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Search results 701 to 800 out of 877 for Atr

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Type Details Score
Publication
29114052 | J:254275
First Author: ElInati E
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line.
Volume: 114
Issue: 47
Pages: 12536-12541
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Publication
31664505 | J:310924
First Author: Yu Y
Year: 2020
Journal: Acta Neuropathol
Title: NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.
Volume: 139
Issue: 1
Pages: 157-174
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Publication
29988075 | J:280257
First Author: Kim SY
Year: 2019
Journal: Cell Death Differ
Title: Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.
Volume: 26
Issue: 3
Pages: 502-515
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Publication
22319212 | J:197719
First Author: Vadnais C
Year: 2012
Journal: Nucleic Acids Res
Title: CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.
Volume: 40
Issue: 10
Pages: 4483-95
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Publication
28977635 | J:246356
First Author: Kumar V
Year: 2017
Journal: Nucleic Acids Res
Title: Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.
Volume: 45
Issue: 18
Pages: 10595-10613
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Publication
29447390 | J:263620
First Author: Zhou Z
Year: 2018
Journal: Nucleic Acids Res
Title: Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis.
Volume: 46
Issue: 7
Pages: 3468-3486
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Publication
30977112 | J:290650
First Author: Ge Z
Year: 2019
Journal: Int J Cancer
Title: Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2-/- Il10-/- gpt delta mice is influenced by sex.
Volume: 145
Issue: 4
Pages: 1042-1054
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Publication
30716097 | J:272029
First Author: Shi B
Year: 2019
Journal: PLoS Genet
Title: Dual functions for the ssDNA-binding protein RPA in meiotic recombination.
Volume: 15
Issue: 2
Pages: e1007952
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Publication
35284939 | J:335377
First Author: Xiong M
Year: 2022
Journal: Biol Reprod
Title: UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice†.
Volume: 107
Issue: 1
Pages: 168-182
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Publication
23185387 | J:195457
First Author: Barro-Soria R
Year: 2012
Journal: PLoS One
Title: Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.
Volume: 7
Issue: 11
Pages: e49624
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Publication
33963872 | J:314418
First Author: Ju MK
Year: 2021
Journal: Nucleic Acids Res
Title: NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Volume: 49
Issue: 10
Pages: 5605-5622
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Publication
29952003 | J:267750
First Author: Champeris Tsaniras S
Year: 2018
Journal: J Pathol
Title: Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.
Volume: 246
Issue: 2
Pages: 134-140
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Publication
24741006 | J:212453
First Author: Biswas AK
Year: 2014
Journal: Cancer Res
Title: E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis.
Volume: 74
Issue: 12
Pages: 3369-77
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Publication
34339838 | J:318650
First Author: Liu Z
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
Volume: 1867
Issue: 11
Pages: 166237
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Publication
36563124 | J:344817
First Author: Liu W
Year: 2023
Journal: Adv Sci (Weinh)
Title: RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.
Volume: 10
Issue: 5
Pages: e2203884
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Publication
15254237 | J:92253
First Author: Arlt MF
Year: 2004
Journal: Mol Cell Biol
Title: BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function.
Volume: 24
Issue: 15
Pages: 6701-9
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Publication
15701627 | J:98741
First Author: Horton JK
Year: 2005
Journal: J Biol Chem
Title: Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.
Volume: 280
Issue: 16
Pages: 15773-85
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Publication
16360315 | J:106236
First Author: Smits VA
Year: 2006
Journal: Curr Biol
Title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.
Volume: 16
Issue: 2
Pages: 150-9
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Publication
18438399 | J:136293
First Author: Ayoub N
Year: 2008
Journal: Nature
Title: HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.
Volume: 453
Issue: 7195
Pages: 682-6
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Publication
18625717 | J:140239
First Author: Wu P
Year: 2008
Journal: Mol Cell Biol
Title: No overt nucleosome eviction at deprotected telomeres.
Volume: 28
Issue: 18
Pages: 5724-35
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Publication
18955498 | J:145042
First Author: Palm W
Year: 2009
Journal: Mol Cell Biol
Title: Functional dissection of human and mouse POT1 proteins.
Volume: 29
Issue: 2
Pages: 471-82
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Publication
19273588 | J:148995
First Author: Fragkos M
Year: 2009
Journal: Mol Cell Biol
Title: H2AX is required for cell cycle arrest via the p53/p21 pathway.
Volume: 29
Issue: 10
Pages: 2828-40
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Publication
16943440 | J:152661
First Author: Ho GP
Year: 2006
Journal: Mol Cell Biol
Title: Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Volume: 26
Issue: 18
Pages: 7005-15
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Publication
20305300 | J:162958
First Author: Greer Card DA
Year: 2010
Journal: J Biol Chem
Title: Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition.
Volume: 285
Issue: 20
Pages: 15653-61
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Publication
18054789 | J:166501
First Author: Shimura T
Year: 2008
Journal: J Mol Biol
Title: Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Volume: 375
Issue: 4
Pages: 1152-64
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Publication
19071136 | J:168938
First Author: Yajima H
Year: 2009
Journal: J Mol Biol
Title: DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.
Volume: 385
Issue: 3
Pages: 800-10
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Publication
22797300 | J:190073
First Author: Xie L
Year: 2012
Journal: J Clin Invest
Title: PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.
Volume: 122
Issue: 8
Pages: 2827-36
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Publication
25873625 | J:232664
First Author: Panigrahi SK
Year: 2015
Journal: Nucleic Acids Res
Title: Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair.
Volume: 43
Issue: 9
Pages: 4531-46
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Publication
27920088 | J:237491
First Author: Eid A
Year: 2016
Journal: Genes Dev
Title: SUV4-20 activity in the preimplantation mouse embryo controls timely replication.
Volume: 30
Issue: 22
Pages: 2513-2526
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Publication
28439015 | J:242221
First Author: Liu K
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Volume: 114
Issue: 19
Pages: E3766-E3775
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Publication
28483909 | J:244331
 
First Author: Wheaton K
Year: 2017
Journal: Mol Cell Biol
Title: Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.
Volume: 37
Issue: 14
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Publication
28381412 | J:242347
First Author: Timashev LA
Year: 2017
Journal: Genes Dev
Title: The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction.
Volume: 31
Issue: 6
Pages: 578-589
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Publication
27538817 | J:258385
 
First Author: Fujikane R
Year: 2016
Journal: Sci Rep
Title: Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis.
Volume: 6
Pages: 31714
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Publication
31405847 | J:279987
First Author: Erber J
Year: 2019
Journal: Cancer Res
Title: Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells.
Volume: 79
Issue: 19
Pages: 4855-4868
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Publication
33619545 | J:313251
First Author: Dereli I
Year: 2021
Journal: Nucleic Acids Res
Title: Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.
Volume: 49
Issue: 5
Pages: 2609-2628
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Publication
29107825 | J:318504
 
First Author: Xia J
Year: 2018
Journal: J Nutr Biochem
Title: Atrazine-induced environmental nephrosis was mitigated by lycopene via modulating nuclear xenobiotic receptors-mediated response.
Volume: 51
Pages: 80-90
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Publication
35051531 | J:319625
 
First Author: Ma S
Year: 2022
Journal: Cancer Lett
Title: Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.
Volume: 530
Pages: 29-44
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Publication
24084170 | J:320206
First Author: Melis JP
Year: 2013
Journal: DNA Repair (Amst)
Title: Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.
Volume: 12
Issue: 12
Pages: 1081-6
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Publication
16908670 | J:112621
First Author: Jehle AW
Year: 2006
Journal: J Cell Biol
Title: ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.
Volume: 174
Issue: 4
Pages: 547-56
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Protein
Q24JP3
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q6P9P0
Organism: Mus musculus/domesticus
Length: 1278  
Fragment?: false
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Protein
Q80WC1
Organism: Mus musculus/domesticus
Length: 1314  
Fragment?: false
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Protein
Q8JZS6
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
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Protein
Q8BZ50
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: true
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Protein
Q8CDR1
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
F6VRS2
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
Q3TST9
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: true
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Protein
A2AAW4
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
Q9D4Y4
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Q06RJ2
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
E9Q839
Organism: Mus musculus/domesticus
Length: 1163  
Fragment?: false
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Protein
A0A494BAY5
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
F6WBP1
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
A0A494BAL0
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: false
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Protein
F6TB64
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: true
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Protein
E9PXB2
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
A0A494BB77
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
A0A3Q4ECA2
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
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Protein
B7ZWK5
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
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Protein
D3Z515
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
A0A0A6YWQ3
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
A0A494BB73
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
A0A0A6YWE8
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
E9PUL8
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
A0A494B9R8
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q8CEN1
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Protein
Q8QZZ4
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q78XZ3
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
B2RXQ3
Organism: Mus musculus/domesticus
Length: 1163  
Fragment?: false
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Protein
Q8C623
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Publication
10075733 | -
First Author: Sun H
Year: 1999
Journal: J Biol Chem
Title: Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease.
Volume: 274
Issue: 12
Pages: 8269-81
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Publication
16540294 | -
First Author: Kaminski WE
Year: 2006
Journal: Biochim Biophys Acta
Title: ABC A-subfamily transporters: structure, function and disease.
Volume: 1762
Issue: 5
Pages: 510-24
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Publication
17081983 | -
First Author: Olsen JV
Year: 2006
Journal: Cell
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Volume: 127
Issue: 3
Pages: 635-48
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Publication
32389690 | -
First Author: Adamus M
Year: 2020
Journal: J Mol Biol
Title: Molecular Insights into the Architecture of the Human SMC5/6 Complex.
Volume: 432
Issue: 13
Pages: 3820-3837
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Publication
19029251 | -
First Author: Banumathy G
Year: 2009
Journal: Mol Cell Biol
Title: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.
Volume: 29
Issue: 3
Pages: 758-70
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Protein Domain
IPR026082 | ABCA
Type: Family
Description: ATP-binding cassette transporters (ABC) are multipass transmembrane proteins that use the energy of ATP hydrolysis to transport substrates across membrane bilayers. Members of ABC transporter subfamily A are full-length transporters [], which consist of a single long polypeptide chain organised into two tandemly arranged halves. Each half contains a membrane-spanning domain (MSD) followed by a cytoplasmic nucleotide binding domain (NBD) []. Several members of this group have been shown to mediate the transport of a variety of physiologic lipid compounds, such as sterols, phospholipids and bile acids [, ].ABCA7 plays a role in clearance of apoptotic cells by affecting their phagocytosis []. In the human visual cycle, ABCA4 acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. ABCA4 may also play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery []. It has been suggested that ABCA9 plays a role in monocyte differentiation and lipid homeostasis [].
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Protein Domain
IPR007268 | Rad9/Ddc1
Type: Family
Description: This entry represents the DNA damage checkpoint protein Rad9 and its homologue in budding yeast, Ddc1. Rad9 forms a complex with Hus1 and Rad1 (called 9-1-1 complex). Ddc1 forms a similar complex with Mec1 and Rad17. Structurally, the 9-1-1 / Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. The 9-1-1 / Ddc1-Mec3-Rad17 complex plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].In humans, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Besides its function in the 9-1-1 complex, Rad9 can also act as a transcriptional factor and participate in immunoglobulin class switch recombination []. It also shows 3'-5' exonuclease activity []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].In budding yeast, Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (the orthologue of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have DNA exonuclease function [].It is worth noting that the Rad9 proteins referred to in this entry are the mammalian and fission yeast homologues of budding yeast Ddc1. Members of this family do not share the sequence homology another DNA damage-dependent checkpoint protein from budding yeast, confusingly also called Rad9.
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Publication
15449545 | J:92574
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 2
Pages: 127-35
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Publication
19851446 | J:161829
First Author: Wojtasz L
Year: 2009
Journal: PLoS Genet
Title: Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.
Volume: 5
Issue: 10
Pages: e1000702
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Publication
9382850 | J:46333
First Author: Flaggs G
Year: 1997
Journal: Curr Biol
Title: Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.
Volume: 7
Issue: 12
Pages: 977-86
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Publication
12514191 | J:82409
First Author: Leal NA
Year: 2003
Journal: J Biol Chem
Title: Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant.
Volume: 278
Issue: 11
Pages: 9227-34
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Publication
31038736 | J:281168
First Author: Sakita JY
Year: 2019
Journal: J Pathol
Title: Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis.
Volume: 249
Issue: 1
Pages: 102-113
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Publication
23468651 | J:195191
First Author: Lyndaker AM
Year: 2013
Journal: PLoS Genet
Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
Volume: 9
Issue: 2
Pages: e1003320
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Publication
23436801 | J:197061
First Author: Liu Q
Year: 2013
Journal: Cancer Res
Title: Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
Volume: 73
Issue: 8
Pages: 2574-86
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Publication
20212154 | J:158685
First Author: Cannell IG
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Volume: 107
Issue: 12
Pages: 5375-80
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Publication
22006019 | J:178305
First Author: Pines A
Year: 2011
Journal: Mol Cell Biol
Title: Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells.
Volume: 31
Issue: 24
Pages: 4964-77
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Publication
30693543 | J:339256
First Author: Ge C
Year: 2019
Journal: Hepatology
Title: The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.
Volume: 69
Issue: 6
Pages: 2608-2622
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Protein
Q8BVV7
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
Q14B65
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q8BWE9
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Publication
9311982 | -
First Author: Longhese MP
Year: 1997
Journal: EMBO J
Title: The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.
Volume: 16
Issue: 17
Pages: 5216-26
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Publication
28882873 | J:269226
First Author: Trigueros-Motos L
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
Volume: 37
Issue: 11
Pages: 2147-2155
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Protein
Q3TZM0
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
Q8BZ38
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: true
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Protein
A2A6R7
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
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Protein
Q8BIS4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
Q8R1I3
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
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Protein
A2AEP6
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
Q8CJA1
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
Q8C137
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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