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Search results 701 to 800 out of 926 for Atf4

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Type Details Score
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE212675 | RNA-seq of muscles from young and aged ATF4 mKO mice and littermate controls
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-39193 | Effect of ATF4 gene knockout on skeletal muscle mRNA levels in fasted mice
Series Id: GSE39193
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
23153536 | J:194098
First Author: Qing G
Year: 2012
Journal: Cancer Cell
Title: ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
Volume: 22
Issue: 5
Pages: 631-44
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HT Experiment
E-GEOD-72658 | Effect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice
Series Id: GSE72658
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE191115 | ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to suppress stress-related ferroptosis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Atf4<tm1Tow> | MGI:2180373
Name: activating transcription factor 4; targeted mutation 1, Timothy Townes
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
23078367 | J:194025
First Author: Pike LR
Year: 2013
Journal: Biochem J
Title: Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.
Volume: 449
Issue: 2
Pages: 389-400
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Publication
32299090 | J:289616
First Author: Huang P
Year: 2020
Journal: Blood
Title: The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression.
Volume: 135
Issue: 24
Pages: 2121-2132
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Publication
29316436 | J:253742
First Author: Gwinn DM
Year: 2018
Journal: Cancer Cell
Title: Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.
Volume: 33
Issue: 1
Pages: 91-107.e6
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Publication
30305285 | J:271170
First Author: Krishnamoorthy GP
Year: 2019
Journal: Cancer Discov
Title: EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC.
Volume: 9
Issue: 2
Pages: 264-281
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Publication
26400930 | J:226389
First Author: Segev Y
Year: 2015
Journal: J Neurosci
Title: PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement Mice.
Volume: 35
Issue: 38
Pages: 12986-93
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Publication
26884600 | J:259485
First Author: Kline CL
Year: 2016
Journal: Sci Signal
Title: ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.
Volume: 9
Issue: 415
Pages: ra18
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Publication
29062139 | -
First Author: Adjibade P
Year: 2017
Journal: Sci Rep
Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
Volume: 7
Issue: 1
Pages: 13832
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Publication
30452882 | J:287995
First Author: Miyoshi A
Year: 2019
Journal: FASEB J
Title: JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation end products.
Volume: 33
Issue: 3
Pages: 3575-3589
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Interaction Experiment
Ord D (2003)
Description: Mouse NIPK interacts with ATF4 and affects its transcriptional activity.
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Allele
Atf4<em1Smoc> | MGI:7288374
Name: activating transcription factor 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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HT Experiment
GSE206760 | The role of Atf4 in the embryonic lens at E16.5
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE66380 | ATF4 governs functional expansion of hematopoietic stem cells partially via Angptl3 in the fetal liver microenvironment (RNA-Seq)
Series Id: E-GEOD-66380
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
21806973 | J:175755
First Author: Fei Y
Year: 2011
Journal: Biochem Biophys Res Commun
Title: The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Volume: 412
Issue: 1
Pages: 160-4
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Publication
26239904 | -
First Author: Tsukumo Y
Year: 2016
Journal: J Cell Biochem
Title: TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.
Volume: 117
Issue: 2
Pages: 500-9
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Interaction Experiment
Ambivero CT (2012)
Description: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
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Interaction Experiment
Horiguchi M (2013)
Description: Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells.
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Interaction Experiment
Zhu K (2013)
Description: ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.
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Allele
Tg(Cryaa-Atf4)4Aki | MGI:3723460
Name: transgene insertion 4, Shizuo Akira
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6474812 | C57BL/6JSmoc-Atf4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Interaction Experiment
Ritter B (2004)
Description: The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development.
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Publication
15277680 | -
First Author: Vattem KM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells.
Volume: 101
Issue: 31
Pages: 11269-74
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Publication
17369260 | -
First Author: Jousse C
Year: 2007
Journal: J Biol Chem
Title: TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.
Volume: 282
Issue: 21
Pages: 15851-61
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Publication
31444471 | -
     
First Author: Wang X
Year: 2019
Journal: Mol Psychiatry
Title: Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.
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GO Term
GO:1990617 | CHOP-ATF4 complex
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GO Term
GO:1990590 | ATF1-ATF4 transcription factor complex
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Genotype
Genotype
Symbol: Atf4/Atf4 Tg(Cryaa-Atf4)4Aki/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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GO Term
GO:1990589 | ATF4-CREB1 transcription factor complex
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Publication
16140988 | -
First Author: Antonell A
Year: 2005
Journal: Genome Res
Title: Evolutionary mechanisms shaping the genomic structure of the Williams-Beuren syndrome chromosomal region at human 7q11.23.
Volume: 15
Issue: 9
Pages: 1179-88
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Publication
25976671 | -
First Author: Tsukumo Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.
Volume: 462
Issue: 4
Pages: 383-8
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Protein Domain
IPR042410 | WBSCR13
Type: Family
Description: Transducin beta-like protein 2 (TBL2), also known as WBSCR13, has been linked to Williams-Beuren syndrome []. It contains an N-terminal transmembrane region and the C-terminal WD40 domain []. Under endoplasmic reticulum (ER) stress, TBL2 is involved in ATF4 translation through its association with the mRNA [].
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GO Term
GO:0036499 | PERK-mediated unfolded protein response
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Pseudogene
MGI:3037720 | Atf1-ps
Type: pseudogene
Organism: mouse, laboratory
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HT Experiment
GSE254524 | ER-stress response in retinal Mller glia occurs significantly earlier than amyloid pathology in in the Alzheimers mouse brain and retina
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
15781252 | -
First Author: Ord D
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.
Volume: 330
Issue: 1
Pages: 210-8
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Publication
21576361 | -
First Author: Dobrikov M
Year: 2011
Journal: Mol Cell Biol
Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Volume: 31
Issue: 14
Pages: 2947-59
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Publication
21907011 | -
First Author: Chartier-Harlin MC
Year: 2011
Journal: Am J Hum Genet
Title: Translation initiator EIF4G1 mutations in familial Parkinson disease.
Volume: 89
Issue: 3
Pages: 398-406
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Publication
11606767 | -
First Author: Ventoso I
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation.
Volume: 98
Issue: 23
Pages: 12966-71
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Publication
12791690 | -
First Author: Foeger N
Year: 2003
Journal: J Biol Chem
Title: Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite.
Volume: 278
Issue: 35
Pages: 33200-7
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Protein Domain
IPR024106 | Tribbles_TRB3
Type: Family
Description: Tribbles encode an evolutionarily conserved protein family that influences proliferation, motility, metabolism, and oncogenic transformation. Originally identified in Drosophila, tribbles homologues are characterised by a central serine/threonine kinase-like domain (KD) and a C-terminal binding site for E3 ubiquitin ligases. Although the KD is the defining feature of the tribbles family, these proteins are considered to be catalytically inactive because they lack conserved residues from the characteristic adenosine triphosphate binding site and catalytic core motif within the KD [].TRB-1, TRB-2 and TRB-3 are the mammalian homologues of Drosophila tribbles. This entry represents TRB-3, which binds to ATF4 and inhibits its transcriptional activation activity []. It also interacts with and regulates activation of MAP kinases [].
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Protein Domain
IPR037584 | EIF4G1
Type: Family
Description: This entry represents eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), which is a component of the eIF4F complex. The eIF4F complex is required for recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Mitogen-activated protein kinases control translation by post-translational modification of translation initiation factors, and eIF4G1 is a substrate for protein kinase C []. As part of the eIF4F complex, EIF4G1 mediates endoplasmic reticulum stress-induced ATF4 (a master stress-induced transcription factor) mRNA translation []. Mutations in the EIF4G1 gene cause Parkinson disease 18, which is a neurodegenerative disorder with the following symptoms: bradykinesia, resting tremor, muscular rigidity and postural instability, and loss of dopaminergic neurons from the substantia nigra []. Viral infection can lead to the shutdown of translation by cleavage of EIF4G1, for example, by HIV-1 retropepsin [], rhinovirus picornain 2A []and foot-and-mouth disease virus L-peptidase [].
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Publication
26543160 | J:227046
First Author: Ye J
Year: 2015
Journal: Genes Dev
Title: GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Volume: 29
Issue: 22
Pages: 2331-6
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Protein Coding Gene
MGI:1298366 | Atf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15299019 | -
First Author: Kiss-Toth E
Year: 2004
Journal: J Biol Chem
Title: Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
Volume: 279
Issue: 41
Pages: 42703-8
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Protein
A0A0J9YTV0
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
A0A338P758
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
Q8BUW8
Organism: Mus musculus/domesticus
Length: 471  
Fragment?: true
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Protein
D3YWC6
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Protein
D3Z439
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
A0A0J9YUL1
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A0J9YU44
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
D3YWY7
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
D6RCH1
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: false
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Protein
A0A338P7C5
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
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Protein
D3YWM1
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
Q6EVH9
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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HT Experiment
GSE164453 | Gene expression profiling of Hif1alpha defective hearts in E12.5 mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
24809345 | J:232292
First Author: Scortegagna M
Year: 2014
Journal: PLoS Genet
Title: Fine tuning of the UPR by the ubiquitin ligases Siah1/2.
Volume: 10
Issue: 5
Pages: e1004348
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Publication
12213205 | J:78914
First Author: Hansen MB
Year: 2002
Journal: Genomics
Title: Mouse Atf5: molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localization.
Volume: 80
Issue: 3
Pages: 344-50
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Publication
26383020 | J:226984
 
First Author: Brina D
Year: 2015
Journal: Nat Commun
Title: eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Volume: 6
Pages: 8261
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Publication
37294632 | J:351839
First Author: Pelligra A
Year: 2023
Journal: Cell Rep
Title: Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism.
Volume: 42
Issue: 6
Pages: 112615
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Publication
24268736 | J:206150
First Author: Ozcan L
Year: 2013
Journal: Cell Metab
Title: Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
Volume: 18
Issue: 6
Pages: 803-15
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Publication
22315398 | J:182014
First Author: Clavarino G
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.
Volume: 109
Issue: 8
Pages: 3006-11
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Publication
28988820 | J:256869
First Author: Linares JF
Year: 2017
Journal: Cell Metab
Title: ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.
Volume: 26
Issue: 6
Pages: 817-829.e6
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Publication
39293433 | J:359869
First Author: Luo JH
Year: 2024
Journal: Cell Metab
Title: PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders.
Volume: 36
Issue: 10
Pages: 2262-2280.e5
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Publication
28549777 | J:277050
 
First Author: Sasaki K
Year: 2017
Journal: EBioMedicine
Title: p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock.
Volume: 20
Pages: 161-172
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Publication
34039602 | J:314226
 
First Author: Kaspar S
Year: 2021
Journal: Sci Adv
Title: Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.
Volume: 7
Issue: 22
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Publication
34877504 | J:330706
First Author: Miyake M
Year: 2021
Journal: iScience
Title: Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity.
Volume: 24
Issue: 12
Pages: 103448
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Publication
26626461 | J:232741
First Author: Szabat M
Year: 2016
Journal: Cell Metab
Title: Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.
Volume: 23
Issue: 1
Pages: 179-93
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Publication
35895846 | J:330790
First Author: Guo Q
Year: 2022
Journal: Sci Adv
Title: Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.
Volume: 8
Issue: 30
Pages: eabo0340
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Publication
31409781 | J:279390
First Author: Stone AEL
Year: 2019
Journal: Nat Commun
Title: RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.
Volume: 10
Issue: 1
Pages: 3649
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Publication
24149372 | J:207785
 
First Author: Piao J
Year: 2013
Journal: Sci Rep
Title: Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.
Volume: 3
Pages: 3022
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Publication
27436896 | J:235138
First Author: Sbodio JI
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease.
Volume: 113
Issue: 31
Pages: 8843-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom