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Search results 701 to 800 out of 2705 for Foxp3

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Type Details Score
Publication  
First Author: Singh Y
Year: 2015
Journal: Sci Rep
Title: Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells.
Volume: 5
Pages: 17723
Publication
First Author: Procaccini C
Year: 2012
Journal: J Immunol
Title: Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.
Volume: 189
Issue: 6
Pages: 2941-53
Publication
First Author: Procaccini C
Year: 2010
Journal: Immunity
Title: An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.
Volume: 33
Issue: 6
Pages: 929-41
Publication
First Author: Chae WJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis.
Volume: 107
Issue: 12
Pages: 5540-4
Publication
First Author: Rieder SA
Year: 2015
Journal: J Immunol
Title: Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.
Volume: 195
Issue: 2
Pages: 553-63
Publication
First Author: Petermann F
Year: 2010
Journal: Immunity
Title: γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.
Volume: 33
Issue: 3
Pages: 351-63
Publication
First Author: Coombes JL
Year: 2007
Journal: J Exp Med
Title: A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.
Volume: 204
Issue: 8
Pages: 1757-64
Publication
First Author: Mihailovic PM
Year: 2017
Journal: PLoS One
Title: The cathelicidin protein CRAMP is a potential atherosclerosis self-antigen in ApoE(-/-) mice.
Volume: 12
Issue: 11
Pages: e0187432
Publication
First Author: Yokosuka T
Year: 2010
Journal: Immunity
Title: Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.
Volume: 33
Issue: 3
Pages: 326-39
Publication
First Author: Liu Z
Year: 2011
Journal: J Immunol
Title: Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity.
Volume: 187
Issue: 1
Pages: 118-25
Publication
First Author: Tung J
Year: 2013
Journal: J Immunol
Title: Orchestration of CD4 T cell epitope preferences after multipeptide immunization.
Volume: 191
Issue: 2
Pages: 764-72
Publication
First Author: Cheng G
Year: 2013
Journal: J Immunol
Title: IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.
Volume: 190
Issue: 4
Pages: 1567-75
Publication
First Author: Lee JH
Year: 2021
Journal: J Allergy Clin Immunol
Title: The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg cell plasticity.
Volume: 148
Issue: 1
Pages: 209-224.e9
Publication
First Author: Hall JA
Year: 2008
Journal: Immunity
Title: Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.
Volume: 29
Issue: 4
Pages: 637-49
Publication
First Author: Anderson CF
Year: 2007
Journal: J Exp Med
Title: CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis.
Volume: 204
Issue: 2
Pages: 285-97
Publication
First Author: Crother TR
Year: 2011
Journal: PLoS One
Title: Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells.
Volume: 6
Issue: 6
Pages: e20784
Publication
First Author: Atretkhany KN
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity.
Volume: 115
Issue: 51
Pages: 13051-13056
Publication
First Author: Pallotta MT
Year: 2011
Journal: Nat Immunol
Title: Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Volume: 12
Issue: 9
Pages: 870-8
Publication
First Author: Onodera T
Year: 2009
Journal: J Immunol
Title: Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.
Volume: 183
Issue: 9
Pages: 5608-14
Publication
First Author: Mir FA
Year: 2015
Journal: Immunology
Title: Thrombospondin-1-dependent immune regulation by transforming growth factor-β2-exposed antigen-presenting cells.
Volume: 146
Issue: 4
Pages: 547-56
Publication
First Author: Dobenecker MW
Year: 2018
Journal: J Exp Med
Title: Signaling function of PRC2 is essential for TCR-driven T cell responses.
Volume: 215
Issue: 4
Pages: 1101-1113
Publication
First Author: Madireddi S
Year: 2012
Journal: PLoS One
Title: SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
Volume: 7
Issue: 8
Pages: e42459
Publication
First Author: Luu M
Year: 2019
Journal: Nat Commun
Title: The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.
Volume: 10
Issue: 1
Pages: 760
Publication
First Author: Facciotti F
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus.
Volume: 117
Issue: 13
Pages: 7305-7316
Publication
First Author: Ukah TK
Year: 2017
Journal: J Immunol
Title: On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.
Volume: 199
Issue: 3
Pages: 894-902
Publication  
First Author: Edwards CL
Year: 2023
Journal: J Clin Invest
Title: IL-10-producing Th1 cells possess a distinct molecular signature in malaria.
Volume: 133
Issue: 1
Publication
First Author: Kleinschmidt D
Year: 2017
Journal: J Immunol
Title: A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.
Volume: 199
Issue: 12
Pages: 4078-4090
Publication
First Author: Rizzo A
Year: 2018
Journal: Cancer Immunol Res
Title: RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.
Volume: 6
Issue: 9
Pages: 1082-1092
Publication  
First Author: Schmitt EG
Year: 2022
Journal: JCI Insight
Title: A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice.
Volume: 7
Issue: 21
Publication
First Author: Elyaman W
Year: 2007
Journal: J Immunol
Title: JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis.
Volume: 179
Issue: 9
Pages: 5990-8
Publication
First Author: Chen Z
Year: 2013
Journal: Immunity
Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.
Volume: 39
Issue: 2
Pages: 272-85
Publication
First Author: Yang XP
Year: 2011
Journal: Nat Immunol
Title: Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.
Volume: 12
Issue: 3
Pages: 247-54
Publication
First Author: Fontenot JD
Year: 2005
Journal: Immunity
Title: Regulatory T cell lineage specification by the forkhead transcription factor foxp3.
Volume: 22
Issue: 3
Pages: 329-41
Publication
First Author: van der Touw W
Year: 2013
Journal: J Immunol
Title: Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells.
Volume: 190
Issue: 12
Pages: 5921-5
Publication
First Author: Lee JH
Year: 2015
Journal: Immunity
Title: E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.
Volume: 42
Issue: 6
Pages: 1062-74
Publication
First Author: Schuster M
Year: 2017
Journal: J Immunol
Title: c-REL and IκBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.
Volume: 199
Issue: 3
Pages: 920-930
Publication
First Author: Yang XO
Year: 2008
Journal: Immunity
Title: Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.
Volume: 29
Issue: 1
Pages: 44-56
Publication
First Author: Shen E
Year: 2019
Journal: Cell Rep
Title: Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor.
Volume: 29
Issue: 7
Pages: 1848-1861.e6
Publication  
First Author: Wu D
Year: 2017
Journal: Nat Commun
Title: Lkb1 maintains Treg cell lineage identity.
Volume: 8
Pages: 15876
Publication
First Author: Qiao G
Year: 2013
Journal: J Immunol
Title: T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.
Volume: 191
Issue: 2
Pages: 632-9
Publication
First Author: Bilate AM
Year: 2016
Journal: Sci Immunol
Title: Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor.
Volume: 1
Issue: 2
Pages: eaaf7471
Publication
First Author: Curotto de Lafaille MA
Year: 2008
Journal: Immunity
Title: Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation.
Volume: 29
Issue: 1
Pages: 114-26
Publication
First Author: Martinez RJ
Year: 2012
Journal: J Immunol
Title: Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Volume: 188
Issue: 1
Pages: 170-81
Publication
First Author: Josefowicz SZ
Year: 2012
Journal: Nature
Title: Extrathymically generated regulatory T cells control mucosal TH2 inflammation.
Volume: 482
Issue: 7385
Pages: 395-9
Publication
First Author: Yanagi M
Year: 2024
Journal: Commun Biol
Title: Bob1 maintains T follicular helper cells for long-term humoral immunity.
Volume: 7
Issue: 1
Pages: 185
Publication
First Author: Rivas EI
Year: 2011
Journal: J Immunol
Title: Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse.
Volume: 186
Issue: 7
Pages: 4078-87
Publication
First Author: Arthur CM
Year: 2017
Journal: J Immunol
Title: Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion.
Volume: 198
Issue: 7
Pages: 2671-2680
Publication
First Author: Aggarwal NR
Year: 2014
Journal: J Immunol
Title: Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.
Volume: 192
Issue: 9
Pages: 4453-4464
Publication
First Author: Florek M
Year: 2014
Journal: Blood
Title: Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models.
Volume: 124
Issue: 11
Pages: 1832-42
Publication
First Author: Lin KL
Year: 2014
Journal: Blood
Title: Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.
Volume: 123
Issue: 10
Pages: 1604-14
Publication
First Author: Fan Z
Year: 2010
Journal: Nat Med
Title: In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response.
Volume: 16
Issue: 6
Pages: 718-22
Publication
First Author: Montel-Hagen A
Year: 2020
Journal: Cell Rep
Title: In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Volume: 33
Issue: 4
Pages: 108320
Publication  
First Author: Watson HA
Year: 2019
Journal: Front Immunol
Title: L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy.
Volume: 10
Pages: 1321
Publication  
First Author: Rocamora-Reverte L
Year: 2019
Journal: Front Immunol
Title: Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.
Volume: 10
Pages: 472
Publication
First Author: Lobo PI
Year: 2012
Journal: J Immunol
Title: Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17.
Volume: 188
Issue: 4
Pages: 1675-85
Publication    
First Author: Peligero-Cruz C
Year: 2020
Journal: Elife
Title: IL18 signaling promotes homing of mature Tregs into the thymus.
Volume: 9
Publication
First Author: Chougnet CA
Year: 2011
Journal: J Immunol
Title: A major role for Bim in regulatory T cell homeostasis.
Volume: 186
Issue: 1
Pages: 156-63
Publication
First Author: Durham NM
Year: 2014
Journal: PLoS One
Title: Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.
Volume: 9
Issue: 11
Pages: e109080
Publication  
First Author: Pyrillou K
Year: 2024
Journal: JCI Insight
Title: Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.
Volume: 9
Issue: 5
Publication
First Author: Gudi R
Year: 2019
Journal: Immunology
Title: Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes.
Volume: 157
Issue: 1
Pages: 70-85
Publication
First Author: Zarin P
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.
Volume: 120
Issue: 14
Pages: e2221255120
Publication
First Author: Peters A
Year: 2015
Journal: J Clin Invest
Title: Podoplanin negatively regulates CD4+ effector T cell responses.
Volume: 125
Issue: 1
Pages: 129-40
Publication
First Author: Vanderleyden I
Year: 2020
Journal: Cell Rep
Title: Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.
Volume: 30
Issue: 3
Pages: 611-619.e4
Publication  
First Author: Jairaman A
Year: 2021
Journal: Sci Adv
Title: Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4(+) T cell responses.
Volume: 7
Issue: 28
Publication
First Author: Bankoti R
Year: 2017
Journal: Sci Rep
Title: Differential regulation of Effector and Regulatory T cell function by Blimp1.
Volume: 7
Issue: 1
Pages: 12078
Publication
First Author: Hawiger D
Year: 2010
Journal: Nat Immunol
Title: The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.
Volume: 11
Issue: 10
Pages: 962-8
Publication
First Author: Ohsaki A
Year: 2018
Journal: J Exp Med
Title: Maternal IgG immune complexes induce food allergen-specific tolerance in offspring.
Volume: 215
Issue: 1
Pages: 91-113
Publication
First Author: Pastille E
Year: 2014
Journal: Cancer Res
Title: Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer.
Volume: 74
Issue: 16
Pages: 4258-69
Publication
First Author: Abel S
Year: 2012
Journal: J Immunol
Title: Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection.
Volume: 188
Issue: 11
Pages: 5467-77
Publication
First Author: Worthington JJ
Year: 2013
Journal: PLoS Pathog
Title: Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
Volume: 9
Issue: 10
Pages: e1003675
Publication
First Author: Cowan JE
Year: 2016
Journal: Cell Rep
Title: CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Volume: 14
Issue: 5
Pages: 1041-1048
Publication
First Author: Mathies F
Year: 2018
Journal: J Immunol
Title: Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells.
Volume: 201
Issue: 12
Pages: 3558-3568
Publication
First Author: Moreno Ayala MA
Year: 2023
Journal: Immunity
Title: CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8(+) T cell antitumor immunity.
Volume: 56
Issue: 7
Pages: 1613-1630.e5
Publication  
First Author: Kim V
Year: 2022
Journal: JCI Insight
Title: IL-17-producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice.
Volume: 7
Issue: 11
Publication
First Author: Wachsmuth LP
Year: 2019
Journal: J Clin Invest
Title: Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.
Volume: 129
Issue: 6
Pages: 2357-2373
Publication
First Author: Clement RL
Year: 2019
Journal: Nat Immunol
Title: Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.
Volume: 20
Issue: 10
Pages: 1360-1371
Publication  
First Author: Klaus T
Year: 2022
Journal: JCI Insight
Title: Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1.
Volume: 7
Issue: 24
Publication
First Author: Wing JB
Year: 2014
Journal: Immunity
Title: Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.
Volume: 41
Issue: 6
Pages: 1013-25
Publication
First Author: Kim D
Year: 2020
Journal: Immunity
Title: Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Volume: 53
Issue: 3
Pages: 581-596.e5
Publication
First Author: Severance AL
Year: 2022
Journal: iScience
Title: Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.
Volume: 25
Issue: 6
Pages: 104400
Publication
First Author: Glatman Zaretsky A
Year: 2017
Journal: Cell Rep
Title: T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.
Volume: 18
Issue: 8
Pages: 1906-1916
Publication
First Author: Delacher M
Year: 2019
Journal: Nat Commun
Title: Rbpj expression in regulatory T cells is critical for restraining TH2 responses.
Volume: 10
Issue: 1
Pages: 1621
Publication
First Author: Mathur AN
Year: 2019
Journal: Immunity
Title: Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.
Volume: 50
Issue: 3
Pages: 655-667.e4
Publication
First Author: Ehrentraut H
Year: 2012
Journal: PLoS One
Title: Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation.
Volume: 7
Issue: 2
Pages: e32416
Publication
First Author: Li C
Year: 2018
Journal: Cell
Title: TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype.
Volume: 174
Issue: 2
Pages: 285-299.e12
Publication
First Author: Jacobse J
Year: 2023
Journal: Cell Rep
Title: Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells.
Volume: 42
Issue: 2
Pages: 112128
Publication
First Author: Ikeda K
Year: 2017
Journal: Cell Rep
Title: Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.
Volume: 21
Issue: 7
Pages: 1824-1838
Publication  
First Author: Lantz BJ
Year: 2023
Journal: Front Physiol
Title: Chronic hypoxia disrupts T regulatory cell phenotype contributing to the emergence of exTreg-T(H)17 cells.
Volume: 14
Pages: 1304732
Publication
First Author: Liu Y
Year: 2019
Journal: Cell Death Differ
Title: Requirement for POH1 in differentiation and maintenance of regulatory T cells.
Volume: 26
Issue: 4
Pages: 751-762
Publication
First Author: Zhang Z
Year: 2020
Journal: Eur J Immunol
Title: Opposing peripheral fates of tissue-restricted self antigen-specific conventional and regulatory CD4+ T cells.
Volume: 50
Issue: 1
Pages: 63-72
Publication
First Author: Zinzow-Kramer WM
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Adaptation by naïve CD4(+) T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance.
Volume: 116
Issue: 30
Pages: 15160-15169
Publication
First Author: Safavi F
Year: 2015
Journal: Immunol Res
Title: c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis.
Volume: 61
Issue: 3
Pages: 294-302
Publication
First Author: Skuljec J
Year: 2016
Journal: Eur J Immunol
Title: Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice.
Volume: 46
Issue: 7
Pages: 1656-68
Publication
First Author: Luo CT
Year: 2016
Journal: Nature
Title: Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.
Volume: 529
Issue: 7587
Pages: 532-6
Publication
First Author: Kang J
Year: 2008
Journal: J Leukoc Biol
Title: De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.
Volume: 83
Issue: 5
Pages: 1230-9
Publication
First Author: Tauro S
Year: 2013
Journal: Eur J Immunol
Title: Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.
Volume: 43
Issue: 5
Pages: 1195-207
Publication
First Author: Jin HS
Year: 2013
Journal: J Clin Invest
Title: Itch expression by Treg cells controls Th2 inflammatory responses.
Volume: 123
Issue: 11
Pages: 4923-34
Publication
First Author: Gaspal F
Year: 2011
Journal: J Exp Med
Title: Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.
Volume: 208
Issue: 8
Pages: 1579-84
Publication
First Author: Chai JG
Year: 2008
Journal: J Immunol
Title: In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells.
Volume: 180
Issue: 2
Pages: 858-69
Publication
First Author: Addey C
Year: 2011
Journal: J Immunol
Title: Functional plasticity of antigen-specific regulatory T cells in context of tumor.
Volume: 186
Issue: 8
Pages: 4557-64