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Search results 701 to 800 out of 831 for Atg5

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Type Details Score
Publication
17192262 | -
First Author: Matsushita M
Year: 2007
Journal: J Biol Chem
Title: Structure of Atg5.Atg16, a complex essential for autophagy.
Volume: 282
Issue: 9
Pages: 6763-72
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Publication
25862459 | -
First Author: Liang Y
Year: 2015
Journal: Mol Cell Biochem
Title: HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2.
Volume: 405
Issue: 1-2
Pages: 63-71
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Publication
12488489 | -
First Author: Andersson U
Year: 2002
Journal: J Leukoc Biol
Title: HMGB1 as a DNA-binding cytokine.
Volume: 72
Issue: 6
Pages: 1084-91
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Publication
23483477 | -
First Author: Lu B
Year: 2013
Journal: Protein Cell
Title: Regulation of HMGB1 release by inflammasomes.
Volume: 4
Issue: 3
Pages: 163-7
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Protein Domain
IPR042527 | Atg5_UblA_dom
Type: Homologous_superfamily
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].Atg5 comprises two ubiquitin-like domains that flank a helix-rich domain. The N- and C-terminal ubiquitin-like domains are called UblA and UblB, respectively, and the helix-rich domain between UblA and UblB, is called HR. Both UblA and UblB comprise a five-stranded -sheet and two-helices, which is a conserved feature in all ubiquitin superfamily proteins. The HR domain consists of three alpha helices [].This superfamily represents the UblA domain.
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Protein Domain
IPR042526 | Atg5_HR
Type: Homologous_superfamily
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].Atg5 comprises two ubiquitin-like domains that flank a helix-rich domain. The N- and C-terminal ubiquitin-like domains are called UblA and UblB, respectively, and the helix-rich domain between UblA and UblB, is called HR. Both UblA and UblB comprise a five-stranded -sheet and two-helices, which is a conserved feature in all ubiquitin superfamily proteins. The HR domain consists of three alpha helices [].This superfamily represents the helix rich domain (HR) found in Atg5.
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Protein Domain
IPR031076 | HMGB1
Type: Family
Description: This entry represents HMGB1 (also known as HMG-1). It has been implicated as an important mediator of many chronic inflammatory diseases, including asthma [, ]. During infection or injury, activated immune cells and damaged cells release HMGB1 into the extracellular space, where HMGB1 functions as a proinflammatory mediator []. Intracellular HMGB1 also has a role during inflammation. Cytosolic HMGB1 regulates apoptosis by protecting the autophagy proteins beclin 1 and ATG5 from calpain-mediated cleavage during inflammation, therefore controlling the switch between the proautophagic and proapoptotic function []. Nuclear HMGB1 is engaged in many DNA activity-associated events.The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [].
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Publication
28231469 | J:256127
First Author: Okerlund ND
Year: 2017
Journal: Neuron
Title: Bassoon Controls Presynaptic Autophagy through Atg5.
Volume: 93
Issue: 4
Pages: 897-913.e7
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Publication
16713577 | J:111292
First Author: Reef S
Year: 2006
Journal: Mol Cell
Title: A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.
Volume: 22
Issue: 4
Pages: 463-75
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Publication
23262492 | J:245290
First Author: Gammoh N
Year: 2013
Journal: Nat Struct Mol Biol
Title: Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.
Volume: 20
Issue: 2
Pages: 144-9
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Publication
24238340 | J:208987
First Author: Sorbara MT
Year: 2013
Journal: Immunity
Title: The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.
Volume: 39
Issue: 5
Pages: 858-73
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Publication
21575909 | J:198333
First Author: Ogawa M
Year: 2011
Journal: Cell Host Microbe
Title: A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens.
Volume: 9
Issue: 5
Pages: 376-89
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Publication
24349490 | J:225172
First Author: Seto S
Year: 2013
Journal: PLoS One
Title: Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
Volume: 8
Issue: 12
Pages: e83324
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Publication
18539900 | J:139213
First Author: Kundu M
Year: 2008
Journal: Blood
Title: Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation.
Volume: 112
Issue: 4
Pages: 1493-502
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Publication
17555713 | J:122388
First Author: Mok SW
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Role of galectin-3 in prion infections of the CNS.
Volume: 359
Issue: 3
Pages: 672-8
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Publication
26663083 | J:259402
First Author: Schnöder L
Year: 2016
Journal: J Biol Chem
Title: Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
Volume: 291
Issue: 5
Pages: 2067-79
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Publication
24317201 | J:229149
First Author: Jang YH
Year: 2014
Journal: Cell Death Differ
Title: Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy.
Volume: 21
Issue: 4
Pages: 533-46
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Publication
16645637 | J:132235
First Author: Hamacher-Brady A
Year: 2007
Journal: Cell Death Differ
Title: Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.
Volume: 14
Issue: 1
Pages: 146-57
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Publication
22003202 | J:179615
First Author: Qi HY
Year: 2011
Journal: J Immunol
Title: A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
Volume: 187
Issue: 10
Pages: 5286-92
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Publication
25935480 | J:228473
First Author: Lyu Q
Year: 2015
Journal: Biochem Biophys Res Commun
Title: The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death.
Volume: 462
Issue: 1
Pages: 38-45
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Publication
27336951 | J:240069
 
First Author: Barrow-McGee R
Year: 2016
Journal: Nat Commun
Title: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.
Volume: 7
Pages: 11942
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Publication
30970253 | J:280580
First Author: DeVorkin L
Year: 2019
Journal: Cell Rep
Title: Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Volume: 27
Issue: 2
Pages: 502-513.e5
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Publication
31358770 | J:279386
First Author: Tian Y
Year: 2019
Journal: Nat Commun
Title: ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.
Volume: 10
Issue: 1
Pages: 3391
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Publication
33459130 | J:315201
First Author: Vujić N
Year: 2021
Journal: Autophagy
Title: ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
Volume: 17
Issue: 11
Pages: 3402-3407
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Publication
19270693 | J:219088
First Author: Zhong Y
Year: 2009
Journal: Nat Cell Biol
Title: Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.
Volume: 11
Issue: 4
Pages: 468-76
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Publication
23357852 | J:211234
First Author: Sirohi K
Year: 2013
Journal: Autophagy
Title: M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.
Volume: 9
Issue: 4
Pages: 510-27
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Publication
18806755 | J:158109
First Author: Gozuacik D
Year: 2008
Journal: Cell Death Differ
Title: DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.
Volume: 15
Issue: 12
Pages: 1875-86
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Publication
20181828 | J:271800
First Author: Kong DK
Year: 2010
Journal: Mol Biol Cell
Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.
Volume: 21
Issue: 8
Pages: 1335-49
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Publication
19855132 | J:154591
First Author: Singh R
Year: 2009
Journal: J Clin Invest
Title: Autophagy regulates adipose mass and differentiation in mice.
Volume: 119
Issue: 11
Pages: 3329-39
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Publication
30842662 | J:274355
First Author: Gui X
Year: 2019
Journal: Nature
Title: Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Volume: 567
Issue: 7747
Pages: 262-266
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Publication
27334109 | J:237872
First Author: Szargel R
Year: 2016
Journal: Hum Mol Genet
Title: The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway.
Volume: 25
Issue: 16
Pages: 3476-3490
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Publication
29951954 | J:319287
First Author: Huang Y
Year: 2018
Journal: Sci China Life Sci
Title: Aquaporin 5 is degraded by autophagy in diabetic submandibular gland.
Volume: 61
Issue: 9
Pages: 1049-1059
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Publication
27063951 | J:324317
First Author: Leng S
Year: 2016
Journal: J Lipid Res
Title: Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.
Volume: 57
Issue: 6
Pages: 1006-16
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Publication
24901456 | J:246920
First Author: Owen KA
Year: 2014
Journal: PLoS Pathog
Title: Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages.
Volume: 10
Issue: 6
Pages: e1004159
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Publication
21217818 | J:168250
First Author: Portillo JA
Year: 2010
Journal: PLoS One
Title: The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.
Volume: 5
Issue: 12
Pages: e14472
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Publication
19229247 | J:164191
First Author: Uhl M
Year: 2009
Journal: Cell Death Differ
Title: Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells.
Volume: 16
Issue: 7
Pages: 991-1005
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Publication
21421856 | J:172749
First Author: Jia W
Year: 2011
Journal: J Immunol
Title: Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy.
Volume: 186
Issue: 9
Pages: 5313-22
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Publication
27616656 | J:235651
First Author: Ni HM
Year: 2016
Journal: Am J Pathol
Title: Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.
Volume: 186
Issue: 10
Pages: 2623-36
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Publication
24727585 | J:221753
First Author: Chen ZH
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells.
Volume: 306
Issue: 11
Pages: L1016-25
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Publication
22875977 | J:346256
First Author: Chakrabarti A
Year: 2012
Journal: J Virol
Title: RNase L triggers autophagy in response to viral infections.
Volume: 86
Issue: 20
Pages: 11311-21
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Publication
28432355 | J:313571
First Author: Into T
Year: 2017
Journal: Sci Rep
Title: Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.
Volume: 7
Issue: 1
Pages: 1009
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Publication
36149892 | J:330041
First Author: Chen Y
Year: 2022
Journal: PLoS Genet
Title: AFF4 regulates cellular adipogenic differentiation via targeting autophagy.
Volume: 18
Issue: 9
Pages: e1010425
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Publication
37963542 | J:344308
First Author: Zou R
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Cardiomyocyte-specific deletion of endothelin receptor A (ET(A)) obliterates cardiac aging through regulation of mitophagy and ferroptosis.
Volume: 1870
Issue: 2
Pages: 166958
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Publication
21505144 | J:182068
First Author: She P
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease.
Volume: 301
Issue: 1
Pages: E49-61
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Publication
26982722 | J:232715
First Author: Ravindran R
Year: 2016
Journal: Nature
Title: The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
Volume: 531
Issue: 7595
Pages: 523-527
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Publication
27514476 | J:240327
First Author: Inaba Y
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Volume: 311
Issue: 4
Pages: G634-G647
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Publication
31061170 | J:276952
 
First Author: Chatterji P
Year: 2019
Journal: EMBO Rep
Title: Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.
Volume: 20
Issue: 6
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Publication
36813768 | J:333477
First Author: Yang F
Year: 2023
Journal: Nat Commun
Title: Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling.
Volume: 14
Issue: 1
Pages: 978
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Publication
29327342 | J:336827
First Author: Zhang L
Year: 2018
Journal: J Pathol
Title: Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori.
Volume: 244
Issue: 4
Pages: 432-444
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Publication
32934215 | J:313554
First Author: Wei C
Year: 2020
Journal: Cell Death Dis
Title: Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells.
Volume: 11
Issue: 9
Pages: 755
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Publication
28558013 | J:243645
First Author: Cho JH
Year: 2017
Journal: PLoS Genet
Title: Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.
Volume: 13
Issue: 5
Pages: e1006819
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Publication
28941726 | J:256726
 
First Author: Cao YL
Year: 2017
Journal: Neurobiol Aging
Title: A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.
Volume: 60
Pages: 104-115
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Publication
27800610 | J:308966
First Author: Sung HK
Year: 2017
Journal: J Cell Physiol
Title: Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia.
Volume: 232
Issue: 8
Pages: 2125-2134
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Publication
23935986 | J:204458
First Author: Joseph AM
Year: 2013
Journal: PLoS One
Title: Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.
Volume: 8
Issue: 7
Pages: e69327
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Publication
28933598 | J:310408
First Author: Qiang L
Year: 2017
Journal: Autophagy
Title: Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.
Volume: 13
Issue: 12
Pages: 2086-2103
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Publication
34215725 | J:320581
First Author: Saltykova IV
Year: 2021
Journal: Cell Death Dis
Title: Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration.
Volume: 12
Issue: 7
Pages: 664
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Publication
19139631 | J:234766
First Author: Herrera VL
Year: 2009
Journal: Autophagy
Title: Autophagy: insights from DEspR-deficiency and haploinsufficiency.
Volume: 5
Issue: 2
Pages: 259-62
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Publication
30319444 | J:311095
 
First Author: Gao W
Year: 2018
Journal: Front Physiol
Title: Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy.
Volume: 9
Pages: 1333
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Publication
27427974 | J:317872
First Author: Pajares M
Year: 2016
Journal: Autophagy
Title: Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Volume: 12
Issue: 10
Pages: 1902-1916
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Publication
26040000 | J:223374
First Author: Teng AC
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Metformin increases degradation of phospholamban via autophagy in cardiomyocytes.
Volume: 112
Issue: 23
Pages: 7165-70
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Publication
22155234 | J:180307
First Author: Yoshizaki T
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Autophagy regulates inflammation in adipocytes.
Volume: 417
Issue: 1
Pages: 352-7
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22162830 | J:179047
First Author: Ireland JM
Year: 2011
Journal: J Exp Med
Title: Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells.
Volume: 208
Issue: 13
Pages: 2625-32
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Publication
35086419 | J:347167
First Author: Lapaquette P
Year: 2022
Journal: Gut Microbes
Title: Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans.
Volume: 14
Issue: 1
Pages: 2004798
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Publication
29277324 | J:262161
First Author: Liu P
Year: 2018
Journal: Biochim Biophys Acta
Title: Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation.
Volume: 1864
Issue: 3
Pages: 764-777
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Publication
32999071 | J:296725
First Author: Xue J
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy.
Volume: 117
Issue: 41
Pages: 25543-25552
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Publication
32045770 | J:292109
 
First Author: Li T
Year: 2020
Journal: Mol Immunol
Title: Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway.
Volume: 120
Pages: 13-22
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Publication
31479110 | J:332886
First Author: Lee HJ
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model.
Volume: 60
Issue: 12
Pages: 3708-3716
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17235397 | J:118044
First Author: Amaravadi RK
Year: 2007
Journal: J Clin Invest
Title: Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.
Volume: 117
Issue: 2
Pages: 326-36
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Publication
18614532 | J:142015
First Author: Zhang G
Year: 2008
Journal: J Biol Chem
Title: Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.
Volume: 283
Issue: 36
Pages: 24343-58
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Publication
18974775 | J:158092
First Author: Huang Q
Year: 2009
Journal: Cell Death Differ
Title: A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.
Volume: 16
Issue: 2
Pages: 264-77
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Publication
21367693 | J:170678
First Author: Cao DJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.
Volume: 108
Issue: 10
Pages: 4123-8
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Publication
21954231 | J:178870
First Author: Lee H
Year: 2012
Journal: Hum Mol Genet
Title: IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.
Volume: 21
Issue: 1
Pages: 101-14
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Publication
23026405 | J:192048
First Author: Ghavami S
Year: 2012
Journal: Biochim Biophys Acta
Title: Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts.
Volume: 1823
Issue: 12
Pages: 2274-86
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Publication
24296261 | J:210030
First Author: Suzuki M
Year: 2014
Journal: Biochim Biophys Acta
Title: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress.
Volume: 1842
Issue: 2
Pages: 245-55
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Publication
25002530 | J:224352
First Author: Chen S
Year: 2014
Journal: Mol Cell Biol
Title: Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Volume: 34
Issue: 18
Pages: 3435-49
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Publication
23175187 | J:227894
First Author: Chang CP
Year: 2013
Journal: Cell Death Differ
Title: TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation.
Volume: 20
Issue: 3
Pages: 515-23
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Publication
26441250 | J:228523
First Author: Mattiolo P
Year: 2015
Journal: Biochem Pharmacol
Title: Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation.
Volume: 98
Issue: 4
Pages: 573-86
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Publication
26787898 | J:229964
First Author: Guha P
Year: 2016
Journal: Proc Natl Acad Sci U S A
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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