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Search results 6401 to 6500 out of 8285 for C2

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Type Details Score
Publication
36071167 | J:339994
First Author: Kedmi R
Year: 2022
Journal: Nature
Title: A RORγt(+) cell instructs gut microbiota-specific T(reg) cell differentiation.
Volume: 610
Issue: 7933
Pages: 737-743
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Allele
Enpp1<ttw> | MGI:1857079
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1; tiptoe walking
Allele Type: Spontaneous
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Enpp1/Enpp1
Background: Jcl:ICR-Enpp1
Zygosity: hm
Has Mutant Allele: true
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Publication
30707251 | J:279061
First Author: Zhang J
Year: 2019
Journal: Diabetologia
Title: DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle.
Volume: 62
Issue: 5
Pages: 845-859
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Protein
Q8C6V6
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Publication
17052212 | -
First Author: Yarwood S
Year: 2006
Journal: Biochem Soc Trans
Title: The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling.
Volume: 34
Issue: Pt 5
Pages: 846-50
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Publication
19433443 | -
First Author: Kupzig S
Year: 2009
Journal: Mol Cell Biol
Title: The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.
Volume: 29
Issue: 14
Pages: 3929-40
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Publication
16431904 | -
First Author: Kupzig S
Year: 2006
Journal: J Biol Chem
Title: GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.
Volume: 281
Issue: 15
Pages: 9891-900
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Publication
12590134 | J:83162
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.
Volume: 278
Issue: 17
Pages: 15390-6
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Publication
10497219 | J:57922
First Author: Wang J
Year: 1999
Journal: J Biol Chem
Title: Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells.
Volume: 274
Issue: 40
Pages: 28542-8
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Publication
16481396 | -
First Author: Tsuboi T
Year: 2006
Journal: Mol Biol Cell
Title: The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.
Volume: 17
Issue: 5
Pages: 2101-12
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Publication
12094216 | -
First Author: Chapman ER
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
Volume: 3
Issue: 7
Pages: 498-508
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Publication
25437758 | -
First Author: Vasquez JK
Year: 2014
Journal: Biochemistry
Title: Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains.
Volume: 53
Issue: 50
Pages: 7904-13
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Publication
21460216 | -
First Author: Dai Y
Year: 2011
Journal: J Biol Chem
Title: Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
Volume: 286
Issue: 22
Pages: 19905-16
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Protein Domain
IPR014770 | Munc13_1
Type: Domain
Description: Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans Unc-13. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster (Fruit fly), Mus musculus (Mouse), Rattus norvegicus (Rat) and Homo sapiens (Human), some of which may function in a Munc13-like manner to regulate membrane trafficking [].The MHD1 and MHD2 domains are predicted to be α-helical []. Some proteins known to contain MHD1 and MHD2 domains are listed below:Mammalian Munc13-1. It is specifically targeted to presynaptic active zones and has a central priming function in synaptic vesicle exocytosis from glutaminergic synapses.Mammalian Munc13-2. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.Mammalian Munc13-3. It probably plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.Mammalian Munc13-4. It is predominantly expressed in lung where it is localized to goblet cells of the bronchial epithelium and to alveolar type II cells, both of which are cell types with secretory function.C. elegans Unc-13. It may form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions.Mammalian BAI1-associated protein 3 (BAP3), which exhibits the typical Munc13-like domain structure with two C2 domains flanking the MHD1 and MHD2 domains, but which lack the long N terminuswith the C1 domain.Animal calcium-dependent activator proteins for secretion (CAPSs), regulators of large dense-core vesicle secretion. They contain only a MHD1 domain and are otherwise unrelated to Munc13 proteins.A. thaliana hypothetical proteins with MHD1 and MHD2 domains but without C1 and C2 domains.Saccharomyces cerevisiae uncharacterised protein YOR296W, where MHD1 and MHD2 enclose a central C2 domain. YOR296W is presumably involved in bud formation.Schizosaccharomyces pombe hypothetical protein C11E3.02c in chromosome I, where MHD1 and MHD2 enclose a central C2 domain.This entry represents the Munc13 homology domain 1.
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Protein Domain
IPR014772 | Munc13_dom-2
Type: Domain
Description: Mammalian uncoordinated homology 13 (Munc13) proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans Unc-13. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster (Fruit fly), Mus musculus (Mouse), Rattus norvegicus (Rat) and Homo sapiens (Human), some of which may function in a Munc13-like manner to regulate membrane trafficking [].The MHD1 and MHD2 domains are predicted to be α-helical []. Some proteins known to contain MHD1 and MHD2 domains are listed below:Mammalian Munc13-1. It is specifically targeted to presynaptic active zones and has a central priming function in synaptic vesicle exocytosis from glutaminergic synapses.Mammalian Munc13-2. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.Mammalian Munc13-3. It probably plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.Mammalian Munc13-4. It is predominantly expressed in lung where it is localized to goblet cells of the bronchial epithelium and to alveolar type II cells, both of which are cell types with secretory function.C. elegans Unc-13. It may form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions.Mammalian BAI1-associated protein 3 (BAP3), which exhibits the typical Munc13-like domain structure with two C2 domains flanking the MHD1 and MHD2 domains, but which lack the long N terminus with the C1 domain.Animal calcium-dependent activator proteins for secretion (CAPSs), regulators of large dense-core vesicle secretion. They contain only a MHD1 domain and are otherwise unrelated to Munc13 proteins.A. thaliana hypothetical proteins with MHD1 and MHD2 domains but without C1 and C2 domains.Saccharomyces cerevisiae uncharacterised protein YOR296W, where MHD1 and MHD2 enclose a central C2 domain. YOR296W is presumably involved in bud formation.Schizosaccharomyces pombe hypothetical protein C11E3.02c in chromosome I, where MHD1 and MHD2 enclose a central C2 domain.This entry represents the Munc13 homology domain 2.
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
15702972 | J:117528
First Author: Hwang JI
Year: 2005
Journal: Biochem J
Title: Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
Volume: 389
Issue: Pt 1
Pages: 181-6
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Protein
A0A286YE00
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: true
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Protein
F7CEK4
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Publication
28177287 | J:241144
   
First Author: Xu J
Year: 2017
Journal: Elife
Title: Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Volume: 6
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Publication
11973130 | -
First Author: Arendt CW
Year: 2002
Journal: Curr Opin Immunol
Title: Protein kinase C-theta;: signaling from the center of the T-cell synapse.
Volume: 14
Issue: 3
Pages: 323-30
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Publication
11410591 | -
First Author: Bauer B
Year: 2001
Journal: J Biol Chem
Title: Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells.
Volume: 276
Issue: 34
Pages: 31627-34
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Publication
11169407 | -
First Author: Bauer B
Year: 2000
Journal: Eur J Immunol
Title: T cell expressed PKCtheta demonstrates cell-type selective function.
Volume: 30
Issue: 12
Pages: 3645-54
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Publication
17640920 | -
First Author: Jin H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Volume: 104
Issue: 30
Pages: 12353-8
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Publication
11211934 | -
First Author: von Poser C
Year: 2001
Journal: Eur J Cell Biol
Title: Synaptotagmin 13: structure and expression of a novel synaptotagmin.
Volume: 80
Issue: 1
Pages: 41-7
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Publication
20840848 | -
First Author: Jahn JE
Year: 2010
Journal: Exp Mol Pathol
Title: Exogenous expression of synaptotagmin XIII suppresses the neoplastic phenotype of a rat liver tumor cell line through molecular pathways related to mesenchymal to epithelial transition.
Volume: 89
Issue: 3
Pages: 209-16
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Publication
22939844 | -
First Author: Andersson SA
Year: 2012
Journal: Mol Cell Endocrinol
Title: Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
Volume: 364
Issue: 1-2
Pages: 36-45
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Publication
17110375 | -
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: Phosphoinositide 3-kinase C2alpha links clathrin to microtubule-dependent movement.
Volume: 282
Issue: 2
Pages: 1249-56
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Publication
17644513 | -
First Author: Falasca M
Year: 2007
Journal: J Biol Chem
Title: The role of phosphoinositide 3-kinase C2alpha in insulin signaling.
Volume: 282
Issue: 38
Pages: 28226-36
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Publication
17233588 | -
 
First Author: Clarke JH
Year: 2007
Journal: Biochem Soc Symp
Title: Type II PtdInsP kinases: location, regulation and function.
Issue: 74
Pages: 149-59
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Publication
17115053 | -
First Author: Jezyk MR
Year: 2006
Journal: Nat Struct Mol Biol
Title: Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Volume: 13
Issue: 12
Pages: 1135-40
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Protein Domain
IPR028555 | RASAL1
Type: Family
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes. Its tandem C2 domains bind phospholipids upon an elevation in the intracellular free Ca2+ concentration ([Ca2+]i) [].
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Protein Domain
IPR028692 | SYT13
Type: Family
Description: Synaptotagmin-13 (SYT13) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains (known as C2A and C2B domains). Most of the synaptotagmins have a unique N-terminal domain (transmembrane region) that is involved in membrane anchoring or specific ligand binding. Unlike most of the synaptotagmins, SYT13 does not have an N-terminal transmembrane region. Its C2 domains are lacking almost all the residues involved in Ca2+ binding []. It is highly expressed in brain and also detectable at lower levels in non-neuronal tissues []. SYT13 can suppress liver tumour cells and this function may be mediated through pathways implicated in mesenchymal to epithelial transition []. It also affects insulin secretion [].
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Protein Domain
IPR014376 | Prot_kin_PKC_delta
Type: Family
Description: This entry represents the novel protein kinase C (nPKC) family.The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent [, , ].PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol [, ]. Members of this family play key regulatory roles in various cellular processes. Currently, there are ten isoforms of PKC which can be classified into classical (alpha, beta I, beta II, gamma), novel (delta, epsilon, eta, theta) and atypical (zeta, iota/lambda) types based on their primary structure and biochemical characteristics [, , ]. All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain.
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Protein Domain
IPR027264 | PKC_theta
Type: Family
Description: Protein kinase C (PKC) theta is classified as a novel PKC (nPKC). PKC theta is involved in T-cell activation and survival [, , ].The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent [, , ].PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol [, ]. Members of this family play key regulatory roles in various cellular processes. Currently, there are ten isoforms of PKC which can be classified into classical (alpha, beta I, beta II, gamma), novel (delta, epsilon, eta, theta) and atypical (zeta, iota/lambda) types based on their primary structure and biochemical characteristics [, , ]. All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain.
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Protein Domain
IPR037705 | PI3K-C2-alpha_dom
Type: Domain
Description: This entry represents the catalytic domain of PI3K-C2-alpha, which is a Class II phosphoinositide-3-kinase (PI3K) that generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). It plays key roles in clathrin assembly and clathrin-mediated membrane trafficking [], insulin signaling [], and vascular smooth muscle contraction [].PI3Ks can be divided into three main classes (I, II, and III), defined by their substrate specificity, regulation, and domain structure. Class I PI3Ks are the only enzymes capable of converting PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class II PI3Ks preferentially use PtdIns as a substrate to produce PtdIns(3)P, but can also phosphorylate PtdIns(4)P. They function as monomers and do not associate with any regulatory subunits. Class II enzymes contain an N-terminal Ras binding domain, a lipid binding C2 domain, a PI3K homology domain of unknown function, an ATP-binding cataytic domain, a Phox homology (PX) domain, and a second C2 domain at the C terminus [, ].
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Protein Domain
IPR037707 | PI3K-C2-gamma_dom
Type: Domain
Description: This entry represents the catalytic domain of PI3K-C2-gamma, which is a Class II phosphoinositide-3-kinase (PI3K) that generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). PI3K-C2gamma is expressed in the liver, breast, and prostate []. PI3Ks can be divided into three main classes (I, II, and III), defined by their substrate specificity, regulation, and domain structure. Class I PI3Ks are the only enzymes capable of converting PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class II PI3Ks preferentially use PtdIns as a substrate to produce PtdIns(3)P, but can also phosphorylate PtdIns(4)P. They function as monomers and do not associate with any regulatory subunits. Class II enzymes contain an N-terminal Ras binding domain, a lipid binding C2 domain, a PI3K homology domain of unknown function, an ATP-binding cataytic domain, a Phox homology (PX) domain, and a second C2 domain at the C terminus [, ].
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Protein Domain
IPR010439 | MUN_dom
Type: Domain
Description: This entry corresponds to the MUN domain []found in Munc13 proteins. These constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. Structural studies have defined MHD1 and MHD2 to be part of the larger MUN domain which forms an elongated structure composed of any pairs of alpha helices.
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Protein Domain
IPR033916 | ML_Npc2-like
Type: Domain
Description: The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like β-sandwich fold similar to that of E-set Ig domains. This domain is present in proteins from plants, animals and fungi, including the following proteins:Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein - Npc2), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes [].House-dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus [].This entry refers to the ML domain found in metazoan Npc2 as well and some similar proteins.
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Protein Domain
IPR033917 | ML_PG-PI_TP
Type: Domain
Description: The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like β-sandwich fold similar to that of E-set Ig domains. This domain is present in proteins from plants, animals and fungi, including the following proteins:Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein - Npc2), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes [].House-dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus [].This entry refers to the ML domain found in phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP). PG/PI-TP has been shown to bind phosphatidylglycerol and phosphatidylinositol, but the biological significance of this is still obscure [].
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Protein Domain
IPR037862 | PLC-beta_PH
Type: Domain
Description: PLC-beta (PLCbeta) is regulated by heterotrimeric G protein-coupled receptors through their C2 domain and long C-terminal extension which forms an autoinhibitory helix. There are four isoforms: PLC-beta1-4. These isoforms mediate the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) to propagate signals for several physiological responses [, ].PLC-beta consists of an N-terminal PH domain, a EF hand domain, a catalytic domain split into X and Y halves, a C2 domain and a C-terminal PDZ. This entry represents the PH domain of PLC-beta. The PH domain of PLC-beta2 and PLC-beta3 plays a dual role, much like PLC-delta1, by binding to the plasma membrane, as well as the interaction site for the catalytic activator [].
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Publication
21319224 | J:169062
First Author: López-Juárez A
Year: 2011
Journal: Glia
Title: Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.
Volume: 59
Issue: 4
Pages: 577-89
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Publication
19286669 | J:148110
First Author: Chiu YH
Year: 2009
Journal: Hum Mol Genet
Title: Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophy.
Volume: 18
Issue: 11
Pages: 1976-89
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Publication
21746860 | J:175690
First Author: Johnson JL
Year: 2011
Journal: Infect Immun
Title: Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.
Volume: 79
Issue: 9
Pages: 3607-18
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Publication
23115246 | J:193760
First Author: Monfregola J
Year: 2012
Journal: J Biol Chem
Title: MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.
Volume: 287
Issue: 53
Pages: 44603-18
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Publication
18584871 | J:137831
First Author: Zou X
Year: 2008
Journal: Mol Immunol
Title: Removal of the BiP-retention domain in Cmicro permits surface deposition and developmental progression without L-chain.
Volume: 45
Issue: 13
Pages: 3573-9
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Publication
19561045 | J:151668
First Author: Matheson LS
Year: 2009
Journal: Int Immunol
Title: Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching.
Volume: 21
Issue: 8
Pages: 957-66
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Publication
36278424 | J:331987
First Author: Weißert K
Year: 2022
Journal: EMBO Mol Med
Title: Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH).
Volume: 14
Issue: 12
Pages: e16085
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Publication
21119217 | J:349625
First Author: Cacciottolo M
Year: 2011
Journal: J Biol Chem
Title: Reverse engineering gene network identifies new dysferlin-interacting proteins.
Volume: 286
Issue: 7
Pages: 5404-13
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Publication
23332128 | J:214561
First Author: Terrill JR
Year: 2013
Journal: FEBS J
Title: Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies.
Volume: 280
Issue: 17
Pages: 4149-64
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Publication
17261636 | J:125373
First Author: Besseyrias V
Year: 2007
Journal: J Exp Med
Title: Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
Volume: 204
Issue: 2
Pages: 331-43
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Publication
21285514 | J:171820
First Author: Varnum-Finney B
Year: 2011
Journal: J Clin Invest
Title: Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.
Volume: 121
Issue: 3
Pages: 1207-16
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Publication
21909072 | J:180027
First Author: Restivo G
Year: 2011
Journal: EMBO J
Title: IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.
Volume: 30
Issue: 22
Pages: 4571-85
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Publication
27063549 | J:252545
 
First Author: Gómez-López S
Year: 2016
Journal: Sci Rep
Title: Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration.
Volume: 6
Pages: 24028
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Publication
12427827 | J:98903
First Author: Komiyama NH
Year: 2002
Journal: J Neurosci
Title: SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.
Volume: 22
Issue: 22
Pages: 9721-32
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Publication
15673435 | J:97490
First Author: Porter K
Year: 2005
Journal: Eur J Neurosci
Title: Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development.
Volume: 21
Issue: 2
Pages: 351-62
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Publication
30892133 | J:319593
First Author: Zhang J
Year: 2019
Journal: Autophagy
Title: Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency.
Volume: 15
Issue: 10
Pages: 1738-1756
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Publication
16285903 | J:103866
First Author: Kindlmann GL
Year: 2005
Journal: Mol Imaging
Title: Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors.
Volume: 4
Issue: 4
Pages: 417-24
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Publication
30894537 | J:273851
First Author: Kashiwagi Y
Year: 2019
Journal: Nat Commun
Title: Computational geometry analysis of dendritic spines by structured illumination microscopy.
Volume: 10
Issue: 1
Pages: 1285
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Publication
25779105 | J:221877
 
First Author: Mountford JK
Year: 2015
Journal: Nat Commun
Title: The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
Volume: 6
Pages: 6535
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Publication
34479944 | J:327015
First Author: Li J
Year: 2021
Journal: J Immunol
Title: Elucidating the Motif for CpG Oligonucleotide Binding to the Dendritic Cell Receptor DEC-205 Leads to Improved Adjuvants for Liver-Resident Memory.
Volume: 207
Issue: 7
Pages: 1836-1847
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Publication
23810565 | J:199146
First Author: Schumacher D
Year: 2013
Journal: Cancer Cell
Title: Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.
Volume: 24
Issue: 1
Pages: 130-7
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Publication
21239699 | J:170516
First Author: Crozat K
Year: 2011
Journal: Blood
Title: Impact of β2 integrin deficiency on mouse natural killer cell development and function.
Volume: 117
Issue: 10
Pages: 2874-82
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Publication
12538695 | J:118712
First Author: Zou X
Year: 2003
Journal: J Immunol
Title: Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.
Volume: 170
Issue: 3
Pages: 1354-61
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Publication
32321913 | J:292818
First Author: Bahar Halpern K
Year: 2020
Journal: Nat Commun
Title: Lgr5+ telocytes are a signaling source at the intestinal villus tip.
Volume: 11
Issue: 1
Pages: 1936
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Publication
29503158 | J:272701
First Author: Thorne CA
Year: 2018
Journal: Dev Cell
Title: Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization.
Volume: 44
Issue: 5
Pages: 624-633.e4
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Genotype
Genotype
Symbol: Pax3/Pax3<+> Tg(CMV-cre)1Cgn/?
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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•
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Genotype
Genotype
Symbol: Pax3/Pax3<+> Pax7/Pax7<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Dlg4/Dlg4 Syngap1/Syngap1<+>
Background: involves: 129P2/OlaHsd * MF1
Zygosity: cx
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2<+> Tg(Tyr-cre)2Lru/?
Background: involves: 129 * BALB/c * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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•
•
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•
Genotype
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2 Tg(Tyr-cre)2Lru/?
Background: involves: 129 * BALB/c * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
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•
Genotype
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2<+> Tg(Tyr-cre)2Lru/?
Background: involves: 129/Sv * BALB/c * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2 Tg(Tyr-cre)2Lru/?
Background: involves: 129 * BALB/c * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2 Tg(Mx1-cre)1Cgn/?
Background: involves: 129 * BALB/c * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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•
•
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•
Genotype
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2 Ptf1a/Ptf1a<+>
Background: involves: 129 * BALB/cJ
Zygosity: cn
Has Mutant Allele: true
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•
•
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Genotype
Genotype
Symbol: Myf6/Myf6<+> Pax3/Pax3 Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Myf6/Myf6<+> Pax3/Pax3 Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Myf6/Myf6<+> Pax3/Pax3
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Myf6/Myf6<+> Pax3/Pax3<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Tcra/Tcra Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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•
•
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•
Genotype
Genotype
Symbol: Dysf/Dysf Fktn/Fktn
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J
Zygosity: cx
Has Mutant Allele: true
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•
•
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•
Genotype
Genotype
Symbol: Dysf/Dysf<+> Fktn/Fktn
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J
Zygosity: cx
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Dysf/Dysf Fktn/Fktn<+>
Background: involves: C57BL/6 * SJL/J
Zygosity: cx
Has Mutant Allele: true
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•
•
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•
Genotype
Genotype
Symbol: Dysf/Dysf<+> Large1/Large1
Background: involves: C57BL/6 * SJL/J
Zygosity: cx
Has Mutant Allele: true
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•
•
•
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Genotype
Genotype
Symbol: Dysf/Dysf Large1/Large1
Background: involves: C57BL/6 * SJL/J
Zygosity: cx
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Ihh/Ihh Lgr5/Lgr5<+>
Background: involves: 129S/SvEv * C57BL/6NTac * ICR
Zygosity: cx
Has Mutant Allele: true
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•
•
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•
Publication
16488114 | J:114915
First Author: Veith AM
Year: 2006
Journal: Genomics
Title: Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse.
Volume: 88
Issue: 2
Pages: 185-95
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Publication
11242035 | J:76452
First Author: Fernández-Chacón R
Year: 2001
Journal: Nature
Title: Synaptotagmin I functions as a calcium regulator of release probability.
Volume: 410
Issue: 6824
Pages: 41-9
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Publication
11751925 | -
First Author: Fukuda M
Year: 2002
Journal: J Biol Chem
Title: Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells.
Volume: 277
Issue: 7
Pages: 4601-4
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Protein
V9GWX4
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Publication
8027085 | -
First Author: Nalefski EA
Year: 1994
Journal: J Biol Chem
Title: Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
Volume: 269
Issue: 27
Pages: 18239-49
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Publication
8051052 | -
First Author: Lee KS
Year: 1994
Journal: J Biol Chem
Title: The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity.
Volume: 269
Issue: 31
Pages: 19725-30
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•
•
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Publication
1856191 | -
First Author: Geppert M
Year: 1991
Journal: J Biol Chem
Title: Synaptotagmin II. A novel differentially distributed form of synaptotagmin.
Volume: 266
Issue: 21
Pages: 13548-52
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Publication
10048922 | -
First Author: Sundberg E
Year: 1999
Journal: Nat Struct Biol
Title: Structural basis for HLA-DQ binding by the streptococcal superantigen SSA.
Volume: 6
Issue: 2
Pages: 123-9
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Publication
11934896 | -
First Author: Chi YI
Year: 2002
Journal: J Biol Chem
Title: Zinc-mediated dimerization and its effect on activity and conformation of staphylococcal enterotoxin type C.
Volume: 277
Issue: 25
Pages: 22839-46
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Publication
10986116 | -
First Author: Hâkansson M
Year: 2000
Journal: J Mol Biol
Title: The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules.
Volume: 302
Issue: 3
Pages: 527-37
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Publication
7628431 | -
First Author: Schad EM
Year: 1995
Journal: EMBO J
Title: Crystal structure of the superantigen staphylococcal enterotoxin type A.
Volume: 14
Issue: 14
Pages: 3292-301
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Publication
10860729 | -
First Author: Arcus VL
Year: 2000
Journal: J Mol Biol
Title: Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes.
Volume: 299
Issue: 1
Pages: 157-68
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Publication
11045630 | -
First Author: Earhart CA
Year: 2000
Journal: Protein Sci
Title: Structure of streptococcal pyrogenic exotoxin A reveals a novel metal cluster.
Volume: 9
Issue: 9
Pages: 1847-51
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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