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Search results 701 to 796 out of 796 for Alpl

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Type Details Score
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:12290
 
First Author: Weiss M
Year: 1987
Journal: Cytogenet Cell Genet
Title: Assignment of the gene encoding the liver/bone/kidney form of alkaline phosphatase ALPL to the region 1p34-p36.1.
Volume: 46
Pages: 714 (Abstr.)
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Allele
Alpl<tm1Smoc> | MGI:7288244
Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6354536 | C57BL/6JSmoc-Alpl<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Alpl<Hpp> | MGI:3051587
Name: alkaline phosphatase, liver/bone/kidney; hypophosphatasia
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph
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Allele
Alpl<Mhdabap020> | MGI:5424919
 
Name: alkaline phosphatase, liver/bone/kidney; Martin Hrabe de Angelis bone alkaline phospatase mutant 020
Allele Type: Chemically induced (ENU)
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Allele
Alpl<BAP023> | MGI:5424920
 
Name: alkaline phosphatase, liver/bone/kidney; bone alkaline phospatase mutant 023
Allele Type: Chemically induced (ENU)
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Allele
Alpl<Mhdabap26> | MGI:5424922
 
Name: alkaline phosphatase, liver/bone/kidney; Martin Hrabe de Angelis bone alkaline phospatase mutant 26
Allele Type: Chemically induced (ENU)
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Allele
Alpl<Mhdabap27> | MGI:5424923
 
Name: alkaline phosphatase, liver/bone/kidney; Martin Hrabe de Angelis bone alkaline phospatase mutant 27
Allele Type: Chemically induced (ENU)
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Allele
Alpl<Mhdabap32> | MGI:5424924
 
Name: alkaline phosphatase, liver/bone/kidney; Martin Hrabe de Angelis bone alkaline phospatase mutant 32
Allele Type: Chemically induced (ENU)
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Allele
Alpl<tm2.1Jlm> | MGI:5818891
Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 2.1, Jose Luis Millan
Allele Type: Targeted
Attribute String: Dominant negative, Humanized sequence
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DO Term
DOID:0110915 | childhood hypophosphatasia
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Allele
Alpl<tm1Sor> | MGI:1857124
Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Philippe Soriano
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Alpl/Alpl<+>
Background: involves: BALB/cAnN * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: involves: BALB/cAnN * C3H/HeH
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: C3HeB/FeJ-Alpl/Ieg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: C3HeB/FeJ-Alpl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: C3HeB/FeJ-Alpl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: C3HeB/FeJ-Alpl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: C3HeB/FeJ-Alpl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl<+>
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0110913 | adult hypophosphatasia
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DO Term
DOID:14213 | hypophosphatasia
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Genotype
Genotype
Symbol: Alpl/Alpl
Background: either: (involves: 129S7/SvEvBrd-Alpl) or (involves: 129S7/SvEvBrd * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Publication
28286232 | J:251211
 
First Author: Watters RJ
Year: 2017
Journal: Mol Cell Endocrinol
Title: Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen.
Volume: 448
Pages: 21-27
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Publication
1979310 | J:47386
First Author: Dudley CR
Year: 1990
Journal: Hum Genet
Title: The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1.
Volume: 86
Issue: 1
Pages: 79-83
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Publication
26759176 | J:246895
First Author: Ishikawa M
Year: 2016
Journal: J Cell Sci
Title: Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns.
Volume: 129
Issue: 5
Pages: 1018-30
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Publication
31142802 | J:279018
First Author: Hans CP
Year: 2019
Journal: Sci Rep
Title: Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization.
Volume: 9
Issue: 1
Pages: 7999
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Publication
33774049 | J:304930
   
First Author: Canalis E
Year: 2021
Journal: J Biol Chem
Title: Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling.
Pages: 100583
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Publication
23782701 | J:201762
First Author: Zanotti S
Year: 2013
Journal: J Biol Chem
Title: Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice.
Volume: 288
Issue: 30
Pages: 21547-57
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Publication
35055125 | J:318852
 
First Author: St-Arnaud R
Year: 2022
Journal: Int J Mol Sci
Title: NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH.
Volume: 23
Issue: 2
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Publication
32671900 | J:309138
First Author: Suresh S
Year: 2020
Journal: FASEB J
Title: Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis.
Volume: 34
Issue: 9
Pages: 11685-11697
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Publication
25128529 | J:217072
First Author: Kuzynski M
Year: 2014
Journal: J Biol Chem
Title: Dual role of the Trps1 transcription factor in dentin mineralization.
Volume: 289
Issue: 40
Pages: 27481-93
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Publication
8104872 | J:13548
First Author: Clamp PA
Year: 1993
Journal: Genomics
Title: Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6.
Volume: 17
Issue: 2
Pages: 324-9
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Publication
26391843 | J:231393
First Author: Hernández-Mosqueira C
Year: 2015
Journal: Biochim Biophys Acta
Title: Tissue alkaline phosphatase is involved in lipid metabolism and gene expression and secretion of adipokines in adipocytes.
Volume: 1850
Issue: 12
Pages: 2485-96
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Publication
38069267 | J:343689
 
First Author: Jantaboon S
Year: 2023
Journal: Int J Mol Sci
Title: Lipopolysaccharide Impedes Bone Repair in FcγRIIB-Deficient Mice.
Volume: 24
Issue: 23
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Publication
- | J:4894
 
First Author: Buetow KH
Year: 1987
Journal: Cytogenet Cell Genet
Title: Linkage analysis of seven markers on human chromosome 1.
Volume: 46
Pages: 588 (Abstr.)
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Publication
36029186 | J:327982
First Author: Fleury MA
Year: 2022
Journal: Physiol Rep
Title: Impact of sex and sex hormones on pathophysiology and progression of aortic stenosis in a murine model.
Volume: 10
Issue: 16
Pages: e15433
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Publication
38331306 | J:347431
 
First Author: Nakanishi T
Year: 2024
Journal: Bone
Title: Complex intrinsic abnormalities in osteoblast lineage cells of X-linked hypophosphatemia: Analysis of human iPS cell models generated by CRISPR/Cas9-mediated gene ablation.
Volume: 181
Pages: 117044
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Publication
27001421 | J:255934
First Author: Alesutan I
Year: 2016
Journal: Cardiovasc Res
Title: Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine.
Volume: 110
Issue: 3
Pages: 408-18
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Publication
24825455 | J:233230
First Author: Yadav MC
Year: 2014
Journal: J Bone Miner Res
Title: Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.
Volume: 29
Issue: 11
Pages: 2369-81
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Publication
23184610 | J:266919
First Author: Warraich S
Year: 2013
Journal: J Bone Miner Res
Title: Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans.
Volume: 28
Issue: 5
Pages: 1135-49
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Publication
26773408 | J:329594
First Author: Yadav MC
Year: 2016
Journal: J Bone Miner Res
Title: Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.
Volume: 31
Issue: 6
Pages: 1275-86
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Publication
27458382 | J:289938
 
First Author: Nakano Y
Year: 2016
Journal: Front Physiol
Title: A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues.
Volume: 7
Pages: 258
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Publication
24489784 | J:212693
First Author: Zanotti S
Year: 2014
Journal: PLoS One
Title: Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.
Volume: 9
Issue: 1
Pages: e86757
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Protein
B1AXF6
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Publication
11124260 | -
First Author: Le Du MH
Year: 2001
Journal: J Biol Chem
Title: Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
Volume: 276
Issue: 12
Pages: 9158-65
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Publication
15938627 | -
First Author: Wang J
Year: 2005
Journal: Biochemistry
Title: Metal specificity is correlated with two crucial active site residues in Escherichia coli alkaline phosphatase.
Volume: 44
Issue: 23
Pages: 8378-86
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Publication
15946677 | -
First Author: Llinas P
Year: 2005
Journal: J Mol Biol
Title: Structural studies of human placental alkaline phosphatase in complex with functional ligands.
Volume: 350
Issue: 3
Pages: 441-51
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Publication
11910033 | -
First Author: Wojciechowski CL
Year: 2002
Journal: Protein Sci
Title: Alkaline phosphatase from the hyperthermophilic bacterium T. maritima requires cobalt for activity.
Volume: 11
Issue: 4
Pages: 903-11
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Publication
17520090 | -
First Author: Sadeghirizi A
Year: 2007
Journal: Acta Biochim Pol
Title: Plasma membrane homing of tissue nonspecific alkaline phosphatase under the influence of 3-hydrogenkwadaphnin, an antiproliferative agent from Dendrostellera lessertii.
Volume: 54
Issue: 2
Pages: 323-9
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Publication
18292227 | J:143957
First Author: Goldberg RF
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.
Volume: 105
Issue: 9
Pages: 3551-6
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Publication
17719863 | -
First Author: Brun-Heath I
Year: 2007
Journal: Eur J Med Genet
Title: Delayed transport of tissue-nonspecific alkaline phosphatase with missense mutations causing hypophosphatasia.
Volume: 50
Issue: 5
Pages: 367-78
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Protein Domain
IPR001952 | Alkaline_phosphatase
Type: Family
Description: This entry represents alkaline phosphatases () (ALP), which act as non-specific phosphomonoesterases to hydrolyse phosphate esters, optimally at high pH. The reaction mechanism involves the attack of a serine alkoxide on a phosphorus of the substrate to form a transient covalent enzyme-phosphate complex, followed by the hydrolysis of the serine phosphate. Alkaline phosphatases are found in all kingdoms of life, with the exception of some plants. Alkaline phosphatases are metalloenzymes that exist as a dimer, each monomer binding metal ions. The metal ions they carry can differ, although zinc and magnesium are the most common. For example, Escherichia coli alkaline phosphatase (encoded by phoA) requires the presence of two zinc ions bound at the M1 and M2 metal sites, and one magnesium ion bound at the M3 site []. However, alkaline phosphatases from Thermotoga maritima and Bacillus subtilis require cobalt for maximal activity []. In mammals, there are four alkaline phosphatase isozymes: placental, placental-like (germ cell), intestinal and tissue-nonspecific (liver/bone/kidney). All four isozymes are anchored to the outer surface of the plasma membrane by a covalently attached glycosylphosphatidylinositol (GPI) anchor []. Human alkaline phosphatases have four metal binding sites: two for zinc, one for magnesium, and one for calcium ion. Placental alkaline phosphatase (ALPP or PLAP) is highly polymorphic, with at least three common alleles []. Its activity is down-regulated by a number of effectors such as l-phenylalanine, 5'-AMP, and by p-nitrophenyl-phosphonate (PNPPate) []. The placental-like isozyme (ALPPL or PLAP-like) is elevated in germ cell tumours. The intestinal isozyme (ALPI or IAP) has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier []. The tissue-nonspecific isozyme (ALPL) is, and may play a role in skeletal mineralisation. Defects in ALPL are a cause of hypophosphatasia, including infantile-type (OMIM:241500), childhood-type (OMIM:241510) and adult-type (OMIM:146300). Hhypophosphatasia is an inherited metabolic bone disease characterised by defective skeletal mineralisation [].This entry also contains the related enzyme streptomycin-6-phosphate phosphatase () (encoded by strK) from Streptomyces species. This enzyme is involved in the synthesis of the antibiotic streptomycin, specifically cleaving both streptomycin-6-phosphate and, more slowly, streptomycin-3-phosphate [].
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Publication
32454289 | J:358222
 
First Author: Liu Y
Year: 2020
Journal: Biomed Pharmacother
Title: The synergistic effect of NELL1 and adipose-derived stem cells on promoting bone formation in osteogenesis imperfecta treatment.
Volume: 128
Pages: 110235
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Protein
P24822
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
P24823
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
P09242
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q91Z87
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q1LZM2
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: true
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Protein
E9Q7P8
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
F8VPQ6
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
B7XGA6
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
F8VQM0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q9EQ79
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q0VD75
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: true
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Protein
Q3TJD3
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q7TPW4
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
B1AXF5
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
Q8JZS4
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q3TQ02
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Publication
1654502 | -
First Author: Mansouri K
Year: 1991
Journal: Mol Gen Genet
Title: Genetics of streptomycin production in Streptomyces griseus: nucleotide sequence of five genes, strFGHIK, including a phosphatase gene.
Volume: 228
Issue: 3
Pages: 459-69
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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