Type |
Details |
Score |
Publication |
First Author: |
To AW |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. |
Volume: |
6 |
Issue: |
2 |
Pages: |
e16991 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung YY |
Year: |
2018 |
Journal: |
Theranostics |
Title: |
Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice. |
Volume: |
8 |
Issue: |
3 |
Pages: |
749-766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Austin SA |
Year: |
2010 |
Journal: |
Circ Res |
Title: |
Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. |
Volume: |
107 |
Issue: |
12 |
Pages: |
1498-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia W |
Year: |
1998 |
Journal: |
Biochemistry |
Title: |
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. |
Volume: |
37 |
Issue: |
47 |
Pages: |
16465-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davis SA |
Year: |
2017 |
Journal: |
Neurobiol Dis |
Title: |
TDP-43 expression influences amyloidβ plaque deposition and tau aggregation. |
Volume: |
103 |
|
Pages: |
154-162 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuyama K |
Year: |
2022 |
Journal: |
Alzheimers Res Ther |
Title: |
Immuno-digital invasive cleavage assay for analyzing Alzheimer's amyloid ß-bound extracellular vesicles. |
Volume: |
14 |
Issue: |
1 |
Pages: |
140 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2021 |
Journal: |
Front Physiol |
Title: |
Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer's Disease. |
Volume: |
12 |
|
Pages: |
715446 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2010 |
Journal: |
Behav Brain Res |
Title: |
Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. |
Volume: |
206 |
Issue: |
2 |
Pages: |
202-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maesako M |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e72796 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koppel J |
Year: |
2013 |
Journal: |
Mol Med |
Title: |
CBâ‚‚ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. |
Volume: |
19 |
Issue: |
1 |
Pages: |
357-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koppel J |
Year: |
2014 |
Journal: |
Mol Med |
Title: |
CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. |
Volume: |
20 |
Issue: |
1 |
Pages: |
29-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitaguchi H |
Year: |
2009 |
Journal: |
Brain Res |
Title: |
Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice. |
Volume: |
1294 |
|
Pages: |
202-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2021 |
Journal: |
PLoS One |
Title: |
The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model. |
Volume: |
16 |
Issue: |
7 |
Pages: |
e0242236 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chintapaludi SR |
Year: |
2020 |
Journal: |
J Alzheimers Dis |
Title: |
Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling. |
Volume: |
73 |
Issue: |
4 |
Pages: |
1421-1434 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kolonics A |
Year: |
2023 |
Journal: |
BMC Neurosci |
Title: |
Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer's disease. |
Volume: |
24 |
Issue: |
1 |
Pages: |
68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheng JG |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. |
Volume: |
22 |
Issue: |
22 |
Pages: |
9794-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
KÃ¥gedal K |
Year: |
2010 |
Journal: |
Biochim Biophys Acta |
Title: |
Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease. |
Volume: |
1801 |
Issue: |
8 |
Pages: |
831-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez Garcia G |
Year: |
2023 |
Journal: |
Front Dement |
Title: |
Beneficial effects of physical exercise and an orally active mGluR2/3 antagonist pro-drug on neurogenesis and behavior in an Alzheimer's amyloidosis model. |
Volume: |
2 |
|
Pages: |
1198006 |
|
•
•
•
•
•
|
Publication |
First Author: |
McClean PL |
Year: |
2014 |
Journal: |
Neuropharmacology |
Title: |
Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. |
Volume: |
76 Pt A |
|
Pages: |
57-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
2024 |
Journal: |
Front Aging Neurosci |
Title: |
ACOT7, a candidate and novel serum biomarker of Alzheimer's disease. |
Volume: |
16 |
|
Pages: |
1345668 |
|
•
•
•
•
•
|
Publication |
First Author: |
Várhelyi ZP |
Year: |
2017 |
Journal: |
Front Neurosci |
Title: |
Adiponectin Receptors Are Less Sensitive to Stress in a Transgenic Mouse Model of Alzheimer's Disease. |
Volume: |
11 |
|
Pages: |
199 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2018 |
Journal: |
Front Aging Neurosci |
Title: |
Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer's Disease. |
Volume: |
10 |
|
Pages: |
85 |
|
•
•
•
•
•
|
Publication |
First Author: |
De la Rosa-Prieto C |
Year: |
2016 |
Journal: |
Front Neurosci |
Title: |
Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-β in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease. |
Volume: |
10 |
|
Pages: |
227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao K |
Year: |
2019 |
Journal: |
Alzheimers Res Ther |
Title: |
Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation. |
Volume: |
11 |
Issue: |
1 |
Pages: |
35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin TW |
Year: |
2015 |
Journal: |
Neurobiol Learn Mem |
Title: |
Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice. |
Volume: |
118 |
|
Pages: |
189-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dumanis SB |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain. |
Volume: |
35 |
Issue: |
37 |
Pages: |
12703-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baltissen D |
Year: |
2023 |
Journal: |
Front Cell Neurosci |
Title: |
APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice. |
Volume: |
17 |
|
Pages: |
1106176 |
|
•
•
•
•
•
|
Publication |
First Author: |
Madhoun S |
Year: |
2023 |
Journal: |
Exp Eye Res |
Title: |
Effects of experimental glaucoma in Lama1(nmf223) mutant mice. |
Volume: |
226 |
|
Pages: |
109341 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ash ES |
Year: |
2010 |
Journal: |
Neurochem Int |
Title: |
Neurochemical changes in a double transgenic mouse model of Alzheimer's disease fed a pro-oxidant diet. |
Volume: |
57 |
Issue: |
5 |
Pages: |
504-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henderson BW |
Year: |
2016 |
Journal: |
J Neurochem |
Title: |
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. |
Volume: |
138 |
Issue: |
4 |
Pages: |
525-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2019 |
Journal: |
Eur J Pharmacol |
Title: |
MicroRNA-128 knockout inhibits the development of Alzheimer's disease by targeting PPARγ in mouse models. |
Volume: |
843 |
|
Pages: |
134-144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fraering PC |
Year: |
2004 |
Journal: |
Biochemistry |
Title: |
Purification and characterization of the human gamma-secretase complex. |
Volume: |
43 |
Issue: |
30 |
Pages: |
9774-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keil U |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. |
Volume: |
279 |
Issue: |
48 |
Pages: |
50310-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruni P |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. |
Volume: |
277 |
Issue: |
38 |
Pages: |
35481-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Broder C |
Year: |
2013 |
Journal: |
Biochem J |
Title: |
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis. |
Volume: |
450 |
Issue: |
2 |
Pages: |
253-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu CG |
Year: |
2014 |
Journal: |
Brain Res |
Title: |
MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein. |
Volume: |
1583 |
|
Pages: |
55-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fenrich KK |
Year: |
2015 |
Journal: |
Behav Brain Res |
Title: |
Improved single pellet grasping using automated ad libitum full-time training robot. |
Volume: |
281 |
|
Pages: |
137-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cimini S |
Year: |
2016 |
Journal: |
Neurobiol Dis |
Title: |
The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt. |
Volume: |
89 |
|
Pages: |
101-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panikker P |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition. |
Volume: |
38 |
Issue: |
19 |
Pages: |
4569-4583 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giliberto L |
Year: |
2008 |
Journal: |
Mol Neurodegener |
Title: |
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. |
Volume: |
3 |
|
Pages: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin FB |
Year: |
2018 |
Journal: |
Nan Fang Yi Ke Da Xue Xue Bao |
Title: |
[Verification of a sporadic Alzheimer disease model in SORL1 gene knockout mice]. |
Volume: |
38 |
Issue: |
3 |
Pages: |
289-295 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang M |
Year: |
2020 |
Journal: |
Neurobiol Aging |
Title: |
Amyloid precursor protein intracellular domain-dependent regulation of FOXO3a inhibits adult hippocampal neurogenesis. |
Volume: |
95 |
|
Pages: |
250-263 |
|
•
•
•
•
•
|
Publication |
First Author: |
Evans AK |
Year: |
2020 |
Journal: |
Neurobiol Dis |
Title: |
Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease. |
Volume: |
146 |
|
Pages: |
105089 |
|
•
•
•
•
•
|
Publication |
First Author: |
Melis V |
Year: |
2015 |
Journal: |
Cell Mol Life Sci |
Title: |
Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. |
Volume: |
72 |
Issue: |
11 |
Pages: |
2199-222 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gammie SC |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Evaluation of animal model congruence to human depression based on large-scale gene expression patterns of the CNS. |
Volume: |
12 |
Issue: |
1 |
Pages: |
108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krueger I |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases. |
Volume: |
40 |
Issue: |
10 |
Pages: |
2391-2403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bai N |
Year: |
2022 |
Journal: |
Mol Metab |
Title: |
CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue. |
Volume: |
63 |
|
Pages: |
101531 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
199
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
467
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Tam SJ |
Year: |
2012 |
Journal: |
Dev Cell |
Title: |
Death receptors DR6 and TROY regulate brain vascular development. |
Volume: |
22 |
Issue: |
2 |
Pages: |
403-17 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
339
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bai XC |
Year: |
2015 |
Journal: |
Nature |
Title: |
An atomic structure of human γ-secretase. |
Volume: |
525 |
Issue: |
7568 |
Pages: |
212-217 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goodwin LO |
Year: |
2019 |
Journal: |
Genome Res |
Title: |
Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis. |
Volume: |
29 |
Issue: |
3 |
Pages: |
494-505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. |
Volume: |
19 |
Issue: |
4 |
Pages: |
473-80 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chromosome aberration, mutant strain, trisomy |
|
•
•
•
•
•
|
Publication |
First Author: |
Ravaioli F |
Year: |
2024 |
Journal: |
Front Aging Neurosci |
Title: |
Increased hippocampal epigenetic age in the Ts65Dn mouse model of Down Syndrome. |
Volume: |
16 |
|
Pages: |
1401109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sussan TE |
Year: |
2008 |
Journal: |
Nature |
Title: |
Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. |
Volume: |
451 |
Issue: |
7174 |
Pages: |
73-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ridnour LA |
Year: |
2012 |
Journal: |
J Neurochem |
Title: |
Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1. |
Volume: |
123 |
Issue: |
5 |
Pages: |
736-49 |
|
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•
•
•
•
|
Publication |
First Author: |
Klein SL |
Year: |
1996 |
Journal: |
Physiol Behav |
Title: |
Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. |
Volume: |
60 |
Issue: |
4 |
Pages: |
1159-64 |
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•
•
•
•
|
Publication |
First Author: |
Ash JA |
Year: |
2014 |
Journal: |
Neurobiol Dis |
Title: |
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. |
Volume: |
70 |
|
Pages: |
32-42 |
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•
•
•
•
|
Publication |
First Author: |
Yang A |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. |
Volume: |
71 |
Issue: |
10 |
Pages: |
3573-81 |
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•
•
•
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Publication |
First Author: |
El Hajjar J |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice. |
Volume: |
9 |
Issue: |
1 |
Pages: |
594 |
|
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•
•
•
•
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Publication |
First Author: |
Flinn JM |
Year: |
2014 |
Journal: |
Front Aging Neurosci |
Title: |
Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels. |
Volume: |
6 |
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Pages: |
174 |
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•
•
•
•
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Publication |
First Author: |
Fryer JD |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. |
Volume: |
25 |
Issue: |
11 |
Pages: |
2803-10 |
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•
•
•
•
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Publication |
First Author: |
Deane R |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. |
Volume: |
25 |
Issue: |
50 |
Pages: |
11495-503 |
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•
•
•
•
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Publication |
First Author: |
Noll C |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. |
Volume: |
4 |
Issue: |
10 |
Pages: |
e7540 |
|
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•
•
•
•
|
Publication |
First Author: |
Li JG |
Year: |
2017 |
Journal: |
Aging Cell |
Title: |
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation. |
Volume: |
16 |
Issue: |
2 |
Pages: |
273-280 |
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•
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•
•
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Publication |
First Author: |
Fryer JD |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. |
Volume: |
280 |
Issue: |
27 |
Pages: |
25754-9 |
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•
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Publication |
First Author: |
Ettcheto M |
Year: |
2015 |
Journal: |
Exp Gerontol |
Title: |
Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice. |
Volume: |
65 |
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Pages: |
69-78 |
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•
•
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Publication |
First Author: |
Bengoechea TG |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
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