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Search results 701 to 777 out of 777 for Crebbp

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Type Details Score
Allele
Srcap<Gt(EUCE0237b11)Hmgu> | MGI:4378302
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0237b11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0252c05)Hmgu> | MGI:4387151
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0252c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0057c05)Hmgu> | MGI:4394323
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0057c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0019e11)Hmgu> | MGI:4395524
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0019e11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCJ00118b02)Hmgu> | MGI:4873703
 
Name: Snf2-related CREBBP activator protein; gene trap EUCJ00118b02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCJ0005d07)Hmgu> | MGI:4878330
 
Name: Snf2-related CREBBP activator protein; gene trap EUCJ0005d07, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13508C5)Tigm> | MGI:5170269
 
Name: Snf2-related CREBBP activator protein; gene trap IST13508C5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13557C6)Tigm> | MGI:5177092
 
Name: Snf2-related CREBBP activator protein; gene trap IST13557C6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13639D8)Tigm> | MGI:5179298
 
Name: Snf2-related CREBBP activator protein; gene trap IST13639D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13595A2)Tigm> | MGI:5181286
 
Name: Snf2-related CREBBP activator protein; gene trap IST13595A2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13675C7)Tigm> | MGI:5183068
 
Name: Snf2-related CREBBP activator protein; gene trap IST13675C7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13796B6)Tigm> | MGI:5187734
 
Name: Snf2-related CREBBP activator protein; gene trap IST13796B6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13769H10)Tigm> | MGI:5192497
 
Name: Snf2-related CREBBP activator protein; gene trap IST13769H10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13960H10)Tigm> | MGI:5197720
 
Name: Snf2-related CREBBP activator protein; gene trap IST13960H10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13968G5)Tigm> | MGI:5200101
 
Name: Snf2-related CREBBP activator protein; gene trap IST13968G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14185C12)Tigm> | MGI:5215869
 
Name: Snf2-related CREBBP activator protein; gene trap IST14185C12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14229G10)Tigm> | MGI:5217748
 
Name: Snf2-related CREBBP activator protein; gene trap IST14229G10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14358F3)Tigm> | MGI:5229964
 
Name: Snf2-related CREBBP activator protein; gene trap IST14358F3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14463F9)Tigm> | MGI:5231467
 
Name: Snf2-related CREBBP activator protein; gene trap IST14463F9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14566F6)Tigm> | MGI:5238731
 
Name: Snf2-related CREBBP activator protein; gene trap IST14566F6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14944D10)Tigm> | MGI:5272434
 
Name: Snf2-related CREBBP activator protein; gene trap IST14944D10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<em1(IMPC)Wtsi> | MGI:6153626
Name: Snf2-related CREBBP activator protein; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7577167 | C57BL/6JGpt-Srcap<em1Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Srcap/Srcap
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Allele
Crebbp<tm1Dli> | MGI:1926888
Name: CREB binding protein; targeted mutation 1, David Livingston
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:2174146 | B6.129S6-Crebbp<tm1Dli>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Crebbp/Crebbp
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
11701890 | -
First Author: Xu W
Year: 2001
Journal: Science
Title: A transcriptional switch mediated by cofactor methylation.
Volume: 294
Issue: 5551
Pages: 2507-11
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Publication
11943779 | -
First Author: Chen Q
Year: 2002
Journal: J Biol Chem
Title: CREB-binding protein/p300 co-activation of crystallin gene expression.
Volume: 277
Issue: 27
Pages: 24081-9
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Publication
8552098 | -
First Author: Parker D
Year: 1996
Journal: Mol Cell Biol
Title: Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.
Volume: 16
Issue: 2
Pages: 694-703
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Publication
15220471 | J:178279
First Author: Daitoku H
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Volume: 101
Issue: 27
Pages: 10042-7
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Publication
18160706 | J:132651
First Author: Cho G
Year: 2008
Journal: Mol Cell Biol
Title: Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.
Volume: 28
Issue: 5
Pages: 1565-72
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Strain
MGI:7381020 | C57BL/6N-Srcap<em1(IMPC)Wtsi>/WtsiOulu
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6335356 | C57BL/6N-Srcap<em1(IMPC)Wtsi>/Wtsi
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Crebbp<Gt(U-San)112Imeg> | MGI:1928775
Name: CREB binding protein; gene trap 112, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Srcap/Srcap<+>
Background: C57BL/6N-Srcap/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+>
Background: involves: C57BL/6 * CBA
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-GEOD-24773 | Expression data from WT, Crebbp+/- and Ep300+/- bone marrow stroma
Series Id: GSE24773
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
16634648 | J:320032
First Author: Ruhl DD
Year: 2006
Journal: Biochemistry
Title: Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.
Volume: 45
Issue: 17
Pages: 5671-7
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+> Ep300/Ep300<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
28062671 | J:238052
First Author: Höpken UE
Year: 2017
Journal: Cancer Discov
Title: Targeting HDAC3 in CREBBP-Mutant Lymphomas Counterstrikes Unopposed Enhancer Deacetylation of B-cell Signaling and Immune Response Genes.
Volume: 7
Issue: 1
Pages: 14-16
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Publication
34398873 | J:309041
First Author: Aiderus A
Year: 2021
Journal: PLoS Genet
Title: Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.
Volume: 17
Issue: 8
Pages: e1009094
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Publication
35171684 | J:321525
First Author: Kim KB
Year: 2022
Journal: Sci Adv
Title: KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.
Volume: 8
Issue: 7
Pages: eabl4618
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Publication
29138493 | J:256297
First Author: Ye B
Year: 2017
Journal: Nat Commun
Title: Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.
Volume: 8
Issue: 1
Pages: 1518
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Protein Domain
IPR038547 | RING_CBP-p300_sf
Type: Homologous_superfamily
Description: CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function [].
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Protein Domain
IPR010303 | RING_CBP-p300
Type: Domain
Description: CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function []. This RING domain has also been referred to as DUF902.
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Publication
23934153 | -
First Author: Delvecchio M
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
Volume: 20
Issue: 9
Pages: 1040-6
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Publication
11694877 | J:76593
First Author: Bamforth SD
Year: 2001
Journal: Nat Genet
Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
Volume: 29
Issue: 4
Pages: 469-74
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Publication
35244684 | J:328717
First Author: Lord T
Year: 2022
Journal: Biol Reprod
Title: A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions†.
Volume: 106
Issue: 6
Pages: 1175-1190
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Publication
30274972 | J:268224
First Author: Dominguez PM
Year: 2018
Journal: Cancer Discov
Title: TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Volume: 8
Issue: 12
Pages: 1632-1653
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Publication
18305227 | J:140811
First Author: Zeng Z
Year: 2008
Journal: Biol Reprod
Title: Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9.
Volume: 78
Issue: 6
Pages: 1029-37
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Publication
31915197 | J:285817
First Author: Mondello P
Year: 2020
Journal: Cancer Discov
Title: Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Volume: 10
Issue: 3
Pages: 440-459
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Publication
19794495 | J:186056
First Author: Morinière J
Year: 2009
Journal: Nature
Title: Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.
Volume: 461
Issue: 7264
Pages: 664-8
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Protein
A0A0U1RPL2
Organism: Mus musculus/domesticus
Length: 1107  
Fragment?: true
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Protein
Q6GQV9
Organism: Mus musculus/domesticus
Length: 1589  
Fragment?: true
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Protein
B2RWS6
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
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Protein
Q8QZV8
Organism: Mus musculus/domesticus
Length: 2429  
Fragment?: true
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Protein
A0A0U1RQB6
Organism: Mus musculus/domesticus
Length: 2403  
Fragment?: false
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Protein
F8VPR5
Organism: Mus musculus/domesticus
Length: 2441  
Fragment?: false
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
20412781 | J:140465
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
23806337 | J:203468
First Author: Park J
Year: 2013
Journal: Mol Cell
Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Volume: 50
Issue: 6
Pages: 919-30
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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