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Search results 6601 to 6700 out of 8285 for C2

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Type Details Score
Protein Domain
IPR028694 | SYTL4
Type: Family
Description: Synaptotagmin-like protein 4 (SYTL4, Slp4), also known as granuphilin or exophilin-2, belongs to the synaptotagmin-like protein family (Slp), which is a group of putative membrane trafficking proteins []. The characteristic feature of the Slp family is the N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain and C-terminal tandem C2 domains (known as the C2A domain and C2B domain), putative Ca2+-binding motifs [, ]. SHD consists of two conserved regions, designated SHD1 and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of Slp4 are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.There are several alternatively spliced isoform of Slp4. Slp4-a (granuphilin-a) has two C2 domains, whereas Slp4-b (granuphilin-b) contains only the first C2 domain. Expression of Slp4-a inhibits regulated secretion in endocrine cells. Slp4-a binds to both the GTP- and GDP-bound forms of Rab27A and inhibits a specific GTP/GDP exchange cycle required for dense-core vesicle exocytosis []. Slp4 has been detected inthe pancreatic islet, in particular in insulin-positive beta cells, and in pituitary [].
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Protein Domain
IPR037732 | C2A_Synaptotagmin-7
Type: Domain
Description: Synaptotagmin is a membrane-trafficking protein characterised by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains []. Synaptotagmin 7, a member of class 2 synaptotagmins, is located in presynaptic plasma membranes in neurons, dense-core vesicles in endocrine cells, and lysosomes in fibroblasts. It has been shown to play a role in regulation of Ca2+-dependent lysosomal exocytosis in fibroblasts and also functions as a vesicular Ca2+-sensor [, ]. It is distinguished from the other synaptotagmins by having over 12 splice forms [].Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10) []. The general function of C2 domains in these is to mediate Ca2+-triggered binding of the protein to a membrane [].C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. This entry represents the first C2 repeat, C2A, and has a type-I topology [].
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Protein Domain
IPR037741 | C2B_Synaptotagmin-7
Type: Domain
Description: Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains []. Synaptotagmin 7, a member of class 2 synaptotagmins, is located in presynaptic plasma membranes in neurons, dense-core vesicles in endocrine cells, and lysosomes in fibroblasts. It has been shown to play a role in regulation of Ca2+-dependent lysosomal exocytosis in fibroblasts and also functions as a vesicular Ca2+-sensor [, ]. It is distinguished from the other synaptotagmins by having over 12 splice forms [].Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10) []. The general function of C2 domains in these is to mediate Ca2+-triggered binding of the protein to a membrane [].C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements: type I and type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. This entry represents the second C2 repeat, C2B, and has a type-I topology [].
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Protein Domain
IPR037776 | RASAL_RasGAP
Type: Domain
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].This entry represents the RasGAP domain of RASAL. RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASA4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. Its tandem C2 domains bind phospholipids upon an elevation in the intracellular free Ca2+ concentration ([Ca2+]i). CAPRI and RASAL differ in that CAPRI is an amplitude sensor while RASAL senses calcium oscillations [, ]. This difference between them resides not in their C2 domains, but in their PH domains leading to speculation that this might reflect an association with either phosphoinositides and/or proteins [].
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Publication
31541165 | J:284228
First Author: Ikegami K
Year: 2019
Journal: Sci Rep
Title: Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.
Volume: 9
Issue: 1
Pages: 13634
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Publication
11562355 | J:71693
First Author: Kume T
Year: 2001
Journal: Genes Dev
Title: The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.
Volume: 15
Issue: 18
Pages: 2470-82
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Publication
25808752 | J:221866
 
First Author: Yoshida M
Year: 2015
Journal: Nat Commun
Title: The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification.
Volume: 6
Pages: 6653
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Publication
12925591 | J:84754
First Author: Mankoo BS
Year: 2003
Journal: Development
Title: The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.
Volume: 130
Issue: 19
Pages: 4655-64
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Publication
17605809 | J:194811
 
First Author: Murphy MW
Year: 2007
Journal: BMC Mol Biol
Title: Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA.
Volume: 8
Pages: 58
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Publication
28369036 | J:260826
First Author: Witzel M
Year: 2017
Journal: Nat Genet
Title: Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.
Volume: 49
Issue: 5
Pages: 742-752
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Publication
17720152 | J:128005
First Author: Hong CS
Year: 2007
Journal: Dev Biol
Title: The function of Dmrt genes in vertebrate development: it is not just about sex.
Volume: 310
Issue: 1
Pages: 1-9
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Publication
34256037 | J:310902
 
First Author: Hayashi S
Year: 2021
Journal: Dev Biol
Title: The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function.
Volume: 478
Pages: 155-162
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Publication
37805104 | J:342013
 
First Author: Ramachandran J
Year: 2023
Journal: Dev Biol
Title: The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.
Volume: 504
Pages: 128-136
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Publication
18582859 | J:139168
First Author: Dakubo GD
Year: 2008
Journal: Dev Biol
Title: Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye.
Volume: 320
Issue: 1
Pages: 242-55
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Publication
15322537 | J:92818
First Author: Petrova TV
Year: 2004
Journal: Nat Med
Title: Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Volume: 10
Issue: 9
Pages: 974-81
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Publication
15107405 | J:89445
First Author: Jeong J
Year: 2004
Journal: Genes Dev
Title: Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.
Volume: 18
Issue: 8
Pages: 937-51
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Publication
21731775 | J:174353
First Author: Boualia SK
Year: 2011
Journal: PLoS One
Title: Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2.
Volume: 6
Issue: 6
Pages: e21529
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Publication
10572046 | J:55583
First Author: Tribioli C
Year: 1999
Journal: Development
Title: The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen.
Volume: 126
Issue: 24
Pages: 5699-711
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Publication
25044936 | J:215601
First Author: Gage PJ
Year: 2014
Journal: Dev Dyn
Title: The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea.
Volume: 243
Issue: 11
Pages: 1391-400
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Publication
18367164 | J:136041
First Author: Gage PJ
Year: 2008
Journal: Dev Biol
Title: The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.
Volume: 317
Issue: 1
Pages: 310-24
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Publication
20059958 | J:156014
First Author: Lagha M
Year: 2009
Journal: Dev Cell
Title: Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors.
Volume: 17
Issue: 6
Pages: 892-9
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Publication
19879845 | J:157301
First Author: Siegenthaler JA
Year: 2009
Journal: Cell
Title: Retinoic acid from the meninges regulates cortical neuron generation.
Volume: 139
Issue: 3
Pages: 597-609
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Publication
16412416 | J:105944
First Author: Mattiske D
Year: 2006
Journal: Dev Biol
Title: The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.
Volume: 290
Issue: 2
Pages: 447-58
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Publication
23862012 | J:199438
First Author: Siegenthaler JA
Year: 2013
Journal: Biol Open
Title: Foxc1 is required by pericytes during fetal brain angiogenesis.
Volume: 2
Issue: 7
Pages: 647-59
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Publication
24370450 | J:206883
First Author: Murashima A
Year: 2014
Journal: Dev Biol
Title: Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.
Volume: 386
Issue: 1
Pages: 216-26
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Publication
23904126 | J:314892
First Author: Stewart CA
Year: 2013
Journal: Mol Endocrinol
Title: CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development.
Volume: 27
Issue: 9
Pages: 1442-54
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Publication
19686679 | J:152968
First Author: Bazigou E
Year: 2009
Journal: Dev Cell
Title: Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.
Volume: 17
Issue: 2
Pages: 175-86
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Publication
29035278 | J:252596
First Author: Janardhan HP
Year: 2017
Journal: J Clin Invest
Title: Hdac3 regulates lymphovenous and lymphatic valve formation.
Volume: 127
Issue: 11
Pages: 4193-4206
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Publication
12413905 | J:79898
First Author: Kochilas L
Year: 2002
Journal: Dev Biol
Title: The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome.
Volume: 251
Issue: 1
Pages: 157-66
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Publication
28253399 | J:254700
First Author: Seo S
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.
Volume: 58
Issue: 3
Pages: 1368-1377
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Publication
25576926 | J:219810
First Author: Qu X
Year: 2015
Journal: Dev Biol
Title: Tie1 is required for lymphatic valve and collecting vessel development.
Volume: 399
Issue: 1
Pages: 117-28
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Publication
31319059 | J:281274
First Author: Qu X
Year: 2019
Journal: Dev Biol
Title: Loss of flow responsive Tie1 results in Impaired
Aortic valve remodeling.
Volume: 455
Issue: 1
Pages: 73-84
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Publication
26986003 | J:231971
First Author: Nguyen H
Year: 2016
Journal: Cell Cycle
Title: Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.
Volume: 15
Issue: 10
Pages: 1317-24
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Publication
22723296 | J:212891
First Author: Bouvrée K
Year: 2012
Journal: Circ Res
Title: Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.
Volume: 111
Issue: 4
Pages: 437-45
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Publication
30332639 | J:269779
First Author: Cha B
Year: 2018
Journal: Cell Rep
Title: Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.
Volume: 25
Issue: 3
Pages: 571-584.e5
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Publication
27313318 | J:233304
First Author: Cha B
Year: 2016
Journal: Genes Dev
Title: Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
Volume: 30
Issue: 12
Pages: 1454-69
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Publication
33934370 | J:308528
First Author: Hernández Vásquez MN
Year: 2021
Journal: EMBO J
Title: Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels.
Volume: 40
Issue: 12
Pages: e107192
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Publication
22513373 | J:184001
First Author: Ahmed M
Year: 2012
Journal: Development
Title: EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Volume: 139
Issue: 11
Pages: 1965-77
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Publication
36736300 | J:333140
First Author: Dominguez MH
Year: 2023
Journal: Cell
Title: Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart.
Volume: 186
Issue: 3
Pages: 479-496.e23
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Publication
24361262 | J:206581
First Author: Bowles J
Year: 2014
Journal: Dev Biol
Title: Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.
Volume: 386
Issue: 1
Pages: 25-33
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Publication
21143873 | J:167213
 
First Author: Lagha M
Year: 2010
Journal: BMC Genomics
Title: Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo.
Volume: 11
Pages: 696
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Publication
22412348 | J:184721
First Author: Viotti M
Year: 2012
Journal: PLoS Biol
Title: Role of the gut endoderm in relaying left-right patterning in mice.
Volume: 10
Issue: 3
Pages: e1001276
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Publication
24785830 | J:214763
First Author: He F
Year: 2014
Journal: Dev Biol
Title: Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect.
Volume: 391
Issue: 2
Pages: 170-81
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Publication
38517430 | J:346597
First Author: Seo S
Year: 2024
Journal: Invest Ophthalmol Vis Sci
Title: Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity.
Volume: 65
Issue: 3
Pages: 30
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Publication
31582413 | J:284120
 
First Author: Mahamud MR
Year: 2019
Journal: Development
Title: GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.
Volume: 146
Issue: 21
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Publication
34446717 | J:310041
First Author: Mariani L
Year: 2021
Journal: Nat Commun
Title: A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm.
Volume: 12
Issue: 1
Pages: 5136
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Publication
12812790 | J:84053
First Author: Wang T
Year: 2003
Journal: Dev Biol
Title: Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.
Volume: 259
Issue: 1
Pages: 83-94
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Publication
34403370 | J:312382
 
First Author: Lyons O
Year: 2021
Journal: JCI Insight
Title: Mutations in EPHB4 cause human venous valve aplasia.
Volume: 6
Issue: 18
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Publication
15342473 | J:93182
First Author: Wang B
Year: 2004
Journal: Development
Title: Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation.
Volume: 131
Issue: 18
Pages: 4477-87
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Publication
32015493 | J:294835
First Author: Anslow MJ
Year: 2020
Journal: Pediatr Res
Title: Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma.
Volume: 88
Issue: 3
Pages: 382-390
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Publication
39580459 | J:358844
First Author: Argiro L
Year: 2024
Journal: Nat Commun
Title: Gastruloids are competent to specify both cardiac and skeletal muscle lineages.
Volume: 15
Issue: 1
Pages: 10172
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Publication
18233958 | J:138257
First Author: Hoshino T
Year: 2008
Journal: Genes Cells
Title: Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT.
Volume: 13
Issue: 2
Pages: 159-70
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Publication
33681192 | J:313930
 
First Author: Tan L
Year: 2021
Journal: Front Cell Dev Biol
Title: Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice.
Volume: 9
Pages: 594640
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Publication
33060128 | J:301556
 
First Author: Cha B
Year: 2020
Journal: Development
Title: YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling.
Volume: 147
Issue: 23
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Publication
24927569 | J:212088
First Author: Mayeuf-Louchart A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.
Volume: 111
Issue: 24
Pages: 8844-9
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Publication
34216590 | J:310903
First Author: Gresakova V
Year: 2021
Journal: Exp Cell Res
Title: Dual role of Fam208a during zygotic cleavage and early embryonic development.
Volume: 406
Issue: 2
Pages: 112723
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Publication
31461654 | J:278463
First Author: Yang Y
Year: 2019
Journal: Cell Rep
Title: VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance.
Volume: 28
Issue: 9
Pages: 2397-2412.e4
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Publication
27991863 | J:239835
First Author: Lee S
Year: 2017
Journal: J Clin Invest
Title: Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
Volume: 127
Issue: 2
Pages: 457-471
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Publication
8661058 | J:33373
First Author: Labosky PA
Year: 1996
Journal: Genomics
Title: The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development.
Volume: 34
Issue: 2
Pages: 241-5
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Publication
14648841 | J:86790
First Author: Gitler AD
Year: 2003
Journal: Dev Dyn
Title: Molecular markers of cardiac endocardial cushion development.
Volume: 228
Issue: 4
Pages: 643-50
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Publication
16459152 | J:109569
First Author: Mitchell EK
Year: 2006
Journal: Gene Expr Patterns
Title: Differential gene expression in the developing mouse ureter.
Volume: 6
Issue: 5
Pages: 519-38
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Publication
35236825 | J:321831
First Author: Bai F
Year: 2022
Journal: Cell Death Dis
Title: Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway.
Volume: 13
Issue: 3
Pages: 195
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Publication
36335117 | J:330708
First Author: Guo P
Year: 2022
Journal: Nat Commun
Title: The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis.
Volume: 13
Issue: 1
Pages: 6696
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Publication
37414855 | J:337873
First Author: Jena SK
Year: 2023
Journal: Sci Rep
Title: Molecular determinants of epithelial mesenchymal transition in mouse placenta and trophoblast stem cell.
Volume: 13
Issue: 1
Pages: 10978
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Publication
27551080 | J:235586
First Author: Li X
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
Volume: 113
Issue: 36
Pages: 10079-84
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Publication
3412448 | J:9323
First Author: Moos M
Year: 1988
Journal: Nature
Title: Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin.
Volume: 334
Issue: 6184
Pages: 701-3
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Publication
9881978 | J:86387
First Author: Ellies LG
Year: 1998
Journal: Immunity
Title: Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
Volume: 9
Issue: 6
Pages: 881-90
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Publication
7781761 | J:25971
First Author: Nakajima N
Year: 1995
Journal: FEBS Lett
Title: Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins.
Volume: 365
Issue: 2-3
Pages: 108-14
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Publication
24882364 | J:211330
First Author: Milochau A
Year: 2014
Journal: FEBS Lett
Title: Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cells.
Volume: 588
Issue: 14
Pages: 2217-22
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Publication
1506686 | J:2074
First Author: Sandrin MS
Year: 1992
Journal: J Immunol
Title: Isolation and characterization of cDNA clones for mouse Ly-9.
Volume: 149
Issue: 5
Pages: 1636-41
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Publication
20956309 | J:166232
First Author: Segovia M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Push-and-pull regulation of the fusion pore by synaptotagmin-7.
Volume: 107
Issue: 44
Pages: 19032-7
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Publication
7804326 | J:34603
First Author: Hailstones D
Year: 1994
Journal: Cell Mol Biol Res
Title: Regulation of nonmuscle myosin light chain 3 gene expression in response to exogenous MLC3nm mRNA.
Volume: 40
Issue: 1
Pages: 53-62
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Publication
2512579 | J:10152
First Author: Passananti C
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Mouse genes coding for "zinc-finger"-containing proteins: characterization and expression in differentiated cells.
Volume: 86
Issue: 23
Pages: 9417-21
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Publication
31285506 | J:288195
First Author: Shibusawa R
Year: 2019
Journal: Sci Rep
Title: Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death.
Volume: 9
Issue: 1
Pages: 9887
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Publication
18544631 | J:139759
First Author: Gervásio OL
Year: 2008
Journal: J Cell Sci
Title: TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy.
Volume: 121
Issue: Pt 13
Pages: 2246-55
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Publication
15933726 | J:111869
First Author: Demarchi F
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