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Search results 701 to 800 out of 9662 for Egf

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Hits by Strain

Type Details Score
Publication
31676723 | J:298470
First Author: Kefaloyianni E
Year: 2019
Journal: J Am Soc Nephrol
Title: Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis.
Volume: 30
Issue: 12
Pages: 2370-2383
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Publication
10192796 | J:54188
First Author: Wilson SE
Year: 1999
Journal: Exp Eye Res
Title: Expression of HGF, KGF, EGF and receptor messenger RNAs following corneal epithelial wounding.
Volume: 68
Issue: 4
Pages: 377-97
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Publication
11062057 | J:65975
 
First Author: Gilgès D
Year: 2000
Journal: Biochem J
Title: Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domains.
Volume: 352 Pt 1
Pages: 49-59
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Publication
34790090 | J:314727
 
First Author: Simon F
Year: 2021
Journal: Front Neurosci
Title: Implication of Vestibular Hair Cell Loss of Planar Polarity for the Canal and Otolith-Dependent Vestibulo-Ocular Reflexes in Celsr1-/- Mice.
Volume: 15
Pages: 750596
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Protein
Q9JJZ5
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
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Publication
8648630 | -
First Author: Stetefeld J
Year: 1996
Journal: J Mol Biol
Title: Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site.
Volume: 257
Issue: 3
Pages: 644-57
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Publication
8648631 | -
First Author: Baumgartner R
Year: 1996
Journal: J Mol Biol
Title: Structure of the nidogen binding LE module of the laminin gamma1 chain in solution.
Volume: 257
Issue: 3
Pages: 658-68
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Publication
28483977 | J:242688
First Author: Shao Q
Year: 2017
Journal: J Neurosci
Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
Volume: 37
Issue: 23
Pages: 5620-5633
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Protein
A0A5F8MPG7
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: true
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Protein
F8WHT8
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
S4R1A5
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Publication
2404817 | -
First Author: Beck K
Year: 1990
Journal: FASEB J
Title: Structure and function of laminin: anatomy of a multidomain glycoprotein.
Volume: 4
Issue: 2
Pages: 148-60
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Publication
15343335 | J:92659
First Author: Mazelin L
Year: 2004
Journal: Nature
Title: Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.
Volume: 431
Issue: 7004
Pages: 80-4
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Publication
30923634 | -
 
First Author: Bruikman CS
Year: 2019
Journal: J Nucleic Acids
Title: Netrin Family: Role for Protein Isoforms in Cancer.
Volume: 2019
Pages: 3947123
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Publication
23263632 | -
First Author: Aumailley M
Year: 2013
Journal: Cell Adh Migr
Title: The laminin family.
Volume: 7
Issue: 1
Pages: 48-55
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Publication
17174565 | -
First Author: Qin S
Year: 2007
Journal: Mol Cell Neurosci
Title: Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains.
Volume: 34
Issue: 2
Pages: 243-50
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Publication
23263635 | -
First Author: Simon-Assmann P
Year: 2013
Journal: Cell Adh Migr
Title: The laminin family: founding members of the basement membrane.
Volume: 7
Issue: 1
Pages: 44-7
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Publication
30108487 | -
 
First Author: Boyer NP
Year: 2018
Journal: Front Cell Neurosci
Title: Revisiting Netrin-1: One Who Guides (Axons).
Volume: 12
Pages: 221
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Publication
30224412 | J:267476
 
First Author: Kang DS
Year: 2018
Journal: EMBO Rep
Title: Netrin-1/DCC-mediated PLCγ1 activation is required for axon guidance and brain structure development.
Volume: 19
Issue: 11
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Publication
12867435 | -
First Author: Innis CA
Year: 2003
Journal: J Biol Chem
Title: Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding.
Volume: 278
Issue: 41
Pages: 39969-77
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Publication
9501084 | -
First Author: Sasaki T
Year: 1998
Journal: EMBO J
Title: Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin.
Volume: 17
Issue: 6
Pages: 1625-34
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Protein Domain
IPR002049 | LE_dom
Type: Domain
Description: This entry represents the laminin-type EGF-like domain (LE) found in Laminin subunit gamma-1 and Netrin-1 from Homo sapiens and Mus musculus. Laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation [, ]. They are composed of distinct but related alpha, beta and gamma chains that form a cross-shaped molecule consisting of a long arm and three short globular arms. The long arm has a coiled coil structure contributed by all three chains and cross-linked by interchain disulphide bonds [, ]. Beside the different types of globular domains each subunit contains, in its first half, consecutive repeats of about 60 amino acids in length that include eight conserved cysteines []. The tertiary structure of this domain is remotely similar in its N-terminal to that of the EGF-like module [, ](see ). The number of copies of the LE domain in the different forms of laminins is highly variable; from 3 up to 22 copies have been found.A schematic representation of the topology of the four disulphide bonds in the LE domain is shown below.+-------------------++-|-----------+ | +--------+ +-----------------+| | | | | | | |xxCxCxxxxxxxxxxxCxxxxxxxCxxCxxxxxGxxCxxCxxgaagxxxxxxxxxxxCxxsssssssssssssssssssssssssssssssssss'C': conserved cysteine involved in a disulphide bond'a': conserved aromatic residue'G': conserved glycine (lower case = less conserved)'s': region similar to the EGF-like domainLong consecutive arrays of LE domains in laminins form rod-like elements of limited flexibility [], which determine the spacing in the formation of laminin networks of basement membranes [].Netrins control guidance of the central nervous system commissural axons and peripheral motor axons [, , , ]. This protein also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis, thus being involved in tumorigenesis [, ].
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Protein Domain
IPR015369 | Follistatin/Osteonectin_EGF
Type: Domain
Description: This domain is predominantly found in osteonectin and follistatin. They adopt an EGF-like structure [, ]. Follistatin is involved in diverse activities from embryonic development to cell secretion.
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Publication
7618084 | J:26833
First Author: Threadgill DW
Year: 1995
Journal: Science
Title: Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.
Volume: 269
Issue: 5221
Pages: 230-4
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Publication
36323264 | J:331495
First Author: Celen C
Year: 2022
Journal: Cell Rep
Title: Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling.
Volume: 41
Issue: 5
Pages: 111581
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Publication
22975369 | J:192909
First Author: Perera RM
Year: 2012
Journal: Cancer Cell
Title: Ready, set, go: the EGF receptor at the pancreatic cancer starting line.
Volume: 22
Issue: 3
Pages: 281-2
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Protein
Q9R0M0-2
Organism: Mus musculus/domesticus
Length: 2911  
Fragment?: false
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Protein
F7BHW1
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: true
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Protein
A0A0A6YX12
Organism: Mus musculus/domesticus
Length: 472  
Fragment?: true
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Protein
A0A494B905
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
A0A494BA41
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
A0A6I8MX05
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
A0A494BA47
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
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Protein
A0A6I8MX25
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
A0A2I3BQH0
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Publication
22975324 | J:189011
First Author: Hopkins S
Year: 2012
Journal: Dev Cell
Title: Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.
Volume: 23
Issue: 3
Pages: 547-59
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Publication
11839782 | J:74513
First Author: Haugh JM
Year: 2002
Journal: J Cell Sci
Title: Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling.
Volume: 115
Issue: Pt 2
Pages: 303-10
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Protein Coding Gene
MGI:102768 | Mfge8
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
25277 | Mfge8
Type: gene
Organism: rat
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Gene
83465 | Celsr2
Type: gene
Organism: rat
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Gene
309209 | Vwce
Type: gene
Organism: rat
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Gene
300128 | Celsr1
Type: gene
Organism: rat
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Gene
83466 | Celsr3
Type: gene
Organism: rat
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Gene
361341 | Ccbe1
Type: gene
Organism: rat
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Gene
494219 | Eogt
Type: gene
Organism: rat
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Gene
502731 | Vwde
Type: gene
Organism: rat
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Gene
305604 | Efemp1
Type: gene
Organism: rat
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Gene
474604 | EFEMP1
Type: gene
Organism: dog, domestic
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Gene
476020 | EFEMP2
Type: gene
Organism: dog, domestic
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Gene
476635 | CELSR3
Type: gene
Organism: dog, domestic
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Gene
479359 | EGFLAM
Type: gene
Organism: dog, domestic
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Gene
479916 | CELSR2
Type: gene
Organism: dog, domestic
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Gene
481203 | CELSR1
Type: gene
Organism: dog, domestic
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Gene
482323 | VWDE
Type: gene
Organism: dog, domestic
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Gene
483801 | VWCE
Type: gene
Organism: dog, domestic
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Gene
488015 | HEG1
Type: gene
Organism: dog, domestic
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Gene
488730 | MFGE8
Type: gene
Organism: dog, domestic
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Gene
488919 | EDIL3
Type: gene
Organism: dog, domestic
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Gene
494221 | EOGT
Type: gene
Organism: dog, domestic
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Gene
607007 | HBEGF
Type: gene
Organism: dog, domestic
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Gene
609463 | SNED1
Type: gene
Organism: dog, domestic
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Gene
610092 | CCBE1
Type: gene
Organism: dog, domestic
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Gene
610107 | CRELD1
Type: gene
Organism: dog, domestic
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Gene
455449 | CCBE1
Type: gene
Organism: chimpanzee
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Gene
460350 | CELSR3
Type: gene
Organism: chimpanzee
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Gene
460648 | HEG1
Type: gene
Organism: chimpanzee
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Gene
461911 | EGFLAM
Type: gene
Organism: chimpanzee
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Gene
463267 | VWDE
Type: gene
Organism: chimpanzee
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Gene
471489 | EDIL3
Type: gene
Organism: chimpanzee
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Gene
494220 | EOGT
Type: gene
Organism: chimpanzee
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Gene
735979 | HBEGF
Type: gene
Organism: chimpanzee
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Gene
293677 | Efemp2
Type: gene
Organism: rat
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Gene
688400 | Edil3
Type: gene
Organism: rat
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Gene
451233 | VWCE
Type: gene
Organism: chimpanzee
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Gene
451335 | EFEMP2
Type: gene
Organism: chimpanzee
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Gene
453631 | MFGE8
Type: gene
Organism: chimpanzee
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Gene
455416 | EFEMP1
Type: gene
Organism: chimpanzee
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Gene
457086 | CELSR2
Type: gene
Organism: chimpanzee
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Gene
458920 | CELSR1
Type: gene
Organism: chimpanzee
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Gene
458927 | CRELD2
Type: gene
Organism: chimpanzee
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Gene
460160 | CRELD1
Type: gene
Organism: chimpanzee
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Gene
504854 | CRELD1
Type: gene
Organism: cattle
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Gene
508782 | EOGT
Type: gene
Organism: cattle
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Gene
511566 | EFEMP1
Type: gene
Organism: cattle
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Gene
511689 | HEG1
Type: gene
Organism: cattle
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Gene
514207 | SNED1
Type: gene
Organism: cattle
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Gene
515222 | CRELD2
Type: gene
Organism: cattle
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Gene
522422 | CELSR1
Type: gene
Organism: cattle
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Gene
522921 | HBEGF
Type: gene
Organism: cattle
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Gene
523793 | CELSR3
Type: gene
Organism: cattle
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Gene
534427 | EGFLAM
Type: gene
Organism: cattle
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Gene
534569 | CCBE1
Type: gene
Organism: cattle
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Gene
535222 | EFEMP2
Type: gene
Organism: cattle
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Gene
538062 | EDIL3
Type: gene
Organism: cattle
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Gene
538194 | CELSR2
Type: gene
Organism: cattle
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Gene
787487 | VWCE
Type: gene
Organism: cattle
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Gene
100301009 | VWDE
Type: gene
Organism: cattle
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Gene
100611799 | SNED1
Type: gene
Organism: chimpanzee
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Gene
100686873 | CRELD2
Type: gene
Organism: dog, domestic
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Gene
100858613 | CRELD1
Type: gene
Organism: chicken
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom