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Search results 701 to 739 out of 739 for Ada

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0.011s

Type

Details

Score

Publication

18340641 | J:351955

First Author:	Brown JB
Year:	2008
Journal:	Inflamm Bowel Dis
Title:	Therapeutic benefit of pentostatin in severe IL-10-/- colitis.
Volume:	14
Issue:	7
Pages:	880-7

•

Publication

12897202 | J:117996

First Author:	Blackburn MR
Year:	2003
Journal:	J Clin Invest
Title:	Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.
Volume:	112
Issue:	3
Pages:	332-44

•

Publication

8226898 | J:297462

First Author:	Mohamedali KA
Year:	1993
Journal:	J Biol Chem
Title:	The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine.
Volume:	268
Issue:	31
Pages:	23728-33

•

Publication

20562830 | J:162081

First Author:	Orpinell M
Year:	2010
Journal:	EMBO J
Title:	The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.
Volume:	29
Issue:	14
Pages:	2381-94

•

Publication

10069416 | J:142710

First Author:	Apasov SG
Year:	1999
Journal:	Int Immunol
Title:	The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase.
Volume:	11
Issue:	2
Pages:	179-89

•

Publication

11266554 | J:68775

First Author:	Stockinger EJ
Year:	2001
Journal:	Nucleic Acids Res
Title:	Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression.
Volume:	29
Issue:	7
Pages:	1524-33

•

Publication

9184207 | J:40764

First Author:	Bieniasz PD
Year:	1997
Journal:	EMBO J
Title:	HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.
Volume:	16
Issue:	10
Pages:	2599-609

•

Publication

16950765 | J:117384

First Author:	Maier EA
Year:	2006
Journal:	J Biol Chem
Title:	Temporal regulation of enhancer function in intestinal epithelium: a role for Onecut factors.
Volume:	281
Issue:	43
Pages:	32263-71

•

Publication

16443378 | J:265965

First Author:	Mistry D
Year:	2006
Journal:	Osteoarthritis Cartilage
Title:	The role of adenosine in chondrocyte death in murine osteoarthritis and in a murine chondrocyte cell line.
Volume:	14
Issue:	5
Pages:	486-95

•

Publication

33131093 | J:305962

First Author:	Manalo JM
Year:	2020
Journal:	FASEB J
Title:	Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.
Volume:	34
Issue:	12
Pages:	15771-15787

•

Protein

Q3U2D4

Organism:	Mus musculus/domesticus
Length:	473
Fragment?:	false

•

Strain

MGI:5650478 | (STOCK Sox18<Ra> Eef1a2<wst> x M. spretus)F1

Attribute String:

F1 hybrid, mutant stock

•

Strain

MGI:2160939 | STOCK Sox18<Ra> Eef1a2<wst>

Attribute String:

mutant stock

•

Publication

26335190 | J:357672

First Author:	Nascimento F
Year:	2015
Journal:	Purinergic Signal
Title:	Presymptomatic and symptomatic ALS SOD1(G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission.
Volume:	11
Issue:	4
Pages:	471-80

•

Publication

11376685 | J:69739

First Author:	Ishikawa T
Year:	2001
Journal:	Mutat Res
Title:	Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies.
Volume:	477
Issue:	1-2
Pages:	41-9

•

Publication

24001940 | J:341670

First Author:	Gupta MK
Year:	2013
Journal:	J Mol Cell Cardiol
Title:	Functional dissection of myosin binding protein C phosphorylation.
Volume:	64

Pages:	39-50

•

Publication

1346732 | J:2752

First Author:	Kulkarni AD
Year:	1992
Journal:	Transplantation
Title:	Immunohemopoietic effects of dietary nucleotide restriction in mice.
Volume:	53
Issue:	2
Pages:	467-72

•

Publication

15677472 | J:98562

First Author:	Maier EA
Year:	2005
Journal:	J Biol Chem
Title:	Cdx binding determines the timing of enhancer activation in postnatal duodenum.
Volume:	280
Issue:	13
Pages:	13195-202

•

Publication

25420047 | J:318290

First Author:	Wang L
Year:	2014
Journal:	PLoS One
Title:	Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.
Volume:	9
Issue:	11
Pages:	e113417

•

Publication

- | J:4793

First Author:	Sakaguchi AY
Year:	1984
Journal:	Cytogenet Cell Genet
Title:	Mouse proto-oncogene assignments (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping)
Volume:	37 (1-4)

Pages:	573-574 (Abstr.) (399-616)

•

Protein

Q9JHD1

Organism:	Mus musculus/domesticus
Length:	813
Fragment?:	false

•

Protein

Q9JHD2

Organism:	Mus musculus/domesticus
Length:	830
Fragment?:	false

•

Protein

Q6P3Z8

Organism:	Mus musculus/domesticus
Length:	829
Fragment?:	false

•

Protein

Q3UD69

Organism:	Mus musculus/domesticus
Length:	830
Fragment?:	false

•

Protein

Q3UM02

Organism:	Mus musculus/domesticus
Length:	833
Fragment?:	false

•

Protein

B2RR30

Organism:	Mus musculus/domesticus
Length:	813
Fragment?:	false

•

Publication

12186975 | -

First Author:	Sterner DE
Year:	2002
Journal:	Proc Natl Acad Sci U S A
Title:	SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.
Volume:	99
Issue:	18
Pages:	11622-7

•

Protein Domain

IPR016612 | Mediator_Med6_fun

Type:

Family

Description:

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Three types of intermediary factors that enable the basal transcription machinery to respond to transcriptional activator proteins bound to regulatory DNA sequences have been identified: (i) TAFIIs, which associate with TATA-binding protein (TBP) to form TFIID; (ii) mediator, which associates with RNA polymerase II to form a holo-polymerase; and (iii) coactivators such as human upstream stimulatory activity (USA), mammalian CBP/P300, yeast ADA complex, and HMG proteins. The interaction of these multiprotein complexes with activators and general transcription factors is essential for transcriptional regulation. This family of proteins represent the transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans [].This entry represents the Med6 subunit of the Mediator complex in fungi.

•

Protein Domain

IPR007018 | Mediator_Med6

Type:

Family

Description:

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Three types of intermediary factors that enable the basal transcription machinery to respond to transcriptional activator proteins bound to regulatory DNA sequences have been identified: (i) TAFIIs, which associate with TATA-binding protein (TBP) to form TFIID; (ii) mediator, which associates with RNA polymerase II to form a holo-polymerase; and (iii) coactivators such as human upstream stimulatory activity (USA), mammalian CBP/P300, yeast ADA complex, and HMG proteins. The interaction of these multiprotein complexes with activators and general transcription factors is essential for transcriptional regulation.This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans [].

•

Protein Domain

IPR016820 | Mediator_Med6_met/pln

Type:

Family

Description:

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Three types of intermediary factors that enable the basal transcription machinery to respond to transcriptional activator proteins bound to regulatory DNA sequences have been identified: (i) TAFIIs, which associate with TATA-binding protein (TBP) to form TFIID; (ii) mediator, which associates with RNA polymerase II to form a holo-polymerase; and (iii) coactivators such as human upstream stimulatory activity (USA), mammalian CBP/P300, yeast ADA complex, and HMG proteins. The interaction of these multiprotein complexes with activators and general transcription factors is essential for transcriptional regulation. This family of proteins represent the transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans [].This group represents a RNA polymerase II mediator complex, subunit 6, metazoa/plant types.

•

Publication

9234719 | -

First Author:	Lee YC
Year:	1997
Journal:	Mol Cell Biol
Title:	A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans.
Volume:	17
Issue:	8
Pages:	4622-32

•

Protein

E0CYA6

Organism:	Mus musculus/domesticus
Length:	181
Fragment?:	false

•

Protein

E0CXQ3

Organism:	Mus musculus/domesticus
Length:	132
Fragment?:	true

•

Publication

15647753 | -

First Author:	Pray-Grant MG
Year:	2005
Journal:	Nature
Title:	Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Volume:	433
Issue:	7024
Pages:	434-8

•

Publication

12446794 | -

First Author:	Pray-Grant MG
Year:	2002
Journal:	Mol Cell Biol
Title:	The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.
Volume:	22
Issue:	24
Pages:	8774-86

•

Publication

25216679 | -

First Author:	Han Y
Year:	2014
Journal:	EMBO J
Title:	Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.
Volume:	33
Issue:	21
Pages:	2534-46

•

Publication

9674425 | J:320277

First Author:	Ogryzko VV
Year:	1998
Journal:	Cell
Title:	Histone-like TAFs within the PCAF histone acetylase complex.
Volume:	94
Issue:	1
Pages:	35-44

•

Protein

Q921D4

Organism:	Mus musculus/domesticus
Length:	246
Fragment?:	false

•

Protein

A0A0R4IZX3

Organism:	Mus musculus/domesticus
Length:	195
Fragment?:	false

•

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