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Search results 601 to 686 out of 686 for Tsc2

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Type Details Score
Publication
25081057 | J:272428
 
First Author: Lozovaya N
Year: 2014
Journal: Nat Commun
Title: Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
Volume: 5
Pages: 4563
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Publication
30988000 | J:276866
 
First Author: Byun JK
Year: 2019
Journal: EMBO Rep
Title: Oncogenic KRAS signaling activates mTORC1 through COUP-TFII-mediated lactate production.
Volume: 20
Issue: 6
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Publication
32294430 | J:306324
First Author: Romero-Pozuelo J
Year: 2020
Journal: Cell Rep
Title: Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1.
Volume: 31
Issue: 2
Pages: 107504
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Protein
Q3UI96
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
A0A2I3BPE9
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
Q3UG84
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
Q3TBX9
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: true
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Publication
9045618 | -
First Author: Xiao GH
Year: 1997
Journal: J Biol Chem
Title: The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
Volume: 272
Issue: 10
Pages: 6097-100
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Publication
15988001 | J:99368
First Author: Sofer A
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of mTOR and cell growth in response to energy stress by REDD1.
Volume: 25
Issue: 14
Pages: 5834-45
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Publication
26037201 | J:225916
First Author: Xu G
Year: 2015
Journal: Diabetologia
Title: Intestinal mTOR regulates GLP-1 production in mouse L cells.
Volume: 58
Issue: 8
Pages: 1887-97
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Publication
23696872 | J:221022
First Author: Prabhakar S
Year: 2013
Journal: PLoS One
Title: Stochastic model of Tsc1 lesions in mouse brain.
Volume: 8
Issue: 5
Pages: e64224
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Publication
19692352 | J:153717
First Author: Zhou J
Year: 2009
Journal: Hum Mol Genet
Title: Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.
Volume: 18
Issue: 22
Pages: 4428-41
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Publication
23851502 | J:212578
First Author: Guo Y
Year: 2014
Journal: Oncogene
Title: Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma.
Volume: 33
Issue: 24
Pages: 3151-60
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Publication
36115548 | J:360290
 
First Author: Zhang J
Year: 2022
Journal: Cell Signal
Title: LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions.
Volume: 100
Pages: 110468
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Publication
33536341 | J:301986
 
First Author: Barone S
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Volume: 118
Issue: 6
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Publication
24599401 | J:210659
First Author: Di Nardo A
Year: 2014
Journal: Hum Mol Genet
Title: Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
Volume: 23
Issue: 14
Pages: 3865-74
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Publication
37310065 | J:359038
First Author: Namikawa M
Year: 2023
Journal: J Pathol
Title: Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
Volume: 260
Issue: 4
Pages: 478-492
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Publication
16912167 | J:112107
First Author: Wilson C
Year: 2006
Journal: Cancer Res
Title: Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice.
Volume: 66
Issue: 16
Pages: 7934-8
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Publication
19690069 | J:159576
First Author: Mori H
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Critical roles for the TSC-mTOR pathway in β-cell function.
Volume: 297
Issue: 5
Pages: E1013-22
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Publication
26296882 | J:225965
First Author: Hu Z
Year: 2015
Journal: J Biol Chem
Title: Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.
Volume: 290
Issue: 42
Pages: 25756-65
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Publication
18495876 | J:136366
First Author: Meikle L
Year: 2008
Journal: J Neurosci
Title: Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.
Volume: 28
Issue: 21
Pages: 5422-32
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Publication
19420259 | J:148479
First Author: Di Nardo A
Year: 2009
Journal: J Neurosci
Title: Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.
Volume: 29
Issue: 18
Pages: 5926-37
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Publication
23197407 | J:232309
First Author: Wang RH
Year: 2013
Journal: EMBO Mol Med
Title: The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling.
Volume: 5
Issue: 1
Pages: 137-48
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Publication
21403402 | J:172004
First Author: Feliciano DM
Year: 2011
Journal: J Clin Invest
Title: Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice.
Volume: 121
Issue: 4
Pages: 1596-607
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Publication
15781664 | J:97168
First Author: El-Hashemite N
Year: 2005
Journal: Cancer Res
Title: Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
Volume: 65
Issue: 6
Pages: 2474-81
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Publication
15601645 | J:96138
First Author: Meikle L
Year: 2005
Journal: Hum Mol Genet
Title: A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes.
Volume: 14
Issue: 3
Pages: 429-35
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Publication
33184932 | J:309557
First Author: Wei Z
Year: 2021
Journal: FASEB J
Title: Death-associated protein kinase 1 (DAPK1) controls CD8+ T cell activation, trafficking, and antitumor activity.
Volume: 35
Issue: 1
Pages: e21138
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Publication
19966866 | J:160400
First Author: Liang MC
Year: 2010
Journal: Oncogene
Title: TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.
Volume: 29
Issue: 11
Pages: 1588-97
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Publication
15888477 | J:99796
First Author: Wilson C
Year: 2005
Journal: Hum Mol Genet
Title: A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma.
Volume: 14
Issue: 13
Pages: 1839-50
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Publication
30760873 | J:305028
First Author: Li C
Year: 2019
Journal: Cell Death Differ
Title: mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis.
Volume: 26
Issue: 10
Pages: 2015-2028
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Publication
21212099 | J:169239
First Author: Malhowski AJ
Year: 2011
Journal: Hum Mol Genet
Title: Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.
Volume: 20
Issue: 7
Pages: 1290-305
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Publication
33071758 | J:313985
 
First Author: Wundrach D
Year: 2020
Journal: Front Mol Neurosci
Title: A Human TSC1 Variant Screening Platform in Gabaergic Cortical Interneurons for Genotype to Phenotype Assessments.
Volume: 13
Pages: 573409
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Publication
24633152 | J:215111
First Author: Pilipow K
Year: 2014
Journal: PLoS One
Title: Monoallelic germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in tuberous sclerosis complex individuals.
Volume: 9
Issue: 3
Pages: e91952
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Publication
26449264 | J:226834
First Author: Jones I
Year: 2015
Journal: Dis Model Mech
Title: A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development.
Volume: 8
Issue: 12
Pages: 1517-29
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Publication
22674026 | J:188431
First Author: Armour EA
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.
Volume: 303
Issue: 4
Pages: F584-92
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Publication
23901139 | J:259996
First Author: Ersoy BA
Year: 2013
Journal: Sci Signal
Title: Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
Volume: 6
Issue: 286
Pages: ra64
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Publication
23049074 | J:191137
First Author: Carson RP
Year: 2013
Journal: Hum Mol Genet
Title: Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.
Volume: 22
Issue: 1
Pages: 140-52
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Publication
25315696 | J:218407
First Author: Britto FA
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.
Volume: 307
Issue: 11
Pages: E983-93
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Publication
26487002 | J:229689
First Author: Steiner JL
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle.
Volume: 309
Issue: 12
Pages: E981-94
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Publication
28933629 | J:337049
First Author: Kim SH
Year: 2017
Journal: Autophagy
Title: Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition.
Volume: 13
Issue: 10
Pages: 1767-1781
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Publication
31599935 | J:281732
First Author: Jin X
Year: 2019
Journal: Endocrinology
Title: Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling.
Volume: 160
Issue: 12
Pages: 3001-3017
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Publication
9721882 | J:49218
First Author: Chung DC
Year: 1998
Journal: Cancer Res
Title: Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors.
Volume: 58
Issue: 16
Pages: 3706-11
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Publication
9861021 | J:51662
First Author: Rennebeck G
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development.
Volume: 95
Issue: 26
Pages: 15629-34
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Publication
10029074 | J:52822
First Author: Satake N
Year: 1999
Journal: Cancer Res
Title: Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.
Volume: 59
Issue: 4
Pages: 849-55
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Publication
15150095 | J:90253
First Author: El-Hashemite N
Year: 2004
Journal: Cancer Res
Title: Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment.
Volume: 64
Issue: 10
Pages: 3436-43
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Publication
12547704 | J:94888
First Author: Cai S
Year: 2003
Journal: Am J Pathol
Title: Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.
Volume: 162
Issue: 2
Pages: 457-68
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Publication
17290308 | J:120746
First Author: Zhang H
Year: 2007
Journal: J Clin Invest
Title: PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.
Volume: 117
Issue: 3
Pages: 730-8
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Publication
18490760 | J:136345
First Author: Dan HC
Year: 2008
Journal: J Immunol
Title: Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.
Volume: 180
Issue: 11
Pages: 7582-9
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Publication
20363874 | J:162261
First Author: Ning J
Year: 2010
Journal: Mol Endocrinol
Title: AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation.
Volume: 24
Issue: 6
Pages: 1218-29
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Publication
20068142 | J:164333
First Author: Chakrabarti P
Year: 2010
Journal: Diabetes
Title: Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.
Volume: 59
Issue: 4
Pages: 775-81
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Publication
23354068 | J:199039
First Author: Zhang B
Year: 2013
Journal: Biochim Biophys Acta
Title: Mitochondrial aldehyde dehydrogenase obliterates endoplasmic reticulum stress-induced cardiac contractile dysfunction via correction of autophagy.
Volume: 1832
Issue: 4
Pages: 574-84
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Publication
24691995 | J:210808
First Author: Tyryshkin A
Year: 2014
Journal: Cancer Res
Title: SRC kinase is a novel therapeutic target in lymphangioleiomyomatosis.
Volume: 74
Issue: 7
Pages: 1996-2005
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Publication
24604753 | J:210827
First Author: Ferrer I
Year: 2014
Journal: J Pathol
Title: Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling.
Volume: 233
Issue: 3
Pages: 247-57
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Publication
29339522 | J:257758
First Author: Le K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Effect of beta-agonists on LAM progression and treatment.
Volume: 115
Issue: 5
Pages: E944-E953
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Publication
25372051 | J:259834
First Author: Mackey AM
Year: 2014
Journal: Sci Signal
Title: PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation.
Volume: 7
Issue: 350
Pages: ra104
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Publication
29406787 | J:275730
First Author: Steagall WK
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: The Lymphangioleiomyomatosis Lung Cell and Its Human Cell Models.
Volume: 58
Issue: 6
Pages: 678-683
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Publication
32078336 | J:306071
First Author: Han F
Year: 2020
Journal: Am J Respir Cell Mol Biol
Title: Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis.
Volume: 62
Issue: 6
Pages: 793-804
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Publication
34301883 | J:308543
 
First Author: Lai M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Tsc1 regulates tight junction independent of mTORC1.
Volume: 118
Issue: 30
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Publication
34544857 | J:311176
 
First Author: Wang J
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Volume: 118
Issue: 39
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Publication
35931213 | J:330809
 
First Author: Koike-Kumagai M
Year: 2022
Journal: Neuropharmacology
Title: Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice.
Volume: 218
Pages: 109203
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Publication
24564913 | J:355930
First Author: Kong SW
Year: 2014
Journal: Mol Autism
Title: Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis.
Volume: 5
Issue: 1
Pages: 16
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Publication
24958103 | J:224268
First Author: Kurbegovic A
Year: 2014
Journal: Mol Cell Biol
Title: Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease.
Volume: 34
Issue: 17
Pages: 3341-53
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Protein
Q61037
Organism: Mus musculus/domesticus
Length: 1814  
Fragment?: false
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Protein
Q3UHB2
Organism: Mus musculus/domesticus
Length: 1808  
Fragment?: false
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Protein
A0A2I3BRT5
Organism: Mus musculus/domesticus
Length: 1741  
Fragment?: false
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Protein
A0A2I3BPP1
Organism: Mus musculus/domesticus
Length: 1785  
Fragment?: false
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Protein
Q3TCQ7
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Protein
Q3UG88
Organism: Mus musculus/domesticus
Length: 1785  
Fragment?: false
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Protein
Q3UGI8
Organism: Mus musculus/domesticus
Length: 1678  
Fragment?: true
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Protein
Q7TT21
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Publication
28473248 | J:359139
 
First Author: Fan W
Year: 2017
Journal: Free Radic Biol Med
Title: Endothelial deletion of mTORC1 protects against hindlimb ischemia in diabetic mice via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation.
Volume: 108
Pages: 725-740
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Publication
26224859 | J:226921
First Author: Nie D
Year: 2015
Journal: J Neurosci
Title: The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
Volume: 35
Issue: 30
Pages: 10762-72
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Publication
28694334 | J:246657
First Author: McLane LE
Year: 2017
Journal: J Neurosci
Title: Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination.
Volume: 37
Issue: 31
Pages: 7534-7546
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Publication
30467464 | J:312062
 
First Author: Cox RL
Year: 2018
Journal: Front Mol Neurosci
Title: Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain.
Volume: 11
Pages: 409
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Publication
29023667 | J:273722
First Author: Zou J
Year: 2017
Journal: Epilepsia
Title: Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.
Volume: 58
Issue: 12
Pages: 2053-2063
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Publication
32375878 | J:317669
First Author: Haji N
Year: 2020
Journal: Mol Autism
Title: Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice.
Volume: 11
Issue: 1
Pages: 29
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Publication
20041218 | J:161738
First Author: Mashimo T
Year: 2009
Journal: PLoS Genet
Title: Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.
Volume: 5
Issue: 12
Pages: e1000784
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Publication
28701918 | J:314369
 
First Author: Lee Y
Year: 2017
Journal: Front Mol Neurosci
Title: Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling.
Volume: 10
Pages: 201
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Publication
28347844 | J:255686
First Author: Zhang Y
Year: 2017
Journal: Biochim Biophys Acta
Title: Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging.
Volume: 1863
Issue: 8
Pages: 1919-1932
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Publication
38028758 | J:343064
 
First Author: Soleimani M
Year: 2023
Journal: Front Physiol
Title: Not all kidney cysts are created equal: a distinct renal cystogenic mechanism in tuberous sclerosis complex (TSC).
Volume: 14
Pages: 1289388
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Publication
31744486 | J:287187
First Author: Liu W
Year: 2019
Journal: BMC Complement Altern Med
Title: Weipiling ameliorates gastric precancerous lesions in Atp4a-/- mice.
Volume: 19
Issue: 1
Pages: 318
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Protein
Q8BNK4
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: true
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Protein
Q921J2
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q9ESR1
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q540E6
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
E9PZP8
Organism: Mus musculus/domesticus
Length: 4859  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom