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Search results 6501 to 6600 out of 8285 for C2

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Type Details Score
Publication
9253413 | -
First Author: Roussel A
Year: 1997
Journal: Nat Struct Biol
Title: Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules.
Volume: 4
Issue: 8
Pages: 635-43
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Publication
15247241 | -
First Author: Baker HM
Year: 2004
Journal: J Biol Chem
Title: Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization.
Volume: 279
Issue: 37
Pages: 38571-6
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Publication
14559915 | -
First Author: Papageorgiou AC
Year: 2004
Journal: J Biol Chem
Title: Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition.
Volume: 279
Issue: 2
Pages: 1297-303
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Publication
8759320 | -
First Author: Papageorgiou AC
Year: 1996
Journal: J Mol Biol
Title: The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.
Volume: 260
Issue: 4
Pages: 553-69
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Publication
12562822 | -
First Author: Pedulla ML
Year: 2003
Journal: J Bacteriol
Title: Corrected sequence of the bacteriophage p22 genome.
Volume: 185
Issue: 4
Pages: 1475-7
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Publication
6350606 | -
First Author: Sauer RT
Year: 1983
Journal: J Mol Biol
Title: Primary structure of the immI immunity region of bacteriophage P22.
Volume: 168
Issue: 4
Pages: 699-713
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Publication
22219378 | -
First Author: Hokanson DE
Year: 2012
Journal: Mol Biol Cell
Title: EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.
Volume: 23
Issue: 4
Pages: 701-15
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Publication
22438581 | J:197810
First Author: Johnson JL
Year: 2012
Journal: Mol Biol Cell
Title: Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Volume: 23
Issue: 10
Pages: 1902-16
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Publication
15190121 | -
First Author: Iezzi M
Year: 2004
Journal: J Cell Sci
Title: Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.
Volume: 117
Issue: Pt 15
Pages: 3119-27
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Publication
11437455 | -
First Author: Michaut M
Year: 2001
Journal: Dev Biol
Title: Synaptotagmin VI participates in the acrosome reaction of human spermatozoa.
Volume: 235
Issue: 2
Pages: 521-9
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Publication
23283987 | -
First Author: Warner A
Year: 2013
Journal: Mol Biol Cell
Title: CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.
Volume: 24
Issue: 5
Pages: 601-16
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Publication
19084023 | -
First Author: Alcorlo M
Year: 2009
Journal: J Mol Biol
Title: Analytical ultracentrifugation studies of phage phi29 protein p6 binding to DNA.
Volume: 385
Issue: 5
Pages: 1616-29
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Protein Domain
IPR016091 | SuperAg_toxin_C
Type: Homologous_superfamily
Description: This entry represents superantigen toxins from Staphylococcus aureus and Streptococcus pyogenes, which share a common core structure consisting of beta(2)-α-β(2). S. aureus toxins with this fold include: enterotoxins A (SEA) [], B (SEB) [], C2 (SEC2) [], C3 (SEC3) []and H (SEH) [], heat shock syndrome toxin-1 [], and superantigen-like proteins SET1 []and SET3 []. S. pyogenes toxins with this fold include: pyrogenic exotoxins A1 []and Spe-J [], and in superantigen proteins Spe-C [], Spe-H [], Smez-2 []and SSA [].
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Protein Domain
IPR031577 | DMRT-C1/C2_C
Type: Domain
Description: The vertebrate DMRT (doublesex-and mab-3-related transcription factor) gene family encodes putative transcription factors related to the sexual regulators Doublesex (Drosophila melanogaster) and MAB-3 (Caenorhabditis elegans). They share a highly conserved DNA binding motif, the DM domain. This entry represents a domain found in the C-terminal of the DMRT C1 and C2 proteins. DMRTC1 (also known as DMRT8) is located on the X chromosome in placental mammals. It is related to DMRTC2 (DMRT7) but has lost the DM domain [].
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Protein Domain
IPR028378 | Sytl1
Type: Family
Description: Synaptotagmin-like protein 1 (Slp1/Jfc1) acts as a Rab27a effector and plays a role in vesicle trafficking [, ]. Through its interaction with Rab27a, Slp1 also contributes to secretory lysosome exocytosis from cytotoxic T lymphocytes. Slp1 (and Slp2) may form part of a docking complex, capturing secretory lysosomes at the immunological synapse [].Slp1 possesses two C2 domains in tandem, domain C2A showing homology with the C2B domain of synaptotagmins [].
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Protein Domain
IPR018875 | Antirepressor_Ant_N
Type: Domain
Description: The Antirepressor protein ant from Salmonella phage P22 prevents the prophage p22 c2 repressor protein from binding to its operators. It also inhibits the action of other prophage repressor proteins, including those of phages lambda and 434. The synthesis of antirepressor is negatively regulated by the protein products of the two other immi genes, mnt and arc [, , ]. This entry represents the N-terminal domain of this protein and similar proteins from tailed bacteriophages (Caudovirales) and bacterial prophages mostly found in Proteobacteria.
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Protein Domain
IPR028701 | SYT6
Type: Family
Description: Synaptotagmin-6 (SYT6) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains (known as C2A and C2B domains) []. Most of the synaptotagmins have a unique N-terminal domain (transmembrane region) that is involved in membrane anchoring or specific ligand binding. SYT6 is localised to the outer acrosomal membrane of the human sperm cells and is involved in acrosomal exocytosis [].
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Protein Domain
IPR028689 | SYT5
Type: Family
Description: Synaptotagmin-5 (SYT5) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains. Most of the synaptotagmins have a unique N-terminal domain that is involved in membrane anchoring or specific ligand binding. SYT5 is involved in the Ca2+-dependent stimulation of insulin exocytosis []. SYT5 is also known as synaptotagmin IX (SYT9) in rodents. In PC12 (phaeochromocytoma) cells, it regulates Ca2+-dependent secretion [].
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Protein Domain
IPR002642 | LysoPLipase_cat_dom
Type: Domain
Description: This family consists of lysophospholipase / phospholipase B and cytosolic phospholipase A2 whichalso has a C2 domain . Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitroof hydrolyzing all phospholipids extractable from yeast cells []. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+and selectively hydrolyses arachidonyl phospholipids [], the aligned region corresponds the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in [].
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Protein Domain
IPR003739 | Lys_aminomutase/Glu_NH3_mut
Type: Family
Description: This entry represents the lysine-2,3-aminomutase (LAM) family of proteins. LAM catalyses the interconversion of L-alpha-lysine and L-beta-lysine, which proceeds by migration of the amino group from C2 to C3 concomitant with cross-migration of the 3-pro-R hydrogen of L-alpha-lysine to the 2-pro-R position of L-beta-lysine. Glutamate 2,3-aminomutase is closely related to LAM, but can be distinguished by architecture (longer N-terminal region, shorter C-terminal region) and replacement of key lysine-binding residues []. Glutamate 2,3-aminomutase catalyses the interconversion of L-glutamate and L-beta-glutamate [].
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Protein Domain
IPR037865 | ABR_PH
Type: Domain
Description: The active breakpoint cluster region-related protein (ABR) protein contains multiple domains including a RhoGEF domain, a PH domain, a C1 domain, a C2 domain, and a C-terminal RhoGAP domain. It is related to a slightly larger protein, BCR, which is structurally similar, but has an additional N-terminal kinase domain. ABR has GAP activity for both Rac and Cdc42. It promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them []. This entry represents the PH domain of ABR.
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Protein Domain
IPR035188 | Histone-like_p6
Type: Family
Description: Family members such as protein p6 from Bacillus subtilis phage phi29 bind double-stranded DNA, forming a large nucleoprotein complex all along the viral genome, and have been proposed to be an architectural protein with a global role in genome organization. P6 is also involved in viral transcriptional control, repressing the C2 early promoter located at the right DNA end, and together with the viral regulatory protein p4, repressing early promoters A2b/A2c and activating late promoter A3 [].
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Protein Domain
IPR031115 | Copine_CPNA-1
Type: Family
Description: CPNA-1 is a copine domain protein required for muscle maintenance/stability in Caenorhabditis elegans []. It is localised to integrin adhesion sites in muscle tissue and might act as a linker between membrane proximal attachment proteins and those deeper within muscle cells. CPNA-1 contains a predicted transmembrane domain and is the first characterised copine domain-containing protein that lacks C2 domains. It is most similar to homologues in other nematodes, but it is also similar to mammalian copines.
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Protein Coding Gene
MGI:1100497 | Doc2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0016749 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:109446 | Doc2a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0030469 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0033003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018689 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018659 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1100497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018555 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018626 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018571 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019154 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033516 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013679 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_PahariEiJ_G0017886 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017592 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein Coding Gene
MGP_SPRETEiJ_G0031583 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
18596155 | J:137824
First Author: Friedrich R
Year: 2008
Journal: J Neurosci
Title: DOC2B acts as a calcium switch and enhances vesicle fusion.
Volume: 28
Issue: 27
Pages: 6794-806
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Publication
9073161 | J:38862
First Author: Naito A
Year: 1997
Journal: Brain Res Mol Brain Res
Title: Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain.
Volume: 44
Issue: 2
Pages: 198-204
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Publication
10594652 | J:89423
First Author: Sakaguchi G
Year: 1999
Journal: Eur J Neurosci
Title: Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.
Volume: 11
Issue: 12
Pages: 4262-8
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Publication
32347796 | J:291939
   
First Author: Khan MM
Year: 2020
Journal: Elife
Title: Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions.
Volume: 9
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Publication
25190515 | J:217823
First Author: Ramalingam L
Year: 2014
Journal: Biochem J
Title: Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cells.
Volume: 464
Issue: 2
Pages: 251-8
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GXD Expression
GXD Expression
     
Probe: MGI:3576311
Assay Type: Western blot
Annotation Date: 2005-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:3576321
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3576311
Assay Type: Western blot
Annotation Date: 2005-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:3576321
Age: embryonic day 18.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3576309
Assay Type: Western blot
Annotation Date: 2005-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:3576322
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3576309
Assay Type: Western blot
Annotation Date: 2005-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:3576322
Age: embryonic day 18.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6444283
Assay Type: RT-PCR
Annotation Date: 2020-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6444881
Age: postnatal week 5
Specimen Label: wild type control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6444283
Assay Type: RT-PCR
Annotation Date: 2020-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6444881
Age: postnatal week 5
Specimen Label: miR-183C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_07
Specimen Label: euxassay_008012_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_08
Specimen Label: euxassay_008012_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_15
Specimen Label: euxassay_008012_15
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_07
Specimen Label: euxassay_008012_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_08
Specimen Label: euxassay_008012_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_13
Specimen Label: euxassay_008012_13
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_09
Specimen Label: euxassay_008012_09
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_10
Specimen Label: euxassay_008012_10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_16
Specimen Label: euxassay_008012_16
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_17
Specimen Label: euxassay_008012_17
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_10
Specimen Label: euxassay_008012_10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_11
Specimen Label: euxassay_008012_11
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4423354
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824368
Age: embryonic day 14.5
Image: euxassay_008012_12
Specimen Label: euxassay_008012_12
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190139
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Doc2b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190139
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Doc2b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190139
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Doc2b
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190139
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Doc2b
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190139
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Doc2b
Detected: true
Specimen Num: 5
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•
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190139
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Doc2b
Detected: true
Specimen Num: 6
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•
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GXD Expression
GXD Expression
   
Probe: MGI:6171390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190139
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Doc2b
Detected: true
Specimen Num: 7
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Protein
A0A286YDV5
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Publication
10861235 | -
First Author: Koch H
Year: 2000
Journal: Biochem J
Title: Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform.
Volume: 349
Issue: Pt 1
Pages: 247-53
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Publication
16228007 | -
First Author: Basu J
Year: 2005
Journal: Nat Struct Mol Biol
Title: A minimal domain responsible for Munc13 activity.
Volume: 12
Issue: 11
Pages: 1017-8
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Publication
15003533 | -
First Author: Manabe S
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells.
Volume: 316
Issue: 1
Pages: 218-25
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Publication
10023082 | -
First Author: Record E
Year: 1999
Journal: Biochim Biophys Acta
Title: Characterization and expression of the cDNA encoding a new kind of phospholipid transfer protein, the phosphatidylglycerol/phosphatidylinositol transfer protein from Aspergillus oryzae: evidence of a putative membrane targeted phospholipid transfer protein in fungi.
Volume: 1444
Issue: 2
Pages: 276-82
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Protein Domain
IPR044134 | FYVE_Slp4
Type: Domain
Description: Synaptotagmin-like protein 4 (SYTL4, Slp4), also known as granuphilin or exophilin-2, belongs to the synaptotagmin-like protein family (Slp), which is a group of putative membrane trafficking proteins []. The characteristic feature of the Slp family is the N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain and C-terminal tandem C2 domains (known as the C2A domain and C2B domain), putative Ca2+-binding motifs [, ]. SHD consists of two conserved regions, designated SHD1 and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of Slp4 are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.There are several alternatively spliced isoform of Slp4. Slp4-a (granuphilin-a) has two C2 domains, whereas Slp4-b (granuphilin-b) contains only the first C2 domain. Expression of Slp4-a inhibits regulated secretion in endocrine cells. Slp4-a binds to both the GTP- and GDP-bound forms of Rab27A and inhibits a specific GTP/GDP exchange cycle required for dense-core vesicle exocytosis []. Slp4 has been detected in the pancreatic islet, in particular in insulin-positive beta cells, and in pituitary []. This entry represents the FYVE-related domain of synaptotagmin-like protein 4.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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