Type |
Details |
Score |
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Arita K |
Year: |
2008 |
Journal: |
Nature |
Title: |
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. |
Volume: |
455 |
Issue: |
7214 |
Pages: |
818-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto H |
Year: |
2008 |
Journal: |
Nature |
Title: |
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. |
Volume: |
455 |
Issue: |
7214 |
Pages: |
826-9 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-77941 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
123
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
true |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitine-protein ligase UHRF1 and modulates UHRF1 biological functions. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma H |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. |
Volume: |
109 |
Issue: |
13 |
Pages: |
4828-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muto M |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks. |
Volume: |
277 |
Issue: |
37 |
Pages: |
34549-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muto M |
Year: |
1995 |
Journal: |
Cell Prolif |
Title: |
The characterization of the monoclonal antibody Th-10a, specific for a nuclear protein appearing in the S phase of the cell cycle in normal thymocytes and its unregulated expression in lymphoma cell lines. |
Volume: |
28 |
Issue: |
12 |
Pages: |
645-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miura M |
Year: |
2001 |
Journal: |
Exp Cell Res |
Title: |
Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication foci. |
Volume: |
263 |
Issue: |
2 |
Pages: |
202-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonapace IM |
Year: |
2002 |
Journal: |
J Cell Biol |
Title: |
Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry. |
Volume: |
157 |
Issue: |
6 |
Pages: |
909-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Unoki M |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. |
Volume: |
23 |
Issue: |
46 |
Pages: |
7601-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rottach A |
Year: |
2010 |
Journal: |
Nucleic Acids Res |
Title: |
The multi-domain protein Np95 connects DNA methylation and histone modification. |
Volume: |
38 |
Issue: |
6 |
Pages: |
1796-804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto H |
Year: |
2009 |
Journal: |
Epigenetics |
Title: |
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. |
Volume: |
4 |
Issue: |
1 |
Pages: |
8-14 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Critical Role of the UBL Domain in Stimulating the E3Ubiquitin Ligase Activity of UHRF1 toward Chromatin. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. |
|
•
•
•
•
•
|
Publication |
First Author: |
De Vos M |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions. |
Volume: |
289 |
Issue: |
23 |
Pages: |
16223-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferry L |
Year: |
2017 |
Journal: |
Mol Cell |
Title: |
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. |
Volume: |
67 |
Issue: |
4 |
Pages: |
550-565.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smets M |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. |
Volume: |
26 |
Issue: |
8 |
Pages: |
1522-1534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foster BM |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
Critical Role of the UBL Domain in Stimulating the E3Â Ubiquitin Ligase Activity of UHRF1 toward Chromatin. |
Volume: |
72 |
Issue: |
4 |
Pages: |
739-752.e9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hata K |
Year: |
2022 |
Journal: |
Nucleic Acids Res |
Title: |
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. |
Volume: |
50 |
Issue: |
21 |
Pages: |
12527-12542 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh YM |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. |
Volume: |
115 |
Issue: |
52 |
Pages: |
E12417-E12426 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3) [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
202
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2017 |
Journal: |
Epigenetics |
Title: |
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures. |
Volume: |
12 |
Issue: |
7 |
Pages: |
551-560 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aibara D |
Year: |
2022 |
Journal: |
iScience |
Title: |
Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation. |
Volume: |
25 |
Issue: |
5 |
Pages: |
104196 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Q |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals. |
Volume: |
7 |
|
Pages: |
12464 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Meyenn F |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells. |
Volume: |
62 |
Issue: |
6 |
Pages: |
848-861 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2019 |
Journal: |
Dev Cell |
Title: |
Epigenetic Compensation Promotes Liver Regeneration. |
Volume: |
50 |
Issue: |
1 |
Pages: |
43-56.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pichler G |
Year: |
2011 |
Journal: |
J Cell Biochem |
Title: |
Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways. |
Volume: |
112 |
Issue: |
9 |
Pages: |
2585-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Q |
Year: |
2020 |
Journal: |
Mol Reprod Dev |
Title: |
Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development. |
Volume: |
87 |
Issue: |
5 |
Pages: |
550-564 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giaccari C |
Year: |
2024 |
Journal: |
Genes Dev |
Title: |
A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos. |
Volume: |
38 |
Issue: |
3-4 |
Pages: |
131-150 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
803
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Trost M |
Year: |
2009 |
Journal: |
Immunity |
Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
Volume: |
30 |
Issue: |
1 |
Pages: |
143-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villén J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Large-scale phosphorylation analysis of mouse liver. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1488-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|