhang H
Year: 2007
Journal: J Clin Invest
Title: PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.
Volume: 117
Issue: 3
Pages: 730-8
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Publication
18490760 | J:136345
First Author: Dan HC
Year: 2008
Journal: J Immunol
Title: Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.
Volume: 180
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Pages: 7582-9
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Publication
27819329 | J:259561
 
First Author: Shan L
Year: 2016
Journal: Sci Rep
Title: mTOR Overactivation in Mesenchymal cells Aggravates CCl4- Induced liver Fibrosis.
Volume: 6
Pages: 36037
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26975583 | J:250629
First Author: Campos T
Year: 2016
Journal: Biochim Biophys Acta
Title: Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival.
Volume: 1863
Issue: 6 Pt A
Pages: 1200-7
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29339522 | J:257758
First Author: Le K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Effect of beta-agonists on LAM progression and treatment.
Volume: 115
Issue: 5
Pages: E944-E953
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Publication
29712777 | J:262236
First Author: Umegaki Y
Year: 2018
Journal: J Neurosci
Title: Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis.
Volume: 38
Issue: 21
Pages: 4985-4995
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Publication
29406787 | J:275730
First Author: Steagall WK
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: The Lymphangioleiomyomatosis Lung Cell and Its Human Cell Models.
Volume: 58
Issue: 6
Pages: 678-683
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37653031 | J:343190
First Author: Zhang J
Year: 2023
Journal: Exp Mol Med
Title: Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice.
Volume: 55
Issue: 10
Pages: 2162-2176
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31024074 | J:304910
First Author: Gui Y
Year: 2019
Journal: Cell Death Differ
Title: Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury.
Volume: 26
Issue: 12
Pages: 2774-2789
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33863779 | J:307156
First Author: Wu H
Year: 2021
Journal: Cancer Res
Title: mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
Volume: 81
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Pages: 3174-3186
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34544857 | J:311176
 
First Author: Wang J
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Volume: 118
Issue: 39
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First Author: Gong Q
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Journal: Hepatology
Title: Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice.
Volume: 64
Issue: 2
Pages: 425-38
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Publication
35931213 | J:330809
 
First Author: Koike-Kumagai M
Year: 2022
Journal: Neuropharmacology
Title: Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice.
Volume: 218
Pages: 109203
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