Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:6295187 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295983 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior ventral BNST. |
Specimen Label: |
S3a Camk2a + Crh - avBNST |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295187 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295983 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons. |
Specimen Label: |
2a Camk2a + Crh - upper |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295980 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons. |
Specimen Label: |
1c Gad65/67 + Crh - upper |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295980 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior dorsal BNST. |
Specimen Label: |
S3a GAD65/67 + Crh - adBNST |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295980 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior ventral BNST. |
Specimen Label: |
S3a GAD65/67 + Crh - avBNST |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295180 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6296657 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons. |
Specimen Label: |
1c Gad65/67 + Crh - upper |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295180 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6296657 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior dorsal BNST. |
Specimen Label: |
S3a GAD65/67 + Crh - adBNST |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295180 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6296657 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior ventral BNST. |
Specimen Label: |
S3a GAD65/67 + Crh - avBNST |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295184 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295986 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior dorsal BNST. |
Specimen Label: |
S3a Vglut2 + Crh - adBNST |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295184 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295986 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior ventral BNST. |
Specimen Label: |
S3a Vglut2 + Crh - avBNST |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295181 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295984 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior dorsal BNST. |
Specimen Label: |
S3a Vglut1 + Crh - adBNST |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6295181 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-05-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3740728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6295984 |
Age: |
postnatal week 10-14 |
|
Note: |
Expression is present in neurons in the anterior ventral BNST. |
Specimen Label: |
S3a Vglut1 + Crh - avBNST |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galinier A |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The Bacillus subtilis crh gene encodes a HPr-like protein involved in carbon catabolite repression. |
Volume: |
94 |
Issue: |
16 |
Pages: |
8439-44 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Garlow SJ |
Year: |
2005 |
Journal: |
Endocrinology |
Title: |
Genetic analysis of the hypothalamic corticotropin-releasing factor system. |
Volume: |
146 |
Issue: |
5 |
Pages: |
2362-8 |
|
•
•
•
•
•
|
Allele |
Name: |
corticotropin releasing hormone; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
corticotropin releasing hormone; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
corticotropin releasing hormone; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
42
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Seasholtz AF |
Year: |
2002 |
Journal: |
J Endocrinol |
Title: |
Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals. |
Volume: |
175 |
Issue: |
1 |
Pages: |
89-97 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development []. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, J M Friedman |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Timpl P |
Year: |
1998 |
Journal: |
Nat Genet |
Title: |
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. |
Volume: |
19 |
Issue: |
2 |
Pages: |
162-6 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Stevens SL |
Year: |
2003 |
Journal: |
J Cereb Blood Flow Metab |
Title: |
Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1. |
Volume: |
23 |
Issue: |
10 |
Pages: |
1151-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Müller MB |
Year: |
2000 |
Journal: |
Endocrinology |
Title: |
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. |
Volume: |
141 |
Issue: |
11 |
Pages: |
4262-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt MV |
Year: |
2007 |
Journal: |
Brain Res |
Title: |
Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function. |
Volume: |
1174 |
|
Pages: |
1-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt MV |
Year: |
2003 |
Journal: |
Neuroscience |
Title: |
Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. |
Volume: |
119 |
Issue: |
2 |
Pages: |
589-95 |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Deussing |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Kerry J Ressler |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion HS57, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Allele |
Name: |
corticotropin releasing hormone; targeted mutation 1.1, Bernardo Sabatini |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Silberstein S |
Year: |
2009 |
Journal: |
Neuroscience |
Title: |
Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions. |
Volume: |
159 |
Issue: |
2 |
Pages: |
610-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deussing JM |
Year: |
2007 |
Journal: |
J Cereb Blood Flow Metab |
Title: |
Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity. |
Volume: |
27 |
Issue: |
8 |
Pages: |
1476-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanstein R |
Year: |
2008 |
Journal: |
Neuroscience |
Title: |
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. |
Volume: |
156 |
Issue: |
3 |
Pages: |
712-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. |
Volume: |
28 |
Issue: |
11 |
Pages: |
2903-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zimprich A |
Year: |
2014 |
Journal: |
Front Behav Neurosci |
Title: |
A robust and reliable non-invasive test for stress responsivity in mice. |
Volume: |
8 |
|
Pages: |
125 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Z |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Stress-induced glucocorticoid desensitizes adrenoreceptors to gate the neuroendocrine response to somatic stress in male mice. |
Volume: |
41 |
Issue: |
3 |
Pages: |
111509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen C |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine. |
Volume: |
29 |
Issue: |
13 |
Pages: |
4349-4361.e4 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 227.1, Wylie W Vale |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
corticotropin releasing hormone receptor 1; targeted mutation 1, Wolfgang Wurst |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
corticotropin releasing hormone; targeted mutation 1.1, David P Olson |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Allele |
Name: |
insulin receptor substrate 4; targeted mutation 1.1, David P Olson |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Crh/Crh<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Crh-cre)1Kres/? |
Background: |
involves: C57BL/6 * FVB |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Nahar J |
Year: |
2015 |
Journal: |
Endocrinology |
Title: |
Rapid Nongenomic Glucocorticoid Actions in Male Mouse Hypothalamic Neuroendocrine Cells Are Dependent on the Nuclear Glucocorticoid Receptor. |
Volume: |
156 |
Issue: |
8 |
Pages: |
2831-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Molander A |
Year: |
2012 |
Journal: |
Neuropsychopharmacology |
Title: |
Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. |
Volume: |
37 |
Issue: |
4 |
Pages: |
1047-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura M |
Year: |
2010 |
Journal: |
Mol Psychiatry |
Title: |
Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. |
Volume: |
15 |
Issue: |
2 |
Pages: |
154-65 |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Crh)227.1Pbl/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Risbrough VB |
Year: |
2009 |
Journal: |
Neuropsychopharmacology |
Title: |
CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues. |
Volume: |
34 |
Issue: |
6 |
Pages: |
1494-503 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Publication |
First Author: |
Schierloh A |
Year: |
2007 |
Journal: |
Neurosci Lett |
Title: |
Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. |
Volume: |
416 |
Issue: |
1 |
Pages: |
82-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sillaber I |
Year: |
2002 |
Journal: |
Science |
Title: |
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. |
Volume: |
296 |
Issue: |
5569 |
Pages: |
931-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. |
Volume: |
101 |
Issue: |
44 |
Pages: |
15782-7 |
|
•
•
•
•
•
|
Allele |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 353, Elizabeth M Simpson |
Allele Type: |
Targeted |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Crhr1/Crhr1<+> |
Background: |
either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1) |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Crhr1/Crhr1 |
Background: |
either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1) |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Camk2a-cre/ERT2)2Gsc/? |
Background: |
involves: 129S2/SvPas * C57BL/6J * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Crhr1/Crhr1 |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu A |
Year: |
2008 |
Journal: |
Mol Psychiatry |
Title: |
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. |
Volume: |
13 |
Issue: |
11 |
Pages: |
1028-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamprath K |
Year: |
2009 |
Journal: |
Genes Brain Behav |
Title: |
Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. |
Volume: |
8 |
Issue: |
2 |
Pages: |
203-11 |
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Publication |
First Author: |
Slominski A |
Year: |
1996 |
Journal: |
Biochim Biophys Acta |
Title: |
The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin. |
Volume: |
1289 |
Issue: |
2 |
Pages: |
247-51 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
322
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
322
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
329
 |
Fragment?: |
false |
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•
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Publication |
First Author: |
Carpenter B |
Year: |
2012 |
Journal: |
Structure |
Title: |
Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. |
Volume: |
20 |
Issue: |
3 |
Pages: |
487-97 |
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•
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Publication |
First Author: |
Wauman J |
Year: |
2017 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
The Leptin Receptor Complex: Heavier Than Expected? |
Volume: |
8 |
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Pages: |
30 |
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Protein Domain |
Type: |
Domain |
Description: |
This is the immunoglobulin-like domain (IGD) found in leptin receptors (LEP-R), also known as obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity [, ]. |
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Allele |
Name: |
steroidogenic acute regulatory protein; targeted mutation 1, Keith L Parker |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
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•
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HT Experiment |
Series Id: |
GSE33457 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
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Publication |
First Author: |
Giardino L |
Year: |
1996 |
Journal: |
Brain Res Mol Brain Res |
Title: |
CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress. |
Volume: |
40 |
Issue: |
2 |
Pages: |
310-4 |
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•
•
•
•
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Publication |
First Author: |
Gafford GM |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction. |
Volume: |
109 |
Issue: |
40 |
Pages: |
16330-5 |
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•
•
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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Genotype |
Symbol: |
Hprt1/? |
Background: |
B6.Cg-Hprt1 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
•
•
•
|
Genotype |
Symbol: |
Irs4/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
•
•
•
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Publication |
First Author: |
Mann SJ |
Year: |
1972 |
Journal: |
Mouse News Lett |
Title: |
crh. |
Volume: |
47 |
|
Pages: |
64 |
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•
•
•
•
|
Publication |
First Author: |
Ware CB |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis. |
Volume: |
579 |
Issue: |
20 |
Pages: |
4465-9 |
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•
•
•
•
•
|
Publication |
First Author: |
Fenzl T |
Year: |
2009 |
Journal: |
Behav Brain Res |
Title: |
Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system. |
Volume: |
203 |
Issue: |
1 |
Pages: |
143-5 |
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•
•
•
•
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Publication |
First Author: |
Murray SE |
Year: |
2004 |
Journal: |
J Neuroimmunol |
Title: |
Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks. |
Volume: |
156 |
Issue: |
1-2 |
Pages: |
31-41 |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
|
Genotype |
Symbol: |
Star/Star |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Publication |
First Author: |
Wang XD |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. |
Volume: |
31 |
Issue: |
38 |
Pages: |
13625-34 |
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•
•
•
•
•
|
Publication |
First Author: |
Pastor R |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism. |
Volume: |
105 |
Issue: |
26 |
Pages: |
9070-5 |
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•
•
•
•
•
|
Publication |
First Author: |
Hurt RC |
Year: |
2015 |
Journal: |
Genes Brain Behav |
Title: |
Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear. |
Volume: |
14 |
Issue: |
7 |
Pages: |
526-33 |
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•
•
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