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Search results 6101 to 6200 out of 6327 for Kit

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Type Details Score
HT Experiment
Series Id: GSE21897
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE8583
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE15150
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE4323
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE33618
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE65063
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE40511
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE68537
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE34786
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE38144
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: E-GEOD-79174
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Lyman SD
Year: 1993
Journal: Cell
Title: Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells.
Volume: 75
Issue: 6
Pages: 1157-67
Publication  
First Author: Hunkapiller T
Year: 1989
Journal: Adv Immunol
Title: Diversity of the immunoglobulin gene superfamily.
Volume: 44
Pages: 1-63
Publication
First Author: Terman BI
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.
Volume: 187
Issue: 3
Pages: 1579-86
Publication
First Author: Lee KH
Year: 1990
Journal: Mol Cell Biol
Title: Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium.
Volume: 10
Issue: 5
Pages: 2237-46
Publication
First Author: Galland F
Year: 1993
Journal: Oncogene
Title: The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.
Volume: 8
Issue: 5
Pages: 1233-40
Protein Domain
Type: Conserved_site
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].A number of growth factors stimulate mitogenesis by interacting with a family of cell surface receptors which possess an intrinsic, ligand-sensitive, protein tyrosine kinase activity []. These receptor tyrosine kinases (RTK) all share the same topology: an extracellular ligand-binding domain, a single transmembrane region and a cytoplasmic kinase domain. However they can be classified into at least five groups. The class III RTK's are characterised by the presence of five to seven immunoglobulin-like domains []in their extracellular section. Their kinase domain differs from that of other RTK's by the insertion of a stretch of 70 to 100 hydrophilic residues in the middle of this domain. The receptors currently known to belong to class III are:Platelet-derived growth factor receptor (PDGF-R). PDGF-R exists as a homo- or heterodimer of two related chains: alpha and beta [].Macrophage colony stimulating factor receptor (CSF-1-R) (also known as the fms oncogene).Stem cell factor (mast cell growth factor) receptor (also known as the kit oncogene).Vascular endothelial growth factor (VEGF) receptors Flt-1 and Flk-1/KDR [].Fl cytokine receptor Flk-2/Flt-3 [].The putative receptor Flt-4 [].This entry represents a short, conserved region found within these proteins.
Publication
First Author: Hu Y
Year: 2000
Journal: Transplantation
Title: Prolonged survival of heart allografts from p53-deficient mice.
Volume: 69
Issue: 12
Pages: 2634-40
Publication
First Author: Kvarik T
Year: 2021
Journal: J Mol Neurosci
Title: The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy.
Volume: 71
Issue: 12
Pages: 2546-2557
Publication  
First Author: Gnanadesikan GE
Year: 2021
Journal: Psychoneuroendocrinology
Title: Specificity of plasma oxytocin immunoassays: A comparison of commercial assays and sample preparation techniques using oxytocin knockout and wildtype mice.
Volume: 132
Pages: 105368
Publication
First Author: Zhao H
Year: 2011
Journal: Biol Reprod
Title: Maternal heme oxygenase 1 regulates placental vasculature development via angiogenic factors in mice.
Volume: 85
Issue: 5
Pages: 1005-12
Publication
First Author: Kondo J
Year: 2015
Journal: Gastroenterology
Title: LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice.
Volume: 149
Issue: 2
Pages: 407-19.e8
Publication
First Author: Xiong G
Year: 2023
Journal: Brain Pathol
Title: Detection and verification of neurodegeneration after traumatic brain injury in the mouse: Immunohistochemical staining for amyloid precursor protein.
Volume: 33
Issue: 6
Pages: e13163
Publication
First Author: Peluso JJ
Year: 2018
Journal: Reproduction
Title: PGRMC1/2 promotes luteal vascularization and maintains the primordial follicles of mice
Volume: 156
Issue: 4
Pages: 365–373
Publication  
First Author: Raïch I
Year: 2022
Journal: Int J Mol Sci
Title: Antagonization of OX(1) Receptor Potentiates CB(2) Receptor Function in Microglia from APP(Sw/Ind) Mice Model.
Volume: 23
Issue: 21
Publication
First Author: Maretzky T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.
Volume: 110
Issue: 28
Pages: 11433-8
Publication  
First Author: Zhang X
Year: 2022
Journal: Int J Mol Sci
Title: Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia.
Volume: 23
Issue: 10
Publication
First Author: Zhou Q
Year: 2008
Journal: Biol Reprod
Title: Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro.
Volume: 78
Issue: 3
Pages: 537-45
Publication
First Author: Hart PH
Year: 1999
Journal: Immunology
Title: Age-related changes in dermal mast cell prevalence in BALB/c mice: functional importance and correlation with dermal mast cell expression of Kit.
Volume: 98
Issue: 3
Pages: 352-6
Publication
First Author: Early E
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Transgenic expression of PML/RARalpha impairs myelopoiesis.
Volume: 93
Issue: 15
Pages: 7900-4
Publication
First Author: Zhang L
Year: 1998
Journal: J Surg Res
Title: Differential display of genes in normal and hypoplastic fetal murine lungs.
Volume: 75
Issue: 1
Pages: 66-73
Publication
First Author: Raudsepp T
Year: 1999
Journal: Mamm Genome
Title: Comparison of horse chromosome 3 with donkey and human chromosomes by cross-species painting and heterologous FISH mapping.
Volume: 10
Issue: 3
Pages: 277-82
Publication
First Author: La Sala G
Year: 2010
Journal: Exp Cell Res
Title: Rapid estrogen signalling in mouse primordial germ cells.
Volume: 316
Issue: 10
Pages: 1716-27
Publication
First Author: Wu GS
Year: 2012
Journal: PLoS One
Title: Phenotype of transgenic mice overexpressed with inducible nitric oxide synthase in the retina.
Volume: 7
Issue: 8
Pages: e43089
Publication  
First Author: de Miranda AS
Year: 2015
Journal: Neuroscience
Title: Evidence for the contribution of adult neurogenesis and hippocampal cell death in experimental cerebral malaria cognitive outcome.
Volume: 284
Pages: 920-33
Publication
First Author: Lu X
Year: 2017
Journal: PLoS One
Title: ClC-3 chloride channel mediates the role of parathyroid hormone [1-34] on osteogenic differentiation of osteoblasts.
Volume: 12
Issue: 4
Pages: e0176196
Publication  
First Author: Malerba F
Year: 2016
Journal: Front Mol Neurosci
Title: NGF and proNGF Reciprocal Interference in Immunoassays: Open Questions, Criticalities, and Ways Forward.
Volume: 9
Pages: 63
Publication
First Author: Ye F
Year: 2024
Journal: Sci Rep
Title: Fast and efficient isolation of murine circulating tumor cells using screencell technology for pre-clinical analyzes.
Volume: 14
Issue: 1
Pages: 15019
Publication
First Author: Shima N
Year: 2003
Journal: Genetics
Title: Phenotype-based identification of mouse chromosome instability mutants.
Volume: 163
Issue: 3
Pages: 1031-40
Publication
First Author: Howell GR
Year: 2007
Journal: Genetics
Title: Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.
Volume: 175
Issue: 2
Pages: 699-707
Publication
First Author: D'Orazio JA
Year: 2006
Journal: Nature
Title: Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning.
Volume: 443
Issue: 7109
Pages: 340-4
Strain
Attribute String: mutant stock
Strain
Attribute String: F1 hybrid, mutant stock
Strain
Attribute String: Not specified
Strain
Attribute String: Not specified
Strain
Attribute String: mutant strain, spontaneous mutation, targeted mutation, transgenic, congenic
Strain
Attribute String: transgenic, targeted mutation, spontaneous mutation, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, spontaneous mutation, targeted mutation, transgenic
Strain
Attribute String: endonuclease-mediated mutation, mutant strain, spontaneous mutation, targeted mutation, transgenic
Strain
Attribute String: congenic, mutant strain, spontaneous mutation, targeted mutation, transgenic
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, spontaneous mutation, targeted mutation, transgenic
Publication
First Author: Lee J
Year: 2017
Journal: Nat Immunol
Title: Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.
Volume: 18
Issue: 8
Pages: 877-888
Publication
First Author: Yoshihara E
Year: 2020
Journal: Nature
Title: Immune-evasive human islet-like organoids ameliorate diabetes.
Volume: 586
Issue: 7830
Pages: 606-611
Publication
First Author: Proto JD
Year: 2018
Journal: J Clin Invest
Title: Hypercholesterolemia induces T cell expansion in humanized immune mice.
Volume: 128
Issue: 6
Pages: 2370-2375
Publication
First Author: Coughlan AM
Year: 2016
Journal: Stem Cells Dev
Title: Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain.
Volume: 25
Issue: 7
Pages: 530-41
Publication
First Author: Crews LA
Year: 2023
Journal: Cell Stem Cell
Title: Reversal of malignant ADAR1 splice isoform switching with Rebecsinib.
Volume: 30
Issue: 3
Pages: 250-263.e6
Publication
First Author: Rondeau V
Year: 2024
Journal: Sci Transl Med
Title: Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Volume: 16
Issue: 766
Pages: eadn1285
Publication
First Author: Wunderlich M
Year: 2016
Journal: JCI Insight
Title: A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.
Volume: 1
Issue: 15
Pages: e88181
Publication  
First Author: Kim TK
Year: 2024
Journal: J Clin Invest
Title: PD-1H/VISTA mediates immune evasion in acute myeloid leukemia.
Volume: 134
Issue: 3
Publication  
First Author: Odunsi A
Year: 2020
Journal: J Immunother Cancer
Title: Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies.
Volume: 8
Issue: 2
Publication
First Author: Diepstraten ST
Year: 2024
Journal: Cancer Cell
Title: Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers.
Volume: 42
Issue: 5
Pages: 850-868.e9
Publication  
First Author: Yu CI
Year: 2021
Journal: J Exp Med
Title: Human KIT+ myeloid cells facilitate visceral metastasis by melanoma.
Volume: 218
Issue: 6
Publication  
First Author: Tam EM
Year: 2019
Journal: Sci Transl Med
Title: Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity.
Volume: 11
Issue: 512
Strain
Attribute String: congenic, mutant strain
Strain
Attribute String: chromosome aberration, inversion, mutant stock, radiation induced mutation
Strain
Attribute String: chemically induced mutation, mutant stock, radiation induced mutation
Strain
Attribute String: mutant stock, chemically induced mutation, radiation induced mutation
Publication
First Author: Han L
Year: 2023
Journal: Cell Stem Cell
Title: METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Volume: 30
Issue: 1
Pages: 52-68.e13
Publication
First Author: Li Y
Year: 2023
Journal: Cell Stem Cell
Title: TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.
Volume: 30
Issue: 8
Pages: 1072-1090.e10
Publication  
First Author: Shi X
Year: 2021
Journal: Sci Adv
Title: Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells.
Volume: 7
Issue: 30
Publication
First Author: Dong Q
Year: 2022
Journal: Nat Commun
Title: HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.
Volume: 13
Issue: 1
Pages: 6107
Publication
First Author: Chen HM
Year: 2018
Journal: J Clin Invest
Title: Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.
Volume: 128
Issue: 12
Pages: 5647-5662
Genotype
Symbol: Rw/Rw
Background: (C3H/HeH x 101/H)F1
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rw/Rw<+>
Background: (C3H/HeH x 101/H)F1
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Rw/Rw<+>
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Tg(Cma1-cre)ARoer/? Tg(Kit*D814V)3Roer/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rw/Rw<+>
Background: B6.Cg-Rw/J
Zygosity: ht
Has Mutant Allele: true
HT Experiment
Series Id: GSE9004
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: E-GEOD-7775
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE12628
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE6275
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE3676
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE26743
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE75889
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress