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Search results 701 to 800 out of 992 for Ccr1

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Hits by Pathway

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394088
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10306
Specimen Label: GUDMAP:10306
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10307
Specimen Label: GUDMAP:10307
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884927
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945765
Age: postnatal day 7
Image: g01466 P7
Specimen Label: g01466 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884927
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945765
Age: postnatal day 42
Image: g01466 Adult
Specimen Label: g01466 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394080
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394080
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884927
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945765
Age: embryonic day 15.5
Image: g01466 E15.5
Specimen Label: g01466 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10306
Specimen Label: GUDMAP:10306
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10307
Specimen Label: GUDMAP:10307
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10307
Specimen Label: GUDMAP:10307
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394080
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394088
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4884927
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945765
Age: embryonic day 15.5
Image: g01466 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01466 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884927
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945765
Age: postnatal day 7
Image: g01466 P7
Specimen Label: g01466 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884927
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945765
Age: postnatal day 42
Image: g01466 Adult
Specimen Label: g01466 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10306
Specimen Label: GUDMAP:10306
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10307
Specimen Label: GUDMAP:10307
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394088
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394088
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3639261
Age: postnatal day 66
Specimen Label: Mouse 394088
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002202
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542756
Age: embryonic day 15.5
Image: GUDMAP:10307
Specimen Label: GUDMAP:10307
Detected: true
Specimen Num: 2
•
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Publication
22227125 | J:185015
First Author: Molica F
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Cannabinoid receptor CB2 protects against balloon-induced neointima formation.
Volume: 302
Issue: 5
Pages: H1064-74
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Publication
30977156 | J:295716
First Author: Mohan S
Year: 2019
Journal: J Cell Biochem
Title: Chemokine receptor 3 is a negative regulator of trabecular bone mass in female mice.
Volume: 120
Issue: 8
Pages: 13974-13984
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Publication
28476575 | J:257071
 
First Author: Lima ILA
Year: 2017
Journal: Bone
Title: Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling.
Volume: 101
Pages: 113-122
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Publication
10657666 | J:60333
First Author: Rajan AJ
Year: 2000
Journal: J Immunol
Title: Experimental autoimmune encephalomyelitis on the SJL mouse: effect of gamma delta T cell depletion on chemokine and chemokine receptor expression in the central nervous system.
Volume: 164
Issue: 4
Pages: 2120-30
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Publication
17588479 | J:123060
First Author: Lee JE
Year: 2007
Journal: Exp Hematol
Title: Stimulation of osteoclastogenesis by enhanced levels of MIP-1alpha in BALB/c mice in vitro.
Volume: 35
Issue: 7
Pages: 1100-8
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Publication
37396582 | J:337749
 
First Author: Keeter WC
Year: 2023
Journal: Front Cardiovasc Med
Title: Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr(-/-) mice.
Volume: 10
Pages: 1175673
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Publication
10235110 | J:54442
First Author: Fukuda S
Year: 1999
Journal: DNA Cell Biol
Title: Genomic organization of the genes for human and mouse CC chemokine LEC.
Volume: 18
Issue: 4
Pages: 275-83
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Publication
29813086 | J:263298
First Author: Jehle J
Year: 2018
Journal: PLoS One
Title: Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.
Volume: 13
Issue: 5
Pages: e0197751
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Publication
32194558 | J:304668
 
First Author: Gibaldi D
Year: 2020
Journal: Front Immunol
Title: CCL3/Macrophage Inflammatory Protein-1α Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFNγ-Enriched Inflammatory Milieu in Trypanosoma cruzi-Induced Chronic Cardiomyopathy.
Volume: 11
Pages: 306
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Publication
20498053 | J:161295
First Author: Núñez V
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Volume: 107
Issue: 23
Pages: 10626-31
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Protein
P51676
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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•
•
Publication
10781587 | J:63604
First Author: Wang W
Year: 2000
Journal: J Biol Chem
Title: Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).
Volume: 275
Issue: 29
Pages: 22313-23
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Publication
20068036 | J:233575
First Author: Röhrl J
Year: 2010
Journal: J Biol Chem
Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.
Volume: 285
Issue: 10
Pages: 7028-34
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Publication
25122636 | -
First Author: Diao R
Year: 2014
Journal: Sci Transl Med
Title: Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.
Volume: 6
Issue: 249
Pages: 249ra108
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Publication
11830666 | J:74509
First Author: Humbles AA
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness.
Volume: 99
Issue: 3
Pages: 1479-84
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Publication
10229797 | J:54920
First Author: Zaballos A
Year: 1999
Journal: J Immunol
Title: Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.
Volume: 162
Issue: 10
Pages: 5671-5
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Protein
A0A1L1STS0
Organism: Mus musculus/domesticus
Length: 32  
Fragment?: true
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Publication
8383238 | -
First Author: Birkenbach M
Year: 1993
Journal: J Virol
Title: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.
Volume: 67
Issue: 4
Pages: 2209-20
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Publication
9153236 | -
First Author: Yoshida R
Year: 1997
Journal: J Biol Chem
Title: Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.
Volume: 272
Issue: 21
Pages: 13803-9
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Publication
11745346 | -
First Author: Bardi G
Year: 2001
Journal: Eur J Immunol
Title: The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC.
Volume: 31
Issue: 11
Pages: 3291-7
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Publication
16278415 | -
First Author: Kim JW
Year: 2005
Journal: Clin Cancer Res
Title: Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis.
Volume: 11
Issue: 21
Pages: 7901-10
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Publication
15778365 | -
First Author: Riol-Blanco L
Year: 2005
Journal: J Immunol
Title: The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed.
Volume: 174
Issue: 7
Pages: 4070-80
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Publication
15059845 | -
First Author: Sánchez-Sánchez N
Year: 2004
Journal: Blood
Title: Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells.
Volume: 104
Issue: 3
Pages: 619-25
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Publication
12019175 | -
First Author: Mashino K
Year: 2002
Journal: Cancer Res
Title: Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma.
Volume: 62
Issue: 10
Pages: 2937-41
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Publication
12673677 | -
First Author: Takanami I
Year: 2003
Journal: Int J Cancer
Title: Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis.
Volume: 105
Issue: 2
Pages: 186-9
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Publication
12960129 | -
First Author: Ding Y
Year: 2003
Journal: Clin Cancer Res
Title: Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma.
Volume: 9
Issue: 9
Pages: 3406-12
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Publication
17560334 | -
First Author: Shields JD
Year: 2007
Journal: Cancer Cell
Title: Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.
Volume: 11
Issue: 6
Pages: 526-38
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Publication
10520991 | J:57976
First Author: Förster R
Year: 1999
Journal: Cell
Title: CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Volume: 99
Issue: 1
Pages: 23-33
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Publication
8146186 | -
First Author: Charo IF
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
Volume: 91
Issue: 7
Pages: 2752-6
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Publication
10587439 | -
First Author: Jarnagin K
Year: 1999
Journal: Biochemistry
Title: Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2.
Volume: 38
Issue: 49
Pages: 16167-77
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Publication
14674010 | -
First Author: Shahrara S
Year: 2003
Journal: Arthritis Rheum
Title: Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis.
Volume: 48
Issue: 12
Pages: 3568-83
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Publication
16215992 | -
First Author: Brand S
Year: 2006
Journal: J Cell Biochem
Title: Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells.
Volume: 97
Issue: 4
Pages: 709-23
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Publication
17351623 | J:121703
First Author: El Khoury J
Year: 2007
Journal: Nat Med
Title: Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
Volume: 13
Issue: 4
Pages: 432-8
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Publication
20136653 | -
First Author: Philipson O
Year: 2010
Journal: FEBS J
Title: Animal models of amyloid-beta-related pathologies in Alzheimer's disease.
Volume: 277
Issue: 6
Pages: 1389-409
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Publication
22607625 | -
First Author: Harries LW
Year: 2012
Journal: Rejuvenation Res
Title: Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults.
Volume: 15
Issue: 4
Pages: 395-404
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Publication
17479183 | -
First Author: Schober A
Year: 2007
Journal: Thromb Haemost
Title: Chemokines in vascular remodeling.
Volume: 97
Issue: 5
Pages: 730-7
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Publication
9276730 | -
First Author: Uguccioni M
Year: 1997
Journal: J Clin Invest
Title: High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
Volume: 100
Issue: 5
Pages: 1137-43
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Publication
9933081 | -
First Author: Ochensberger B
Year: 1999
Journal: Eur J Immunol
Title: Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists.
Volume: 29
Issue: 1
Pages: 11-22
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Publication
9480044 | -
First Author: Gerber BO
Year: 1997
Journal: Curr Biol
Title: Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils.
Volume: 7
Issue: 11
Pages: 836-43
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Publication
16210640 | J:102034
First Author: Pope SM
Year: 2005
Journal: J Immunol
Title: The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia.
Volume: 175
Issue: 8
Pages: 5341-50
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Publication
16453027 | -
First Author: Blanchard C
Year: 2006
Journal: J Clin Invest
Title: Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.
Volume: 116
Issue: 2
Pages: 536-47
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Publication
10640766 | -
First Author: Nibbs RJ
Year: 2000
Journal: J Immunol
Title: C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.
Volume: 164
Issue: 3
Pages: 1488-97
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Publication
10984371 | -
First Author: Fujisawa T
Year: 2000
Journal: J Allergy Clin Immunol
Title: Chemokines induce eosinophil degranulation through CCR-3.
Volume: 106
Issue: 3
Pages: 507-13
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Publication
16978084 | -
First Author: Fortin M
Year: 2006
Journal: Oligonucleotides
Title: Effects of antisense oligodeoxynucleotides targeting CCR3 on the airway response to antigen in rats.
Volume: 16
Issue: 3
Pages: 203-12
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Publication
9182688 | -
First Author: Forssmann U
Year: 1997
Journal: J Exp Med
Title: Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes.
Volume: 185
Issue: 12
Pages: 2171-6
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Publication
10754297 | -
First Author: Inngjerdingen M
Year: 2000
Journal: J Immunol
Title: Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.
Volume: 164
Issue: 8
Pages: 4048-54
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Publication
22355103 | J:182145
First Author: Poppensieker K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.
Volume: 109
Issue: 10
Pages: 3897-902
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Publication
10637271 | -
First Author: Lloyd CM
Year: 2000
Journal: J Exp Med
Title: CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo.
Volume: 191
Issue: 2
Pages: 265-74
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Publication
15683617 | -
First Author: Garcia G
Year: 2005
Journal: Curr Allergy Asthma Rep
Title: New chemokine targets for asthma therapy.
Volume: 5
Issue: 2
Pages: 155-60
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Publication
20148806 | -
First Author: Banfield G
Year: 2010
Journal: Allergy
Title: CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses.
Volume: 65
Issue: 9
Pages: 1126-33
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Publication
8663314 | J:45024
First Author: Raport CJ
Year: 1996
Journal: J Biol Chem
Title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
Volume: 271
Issue: 29
Pages: 17161-6
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Publication
9655467 | -
First Author: Jiang Y
Year: 1998
Journal: J Neuroimmunol
Title: Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis.
Volume: 86
Issue: 1
Pages: 1-12
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Publication
11994538 | -
First Author: Habasque C
Year: 2002
Journal: Mol Hum Reprod
Title: Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.
Volume: 8
Issue: 5
Pages: 419-25
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Publication
12682253 | -
First Author: Ng-Cashin J
Year: 2003
Journal: J Immunol
Title: Host absence of CCR5 potentiates dendritic cell vaccination.
Volume: 170
Issue: 8
Pages: 4201-8
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Publication
9169459 | -
First Author: Baba M
Year: 1997
Journal: J Biol Chem
Title: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.
Volume: 272
Issue: 23
Pages: 14893-8
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9886385 | -
First Author: Liao F
Year: 1999
Journal: J Immunol
Title: CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.
Volume: 162
Issue: 1
Pages: 186-94
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Publication
9294137 | -
First Author: Power CA
Year: 1997
Journal: J Exp Med
Title: Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
Volume: 186
Issue: 6
Pages: 825-35
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17486092 | -
First Author: Acosta-Rodriguez EV
Year: 2007
Journal: Nat Immunol
Title: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Volume: 8
Issue: 6
Pages: 639-46
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10521347 | -
First Author: Yang D
Year: 1999
Journal: Science
Title: Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Volume: 286
Issue: 5439
Pages: 525-8
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19249008 | -
First Author: Wang K
Year: 2009
Journal: Am J Hum Genet
Title: Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
Volume: 84
Issue: 3
Pages: 399-405
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Publication
9211859 | -
First Author: Roos RS
Year: 1997
Journal: J Biol Chem
Title: Identification of CCR8, the receptor for the human CC chemokine I-309.
Volume: 272
Issue: 28
Pages: 17251-4
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Publication
10540332 | -
First Author: Garlisi CG
Year: 1999
Journal: Eur J Immunol
Title: The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.
Volume: 29
Issue: 10
Pages: 3210-5
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Publication
10419462 | -
First Author: Dairaghi DJ
Year: 1999
Journal: J Biol Chem
Title: HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.
Volume: 274
Issue: 31
Pages: 21569-74
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Publication
9521068 | -
First Author: Bernardini G
Year: 1998
Journal: Eur J Immunol
Title: Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.
Volume: 28
Issue: 2
Pages: 582-8
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Publication
14576057 | -
First Author: Haque NS
Year: 2004
Journal: Blood
Title: Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion.
Volume: 103
Issue: 4
Pages: 1296-304
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Publication
11340325 | -
First Author: Kaplan AP
Year: 2001
Journal: Int Arch Allergy Immunol
Title: Chemokines, chemokine receptors and allergy.
Volume: 124
Issue: 4
Pages: 423-31
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Publication
10611408 | -
First Author: Napolitano M
Year: 1999
Journal: Forum (Genova)
Title: Structure and function of the CC chemokine receptor (CCR) 8.
Volume: 9
Issue: 4
Pages: 315-24
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Publication
10498628 | -
First Author: Youn BS
Year: 1999
Journal: Blood
Title: TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor.
Volume: 94
Issue: 7
Pages: 2533-6
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Publication
11159507 | -
First Author: Carramolino L
Year: 2001
Journal: Blood
Title: Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs.
Volume: 97
Issue: 4
Pages: 850-7
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16253981 | -
First Author: Honczarenko M
Year: 2006
Journal: Stem Cells
Title: Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors.
Volume: 24
Issue: 4
Pages: 1030-41
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11046037 | -
First Author: Papadakis KA
Year: 2000
Journal: J Immunol
Title: The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system.
Volume: 165
Issue: 9
Pages: 5069-76
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11487533 | -
First Author: Papadakis KA
Year: 2001
Journal: Gastroenterology
Title: CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.
Volume: 121
Issue: 2
Pages: 246-54
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15623660 | -
First Author: Singh S
Year: 2004
Journal: Clin Cancer Res
Title: Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Volume: 10
Issue: 24
Pages: 8743-50
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Publication
10725697 | -
First Author: Homey B
Year: 2000
Journal: J Immunol
Title: Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).
Volume: 164
Issue: 7
Pages: 3465-70
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11821900 | -
First Author: Homey B
Year: 2002
Journal: Nat Med
Title: CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.
Volume: 8
Issue: 2
Pages: 157-65
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14581607 | -
First Author: Murakami T
Year: 2003
Journal: J Exp Med
Title: Immune evasion by murine melanoma mediated through CC chemokine receptor-10.
Volume: 198
Issue: 9
Pages: 1337-47
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Protein Domain
IPR004069 | Chemokine_CCR9
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 9 (CCR9), which was previously designated as the orphan receptors GPR28 and GPR 9-6. CCR9 is expressed predominantly in the thymus, in both mature and immature T cells, and is also found in the lymph nodes, spleen, glomerular podocytes, bone marrow stromal cells and the small intestine [, , , , ]. Transfected cells expressing CCR9 receptor bind specifically to CCL25 (also known as Thymus-Expressed Chemokine) []. This interaction may play a pivotal role in T-cell migration in the thymus []. CCR9 activation has also been shown to influence cancer cell migration, invasion and matrix metallopeptidase expression, which together may affect prostate cancer metastasis [].
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Protein Domain
IPR004067 | Chemokine_CCR6
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 6 (CCR6). It is expressed on unactivated memory T-cells [, ]and some dendritic cells [, ]. CCR6 is also expressed on Th17 cells [], but is down-regulated in activated T-cells []. The receptor is noted as playing a role in Crohn's disease []. CCR6 major ligand is CCL20, also known as Liver and Activation-Regulated Chemokine but it can also bind non-chemokine ligands such as beta-defensines [, ]. Binding to beta-defensine 1 (DEFB1) is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity []and it mediates the chemotactic effects of defensins DEFB4 and DEFB4A/B [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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