Type |
Details |
Score |
Allele |
Name: |
transgene insertion 1, Richard S Blumberg |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Richard S Blumberg |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Agnew C |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. |
Volume: |
108 |
Issue: |
37 |
Pages: |
15174-8 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CD2-Ceacam1*4L)1Rsb/? |
Background: |
involves: C57BL/6 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CD2-Ceacam1*4L)1Rsb/? Tg(TcraTcrb)425Cbn/? |
Background: |
involves: BALB/c * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghanem SS |
Year: |
2017 |
Journal: |
Diabetologia |
Title: |
Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. |
Volume: |
60 |
Issue: |
9 |
Pages: |
1751-1760 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sutherland HG |
Year: |
2004 |
Journal: |
Exp Cell Res |
Title: |
3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. |
Volume: |
294 |
Issue: |
1 |
Pages: |
94-105 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
220
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
356
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
164
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
393
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
382
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
91
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Britt DE |
Year: |
2004 |
Journal: |
Exp Cell Res |
Title: |
Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. |
Volume: |
300 |
Issue: |
1 |
Pages: |
134-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ash SC |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. |
Volume: |
371 |
Issue: |
2 |
Pages: |
333-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SG |
Year: |
2008 |
Journal: |
Oncogene |
Title: |
Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. |
Volume: |
27 |
Issue: |
8 |
Pages: |
1114-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emdad L |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. |
Volume: |
106 |
Issue: |
50 |
Pages: |
21300-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emdad L |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. |
Volume: |
66 |
Issue: |
3 |
Pages: |
1509-16 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
LYRIC (Lysine-rich CEACAM1 co-isolated protein), also known as Astrocyte-elevated gene-1 (AEG-1), is a type-1b membrane protein with a single transmembrane domain and localises to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments []. It is found to be colocalised with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex []. LYRIC has been shown to promote angiogenesis []and tumour cell migration and invasion by activating the transcription factor NF-kappaB [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Zebhauser R |
Year: |
2005 |
Journal: |
Genomics |
Title: |
Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. |
Volume: |
86 |
Issue: |
5 |
Pages: |
566-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiokawa D |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells. |
Volume: |
19 |
Issue: |
5 |
Pages: |
981-994 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosenbaum SR |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects. |
Volume: |
37 |
Issue: |
10 |
Pages: |
110085 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Publication |
First Author: |
Salaheldeen E |
Year: |
2012 |
Journal: |
Mol Reprod Dev |
Title: |
Molecular cloning and localization of a CEACAM2 isoform, CEACAM2-L, expressed in spermatids in mouse testis. |
Volume: |
79 |
Issue: |
12 |
Pages: |
843-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heinrich G |
Year: |
2010 |
Journal: |
Gastroenterology |
Title: |
Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice. |
Volume: |
139 |
Issue: |
2 |
Pages: |
644-52, 652.e1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel PR |
Year: |
2012 |
Journal: |
Diabetologia |
Title: |
Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. |
Volume: |
55 |
Issue: |
3 |
Pages: |
763-72 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
brain |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
heart |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
kidney |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
spleen |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
thymus |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
liver |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
stomach |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3283428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
small intestine |
Detected: |
false |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
muscle |
Detected: |
false |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
lung |
Detected: |
false |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
testis |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
skin |
Detected: |
false |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
adrenal gland |
Detected: |
false |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
ovary |
Detected: |
false |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
uterus |
Detected: |
false |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1928728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3037315 |
Age: |
postnatal adult |
|
|
Specimen Label: |
prostate gland |
Detected: |
false |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
|
Stage: |
TS13 |
Assay Id: |
MGI:3037321 |
Age: |
embryonic day 8.5 |
|
|
Specimen Label: |
embryo/8.5d |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
|
Stage: |
TS15 |
Assay Id: |
MGI:3037321 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
embryo/9.5d |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
|
Stage: |
TS20 |
Assay Id: |
MGI:3037321 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
embryo/12.5d |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3036564 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-04-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603926 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3037321 |
Age: |
embryonic day 19.0 |
|
|
Specimen Label: |
embryo/19d |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Müller MM |
Year: |
2009 |
Journal: |
J Cell Biol |
Title: |
Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. |
Volume: |
187 |
Issue: |
4 |
Pages: |
569-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramakrishnan SK |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity. |
Volume: |
291 |
Issue: |
46 |
Pages: |
23915-23924 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muenzner P |
Year: |
2016 |
Journal: |
PLoS Pathog |
Title: |
Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa. |
Volume: |
12 |
Issue: |
5 |
Pages: |
e1005608 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu A |
Year: |
2011 |
Journal: |
Exp Cell Res |
Title: |
Angiopoietins-1 and -2 play opposing roles in endothelial sprouting of embryoid bodies in 3D culture and their receptor Tie-2 associates with the cell-cell adhesion molecule PECAM1. |
Volume: |
317 |
Issue: |
15 |
Pages: |
2171-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klaile E |
Year: |
2019 |
Journal: |
Front Microbiol |
Title: |
Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. |
Volume: |
10 |
|
Pages: |
2703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghanem SS |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). |
Volume: |
291 |
Issue: |
2 |
Pages: |
980-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alshahrani MM |
Year: |
2014 |
Journal: |
Blood |
Title: |
CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo. |
Volume: |
124 |
Issue: |
15 |
Pages: |
2431-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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