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Search results 6301 to 6400 out of 7671 for Th

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Type Details Score
Publication
37907525 | J:342246
First Author: Ng JQ
Year: 2023
Journal: Nat Commun
Title: Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis.
Volume: 14
Issue: 1
Pages: 6909
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Publication
38336876 | J:360439
First Author: Rauch E
Year: 2024
Journal: Nat Commun
Title: T-bet(+) B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms.
Volume: 15
Issue: 1
Pages: 1229
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Publication
28232668 | J:350102
 
First Author: Yu Y
Year: 2017
Journal: Nat Commun
Title: Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.
Volume: 8
Pages: 14364
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Publication
39672169 | J:360738
First Author: Son HG
Year: 2025
Journal: Cancer Cell
Title: Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.
Volume: 43
Issue: 1
Pages: 36-48.e10
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Protein
D6RJM5
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
14993283 | J:89059
First Author: Tomlinson MG
Year: 2004
Journal: Mol Cell Biol
Title: Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
Volume: 24
Issue: 6
Pages: 2455-66
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Publication
11859127 | -
First Author: Takeba Y
Year: 2002
Journal: J Immunol
Title: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Volume: 168
Issue: 5
Pages: 2365-70
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Protein Domain
IPR035870 | Txk_SH2
Type: Domain
Description: Txk is a member of the Tec protein tyrosine kinase family. It plays a role in TCR signal transduction, T cell development, and selection which is analogous to the function of Itk. Txk has been shown to interact with IFN-gamma [, ]. Unlike most of the Tec family members Txk lacks a PH domain. Instead Txk has a unique region containing a palmitoylated cysteine string which has a similar membrane tethering function as the PH domain []. This entry includes the SH2 domain of Txk.The Tec protein tyrosine kinase family includes Tec,Btk, Itk, Bmx, and Txk. They contain an NH2-terminal pleckstrin homology (PH) domain (absent in Txk), a proline-rich region, Src-homology 3 (SH3) and SH2 domains, and a COOH-terminal PTK domain. The TH domain consists of a Zn2+-binding Btk motif and a proline-rich region. The Btk motif is found in Tec kinases, Ras GAP, and IGBP and crucial to the function of the PH domain. It is not present in Txk which is not surprising since it lacks a PH domain. The type 1 splice form of the Drosophila homologue also lacks both the PH domain and the Btk motif. The proline-rich regions are highly conserved for the most part with the exception of Bmx whose residues surrounding the PXXP motif are not conserved (TH-like) and Btk29A which is entirely unique with large numbers of glycine residues (TH-extended). Tec family members all lack a C-terminal tyrosine having an autoinhibitory function in its phosphorylated state [, ].
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Protein Domain
IPR025136 | MAP3K_TRAF-bd
Type: Domain
Description: Apoptosis signal-regulating kinases (ASK1/2/3 or MAP3K5/6/15) are mitogen-activated protein kinase kinase kinases (MAP3Ks) that mediate cellular responses to redox stress and inflammatory cytokines and play a key role in innate immunity and viral infection. This kind of signalling kinases are regulated by oligomerization and regulatory domains. In its N-terminal there is a thioredoxin-binding domain that negatively regulates activity and a TNF receptor-associated factors (TRAFs)-binding domain which triggers ASK activation and kinase activity. TRAFs-binding domain is composed by 14 helices, which form seven tetratricopeptide repeats (TPRs), followed by a PH-like domain to complete de central regulatory domain of ASK. The central regulatory region promotes ASK1 activity via its PH domain but also facilitates ASK1 autoinhibition by bringing the thioredoxin-binding and kinase domains into close proximity. The PH-like domain, adjacent to the kinase domain, is required together with an intact TPR region for ASK1 activity.The major role of the central regulatory region is to bring the thioredoxin-binding domain into close proximity to the kinase domain to inhibit its activity [].This domain corresponds to the TRAFs-binding domain found at the N terminus of some MAP3Ks. This domain includes seven tetratricopeptide repeats (TPRs) and, together with th PH-like domain, constitutes the central regulatory domain of ASK1.
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HT Experiment
GSE225664 | Leukocyte Recruitment and iBALT Formation Require Chemokine-Secreting Pf4+ Interstitial Macrophages [scRNA-seq: mLu]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Allele
Cacna1a<tg> | MGI:1856209
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; tottering
Allele Type: Spontaneous
Attribute String: Not Specified
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Publication
32217665 | J:289086
First Author: Ignatova VV
Year: 2020
Journal: Genes Dev
Title: The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
Volume: 34
Issue: 9-10
Pages: 715-729
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Publication
27231034 | -
 
First Author: Jansen EJ
Year: 2016
Journal: Nat Commun
Title: ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation.
Volume: 7
Pages: 11600
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Publication
26235987 | J:242799
First Author: Vivante A
Year: 2015
Journal: Am J Hum Genet
Title: Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.
Volume: 97
Issue: 2
Pages: 291-301
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Publication
20975714 | -
 
First Author: Pethe K
Year: 2010
Journal: Nat Commun
Title: A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Volume: 1
Pages: 57
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Publication
30907060 | J:275235
First Author: Palmer AK
Year: 2019
Journal: Aging Cell
Title: Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
Volume: 18
Issue: 3
Pages: e12950
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Publication
34554188 | J:331919
 
First Author: Bittner ZA
Year: 2021
Journal: J Exp Med
Title: BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Volume: 218
Issue: 11
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Publication
32313104 | J:291171
First Author: Perry JM
Year: 2020
Journal: Nat Cell Biol
Title: Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells.
Volume: 22
Issue: 6
Pages: 689-700
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Publication
29198940 | J:253885
First Author: Chen X
Year: 2017
Journal: Cell Stem Cell
Title: Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.
Volume: 21
Issue: 6
Pages: 747-760.e7
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Publication
27723756 | J:258695
First Author: Wang J
Year: 2016
Journal: Nat Genet
Title: Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Volume: 48
Issue: 11
Pages: 1396-1406
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Publication
35561684 | J:325979
First Author: Choi YS
Year: 2022
Journal: Cell
Title: Topical therapy for regression and melanoma prevention of congenital giant nevi.
Volume: 185
Issue: 12
Pages: 2071-2085.e12
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Publication
22730437 | J:187640
First Author: Hüttemann M
Year: 2012
Journal: FASEB J
Title: Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
Volume: 26
Issue: 9
Pages: 3916-30
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Publication
27820809 | J:259152
First Author: Pfeifle R
Year: 2017
Journal: Nat Immunol
Title: Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.
Volume: 18
Issue: 1
Pages: 104-113
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Publication
25891430 | J:222707
 
First Author: Li J
Year: 2015
Journal: Nat Commun
Title: Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
Volume: 6
Pages: 6804
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Publication
34788600 | J:335922
First Author: Burnett DL
Year: 2021
Journal: Immunity
Title: Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability.
Volume: 54
Issue: 12
Pages: 2908-2921.e6
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Publication
25892112 | J:230337
First Author: Mlynarski EE
Year: 2015
Journal: Am J Hum Genet
Title: Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome.
Volume: 96
Issue: 5
Pages: 753-64
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Publication
25704602 | J:230349
First Author: Leslie EJ
Year: 2015
Journal: Am J Hum Genet
Title: Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci.
Volume: 96
Issue: 3
Pages: 397-411
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Publication
35296864 | J:357162
First Author: Emont MP
Year: 2022
Journal: Nature
Title: A single-cell atlas of human and mouse white adipose tissue.
Volume: 603
Issue: 7903
Pages: 926-933
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Publication
15590694 | -
First Author: Kario E
Year: 2005
Journal: J Biol Chem
Title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
Volume: 280
Issue: 8
Pages: 7038-48
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Publication
11342597 | J:69272
First Author: Schaefer G
Year: 2001
Journal: J Immunol
Title: Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells.
Volume: 166
Issue: 10
Pages: 5859-63
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Publication
9630247 | J:62783
First Author: Jarrous N
Year: 1998
Journal: RNA
Title: Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.
Volume: 4
Issue: 4
Pages: 407-17
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Publication
12065839 | J:77098
First Author: Aguado E
Year: 2002
Journal: Science
Title: Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.
Volume: 296
Issue: 5575
Pages: 2036-40
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Publication
14688323 | J:87094
First Author: Miaw SC
Year: 2004
Journal: J Immunol
Title: A repressor of GATA-mediated negative feedback mechanism of T cell activation.
Volume: 172
Issue: 1
Pages: 170-7
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Publication
10536275 | J:58208
First Author: Sawada K
Year: 1999
Journal: Brain Res
Title: Abnormal expression of tyrosine hydroxylase immunoreactivity in Purkinje cells precedes the onset of ataxia in dilute-lethal mice.
Volume: 844
Issue: 1-2
Pages: 188-91
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Publication
- | J:13459
 
First Author: Erway L
Year: 1967
Journal: Mouse News Lett
Title: ub is allele of th.
Volume: 36
Pages: 29
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Publication
15728239 | J:96627
First Author: Grenningloh R
Year: 2005
Journal: J Exp Med
Title: Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.
Volume: 201
Issue: 4
Pages: 615-26
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Publication
9551889 | J:45188
First Author: Noble A
Year: 1998
Journal: J Immunol
Title: Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses.
Volume: 160
Issue: 2
Pages: 566-71
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Publication
20675594 | J:163256
First Author: Barr TA
Year: 2010
Journal: J Immunol
Title: TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica.
Volume: 185
Issue: 5
Pages: 2783-9
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Publication
28506393 | J:252215
First Author: Goldfinger M
Year: 2017
Journal: Mol Genet Metab
Title: Partial rescue of neuropathology in the murine model of PKU following administration of recombinant phenylalanine ammonia lyase (pegvaliase).
Volume: 122
Issue: 1-2
Pages: 33-35
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Publication
17350071 | J:124475
First Author: Calamusa M
Year: 2007
Journal: Vision Res
Title: Specific alterations of tyrosine hydroxylase immunopositive cells in the retina of NT-4 knock out mice.
Volume: 47
Issue: 11
Pages: 1523-36
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Publication
9851932 | J:51510
First Author: Dong C
Year: 1998
Journal: Science
Title: Defective T cell differentiation in the absence of Jnk1.
Volume: 282
Issue: 5396
Pages: 2092-5
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Publication
16230473 | J:113262
First Author: Tu L
Year: 2005
Journal: J Exp Med
Title: Notch signaling is an important regulator of type 2 immunity.
Volume: 202
Issue: 8
Pages: 1037-42
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Publication
15067040 | J:89112
First Author: Artis D
Year: 2004
Journal: J Immunol
Title: Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.
Volume: 172
Issue: 8
Pages: 4672-5
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Publication
1541833 | J:1942
First Author: Miyazawa M
Year: 1992
Journal: J Immunol
Title: Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.
Volume: 148
Issue: 6
Pages: 1964-7
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Publication
11120785 | J:66158
First Author: Takemoto N
Year: 2000
Journal: J Immunol
Title: Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster.
Volume: 165
Issue: 12
Pages: 6687-91
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Publication
849243 | J:5796
First Author: Eicher EM
Year: 1977
Journal: Biochem Genet
Title: Chromosomal location of soluble glutamic-pyruvic transaminase-1 (Gpt-1) in the mouse.
Volume: 15
Issue: 1-2
Pages: 1-8
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Publication
6818042 | J:6938
First Author: Virelizier JL
Year: 1982
Journal: Eur J Immunol
Title: Murine genotype influences the in vitro production of gamma (immune) interferon.
Volume: 12
Issue: 11
Pages: 988-90
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Publication
7586730 | J:29840
First Author: Mohan C
Year: 1995
Journal: Clin Immunol Immunopathol
Title: Lupus: key pathogenic mechanisms and contributing factors.
Volume: 77
Issue: 3
Pages: 209-20
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Publication
7761837 | J:109915
First Author: Katz JD
Year: 1995
Journal: Science
Title: T helper cell subsets in insulin-dependent diabetes.
Volume: 268
Issue: 5214
Pages: 1185-8
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Publication
17919942 | J:126102
First Author: van Beelen AJ
Year: 2007
Journal: Immunity
Title: Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.
Volume: 27
Issue: 4
Pages: 660-9
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Publication
8097338 | J:139862
First Author: Hsieh CS
Year: 1993
Journal: Science
Title: Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
Volume: 260
Issue: 5107
Pages: 547-9
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Protein
F6W8M5
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q8BNW5
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: true
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Protein
Q8C6G4
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Publication
19088068 | -
First Author: Wu WH
Year: 2009
Journal: J Biol Chem
Title: N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex.
Volume: 284
Issue: 10
Pages: 6200-7
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Publication
16299513 | -
First Author: Wu WH
Year: 2005
Journal: Nat Struct Mol Biol
Title: Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.
Volume: 12
Issue: 12
Pages: 1064-71
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Publication
17177976 | -
First Author: Maruyama T
Year: 2007
Journal: Clin Exp Immunol
Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Volume: 147
Issue: 1
Pages: 164-75
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Protein Domain
IPR020195 | SWR1_Swc7
Type: Family
Description: Th SWR1 complex is involved in chromatin-remodelling by promoting the the ATP-dependent exchange of histone H2A for the H2A variant HZT1 in Saccharomyces cerevisiae (Baker's yeast) or H2AZ in mammals. The SWR1 chromatin-remodelling complex is composed of at least 14 subunits and has a molecular mass of about 1.2 to 1.5 MDa. In S. cerevisiae the core conserved subunits are: ATPase; Swr1.RuvB-like; Rvb1 and Rvb2.Actin; Act1.Actin-related: Arp4 and Arp6.YEATS protein []; Yaf9.The non-conserved subunits are: Vps71 (Swc6), Vps72 (Swc2), Swc3, Swc4, Swc5, Swc7, Bdf1 [].Seven of the SWR1 subunits are involved in maintaining complex integrity and H2AZ histone replacement activity: Swr1, Swc2, Swc3, Arp6, Swc5, Yaf9 and Swc6. Arp4 is required for the association of Bdf1, Yaf9, and Swc4 and Arp4 is also required for SWR1 H2AZ histone replacement activity in vitro. Furthermore the N-terminal region of the ATPase Swr1 provides the platform upon which Bdf1, Swc7, Arp4, Act1, Yaf9 and Swc4 associate []; it also contains an additional H2AZ-H2B specific binding site, distinct from the binding site of the Swc2 subunit []. In eukaryotes the deposition of variant histones into nucleosomes by the chromatin-remodelling complexes such as the SWR1 and INO80 complexes have many crucial functions including the control of gene regulation and expression, checkpoint regulation, DNA replication and repair, telomer maintenance and chromosomal segregation and as such represent critical components of pathways that maintain genomic integrity. This entry represents the subunit Swc7; the smallestsubunit of the SWR1 complex. Swc7 is not required for H2AZ binding. Swc7 associates with the N terminus of Swr1, and the association of Bdf1 requires Swc7, Yaf9, and Arp4 [].
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Publication
15716360 | J:96985
First Author: Seeman P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
Volume: 102
Issue: 9
Pages: 3513-8
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Publication
27693472 | J:238201
 
First Author: Niu XY
Year: 2016
Journal: Neuroscience
Title: Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP.
Volume: 339
Pages: 22-31
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Publication
25009587 | J:224801
First Author: Dai TL
Year: 2014
Journal: Exp Ther Med
Title: Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.
Volume: 8
Issue: 2
Pages: 384-390
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Publication
34246625 | J:311151
 
First Author: Nakano T
Year: 2021
Journal: Dev Biol
Title: Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle.
Volume: 478
Pages: 222-235
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Publication
17708336 | J:125212
First Author: Michell AW
Year: 2007
Journal: Cell Transplant
Title: The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.
Volume: 16
Issue: 5
Pages: 461-74
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Publication
16611810 | J:108310
First Author: Tofaris GK
Year: 2006
Journal: J Neurosci
Title: Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.
Volume: 26
Issue: 15
Pages: 3942-50
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Publication
29688489 | J:265103
First Author: Mironova YA
Year: 2018
Journal: Hum Mol Genet
Title: Protective role of the lipid phosphatase Fig4 in the adult nervous system.
Volume: 27
Issue: 14
Pages: 2443-2453
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Publication
28722508 | J:306953
First Author: Su LY
Year: 2017
Journal: Autophagy
Title: Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine.
Volume: 13
Issue: 9
Pages: 1496-1511
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Strain
MGI:3655817 | STOCK Tg(YACW408A5)1952Ricc/J
Attribute String: mutant stock, transgenic
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Publication
15640248 | J:96366
First Author: Cerrato F
Year: 2005
Journal: Hum Mol Genet
Title: The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster.
Volume: 14
Issue: 4
Pages: 503-11
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Publication
20369382 | J:170043
First Author: Li Z
Year: 2011
Journal: Transgenic Res
Title: Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus.
Volume: 20
Issue: 1
Pages: 191-200
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Genotype
Genotype
Symbol: Tg(YACW408A5)1952Ricc/?
Background: involves: 129/Sv * SD7
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tgfb1/Tgfb1 Tg(Cd4-cre)1Cwi/? Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/?
Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Th-phiC31*)1Imayo/?
Background: either: (involves: 129S4/SvJaeSor * C57BL/6J) or (involves: 129S4/SvJaeSor * C57BL/6 * DBA)
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Th/Th<+>
Background: involves: 129 * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Sox6/Sox6<+> Th/Th<+>
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
21151127 | J:169033
First Author: Melum E
Year: 2011
Journal: Nat Genet
Title: Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
Volume: 43
Issue: 1
Pages: 17-9
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Publication
29386193 | J:260709
First Author: Ozer HG
Year: 2018
Journal: Cancer Discov
Title: BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Volume: 8
Issue: 4
Pages: 458-477
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Publication
25145936 | J:251751
First Author: Stuart HM
Year: 2015
Journal: J Am Soc Nephrol
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Protein
D3Z5H1
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Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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