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Search results 701 to 800 out of 954 for Crh

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Type Details Score
GXD Expression  
Probe: MGI:6295187
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295983
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior ventral BNST.
Specimen Label: S3a Camk2a + Crh - avBNST
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6295187
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295983
Age: postnatal week 10-14
Note: Expression is present in neurons.
Specimen Label: 2a Camk2a + Crh - upper
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6295179
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295980
Age: postnatal week 10-14
Note: Expression is present in neurons.
Specimen Label: 1c Gad65/67 + Crh - upper
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6295179
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295980
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior dorsal BNST.
Specimen Label: S3a GAD65/67 + Crh - adBNST
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6295179
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295980
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior ventral BNST.
Specimen Label: S3a GAD65/67 + Crh - avBNST
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6295180
Assay Type: RNA in situ
Annotation Date: 2019-05-07
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6296657
Age: postnatal week 10-14
Note: Expression is present in neurons.
Specimen Label: 1c Gad65/67 + Crh - upper
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6295180
Assay Type: RNA in situ
Annotation Date: 2019-05-07
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6296657
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior dorsal BNST.
Specimen Label: S3a GAD65/67 + Crh - adBNST
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6295180
Assay Type: RNA in situ
Annotation Date: 2019-05-07
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6296657
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior ventral BNST.
Specimen Label: S3a GAD65/67 + Crh - avBNST
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6295184
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295986
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior dorsal BNST.
Specimen Label: S3a Vglut2 + Crh - adBNST
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6295184
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295986
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior ventral BNST.
Specimen Label: S3a Vglut2 + Crh - avBNST
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6295181
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295984
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior dorsal BNST.
Specimen Label: S3a Vglut1 + Crh - adBNST
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6295181
Assay Type: RNA in situ
Annotation Date: 2019-05-06
Strength: Present
Sex: Male
Emaps: EMAPS:3740728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6295984
Age: postnatal week 10-14
Note: Expression is present in neurons in the anterior ventral BNST.
Specimen Label: S3a Vglut1 + Crh - avBNST
Detected: true
Specimen Num: 3
Publication
First Author: Galinier A
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The Bacillus subtilis crh gene encodes a HPr-like protein involved in carbon catabolite repression.
Volume: 94
Issue: 16
Pages: 8439-44
GO Term
GO Term
Publication
First Author: Garlow SJ
Year: 2005
Journal: Endocrinology
Title: Genetic analysis of the hypothalamic corticotropin-releasing factor system.
Volume: 146
Issue: 5
Pages: 2362-8
Allele
Name: corticotropin releasing hormone; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: corticotropin releasing hormone; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
GO Term
GO Term
GO Term
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: corticotropin releasing hormone; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
GO Term
GO Term
Protein
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
Publication
First Author: Seasholtz AF
Year: 2002
Journal: J Endocrinol
Title: Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals.
Volume: 175
Issue: 1
Pages: 89-97
Protein Domain
Type: Family
Description: This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development [].
Allele
Name: transgene insertion 1, J M Friedman
Allele Type: Transgenic
Attribute String: Reporter
Publication
First Author: Timpl P
Year: 1998
Journal: Nat Genet
Title: Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Volume: 19
Issue: 2
Pages: 162-6
GO Term
GO Term
Publication
First Author: Stevens SL
Year: 2003
Journal: J Cereb Blood Flow Metab
Title: Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1.
Volume: 23
Issue: 10
Pages: 1151-9
Publication
First Author: Müller MB
Year: 2000
Journal: Endocrinology
Title: Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.
Volume: 141
Issue: 11
Pages: 4262-9
Publication  
First Author: Schmidt MV
Year: 2007
Journal: Brain Res
Title: Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function.
Volume: 1174
Pages: 1-6
Publication
First Author: Schmidt MV
Year: 2003
Journal: Neuroscience
Title: Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice.
Volume: 119
Issue: 2
Pages: 589-95
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Deussing
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
Allele
Name: transgene insertion 1, Kerry J Ressler
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion HS57, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: transgenic, mutant stock
Allele
Name: corticotropin releasing hormone; targeted mutation 1.1, Bernardo Sabatini
Allele Type: Targeted
Attribute String: Recombinase
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Silberstein S
Year: 2009
Journal: Neuroscience
Title: Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.
Volume: 159
Issue: 2
Pages: 610-7
Publication
First Author: Deussing JM
Year: 2007
Journal: J Cereb Blood Flow Metab
Title: Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity.
Volume: 27
Issue: 8
Pages: 1476-95
Publication
First Author: Hanstein R
Year: 2008
Journal: Neuroscience
Title: Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Volume: 156
Issue: 3
Pages: 712-21
Publication
First Author: Chen Y
Year: 2008
Journal: J Neurosci
Title: Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone.
Volume: 28
Issue: 11
Pages: 2903-11
Publication  
First Author: Zimprich A
Year: 2014
Journal: Front Behav Neurosci
Title: A robust and reliable non-invasive test for stress responsivity in mice.
Volume: 8
Pages: 125
Publication
First Author: Jiang Z
Year: 2022
Journal: Cell Rep
Title: Stress-induced glucocorticoid desensitizes adrenoreceptors to gate the neuroendocrine response to somatic stress in male mice.
Volume: 41
Issue: 3
Pages: 111509
Publication
First Author: Chen C
Year: 2019
Journal: Cell Rep
Title: Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine.
Volume: 29
Issue: 13
Pages: 4349-4361.e4
Allele
Name: transgene insertion 227.1, Wylie W Vale
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: corticotropin releasing hormone receptor 1; targeted mutation 1, Wolfgang Wurst
Allele Type: Targeted
Attribute String: Null/knockout
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Allele
Name: corticotropin releasing hormone; targeted mutation 1.1, David P Olson
Allele Type: Targeted
Attribute String: Recombinase
Strain
Attribute String: targeted mutation, mutant strain, congenic
Allele
Name: insulin receptor substrate 4; targeted mutation 1.1, David P Olson
Allele Type: Targeted
Attribute String: Recombinase
Genotype
Symbol: Crh/Crh<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Tg(Crh-cre)1Kres/?
Background: involves: C57BL/6 * FVB
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Nahar J
Year: 2015
Journal: Endocrinology
Title: Rapid Nongenomic Glucocorticoid Actions in Male Mouse Hypothalamic Neuroendocrine Cells Are Dependent on the Nuclear Glucocorticoid Receptor.
Volume: 156
Issue: 8
Pages: 2831-42
Publication
First Author: Molander A
Year: 2012
Journal: Neuropsychopharmacology
Title: Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.
Volume: 37
Issue: 4
Pages: 1047-56
Publication
First Author: Kimura M
Year: 2010
Journal: Mol Psychiatry
Title: Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep.
Volume: 15
Issue: 2
Pages: 154-65
Transgene
Type: transgene
Organism: mouse, laboratory
Genotype
Symbol: Tg(Crh)227.1Pbl/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Risbrough VB
Year: 2009
Journal: Neuropsychopharmacology
Title: CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues.
Volume: 34
Issue: 6
Pages: 1494-503
Strain
Attribute String: targeted mutation, mutant stock
Publication
First Author: Schierloh A
Year: 2007
Journal: Neurosci Lett
Title: Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity.
Volume: 416
Issue: 1
Pages: 82-6
Publication
First Author: Sillaber I
Year: 2002
Journal: Science
Title: Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
Volume: 296
Issue: 5569
Pages: 931-3
Publication
First Author: Chen Y
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.
Volume: 101
Issue: 44
Pages: 15782-7
Allele
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 353, Elizabeth M Simpson
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Genotype
Symbol: Crhr1/Crhr1<+>
Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Crhr1/Crhr1
Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Camk2a-cre/ERT2)2Gsc/?
Background: involves: 129S2/SvPas * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Crhr1/Crhr1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Lu A
Year: 2008
Journal: Mol Psychiatry
Title: Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.
Volume: 13
Issue: 11
Pages: 1028-42
Publication
First Author: Kamprath K
Year: 2009
Journal: Genes Brain Behav
Title: Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling.
Volume: 8
Issue: 2
Pages: 203-11
Publication
First Author: Slominski A
Year: 1996
Journal: Biochim Biophys Acta
Title: The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin.
Volume: 1289
Issue: 2
Pages: 247-51
Protein
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
Publication
First Author: Carpenter B
Year: 2012
Journal: Structure
Title: Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.
Volume: 20
Issue: 3
Pages: 487-97
Publication  
First Author: Wauman J
Year: 2017
Journal: Front Endocrinol (Lausanne)
Title: The Leptin Receptor Complex: Heavier Than Expected?
Volume: 8
Pages: 30
Protein Domain
Type: Domain
Description: This is the immunoglobulin-like domain (IGD) found in leptin receptors (LEP-R), also known as obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity [, ].
Allele
Name: steroidogenic acute regulatory protein; targeted mutation 1, Keith L Parker
Allele Type: Targeted
Attribute String: Null/knockout
HT Experiment
Series Id: GSE33457
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Giardino L
Year: 1996
Journal: Brain Res Mol Brain Res
Title: CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress.
Volume: 40
Issue: 2
Pages: 310-4
Publication
First Author: Gafford GM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction.
Volume: 109
Issue: 40
Pages: 16330-5
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Hprt1/?
Background: B6.Cg-Hprt1
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Irs4/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ot
Has Mutant Allele: true
Publication  
First Author: Mann SJ
Year: 1972
Journal: Mouse News Lett
Title: crh.
Volume: 47
Pages: 64
Publication
First Author: Ware CB
Year: 2005
Journal: FEBS Lett
Title: Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.
Volume: 579
Issue: 20
Pages: 4465-9
Publication
First Author: Fenzl T
Year: 2009
Journal: Behav Brain Res
Title: Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system.
Volume: 203
Issue: 1
Pages: 143-5
Publication
First Author: Murray SE
Year: 2004
Journal: J Neuroimmunol
Title: Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks.
Volume: 156
Issue: 1-2
Pages: 31-41
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Genotype
Symbol: Star/Star
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Wang XD
Year: 2011
Journal: J Neurosci
Title: Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits.
Volume: 31
Issue: 38
Pages: 13625-34
Publication
First Author: Pastor R
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism.
Volume: 105
Issue: 26
Pages: 9070-5
Publication
First Author: Hurt RC
Year: 2015
Journal: Genes Brain Behav
Title: Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear.
Volume: 14
Issue: 7
Pages: 526-33